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A vest or belt is integrally formed with tubular, pet receiving passageways which extend around the wearer's body and terminate in pocket-like chambers for feeding and retrieval.
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| Application No. | Application Title | Issue Date |
| 20120129806 | ARGINASE INHIBITORS AS THERAPEUTICS Compounds according to Formula I are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, D, W, X, Y, and Z are defined in the specification. The ... | 05/24/2012 |
| 20120128662 | SUBSTITUTED IMIDAZOQUINOXALINES The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer. ... | 05/24/2012 |
| 20120129807 | METHODS OF TREATMENT, IMPROVEMENT AND PREVENTION USING HALOARYL SUBSTITUTED AMINOPURINES Provided herein are Aminopurine Compounds having the following structure: wherein R1, R2 and R3 are as defined herein, compositions comprising an effective amount of an Aminop... | 05/24/2012 |
| 20120107307 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.... | 05/03/2012 |
| 20120083469 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity:
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| 20120071445 | Combination Therapy for the Treatment of Multiple Myeloma The present invention provides a method for treating multiple myeloma in a subject, comprising the step of administering to the subject a combination of COMPOUND 1 and bortezomib. The invention further provides a method for treating multiple myeloma in a subject, compri... | 03/22/2012 |
| 20120052025 | BORINIC COMPOSITIONS A stabilized topical composition comprising a borinic acid derivative, e.g., a borinic ester.... | 03/01/2012 |
| 20120046242 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compou... | 02/23/2012 |
| 20120045519 | USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of deoxyelephantopin or an analogue thereof; and a pharmaceutically acceptable carrier... | 02/23/2012 |
| 20120046243 | Aminopyridine- and Aminopyrimidinecarboxamides as CXCR2 Modulators There is disclosed aminopyridine-and aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyridine- and aminopyrimidinecarboxamides compounds. More specifically, there is disclosed ... | 02/23/2012 |
| 20120040904 | Boronate Medicaments for Preventing Thrombosis During Surgery The use for the manufacture of a medicament for preventing unwanted coagulation during surgery, and particularly a Coronary Artery By pass Graft (CABG) procedure, of boronic acids of formula (I), and salts, prodrugs and prodrug salts thereof; wherein Y comprises a moiet... | 02/16/2012 |
| 20120039805 | Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial; lymphomas, sarcomas, melanomas, and the li... | 02/16/2012 |
| 20120040933 | 9-(PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including neurodegenerative disorders, diseases associated with polyglutamine tracts, epilepsy,... | 02/16/2012 |
| 20120042398 | COMPOSITIONS FOR LABELING AND IDENTIFYING AUTOPHAGOSOMES AND METHODS FOR MAKING AND USING THEM The invention provides methods and compositions for detecting and measuring the amount of autophagosomes in cells or tissues, including biopsy samples, in vitro, in situ and/or in vivo. By detecting and measuring the amount of autophagosomes in cells or tissues, the met... | 02/16/2012 |
| 20120040932 | CYCLIC BORONIC ACID ESTER DERIVATIVES AND THERAPEUTIC USES THEREOF Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to 1 cyclic boronic acid ester derivatives and their use as therapeutic agents.... | 02/16/2012 |
| 20120035133 | Lyophilization Cakes of Proteasome Inhibitors Lyophilized cakes of proteasome inhibitors are described, as well as methods for their production and use.... | 02/09/2012 |
| 20120035132 | BORON-CONTAINING SMALL MOLECULES Compounds, pharmaceutical formulations, and methods of treating anti-inflammatory conditions and/or helminth-associated diseases are disclosed.... | 02/09/2012 |
| 20120015906 | USES OF BORTEZOMIB IN PREDICTING SURVIVAL IN MULTIPLE MYELOMA PATIENTS The present invention provides a method of predicting outcome of treatment for multiple myeloma based on determining certain cytogenetic anomalies and considering gene expression profiling risks. Also provided are statistical methods employed to define variables indepen... | 01/19/2012 |
| 20120004197 | PROPHYLACTIC AND/OR THERAPEUTIC AGENT FOR ANEMIA COMPRISING TETRAHYDROQUINOLINE COMPOUND AS ACTIVE INGREDIENT Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer co... | 01/05/2012 |
| 20110319361 | BORON-CONTAINING SMALL MOLECULES This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the c... | 12/29/2011 |
| 20110319360 | Method of including apoptosis/Cell death in leukemia cell using a purine nucleoside analogue A method of inducing apoptosis or cell death in a leukemia cell includes subjecting the cell to a purine nucleotide analogue, LMP-420 (2-amino-6-chloro-9-[5(dihydroxyboryl)-pentyl] purine).... | 12/29/2011 |
| 20110311624 | FORMULATIONS OF HISTONE DEACETYLASE INHIBITOR AND USES THEREOF Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.... | 12/22/2011 |
| 20110306560 | BORONIC ESTER AND ACID COMPOUNDS, SYNTHESIS AND USES Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and use... | 12/15/2011 |
| 20110305632 | PROCESS FOR THE PREPARATION OF ASYMMETRICAL BIS(THIOSEMICARBAZONES) The present invention relates to a method of making asymmetrical bis(thiosemicarbazones), compounds useful as synthetic intermediates in the method, new bis(thiosemicarbazones) that can be readily accessed by use of the method and methods of treatment and imaging utilis... | 12/15/2011 |
| 20110300137 | Use of lumefantrine and related compounds in the treatment of cancer The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.... | 12/08/2011 |
| 20110301124 | PROTEASOME INHIBITORS The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.... | 12/08/2011 |
| 20110294717 | Therapeutic Polymeric Nanoparticle Compositions with High Glass Transition Temperature or High Molecular Weight Copolymers The present disclosure relates in part to pharmaceutical compositions comprising polymeric nanoparticles having certain glass transition temperatures. Other aspects of the invention include methods of making such nanoparticles.... | 12/01/2011 |
| 20110288052 | NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME The class compounds of the present invention may be represented by Formula (I), wherein X may be O, S, or N. R1 and R2 are independently either H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. R3 11/24/2011 | |
| 20110275597 | PHARMACEUTICAL COMPOSITION The present invention relates to a parenteral pharmaceutical composition comprising therapeutically effective amounts of N-(2-pyrazine)carbonyl-L-phenylalanine-L-leucine boronic acid or its salts or its derivatives and tromethamine wherein the composition is stable.... | 11/10/2011 |
| 20110275596 | METHODS FOR TREATING NEOPLASIA AND FOR IDENTIFYING COMPOSITIONS USEFUL IN SUCH THERAPY Various methods for treating a patient with neoplasia are disclosed, in particular, methods using topoisomerase Ila-preferential poisons, methods using a combination of a topoisomerase Illi-preferential inhibitor and a topoisomerase II poison, and methods using a combin... | 11/10/2011 |
| 20110269715 | ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular hypertension of a compound of formula I | 11/03/2011 |
| 20110268769 | DRUG DELIVERY VEHICLE FOR CANCER THERAPY, PROCESS FOR PRODUCING THE SAME, AND PHARMACEUTICAL PREPARATION USING THE SAME The invention provides a vehicle that can deliver drugs specifically to the body and a pharmaceutical preparation using the same. Disclosed is a drug delivery vehicle for cancer therapy, comprising a cationized viral envelope vector, as well as a pharmaceutical preparat... | 11/03/2011 |
| 20110263519 | REGULATORS OF THE HEDGEHOG PATHWAY, COMPOSITIONS AND USES RELATED THERETO The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, suc... | 10/27/2011 |
| 20110263530 | Aurora Kinase Modulators and Method of Use The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4... | 10/27/2011 |
| 20110245203 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.... | 10/06/2011 |
| 20110236471 | PLATINUM COMPLEXES AND METHODS FOR INHIBITING TUMOR CELL PROLIFERATION The subject invention concerns platinum complexes that exhibit antitumor cell and/or antiparasitic activity. The subject invention also concerns the use of platinum complexes of the invention to treat oncological and inflammatory disorders. The platinum complexes of the... | 09/29/2011 |
| 20110237547 | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF FUNGAL INFECTIONS Synergistic combinations of a squalene epoxidase inhibitor and a leucyl-tRNA synthetase inhibitor are provided, which are useful in particular in the treatment of diseases involving fungal or suspected fungal infection, for immunomodulation or immunosuppression in condi... | 09/29/2011 |
| 20110230442 | NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [... | 09/22/2011 |
| 20110230441 | STABLE BORTEZOMIB FORMULATIONS Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly compri... | 09/22/2011 |
| 20110230440 | INHIBITORS OF FATTY ACID AMIDE HYDROLASE The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated dise... | 09/22/2011 |
