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Patent No. 5719655

System for magnetically attaching templeless eyewear to a person

A system of eyewear that eliminates the need for hinges on the frames of the eyewear.

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Class 514/569 - Polycyclo ring system


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the active ingredient has a fused
No. of applications: 492
Last issue date: 05/03/2012


1                      
Application No.Application TitleIssue Date
20120107400SUSTAINED RELEASE COMPOSITION OF THERAPUTIC AGENT
A pH dependent drug delivery system comprising a pH sensitive graft copolymer, a therapeutically active agent and other pharmaceutically acceptable ingredients. More specifically, a composition which is capable of suppressing the drug release in the acidic pH prevalent ...
05/03/2012
20120108551OPHTHALMIC COMPOSITIONS
The present invention relates to compositions that may alleviate symptoms of ocular stress, as well as methods of their production, use, and storage compositions. The compositions comprise at least one ocular epithelial cell associating group and at least one hydrophili...
05/03/2012
20120070492RHEIN OR DIACEREIN COMPOSITIONS
The invention relates to pharmaceutical compositions comprising rhein or diacerein or salts or esters or prodrugs thereof, optionally with one or more pharmaceutically acceptable excipients. The invention also relates to the methods for preparing such compositions....
03/22/2012
20120071550Synergistic combinations of cartonoids and polyphenols
The present invention provides a therapeutic composition comprising one or more polyphenols and one or more carotenoids selected from the group consisting of lutein, lycopene and beta-carotene. The invention also provides methods for inhibiting or reducing the productio...
03/22/2012
20120046307ALLOSTERIC PROTEIN KINASE MODULATORS
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein kinases, methods for their production, pharmaceutical compositions compris...
02/23/2012
20120035196CARBOXYLIC ACID COMPOUND
[Problem]

The present invention has an object to provide a compound having a GPR40 agonistic activity, which is useful as a pharmaceutical composition, an insulin secretion promoter, or an agent for preventing/treating diabetes.

02/09/2012

20120015992Napthalene-Based Inhibitors of Anti-Apoptotic Proteins
Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided:

01/19/2012

20120016031BIPHENYL COMPOUND SELECTIVE AGONISTS OF GAMMA RAR RECEPTORS
Biphenyl compounds having the formula (I):

are useful for preventing/treating pathologies linked to a deficiency of the activation of the RAR gamma receptor, e.g., for treating a pathology linked to a cell di...

01/19/2012
20120015960CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT
Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or pre...
01/19/2012
20120009243LIPOSOMES FOR DRUG DELIVERY AND METHODS FOR PREPARATION THEREOF
The present invention provides liposomes that are useful for delivery of bioactive agents such as therapeutics. Among others, the liposomes of the invention are capable of delivering their payload at sites of increased secretory phospholipase A2 (sPLA2) activity, becaus...
01/12/2012
20120004307ORAL TREATMENT OF DIGITAL ISCHEMIC LESIONS
Provided are methods of orally treating ischemic diseases and conditions, such as digital ulcers, associated with or caused by the ischemic diseases....
01/05/2012
20120003181Novel Retinoid Inducible Factor and Uses Thereof
The present invention describes a novel retinoid-responsive nucleic acid, and a novel protein. Further, the invention describes the use of such a nucleic acid or protein in various diseases, and for the treatment, the diagnosis and prognosis of various diseases, and als...
01/05/2012
20120003156METHODS FOR TREATING NEOPLASIA BY INHIBITING LACTATE DEHYDROGENASE AND/OR NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
The invention provides compositions for the diagnosis or treatment of neoplasias, including lymphomas, leukemias, brain cancers (e. glioblastomas, medulloblastomas), breast cancer, colon cancer, and pancreatic cancer, and methods of use therefor....
01/05/2012
20110318321CONTROLLED RELEASE PHARMACEUTICAL OR FOOD FORMULATION AND PROCESS FOR ITS PREPARATION
The present invention relates to a controlled release pharmaceutical or food formulation comprising at least one active pharmaceutical or food ingredient dispersed in a mixture of a glycogen with a polysaccharide, and the process for its preparation. The invention also ...
12/29/2011
20110319399EXTERNAL PREPARATION CONTAINING ANALGESIC/ANTI-INFLAMMATORY AGENT
An external preparation containing the following components (A) and (B):
    • (A) a non-steroidal analgesic/anti-inflammator...
12/29/2011
20110319491ANHYDROUS DEPIGMENTING COMPOSITIONS COMPRISING, WITHIN THE FATTY PHASE THEREOF, A SOLUBILIZED PHENOLIC COMPOUND AND A RETINOID
Novel anhydrous dermatological depigmenting compositions, especially for topical application, contain, within the fatty phase thereof, as pharmaceutical active agents, a dissolved phenolic compound and a retinoid....
12/29/2011
20110318396DERMATOLOGICAL/COSMETIC COMPOSITIONS COMPRISING A RETINOID AND BENZOYL PEROXIDE
Dermatological/cosmetic compositions contain, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and a gelling system comprising at least two categories of compounds....
12/29/2011
20110313032COMPETITIVE INHIBITORS OF TYPE II DEHYDROQUINASE ENZYME
The present invention is directed to a compound of formula (I), its diastereoisomers, its enantiomers or its pharmaceutically acceptable salts or solvates, formula (I), to procedures of obtaining the same, to intermediates thereof, and use as competitive inhibitors of t...
12/22/2011
20110311594CONTROLLED RELEASE COMPOSITIONS WITH REDUCED FOOD EFFECT
The present invention provides a controlled release pharmaceutical composition which exhibits reduced food effect....
12/22/2011
20110312984STAT3 INHIBITORS
Small molecule inhibitors of Stat3 and their derivatives are disclosed. Also described are methods to inhibit cell growth by use of Stat3 inhibitors, and the use of Stat3 inhibitors for the prevention and/or treatment of cancer. Further, inhibitors of Stat3 that also do...
12/22/2011
20110305747COMBINATION OF DAPSONE WITH OTHER ANTI-ACNE AGENTS
A composition suitable for topical application that contains at least two active ingredients, one of these being dapsone and one selected from the group consisting of adapalene, tazarotene and treinion for the effective treatment of acne and other dermatological conditi...
12/15/2011
20110305676METHODS FOR ENHANCING HEMATOPOIETIC STEM/PROGENITOR CELL ENGRAFTMENT
Described herein are methods for enhancing engraftment of hematopoietic stem and progenitor cells using compounds identified using a zebrafish model of hematopoietic cell engraftment. The compounds can be used to treat hematopoietic stem cells ex vivo prior to transplan...
12/15/2011
20110301131Drug Delivery Implants and Processes for Their Preparation
The invention discloses an implant suitable for delivery of at least one drug, the implant comprising a fibrillar collagen matrix having, as measured in Example 1, a viscosity of greater than 100 mPas, optionally greater than 103 mPas, further optionally greater than 10...
12/08/2011
20110294815PROSTACYCLIN ANALOGS
This invention relates to novel prostacyclin analogs and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel prostacyclin analogs that are derivatives of treprostinil. This invention also provides compositions comprising a compou...
12/01/2011
20110288022TREATMENT OF DEPRESSIVE DISORDERS
The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also relates to improved animal models and methods for screening and identifying compounds the treatment of depressiv...
11/24/2011
20110288146DIRECTLY COMPRESSIBLE GRANULAR MICROCRYSTALLINE CELLULOSE BASED, EXCIPIENT, MANUFACTURING PROCESS AND USE THEREOF
An improved excipient comprising substantially homogeneous particles of a compressible, high functionality granular microcrystalline cellulose based excipient is provided. The improved excipient comprises microcrystalline cellulose and a binder, and optionally a disinte...
11/24/2011
20110287091CHRONOTHERAPEUTIC PHARMACEUTICAL COMPOSITION
The present invention relates to chronotherapeutic pharmaceutical compositions and a method of preparing the same. The composition comprises of at least one active ingredient, a pH independent agent and a hydrophilic agent. The active ingredient in the composition is co...
11/24/2011
20110288066PHENOXY ACETIC ACID DERIVATIVES
The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses....
11/24/2011
20110281948COSMETIC AND PHARMACEUTICAL FORMULATIONS OF CALIXARENE MOLECULES
The invention relates to the use of calixarenes for preventing or limiting the transfer of an actinide in the body from a site of skin contamination....
11/17/2011
20110281944METHOD OF A RHEIN COMPOUND FOR INHIBITING PANCREATIC ISLET BETA-CELL DYSFUNCTION AND PREVENTING OR TREATING A PANCREATIC ISLET BETA-CELL DYSFUNCTION RELATED DISORDER
This invention provides a method for inhibiting pancreatic islet β-cell dysfunction, comprising administering to a subject in need thereof an inhibitory effective amount of a rhein compound having the general formula (I) or a pharmaceutically acceptable salt thereof,
11/17/2011
20110274724DERMATOLOGICAL/COSMETIC GELS COMPRISING AT LEAST ONE RETINOID AND/OR RETINOID SALT AND BENZOYL PEROXIDE
Dermatological/cosmetic gel compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise (i) at least one retinoid, (ii) dispersed benzoyl peroxide and (i...
11/10/2011
20110275658OPIOID-CONTAINING ORAL PHARMACEUTICAL COMPOSITIONS AND METHODS
The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an opioid (including salts thereof) and a salt of a non-steroidal anti-inflammatory drug (NSAID)....
11/10/2011
20110275691METHODS OF TREATING HEADACHES USING 5-HT AGONISTS IN COMBINATION WITH LONG-ACTING NSAIDS
The invention is directed to methods and compositions that can be used in the treatment of headaches. In particular, methods and compositions are described involving the combination of a long-acting NSAID and a 5-HT1B/1D agonist....
11/10/2011
20110275581NUCLEAR EXPORT INHIBITORS OF TOPOISOMERASE II ALPHA
A method of treating cancer in a subject comprising the step of administering to the subject in need thereof an effective amount of a combination of a compound that binds a nuclear export signal (NES inhibitor) on topoisomerase IIα and a topoisomerase inhibitor. Twenty...
11/10/2011
20110268808DUAL-RELEASE PHARMACEUTICAL SUSPENSION
Orally deliverable dual-release pharmaceutical suspensions, having a first portion comprising an immediate release form of the active in the solution form or granules or suspended form in the vehicle/medium preferably in the solution form and a second portion comprising...
11/03/2011
20110269723SPILL RESISTANT FORMULATIONS CONTAINING CLAYS
The invention relates to novel spill resistant formulations comprising either a weak base or a weak acid as the pharmaceutical ingredient, a liquid base, a clay and a water soluble cellulose ether. The clay and cellulose ether allow for a broader pH range into which the...
11/03/2011
20110263693CELASTROL, GEDUNIN, AND DERIVATIVES THEREOF AS HSP90 INHIBITORS
Based on the discovery that celastrol and gedunin are Hsp90 inhibitors, the present invention provides novel inhibitors of Hsp90. and pharmaceutically acceptable salts, derivatives, and compositions thereof. The invention provides two classes of compounds. One class inc...
10/27/2011
20110263539SHIP 1 MODULATOR COMPOUNDS
The present invention provides the use of pelorol analogs of Formula, (I) and pharmaceutical compositions thereof as modulators of SHIP 1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inf...
10/27/2011
20110257269PREVENTIVE AND/OR THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASES
The present invention relates to a preventive and/or a therapeutic agent for inflammatory bowel diseases containing a fermentation product of a propionic acid bacterium as an active ingredient....
10/20/2011
20110257134CO-CRYSTALS OF TRAMADOL AND NSAIDs
The present invention relates to co-crystals of tramadol and co-crystal formers selected from NSAIDs, processes for preparation of the same, their uses in pharmaceutical formulations, and for the treatment of various disorders, including pain....
10/20/2011
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