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| Application No. | Application Title | Issue Date |
| 20110313000 | CCR9 INHIBITORS AND METHODS OF USE THEREOF The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds re... | 12/22/2011 |
| 20110245307 | Methods for Alzheimer's Disease Treatment and Cognitive Enhancement The present invention relates to compositions comprising a combination of PKC activators and PKC inhibitors and methods to modulate α-secretase activity; improve or enhance cognitive ability; and/or reduce neurodegeneration in individuals suffering from diseases that i... | 10/06/2011 |
| 20110223177 | TREATMENT OF FIBROTIC EYE DISORDERS Inhibitors of myosin activity are used to treat or prevent a fibrotic disorder of the eye, for example posterior capsule opacification (PCO).... | 09/15/2011 |
| 20110212911 | TRANSCRIPTION FACTOR INHIBITORS AND RELATED COMPOSITIONS, FORMULATIONS AND METHODS The present invention provides small molecules useful to affect cancer cells, along with related methods. The present compounds, formulations, kits and methods are useful for a variety of research, diagnostic and therapeutic purposes. STAT3 inhibitors, particularly LLL1... | 09/01/2011 |
| 20110190302 | Aryl-Phenyl-Sulfonamide-Phenylene Compounds and Their Use The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-phenylene compounds of the following formula (I) (collectively referred to herein as “APSAP compounds”). The present invention al... | 08/04/2011 |
| 20110172189 | Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “APSAC compounds”). The present invention also ... | 07/14/2011 |
| 20110039802 | NPY Y5 ANTAGONIST The present invention provides a pharmaceutical composition for use as an NPY Y5 receptor antagonist comprising a compound of the formula (I): wherein R1 is lower alkyl, cycloalkyl or the like, | |
| 20110021578 | Compounds which Potentiate the AMPA Receptor and Uses Thereof in Medicine Compounds of formula (I) and salts thereof are provided: wherein n is 0, 1, 2 or 3; R1 is selected from phenyl and pyridyl, each of which is optionally substituted by one or two groups independently selected from C1-4alkyl and halogen; and R2 ... | 01/27/2011 |
| 20110014186 | ARYLSULFONAMIDE-BASED MATRIX METALLOPROTEASE INHIBITORS The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder... | 01/20/2011 |
| 20100298321 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.... | 11/25/2010 |
| 20100286266 | Biphenyl-4-yl-sulfonic acid arylamides and their use as therapeutic agents The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl sulfonamides and related compounds (collectively referred to herein as ‘BPSAAA compounds’), as described herein, and including, for example, bipheny... | 11/11/2010 |
| 20100280074 | CCR9 INHIBITORS AND METHODS OF USE THEREOF The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds re... | 11/04/2010 |
| 20100256096 | Sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides and ureas, pharmaceutical compositions thereof, and methods for treating hemorrhagic fever viruses, including infections associated with arenaviruses Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel sulfonyl semicarbazides, carbonyl semicarbazides, semicarbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for... | 10/07/2010 |
| 20100240715 | Apoptosis promoters Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-ap... | 09/23/2010 |
| 20100184650 | Treating post-seizure patients Patients are subject to a post-seizure treatment regime to separately inhibitor consecutive targets of an epileptogenic cascade comprising neurotransmitter receptor signaling, kinase/phosphatase activity, protein translation, and apoptosis or inflammation.... | 07/22/2010 |
| 20100152183 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.... | 06/17/2010 |
| 20100137250 | NAPHTHYLACETIC ACIDS The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and ... | 06/03/2010 |
| 20100069378 | SUBSTITUTED INDANYL SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. The new compounds of formula (I) show aff... | 03/18/2010 |
| 20100048549 | Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4 The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1, R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt or ester thereof. Compounds of formula (I) possess high affinity and selec... | 02/25/2010 |
| 20100022601 | SULFONAMIDE COMPOUNDS AND THE USE The sulfoneamide compounds having the following Formula (1), which can be used as an effective component of a CaSR antagonizing agent useful for prophylaxis and/or treatment of bone disorders including osteoporosis and etc., are provided. The compounds have an excellent... | 01/28/2010 |
| 20090298785 | Method for Treating Ocular Cancer It has now been found that the p53 pathway is inactivated in ocular cancers such as retinoblastoma. As such, the present invention is a method for inducing ocular cancer cell death using a p53 activator. In particular embodiments, the p53 activator blocks the interactio... | 12/03/2009 |
| 20090209473 | Componds and methods for pormoting angiogenesis Angiogenesis may be initiated or increased through the use of gamma-secretase inhibitors. The gamma-secretase inhibitor can be a dipeptide class, sulfonamide class, transition state mimic class, benzodiazepine class, or benzocaprolactam class gamma secretase inhibitor. ... | 08/20/2009 |
| 20090149445 | TRICYCLIC STEROID HORMONE NUCLEAR RECEPTOR MODULATORS The present invention relates to methods of treating pathological disorders susceptible to steroid hormone nuclear receptor modulation comprising administering to a patient in need thereof an effective amount of a compound of the formula: ... | 06/11/2009 |
| 20090149510 | Compositions and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade.... | 06/11/2009 |
| 20090131441 | Metabolites Of 2-Arylpropionic Acid Derivatives And Pharmaceutical Compositions Containing Them Metabolites of 2-(R)-4-isobutylarylpropionamides and pharmaceutical compositions containing such compounds are useful in inhibiting the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCR1 and CXCR2 membran... | 05/21/2009 |
| 20090124498 | 2-CYANOBENZENESULFONAMIDE COMPOUNDS FOR SEED TREATMENT The present invention provides a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a 2-cyanobenzenesulfon... | 05/14/2009 |
| 20090118323 | ANTITUMOR BENZOYLSULFONAMIDES The present invention provides antitumor compounds of the formula (I); and antitumor methods. ... | 05/07/2009 |
| 20090105319 | NAPHTHALENE-BASED INHIBITORS OF ANTI-APOPTOTIC PROTEINS Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided: 04/23/2009 | |
| 20090093485 | Novel Sulphonamide Derivatives as Glucocorticoid Receptor Modulators for the Treatment of Inflammatory Diseases Compounds of formula (I) or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded animal). 04/09/2009 | |
| 20090069420 | Small molecule inhibitors of STAT3 with anti-tumor activity The present invention concerns compounds, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of Stat3 signaling, Stat3 dimerization, Stat3-DNA binding, Stat5-DNA binding, and/or aberrant cell growth in vitro or i... | 03/12/2009 |
| 20090047278 | Novel Combinational Use of Sulfonamide Compound The present invention relates to a pharmaceutical composition, a kit and a method for treating cancer, comprising a sulfonamide compound in combination with a substance having an EGF inhibitory activity.... | 02/19/2009 |
| 20090048224 | COMPOUNDS AND METHODS OF USE Selected compounds are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for pro... | 02/19/2009 |
| 20090042929 | 11-Beta-Hydroxysteroid Dehydrogenase Inhibitors There is provided a compound having Formula (I) R1-Z-R2 wherein R1 is a group selected from optionally substituted fused polycyclic groups, substituted alkyl groups, branched alkyl groups, and optionally substituted cycloalkyl groups Z i... | 02/12/2009 |
| 20090030038 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor The present invention relates to new compounds of formula I. (I) wherein R1 to R12, X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used in the prepar... | 01/29/2009 |
| 20090030055 | PKC activation as a means for enhancing sAPPALPHA secretion and improving cognition using bryostatin type compounds The present invention relates to compositions and methods to modulate α-secretase and/or to improve cognitive ability. The invention further relates the improved/enhanced cognitive ability in diseased individuals, particularly Alzheimer's Disease patients, and treatmen... | 01/29/2009 |
| 20090023735 | Sulphonamide Derivatives The invention relates to sulphonamide derivatives of formula (I), where RC is selected from a group consisting of dialkylamino, NO2, CN, aminocarbonyl, monoalkylaminocarbonyl, dialkylaminocarbonyl, alkanoyl, oxazol-2-yl, oxazolylaminocarbonyl, aryl... | 01/22/2009 |
| 20090012053 | Use of LXR agonists for the treatment of osteoarthritis Disclosed herein are methods of preventing and treating osteoarthritis through the use of LXR agonists.... | 01/08/2009 |
| 20080311074 | Inhibitors against activation of NF-kappaB A method of inhibiting NF-κB activation in a mammal including a human, which comprises the step of administering an effective dose of a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically a... | 12/18/2008 |
| 20080293751 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof,
| 11/27/2008 |
| 20080255169 | Sulphonamide Derivatives The invention relates to sulphonamide derivatives of formula (I), where
| 10/16/2008 |
