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| Application No. | Application Title | Issue Date |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120108666 | Treatment of Cell Proliferative Disorders The invention relates to compounds and their use in treating cell proliferative disorders, more specifically Syk tyrosine kinase-mediated disorders.... | 05/03/2012 |
| 20120045448 | TRP-P8 ACTIVE COMPOUNDS AND THERAPEUTIC TREATMENT METHODS Compounds of the disclosure provide compositions, which are effective for prophylaxis and treatment of diseases or disorders, such as cell-proliferation, angiogenesis, or apoptosis mediated diseases. The disclosure encompasses compounds, analogs, prodrugs, metabolites, ... | 02/23/2012 |
| 20120039909 | EPIGENETIC MECHANISMS RE-ESTABLISH ACCESS TO LONG-TERM MEMORY AFTER NEURONAL LOSS The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.... | 02/16/2012 |
| 20120041068 | Extended Release Pharmaceutical Preparations for Active Pharmaceutical Ingredients with pH Dependent Solubility An extended release preparation of an active pharmaceutical ingredient with pH dependent solubility dissolved or dispersed in a semi-solid or liquid nonionic solubilizer and further containing a non-pH dependent sustained release agent as well as a process for the prepa... | 02/16/2012 |
| 20120035179 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD... | 02/09/2012 |
| 20120034284 | Microencapsulation Product and Process Microcapsules possessing Lewis acid-Lewis base salt walls incorporate water-immiscible materials, such as N,N-di-ethyl-m-toluamide (DEET), as a core component. Such microcapsules, or similar microcapsules incorporating other core components, may be made by emulsifying a... | 02/09/2012 |
| 20120015978 | THERAPEUTIC AGENTS FOR OCULAR HYPERTENSION This invention provides well defined 6-alkyl or hydroxyalkyl-1-naphthamide or quinoline compounds for treating glaucoma or ocular hypertension.... | 01/19/2012 |
| 20120010248 | Mitochondrial Aldehyde Dehydrogenase-2 Modulators and Methods of Use Thereof The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subjec... | 01/12/2012 |
| 20120004310 | NON-PEPTIDE BDNF NEUROTROPHIN MIMETICS Methods and compounds for treating neurological and other disorders are provided. Included is the administering to a subject in need thereof an effective amount of a compound having binding and/or modulation specificity for a TrkB receptor molecule.... | 01/05/2012 |
| 20110313046 | COMBINATION THERAPY WITH LISDEXAMPHETAMINE AND EXTENDED RELEASE GUANFACINE The present invention relates to treating children and adults with suboptimal responses to Attention Deficit Hyperactivity Disorder (ADHD) monotherapy. More specifically, the present invention relates to a method for treating ADHD in a patient which comprises administer... | 12/22/2011 |
| 20110311503 | Active ingredient combinations having insecticidal and acaricidal properties The novel active ingredient combinations which consist of the compounds of the formula (I) in combination with further active insecticidal ingredients (II) are very suitable for control of animal pests such as insects and/or unwanted acarids.... | 12/22/2011 |
| 20110306621 | ACYLGUANIDINE DERIVATIVES An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that acylguanidine derivatives, which... | 12/15/2011 |
| 20110300083 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE Personal care formulations containing alkyl ketal esters having the structure wherein a is 0 or an integer of 1 to 12; b is 0 or 1; R2 is a divalent C1-8 group optionally substituted wit... | 12/08/2011 |
| 20110300152 | COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of intermediate-conductance calcium-activated potassium (SK4) channel. In some embodiments, the compositions and methods of the inventio... | 12/08/2011 |
| 20110288133 | HISTONE DEACETYLASE INHIBITORS This invention relates to novel Histone deacetylases inhibitors. Also disclosed is a method for treating mucositis or cancer with these inhibitors.... | 11/24/2011 |
| 20110281871 | TAAR1 LIGANDS The invention relates to a compound of formula wherein
11/17/2011 | |
| 20110281872 | COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.... | 11/17/2011 |
| 20110269834 | COMPOUNDS AND METHODS FOR TREATING RESPIRATORY DISEASES Described herein are compounds and compositions, and methods for using the compounds and compositions, for treating respiratory diseases and illness, such as severe acute respiratory syndrome (SARS).... | 11/03/2011 |
| 20110262496 | THERAPEUTIC FORMULATION FOR REDUCED DRUG SIDE EFFECTS The present invention provides drug therapy formulations for reducing the side effects associated with a therapeutic. In some embodiments, the present invention provides a reduction in sleep- and diet-related side effects associated with a therapeutic.... | 10/27/2011 |
| 20110262362 | METHODS FOR TREATING OBESITY The present invention provides methods to reduce or inhibit weight gain by administering inhibitors of the SirT1 protein to a subject. Methods to identify such inhibitors are also disclosed.... | 10/27/2011 |
| 20110251196 | Modulators of G Protein-Coupled Receptor 88 The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.... | 10/13/2011 |
| 20110245262 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceut... | 10/06/2011 |
| 20110245264 | Modulators of G Protein-Coupled Receptor 88 The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.... | 10/06/2011 |
| 20110237678 | N-(1-METHYL-2PHENYLETHYL)BENZAMIDE DERIVATIVES A compound of general formula (I). A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it. | 09/29/2011 |
| 20110224304 | BIPHENYLACETAMIDE DERIVATIVE The present invention provides a compound of formula (I) or a salt thereof, wherein R1, R2 and R3 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, bromine atom, C1-6 alkyl, C... | 09/15/2011 |
| 20110217373 | EXTENDED RELEASE PHARMACEUTICAL COMPOSITIONS OF GUANFACINE HYDROCHLORIDE The present invention relates to an extended release pharmaceutical tablet composition comprising guanfacine comprising: a core containing guanfacine or a pharmaceutically acceptable salt thereof and one or more of pH-independent rate controlling polymer(s) and other ph... | 09/08/2011 |
| 20110212156 | Use of a mixture of two or more enteric materials to regulate drug release via membrance or matrix for systemic therapeutics Disclosed are pharmaceutical compositions, particularly oral dosage forms, which comprise two or more enteric coating materials, either as a coating or as part of a matrix dosage form, and methods of making and using the same. The compositions are characterized by havin... | 09/01/2011 |
| 20110207758 | Methods for Therapeutic Renal Denervation Methods for therapeutic renal denervation are disclosed herein. One aspect of the present application, for example, is directed to methods that block, reduce and/or inhibit renal sympathetic nerve activity to achieve a reduction in central sympathetic tone. Renal sympat... | 08/25/2011 |
| 20110203018 | Use of Carboxamides on Cultivated Plants The present invention relates to a method of controlling pests and/or increasing the health of a plant as compared to a corresponding control plant by treating the cultivated plant, parts of a plant, seed, or their locus of growth with a carboxamide compound.... | 08/18/2011 |
| 20110195967 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Selected 2-arylacetic acids, their derivatives and pharmaceutical compositions that contain these compounds are useful in inhibiting chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membrane r... | 08/11/2011 |
| 20110195042 | Compositions, Methods and Kits Useful for Treating a Respiratory Symptom The present disclosure describes methods for enhancing an overall cooling sensation of an oral mucosa comprising administering a liquid composition comprising a thickening agent and/or a mucoadhesive polymer, a non-menthol coolant; and contacting the oral mucosa with th... | 08/11/2011 |
| 20110189199 | METHODS FOR P2RY5 MEDIATED REGULATION OF HAIR GROWTH AND MUTANTS THEREOF The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention further provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.... | 08/04/2011 |
| 20110178088 | TETRAHYDRO-NAPHTHALENE DERIVATIVES This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful f... | 07/21/2011 |
| 20110178077 | Anti-infective compounds The present invention relates to small molecule compounds and their use in the treatment of bacterial infections, in particular Tuberculosis.... | 07/21/2011 |
| 20110178102 | SIR2 REGULATION Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for... | 07/21/2011 |
| 20110172185 | THERAPEUTIC DRUG FOR ADULT T-CELL LEUKEMIA An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a... | 07/14/2011 |
| 20110166109 | Synergistic Active Compound Combinations Comprising Phenyltriazoles The present invention relates to novel active compound combinations comprising, firstly, at least one known compound of the formula (I) in which | 07/07/2011 |
| 20110160195 | Arthroscopic Irrigation Solution and Method for Peripheral Vasoconstriction and Inhibition of Pain and Inflammation A method and solution for perioperatively inhibiting a variety of pain and inflammation processes during arthroscopic procedures. The solution preferably includes a vasoconstrictor that exhibits alpha-adrenergic activity and one or more additional pain and inflammation ... | 06/30/2011 |
| 20110159050 | AMPHIPHILIC PROTEINS AS MORPHOLOGY MODIFIERS Disclosed is a process for modifying the morphology and/or polymorphism of an organic substance, which process comprises treating the solid substance, or a solution or dispersion thereof, with one or more amphiphilic proteins.... | 06/30/2011 |
