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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Application No. | Application Title | Issue Date |
| 20120108573 | SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM The present invention relates to compounds of the formula I wherein A1, A2, R1, R3, X and n are as defined in the claims, which are valuable pharmaceutically active... | 05/03/2012 |
| 20120035179 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD... | 02/09/2012 |
| 20110313000 | CCR9 INHIBITORS AND METHODS OF USE THEREOF The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds re... | 12/22/2011 |
| 20110301241 | NEW HALO ACTIVE AROMATIC SULFONAMIDE ORGANIC COMPOUNDS AND USES THEREFOR Aromatic N-halosulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to release active halogen ions has been utilized in a range of biocidal and fungicidal applications. This disclosure deals with the use of halo active... | 12/08/2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compou... | 12/01/2011 |
| 20110294775 | NOVEL COMPOUNDS Novel compounds which are useful for treating acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumour pain and headache diseases. The following is exemplary: ... | 12/01/2011 |
| 20110275635 | SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT Small molecule inhibitors of bacterial nicotinamide adenine dinucleotide synthetase (NADs), bacterial nicotinic acid mononucleotide adenylyltransferase (NaMNAT), and human nicotinamide mononucleotide adenylyltransferase (NMNAT) are provided, as well as methods of making... | 11/10/2011 |
| 20110275612 | ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of ... | 11/10/2011 |
| 20110268662 | FUNCTIONALIZED NANOCERIA COMPOSITION FOR OPHTHALMIC TREATMENT The invention provides a composition comprising a plurality of nanoceria particles, a sufficient amount of at least one inhibitor of human carbonic anhydrase II associated with said plurality of nanoceria particles, and a pharmaceutically acceptable carrier containing s... | 11/03/2011 |
| 20110257183 | BIS-ARYL SULFONAMIDES Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in as... | 10/20/2011 |
| 20110251284 | HALO ACTIVE AROMATIC SULFONAMIDE ORGANIC COMPOUNDS AND USES THEREFOR Aromatic N-halosulfonamide organic compounds have been known for over one hundred years. The ability of these compounds to release active halogen ions has been utilized in a range of biocidal and fungicidal applications. This disclosure deals with the use of halo active... | 10/13/2011 |
| 20110217301 | METHODS FOR TREATING OR SCREENING FOR COMPOUNDS FOR THE TREATMENT OF SEPSIS The present invention relates to a method for treating and screening for compounds for the treatment of sepsis. More specifically, the treatment and screening methods are based on the discovery that granzyme B containing platelets (GzmB-platelet) causes apoptosis by dir... | 09/08/2011 |
| 20110190302 | Aryl-Phenyl-Sulfonamide-Phenylene Compounds and Their Use The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as “APSAP compounds”). The present invention al... | 08/04/2011 |
| 20110189125 | Modulators of HSP70/DnaK Function and Methods of Use Thereof Compositions and methods for modulating HSP70 function, particularly for the targeted killing of cancer cells, are disclosed.... | 08/04/2011 |
| 20110178123 | NONPEPTIDE HIV-1 PROTEASE INHIBITORS Novel compounds and compositions for treating patients in need of relief from HIV, AIDS, and AIDS-related diseases are described. Methods for treating HIV, AIDS, and AIDS-related diseases using the compounds described herein are also described.... | 07/21/2011 |
| 20110159005 | 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) INHIBITORS AND USES THEREOF A method for treating a patient suffering from inflammation, chronic inflammation, pain, rheumatoid arthritis (RA), osteoarthritis and osteoporosis, comprising administering an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 en... | 06/30/2011 |
| 20110160200 | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension The invention relates to methods of treating, preventing or delaying the onset or development of pulmonary hypertension using hydroxyl donors or pharmaceutically acceptable salts thereof. The invention further relates to methods of reducing mean pulmonary arterial press... | 06/30/2011 |
| 20110144124 | Compounds and Compositions for Use as Modulators of Tau Aggregation and Alleviation of Tauopathies This invention relates to the use of bis- and tris-dihydroxyaryl compounds as well as sulfonamides, heteroaryls, tricycloalkyl and their analogs and pharmaceutically acceptable salts, for modulating tau aggregation and alleviating tauopathies, such as Alzheimer's diseas... | 06/16/2011 |
| 20110136877 | 2-PHENYL PHENOXYACETIC ACIDS USEFUL FOR TREATING INFLAMMATORY DISORDERS The present invention provides novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. The compounds are of the general formula (I): ... | 06/09/2011 |
| 20110136735 | CYCLOHEXANE DERIVATIVES AND USES THEREOF The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacolog... | 06/09/2011 |
| 20110123512 | METHOD OF REGULATING THE HEAT SHOCK RESPONSE The present invention is directed to method of modulating a heat shock response in a first cell of a multicellular organism comprising stimulating or inhibiting an HSR signaling activity of a second cell, wherein the second cell is a neuronal cell that regulates heat sh... | 05/26/2011 |
| 20110118248 | Heteroaryl sulfonamides and CCR2/CCR9 Compounds are provided that act as potent antagonists of the CCR2 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2. The compounds are generally aryl sulfonamide derivatives and are useful in pha... | 05/19/2011 |
| 20110105485 | Alpha-(N-Sulfonamido)Acetamide Derivatives as Beta-Amyloid Inhibitors There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid pe... | 05/05/2011 |
| 20110077305 | 5-LIPOXYGENASE INHIBITORS The use of compounds of the formula (I) Ar1-L1-Ar2-L2-C(R3)(R4)N(OR1)C(═Y)—R2 (I) where Y is selected from O or S; R1 is H, a salt or readily hydrolysable substituent;... | 03/31/2011 |
| 20110077231 | COMPOUNDS Novel compounds, with the following being exemplary: ... | 03/31/2011 |
| 20110065760 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF The present invention is related to a compound of the formula (I), (II), (III), (IV), (V): wherein Z1, Z2, Z3 and Z4 are each and independently selected from the group comprising C(O)—, —C(S)—, —C(O)—NR10... | 03/17/2011 |
| 20110065799 | UROKINASE INHIBITORS, PRODUCTION AND USE THEREOF The invention relates to novel inhibitors of urokinase and to their preparation and use for the therapy, prophylaxis and diagnosis of a tumor, in particular for reducing the formation of tumor metastases.... | 03/17/2011 |
| 20110065704 | COMPOUNDS FOR MODULATING RNA BINDING PROTEINS AND USES THEREFOR The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.... | 03/17/2011 |
| 20110059940 | 2-Aryl Glycinamide Derivatives The disclosure provides compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their uses in inhibiting β-amyloid peptide (β-AP) production. ... | 03/10/2011 |
| 20110053995 | BENZENESULFONANILIDE COMPOUND INHIBITORS OF UREA TRANSPORTERS Provided herein are small molecule compounds that alter the transport activity of solute transporters, particularly urea transporters. The compounds described herein belong to the benzenesulfonanilide class of compounds. The compounds described herein are useful for inc... | 03/03/2011 |
| 20110028509 | Sulfonamides The invention relates to compounds of formula I wherein R1, R2, R4, Ra, Rb, Rc, Re, A*, W1, W2 and W3 | |
| 20100331380 | Compounds, Compositions, and Methods for the Treatment of Beta-Amyloid Diseases and Synucleinopathies Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parki... | 12/30/2010 |
| 20100298308 | Compositions and methods for bone formation and remodeling The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domai... | 11/25/2010 |
| 20100292240 | SULFONAMIDE COMPOUNDS Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.... | 11/18/2010 |
| 20100286266 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as ‘BPSAAA compounds’), as described herein, and including, for example, bipheny... | 11/11/2010 |
| 20100280074 | CCR9 INHIBITORS AND METHODS OF USE THEREOF The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds re... | 11/04/2010 |
| 20100273739 | Aminotetraline Derivatives, Pharmaceutical Composition, Containing Them, and Their Use in Therapy The present invention relates to aminotetraline derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions c... | 10/28/2010 |
| 20100261788 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.... | 10/14/2010 |
| 20100256096 | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for... | 10/07/2010 |
| 20100240581 | SELECTIVE PROTEASOME INHIBITORS FOR TREATING DIABETES Methods of modulating chronic low-grade inflammation are provided. More particularly, methods of treating diabetes, such as for example, type-2 diabetes mellitus, in a mammal by administering an effective amount of a selective proteasome inhibitor are provided. Also pro... | 09/23/2010 |
