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Class 514/632 - Amidino hydrazines or hydrazones (i.e., N-N=C-N or N=C-N-N)


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter including a compound which is an amidino
No. of applications: 41
Last issue date: 05/03/2012


1    
Application No.Application TitleIssue Date
20120108668METABOLIC PROFILES
The invention relates to the use of endogenous metabolites to produce a metabolic profile of a disorder or disease in a subject, e.g. an autoimmune disease, in particular rheumatoid arthritis, and the analysis of such metabolic profiles in order to find disturbances in ...
05/03/2012
20120022166Methods for Modulating Macrophage Proliferation Using Polyamine Analogs
Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated in a...
01/26/2012
20110172258INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS
Compounds of formula (Ia):

    • wherein R1, R2, R3, R4a...
07/14/2011
20110144043Stat modulators
The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for treating and/or preventing disorders characterized by Stat dysregulation, such...
06/16/2011
20110112199PHARMACEUTICAL FOR ORAL DELIVERY COMPRISING MGBG AND METHODS OF TREATING DISEASE
Disclosed herein are new oral pharmaceutical compositions of MGBG and related polyamine analogs, polyamine biosynthesis inhibitors, polyamine inhibitors of AMD-I and regulators of osteopontin, and their application for the treatment of disease....
05/12/2011
20110091418METHODS FOR TREATING VIRAL INFECTIONS USING POLYAMINE ANALOGS
Methods for treating viral infections using polyamine analogs, including mitoguazone (MGBG), are provided. In these methods, polyamine analogs destroy macrophages that act as viral reservoirs, facilitating the destruction of the viruses that dwell within the macrophages...
04/21/2011
20100285032ESTROGEN RECEPTOR-RELATED RECEPTOR GAMMA (ERR GAMMA) IN BONE AND CARTILAGE FORMATION AND METHODS AND COMPOSITIONS RELATING TO SAME
ERRγ is expressed in bone and cartilage in vivo and osteoblastic and chondrocytic cells in vitro. ERRγ is a transcriptional activator of an osteoblast-associated osteopontin (OPN) and chondrocyte-associated (Sox9) gene in osteoblasts and chondrocytes respectively. Kno...
11/11/2010
20100196286INHALATION DELIVERY METHODS AND DEVICES
Methods, devices and kits for treating sleep disorders, anxiety disorders, and developmental disorders, and/or for inducing an arousable state of sedation in a subject, are described. For example, inhalation methods, devices and kits for treating insomnia, anxiety and/o...
08/05/2010
20100179225POI Prevention
A method is provided, comprising administering at least one guanylhydrazone or salt thereof or a combination thereof to a subject to prevent or ameliorate in said subject at least one of postoperative intestinal inflammation, postoperative ileus, ischemia reperfusion in...
07/15/2010
20100160332a2-Adrenoceptor Ligands
The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into α and β subclasses. The adrenoceptors have important roles in regulating a myriad of physiological conditions and their malfunction has been implicated in the pathophysiol...
06/24/2010
20100152220INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS
Compounds of formula (Ia):

    • wherein R1, R2, R3, R4a...
06/17/2010
20100152299Process for making compositions with poorly compressible therapeutic compounds
A process for preparing solid dosage forms that contain poorly compressible therapeutic compound. The process, for example, provides for the inventive use of an extruder, especially a twin screw extruder, to melt granulate a therapeutic compound(s) with a granulation ex...
06/17/2010
20100081661HEME OXYGENASE INHIBITORS, SCREENING METHODS FOR HEME OXYGENASE INHIBITORS AND METHODS OF USE OF HEME OXYGENASE INHIBITORS FOR ANTIMICROBIAL THERAPY
Inhibitors of microbial heme oxygenase and their use for treatment of microbial infections and bioremediation. The inhibitors of microbial heme oxygenase are useful against a new class of antimicrobial agents to target infections that are persistently difficult to comba...
04/01/2010
20100069423Use of Chk2 Kinase Inhibitors for Cancer Treatment
Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof....
03/18/2010
20100055086Antimicrobial Flush Solutions
The present invention provides antimicrobial solutions that comprise at least one alcohol, at least one antimicrobial agent and at least one chelator and/or anticoagulant. Also provided are methods for rapidly reducing a microbe or a virus from surfaces including surfac...
03/04/2010
20100029725RESISTANCE MANAGEMENT STRATEGIES
Insect refuge strategies are described for the management of insect resistance development. The present invention relates generally to the control of pests that cause damage to crop plants, and in particular to corn plants, by their feeding activities directed to root d...
02/04/2010
20100029773Systematic identification of new anti-prion drugs by high-throughput screening based on scanning for intensely fluorescent targets (sift)
The present invention relates to a method of identifying a compound for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases, comprising the steps of: (a) bringing into contact a labeled monomeric protei...
02/04/2010
20090324580Use of Inhibitors of Scavenger Receptor Class Proteins for the Treatment of Infectious Diseases
The present invention relates to the use of inhibitors of scavenger receptor class proteins, in particular ScarB1 for the production of a medicament for treatment of and/or prophylaxis against infections, involving liver cells and/or hematopoietic cells, in particular m...
12/31/2009
20090298902PESTICIDE COMPOSITIONS FOR COMBATING ARTHROPOD PESTS, SNAILS AND NEMATODES
The present invention relates to a pesticide composition in the form of a water absorbent granular material and to the use of such compositions for combating arthropod pests, in particular soil-living arthropod pests, and nematodes, with particular preference given to s...
12/03/2009
20090239817ORGANIC THIOPHOSPHATE ANTIRETROVIRAL AGENTS
A method for the prevention or treatment of human immunodeficiency virus infection by administering an effective amount of amifostine, phosphonol, or similar compound to an individual in need is provided....
09/24/2009
20090036540Guanylhydrazones in Methods of Treatment or Diagnosis as Modulators of Signal Transduction
A method is provided for the treatment of a condition mediated by raf kinase, which includes administering a guanylhydrazone to a subject in need thereof. A method is also provided, which includes modulating or inhibiting signal transduction in a c-raf pathway with at l...
02/05/2009
20090018201Method of Combating Bugs
A method of combating bugs comprising contacting the bugs or their food supply, habitat, breeding grounds or their locus with a pesticidally effective amount of a compound of the formula (I) wherein W is Cl or CF3; X and Y are each independently Cl or Br; R
01/15/2009
20080300313Solvent Mixture for Preparing Water-Dilutable Liquid Concentrate Formulation of Organic Pesticide Compounds
The present invention relates to a solvent mixture SM for preparing a water-dilutable liquid concentrate formulation of sparingly soluble organic pesticide compounds C having a water solubilty of not more than 5 g/l at 25° C./1013 mbar. The present invention also relat...
12/04/2008
20080275129Methods and Pharmaceutical Compositions for the Treatment of Neurological Damage
The invention relates to a method of treating neurological damage, preferably spinal chord injury, said treatment comprising the topical administration of guanabenz. The invention also relates to the use of guanabenz for the preparation of a medicament for the treatment...
11/06/2008
20080262092REGULATION OF OSTEOPONTIN
The present invention provides methods for the regulation of osteopontin activity in a subject as well as for treating or preventing conditions associated with an increased activity of osteopontin activity in a subject....
10/23/2008
20080199606Composition for the Impregnation of Fibers, Fabrics and Nettings Imparting a Protective Activity Against Pests
Insecticide composition for application to a non-living material, which insecticide composition comprises a mixture including at least one N-arylhydrazine derivative, and at least one polymeric binder; an impregnated non-living material comprising at least one N-arylhyd...
08/21/2008
20080194641Pesticidal Mixtures
Pesticidal mixtures comprising, as active components 1) a compound of the formula I wherein W is CI or CF3; X and Y are each independently CI or Br; R1 is alkyl, alkenyl, alkynyl, or cycloalkyl optionally substituted with 1 to 3 halogens, or alkyl ...
08/14/2008
20080181946Controlled Release Delivery System For Metformin
The invention relates to a controlled release delivery system for Metformin comprising of (a) therapeutically effective amount of Metformin or pharmaceutically acceptable salts there of; (b) hydrophilic polymers and (c) hydrophobic lubricating agent(s). The invention al...
07/31/2008
20080070959GUANYLHYDRAZONE COMPOUNDS, COMPOSITIONS, METHODS OF MAKING AND USING
The present invention relates to compounds having the formula: salts thereof; compositions comprising one or more of the compounds and/or salts thereof; methods of using; and methods of making. ...
03/20/2008
20080064687Novel thiourea derivatives and the pharmaceutical compositions containing the same
The present invention relates to novel thiourea derivatives as a modulator for vanilloid receptor (VR) and the pharmaceutical compositions containing the same. As diseases associated with the activity of vanilloid receptor, pain acute pain, chronic pain, neuropathic pai...
03/13/2008
20070292412 Novel genes and markers in type 2 diabetes and obesity
Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D and related medical conditions are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D, obesity and related phenotypes usi...
12/20/2007
20070238789PREDNISOLONE ACETATE COMPOSITIONS
Prednisolone acetate compositions, and methods, eye drops, and medicaments related thereto, are disclosed herein. ...
10/11/2007
20070231267Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected fro...
10/04/2007
20070129442N-arylhydrazine derivatives for seed treatment
Method for the protection of seeds from soil pests comprising contacting the seeds before sowing and/or after pregermination with a compound of formula I: wherein W is chlorine or trifluoromethyl; X and Y are each independently chlorine or bromine;
    06/07/2007
    20070117868Use of n-arylhydrazine derivatives for combating non-crop pests
    Use of hydrazine derivatives of formula I: wherein W is chlorine or trifluoromethyl; X and Y are each independently chlorine or bromine;
    • R1 is alkyl, alkenyl, alkynyl, or cycloalkyl w...
    05/24/2007
    20070088085Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
    The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected fro...
    04/19/2007
    20060292244Use of pvp-iodine liposomes for treatment of acne
    The invention concerns a method for the production of a pharmaceutical preparation for the treatment of acne forms that is characterized in, that the preparation comprises at least one antiseptic compound associated with a particular carrier. ...
    12/28/2006
    20060293328Linear dicationic terphenyls and their aza analogues as antiparasitic agents
    Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues. ...
    12/28/2006
    20060019883Use of cyclin D1 inhibitors
    The present invention relates to use of certain cyclin D1 inhibitors at the manufacture of pharmaceutical preparations to be used in the treatment of patients to improve their response to tamoxifen treatment following a breast cancer treatment, either surgically, using ...
    01/26/2006
    20050282909Guanylhydrazones in methods of treatment or diagnosis as modulators of signal transduction
    A method is provided for the treatment of a condition mediated by raf kinase, which includes administering a guanylhydrazone to a subject in need thereof. A method is also provided, which includes modulating or inhibiting signal transduction in a c-raf pathway with at l...
    12/22/2005
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