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| Application No. | Application Title | Issue Date |
| 20120108669 | METHOD OF TREATING SLEEP DISORDERS USING EPLIVANSERIN Method for treating sleep disorders by using eplivanserin Method of providing eplivanserin. Method of managing the risk to allow an effective and safe use of eplivanserin Method of promoting the use of eplivanserin. Article of manufacture and package.... | 05/03/2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120046255 | NON-STEROIDAL COMPOUNDS The present invention relates to non-steroidal compounds useful in the treatment of inflammatory conditions and pharmaceutical compositions comprising them. A representative example of these compounds is ... | 02/23/2012 |
| 20110288101 | SURGICAL COMPOSITIONS CONTAINING SIGMA-RECEPTOR AGONISTS One aspect of the present invention relates to aqueous surgical compositions comprising a sigma-1 receptor agonist. Another aspect of the present invention relates to methods of irrigating ocular tissues during an ophthalmic surgical procedure such as cataract surgery. ... | 11/24/2011 |
| 20110275680 | NOXEL OXIME DERIVATIVES OF 3, 5-SECO-4-NOR-CHOLESTANE, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHOD FOR PREPARING SAME The invention relates to novel chemical compounds, in particular oxime derivatives of 3,5-seco-4-nor-cholestane, to the application thereof as drugs, in particular cytoprotective drugs, and more particularly as neuroprotective, cardioprotective and/or hepatoprotective d... | 11/10/2011 |
| 20110263567 | COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting semicarbazide-sensitive amine oxidase (SSAO), also known as vascular adhesion protein-1 ... | 10/27/2011 |
| 20110230428 | CERTAIN KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF Certain chemical entities are provided herein. Pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibitio... | 09/22/2011 |
| 20110136840 | ANTI-INFECTIVE AGENTS The present invention relates to the use of molecules having a spacer unit, linker and recognition unit(s) for the treatment and prevention of various diseases, disorders and conditions. In particular, the present invention provides compounds useful in preventing or tre... | 06/09/2011 |
| 20110039818 | Dosage regimen of an S1P receptor agonist S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.... | 02/17/2011 |
| 20110028453 | Treating Negative Symptoms of Schizophrenia Associated with Defective Neuregulin 1 Use of a compound that is a serotonin transporter inhibitor, a selective norepinephrine reuptake inhibitor, or a 5-HT1A agonist for alleviating negative symptoms in a schizophrenia patient who carries a defective neuregulin 1 gene.... | 02/03/2011 |
| 20110021499 | URETHRAL SUPPOSITORIES FOR OVERACTIVE BLADDER Urethral suppositories containing a mixed-activity anti-cholinergic drug and methods of use for treatment of over-active bladder are provided. Buffering drugs to pH near their pKas can result in a desired proportion of uncharged drug and can enhance absorption of the ag... | 01/27/2011 |
| 20100305095 | Use of HPPD Inhibitors in the Treatment of Depression and/or Withdrawal Symptoms Associated with Addictive Drugs The present invention relates to, inter alia, the use of a compound capable of inhibiting 4-hydroxyphenylpyruvate dioxygenase (HPPD) in an animal in the manufacture of a medicament for use in the treatment and/or prevention of depression. The invention also provides for... | 12/02/2010 |
| 20100292237 | Method for Combating Phytopathogenic Fungi The present invention relates to the use of an active compound that inhibits the mitochondrial breathing chain at the level of the b/c1 complex for combating phytopathogenic fungi.... | 11/18/2010 |
| 20100273801 | BETULIN DERIVED COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.... | 10/28/2010 |
| 20100267837 | USE OF AT LEAST ONE OXIME DERIVATIVE OF 3,5-SECO-4-NOR-CHOLESTANE AS ANTIOXIDANTS The invention relates to the use of at least one oxime derivative of 3,5-seco-4-norcholestane as antioxidants in the cosmetics and food fields, and as antioxidant preservatives that can be used, in particular, in cosmetic, food and pharmaceutical products.... | 10/21/2010 |
| 20100234349 | PHARMACEUTICAL COMBINATIONS OF A NICOTINE RECEPTOR MODULATOR AND A COGNITIVE ENHANCER This invention relates to novel pharmaceutical compositions comprising therapeutically effective combination of a positive allosteric modulator of nicotine receptors; and a cognitive enhancer selected from the group consisting of a nicotine acetylcholine receptor agonis... | 09/16/2010 |
| 20100210524 | NOVEL ESTROGEN RECEPTOR LIGANDS The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of such an ester or amide, and a solvate of such an ester, amide or salt, wherein W, X, Y, Z, R1, R2, R7<... | 08/19/2010 |
| 20100192945 | Inhalation devices and related methods for administration of sedative hypnotic compounds An inhalation device for administering one or more sedatives via pulmonary delivery for treating a sleep disturbance.... | 08/05/2010 |
| 20100093805 | METHOD OF TREATING AMBLYOPIA The present invention relates to a method of treating or alleviating the symptoms of amblyopia. It is based on the discovery that repeated administration of a specific drug, which is known to be clinically active to treat depression in humans, results in improved vision... | 04/15/2010 |
| 20100092454 | NOVEL USE OF ANTIDEPRESSANT COMPOUNDS AND RELATED COMPOSITIONS What is described is a use of an antidepressant compound, preferably belonging to the class of selective serotonin reuptake inhibitors (SSRI), for regenerating the integumentary system and/or for stimulating the growth, the original trophism and/or original pigmentation... | 04/15/2010 |
| 20100076009 | Adjuvant Chemotherapy For Anaplastic Gliomas The present invention involves the use of 2,4-disulfonyl phenyl tert-butyl nitrone (2,4-ds-PBN) in the treatment and prevention of gliomas. The 2,4-ds-PBN may be used alone or combined with other traditional chemo- and radiotherapies and surgery, to treat or prevent gli... | 03/25/2010 |
| 20100069423 | Use of Chk2 Kinase Inhibitors for Cancer Treatment Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.... | 03/18/2010 |
| 20100022458 | METHODS FOR TREATING ACUTE ACOUSTIC TRAUMA The current invention provides methods and compositions for treating sensorineural hearing loss including but not limited to acute acoustic trauma (AAT). The composition includes compounds which function as free radical traps such as phenyl butyl nitrone (PBN), free rad... | 01/28/2010 |
| 20100010084 | HIGH PENETRATION PRODRUG COMPOSITIONS OF RETINOIDS AND RETINOID-RELATED COMPOUNDS The invention provides compositions of novel high penetration compositions (HPC) or high penetration prodrugs (HPP) of retinoids and retinoid-related compounds, which are capable of crossing biological barriers with high penetration efficiency. The HPPs are capable of b... | 01/14/2010 |
| 20090312434 | USE OF 3,5-SECO-4-NOR-CHOLESTANE DERIVATIVES FOR OBTAINING A CYTOPROTECTIVE DRUG The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or hepatoprotective drug.... | 12/17/2009 |
| 20090306060 | METHOD FOR IMPROVING SEED LOT QUALITY The present invention relates to a method for improving seed lot quality, seed shelf life, and seed lot retention, comprising applying to a seed within the seed lot an effective amount of a strobilurin fungicide alone, or in combination with at least one additional fung... | 12/10/2009 |
| 20090233917 | Stroke recovery The present invention provides methods of treating stroke comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. The invention also provides pharmaceutical compositions comprising a certain hydroxyl... | 09/17/2009 |
| 20090227572 | TREATMENT OF DIABETIC WOUNDS AND PERIPHERAL NEUROPATHIES The present invention provides methods of enhancing healing of wound associated with diabetes, comprising administering an effective amount of one or more of certain hydroxylamine derivatives to a subject in need thereof. In another aspect, the instant invention provide... | 09/10/2009 |
| 20090221596 | Substtituted aryl oximes The invention relates to compounds of the formula (I) in which | 09/03/2009 |
| 20090192166 | METHOD FOR AUGMENTING THE EFFECTS OF SEROTONIN REUPTAKE INHIBITORS A method of treating a subject for a serotonergic neurotransmission dysregulation disorder, comprises administering the subject a serotonin enhancer (e.g., a serotonin reuptake inhibitor) in an amount effective to treat the disorder; and concurrently administering the s... | 07/30/2009 |
| 20090175882 | METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA This invention provides compounds which specifically inhibit TRPA1 but not other members of the thermoTRP ion channel family. Also provided in the invention are methods of using TRPA1-specific inhibitors to treat or alleviate pains mediated by noxious mechanosensation.... | 07/09/2009 |
| 20090176883 | TRPA1 Antagonists Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating c... | 07/09/2009 |
| 20090092642 | Skin and/or Hair Products, Containing Compounds With an Isoprenoid Structure A composition of matter that is suitable for use on skin or hair. The composition comprises one or more compounds of formula wherein Rx, Ry, R3 and R5 are as defined in the specification... | 04/09/2009 |
| 20090036501 | 2-Cyclopenten-1-One Oxime Derivatives Inhibiting Production of TNF-Alpha 2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-α or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-α or PDE4.... | 02/05/2009 |
| 20080275130 | Novel Derivatives of 3.5-Seco-4-Norcholestane and Use Thereof The invention relates to compounds of formula (I): where X+Y=keto, or X=OH and Y=H, or X+Y=oxime or methyloxime, B=OH and C+D=H, or C+D=C1-C4 linear or branched alkyl, or C=H and D=C1-C4 linear or branched alkyl, or B+C=keto and D=methyl, hydroxyl, or methylamino, or B ... | 11/06/2008 |
| 20080227813 | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration The present invention relates to methods for treating diseases, conditions or disorders using hydroxyamine compounds, and in particular, N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride (Compound I) alone or in combination with one or mo... | 09/18/2008 |
| 20080221220 | 2',4'-DICHLORO-BIPHENYL-4-YL-HYDROXY-KETONES AND RELATED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 2′,4′-dichloro-biphenyl-4-yl-hydroxy-ketones and related compounds (collectively referred to herein as “DCBP compounds”), and more particularly to co... | 09/11/2008 |
| 20080200525 | PESTICIDALLY ACTIVE KETONE AND OXIME DERIVATIVES Compounds of formula
| 08/21/2008 |
| 20080182804 | CYANOOXIME INHIBITORS OF CARBONYL REDUCTASE AND METHODS OF USING SAID INHIBITORS IN TREATMENTS INVOLVING ANTHRACYCLINES Compositions of matter and methods of treating cancer patients are used to prevent or limit cardiotoxicity during or after cancer treatment with anthracycline drugs, and to prevent or lower resistance to anthracycline drugs, both of which are believed to be caused by th... | 07/31/2008 |
| 20080161406 | Novel formulations of alpha-2,4-disulfophenyl-N-tert-butylnitrone Novel pharmaceutical formulations of α-(2,4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof and the use of such formulations in the treatment of various diseases and conditions, especially stroke, are disclosed.... | 07/03/2008 |
