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| Application No. | Application Title | Issue Date |
| 20120070390 | Topical drug delivery system with dual carriers An over-the-counter (OTC) regulated therapeutic composition for self-medication use for application to wounds having a potential pathogen load, in which the composition comprises a tissue penetration enhancer comprising a Class I pharmaceutical incipient; a pharmaceutic... | 03/22/2012 |
| 20120046242 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compou... | 02/23/2012 |
| 20120035265 | COMPOSITIONS, METHODS, AND DEVICES FOR THE TREATMENT OF DYSMENORRHEA A method for a prevention and/or treatment of dysmenorrhea or amelioration of a symptom thereof in a subject, comprising administering to said subject an effective amount of a compound of formula I: ... | 02/09/2012 |
| 20120029084 | Topical Nepafenac Formulations Topical suspension compositions of nepafenac are disclosed. The compositions are especially suitable for topical ophthalmic administration.... | 02/02/2012 |
| 20120021989 | GENETIC MARKERS FOR RISK MANAGEMENT OF ATRIAL FIBRILLATION AND STROKE The invention relates to procedures and methods of determining a susceptibility to cardiac arrhythmia, including Atrial Fibrillation, Atrial Flutter and Stroke, by assessing the presence or absence of alleles at polymorphic markers found to be associated with risk of th... | 01/26/2012 |
| 20120015050 | METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for determining whether or not a cell (e.g., a cancer cell) contains an LOH s... | 01/19/2012 |
| 20120015001 | METHODS OF TREATING THYROID EYE DISEASE The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount... | 01/19/2012 |
| 20120004260 | INHIBITION OF FATTY ACID SYNTHESIS BY IODO-NITROBENZAMIDE COMPOUNDS AND METHODS OF TREATMENT THEREOF The present invention relates to a method of treating a fatty acid synthesis related disease comprising administering to a patient in need thereof an effective amount of a PARP inhibitor or metabolite thereof to inhibit fatty acid synthesis, wherein the fatty acid synth... | 01/05/2012 |
| 20110301242 | Inhibitors of Cathepsin S for Prevention or Treatment of Obesity-Associated Disorders The present invention relates to methods (and pharmaceutical compositions) for treating and/or preventing for obesity associated disorders, particularly related to a deregulation of glucose homeostasis, by administrating Cathepsin S inhibitors. The invention also relate... | 12/08/2011 |
| 20110301110 | TRIM33 (TIF1gamma) AS A NEW DIAGNOSTIC MARKER OF CHRONIC MYELOMONOCYTIC LEUKEMIA (CMML) A method for diagnosing a chronic myelomonocytic leukemia (CMML) in a subject includes the steps of (i) determining the level of expression of the Trim33 (tripartite motif-containing 33) gene in a biological sample from the subject, and (ii) comparing the level of expre... | 12/08/2011 |
| 20110287026 | SIRT4 AND USES THEREOF Provided herein are SIRT4 compositions and methods of use thereof. The invention provides functional information for use in the identification and design of compounds that modulate SIRT4 enzyme activity (e.g., inhibition of fatty acid oxidation, ADP ribosylation, and/or... | 11/24/2011 |
| 20110269706 | Hydroxamic Acid Derivatives The disclosure includes hydroxamic compounds of Formula I: (I) wherein P, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compounds. ... | 11/03/2011 |
| 20110269834 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS).... | 11/03/2011 |
| 20110269785 | Substituted 2-Aminoacetamides and the Use Thereof The invention is directed to substituted 2-aminoacetamides represented by formula (II): and to pharmaceutically acceptable salts and prodrugs thereof, wherein the substituents are defined herein. The inventio... | 11/03/2011 |
| 20110263604 | Oxidase inhibitors and their use The invention relates to phenylcyclopropylamine acetamide derivatives and their use in treating diseases.... | 10/27/2011 |
| 20110245335 | NEW INHIBITORS FOR TREATING DISEASES ASSOCIATED WITH AN EXCESS TRANSPORT OF HYALURONAN The present invention relates in general to a compound which is characterized by a formula selected from the following formulas A, B, C, D, E or F; or a pharmaceutically acceptable salt thereof. The present invention further relates to pharmaceutical composition compris... | 10/06/2011 |
| 20110245250 | POTASSIUM ION CHANNEL MODULATORS & USES THEREOF Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs thereof wherein:
| |
| 20110224303 | USE OF CI-994 AND DINALINE FOR THE TREATMENT OF MEMORY/COGNITION AND ANXIETY DISORDERS The invention relates to methods and compositions for promoting cognitive function and/or treating cognitive function disorders and impairments. In particular the methods are accomplished by administering to a subject CI-994 or dinaline or a pharmaceutically acceptable ... | 09/15/2011 |
| 20110207823 | 12-HOUR SUSTAINED-RELEASE METOCLOPRAMIDE The present invention consists of an extended-release metoclopramide hydrochloride pharmaceutical composition, in 15 mg drug substance tablets, for use in gastrointestinal disorders. The formulation is mainly composed of a hydrophilic polymer, a hydrophobic polymer, a h... | 08/25/2011 |
| 20110201601 | INHIBITORS OF THE SHIGA TOXINS TRAFFICKING THROUGH THE RETROGRADE PATHWAY The present invention relates to the use of compounds of general formula (I) and (II) for the preparation of a drug for preventing and/or treating disorders caused by Shiga toxins and related toxins.... | 08/18/2011 |
| 20110201603 | Novel Acylaminobenzamide Derivatives The present invention relates to novel Acylaminobenzamide derivatives represented by the following formula (I) and use thereof as pesticides: wherein V represents an aromatic ring group of V1 to V5 described in the detailed description, Q represents an aromatic ring gro... | 08/18/2011 |
| 20110178163 | MIR-182 IN THE DIAGNOSIS AND TREATMENT OF CANCER The present disclosure provides methods of determining the levels of BRCA1 in a cell, altering the levels of BRCA1 in a cell, determining the likelihood of developing cancer, and determining the prognosis of a patient with cancer using miR-182 and analogs thereof. Impor... | 07/21/2011 |
| 20110178077 | Anti-infective compounds The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.... | 07/21/2011 |
| 20110177085 | Bitter Taste Receptors The present invention relates to bitter-taste receptors and their role in bitter taste transduction. The invention also relates to assays for screening molecules that modulate, e.g. suppress or block, bitter taste transduction, or enhance bitter taste response.... | 07/21/2011 |
| 20110178153 | METHODS OF TREATING CHEMORESISTANCE AND RELAPSE IN CANCER CELLS Methods of treating or preventing chemoresistance or relapse growth of cancer cells are provided. Methods of treating or preventing resistance to tyrosine kinase based chemotherapeutic treatment in hematologic and solid tumors are provided. BCR-ABL drug resistance in ch... | 07/21/2011 |
| 20110150775 | GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods for Down Syndrome involving, in some embodiments, gene expression analyses... | 06/23/2011 |
| 20110124653 | ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below (M)-L-(M′) (I), wherein M and M′, the same or different from each other, represent the residues of the metalloproteas... | 05/26/2011 |
| 20110124502 | PEST CONTROL COMPOSITIONS AND METHODS Embodiments of the present invention provide compositions for controlling a target pest including a first agent and a second agent comprising a pest control product or a signal cascade modulator, wherein the first agent and the second agent act synergistically to contro... | 05/26/2011 |
| 20110117213 | TREATMENT OF ACUTE EXACERBATION OF ASTHMA AND REDUCTION OF LIKELIHOOD OF HOSPITALIZATION OF PATIENTS SUFFERING THEREFROM The invention provides a method of improving one or more clinical outcomes of an individual experiencing an acute respiratory attack. The acute respiratory attack may include acute reversible bronchospasm, severe acute bronchospasm, or acute exacerbation of asthma. The ... | 05/19/2011 |
| 20110104213 | Porous Biomolecule-Containing Metal-Organic Frameworks The present invention relates to compositions including porous biomolecule-containing metal-organic frameworks and methods for their preparation. The porous biomolecule-containing metal-organic frameworks can include a metal component and a biomolecule component. The po... | 05/05/2011 |
| 20110082109 | NOVEL ACYL GUANIDINE DERIVATIVES The present invention provides a pharmaceutical which possesses an excellent inhibitory effect on NHE3 (Na+/H+ exchanger type 3) and effectively improves diseases or conditions of organs in which NHE3 is expressed.... | 04/07/2011 |
| 20110077239 | GLYCINE RECEPTOR AGONISTS FOR THE TREATMENT OF PHANTOM PHENOMENA A medicament for the treatment of the phantom phenomena of acute tinnitus and/or phantom pain, a method for the production of such a medicament, and a method for the treatment of such phantom phenomena... | 03/31/2011 |
| 20110071104 | Methods for Treating Osteoarthritis A method and composition for treating osteoarthritis with ion-channel regulators is disclosed. The ion-channel regulators are used alone or in combination with other osteoarthritis treatment agents, including but not limited to injectable agents such as viscosupplements... | 03/24/2011 |
| 20110071125 | SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combinat... | 03/24/2011 |
| 20110052552 | COMPOSITIONS TO EFFECT NEURONAL GROWTH Compositions containing neurogenic agents for inhibition of neuron death and inducing proliferation of neural cells are disclosed... | 03/03/2011 |
| 20110053939 | NOVEL AROMATIC NITRO COMPOUNDS Pharmaceutical compositions comprising at least one compound of e.g. the formulas (Ie) and a pharmaceutically acceptable carrier which is useful in a medicine wherein the symbols and substituents have the following meaning—X— is e.g. and Y is e.g. or the pharmaceuti... | 03/03/2011 |
| 20110039819 | SUBSTITUTED PHENOXYBENZAMIDES The present invention relates to substituted phenoxybenzamide compounds of general formula (I): in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compound... | 02/17/2011 |
| 20110039834 | NOVEL PHARMACEUTICAL COMPOSITIONS FOR OPTIMIZING SUBSTITUTION TREATMENTS AND EXTENDING THE PHARMACOPOEIA TO GLOBAL TREATMENT OF ADDICTIONS The present invention relates to the field of life needs and more particularly to the therapeutic field. The invention relates more particularly to pharmaceutical compositions for helping the takers of addictive drugs to return to abstinenc... | 02/17/2011 |
| 20110038800 | METHOD FOR THE TREATMENT OR PROPHYLAXIS OF LYMPHAGIOLEIOMYMATOSIS (LAM) AND ANIMAL MODEL FOR USE IN LAM RESEARCH Treatment of lymphangioleiomyomatosis with the MEK1/2 inhibitor CI-1040 delayed the development of primary tumors and blocked the estrogen-induced lung metastases in treated animals. Such treatment also reduced the number of circulating ELT3 cells and decreased their lu... | 02/17/2011 |
| 20110033536 | 24-HOUR SUSTAINED-RELEASE METOCLOPRAMIDE The present invention consists of an extended-release metoclopramide hydrochloride pharmaceutical composition, in 30 mg drug substance 5 tablets, for use in gastrointestinal disorders. The formulation is mainly composed of a hydrophilic polymer, a hydrophobic polymer, a... | 02/10/2011 |
