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| Application No. | Application Title | Issue Date |
| 20110288168 | HISTONE DEACETYLASE INHIBITORS Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expre... | 11/24/2011 |
| 20110245262 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceut... | 10/06/2011 |
| 20110224156 | Propionic Acids, Propionic Acid Esters, and Related Compounds The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the treatment of various diseases or conditions, including but not limited to disease... | 09/15/2011 |
| 20110196034 | Green garlic and methods of production A new vegetable, referred to herein as green garlic, grown from garlic bulbils is disclosed. In particular examples, the green garlic is rich in one or more thiosulfinates. Methods of producing green garlic are also disclosed. In some examples, such methods permit year-... | 08/11/2011 |
| 20110190368 | Organosulfur Compounds, a Method of Making Organosulfur Compounds and their Use for Inhibiting the Growth of Tumour Cells Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C... | 08/04/2011 |
| 20110178108 | Group of amino substituted benzoyl derivatives and their preparation and their use A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also ... | 07/21/2011 |
| 20100286073 | COMPOUNDS AND METHODS FOR PHARMACEUTICAL USE The present invention relates to compounds, as well as to compositions, methods and kits comprising such compounds, for use in the treatment or prophylaxis of fibromyalgia, chronic fatigue syndrome, myofascial pain syndrome, Gulf War syndrome and related conditions, whe... | 11/11/2010 |
| 20100267801 | CYCLOHEXYL SULPHONES FOR TREATMENT OF CANCER Sulphones of formula (I) are disclosed for use in treatment of cancer. ... | 10/21/2010 |
| 20100152289 | ORGANIC SULFUR COMPOUND AND ITS USE FOR CONTROLLING HARMFUL ARTHROPOD There is provided an organic sulfur compound having an excellent controlling effect on harmful arthropods which is represented by formula (I): wherein R1 represents a C3-C6 haloalkyl group having a... | 06/17/2010 |
| 20100130507 | PROSTAGLANDIN DERIVATIVES Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.... | 05/27/2010 |
| 20100105685 | S-Nitrosothiol Compounds and Related Derivatives The present invention is directed to a method of treating a lack of normal breathing control including the treatment of apnea and hypoventilation associated with sleep, obesity, certain medicines and other medical conditions. In an aspect, the invention is directed to t... | 04/29/2010 |
| 20100047327 | Adjuvant for Transdermal or Transmucosal Administration and Pharmaceutical Preparation Containing the Same It is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an ... | 02/25/2010 |
| 20090312358 | METHOD FOR MANAGEMENT OF DIARRHEA The present invention is directed to methods of treatment and/or management of diarrhea, such as chronic diarrhea using sequential administration of opioid agonists to suppress gut mobility and opioid antagonists to reverse the effect to controllably allow bowel movemen... | 12/17/2009 |
| 20090005445 | Article comprising calcium for reducing the production of TSST-1 Articles comprising one or more calcium salts are provided. The articles can contain one or more calcium salts in an amount effective to reduce the production of TSST-1 by at least about 50% when measured by the Shake Flask Method. In certain embodiments, the one or mor... | 01/01/2009 |
| 20080300303 | Substances and Pharmaceutical Compositions for the Inhibition of Glyoxalases and Their Use As Anti-Fungal Agents The present invention pertains to substances of the formula (I) wherein X is O or S; and R1-R4 are defined in the claims as inhibitors of glyoxalase I and/or II, pharmaceutical compositions comprising one or more compounds according to formula (I) and the use of one or ... | 12/04/2008 |
| 20080194681 | Novel Inhibitors of Histone Deacetylase for the Treatment of Disease Disclosed herein are carbonyl compounds of Formula: (I) as described herein. Compounds as modulators of his-tone deacetylase (HDAC), pharmaceutical compositions comprising the same, and methods of treating disease using the same are disclosed. 08/14/2008 | |
| 20080188557 | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and use thereof The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen a... | 08/07/2008 |
| 20080161395 | Derivatives of Aminobutanoic Acid Inhibiting Cpt The invention relates to a new class of compounds with action inhibiting carnitine palmitoyl transferase (CPT), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic cond... | 07/03/2008 |
| 20080131503 | Stable Pharmaceutical Composition Comprising a Fixed Dose Combination of Fenofibrate and an Hmg-Coa Reductase Inhibitor A pharmaceutical composition for oral administration comprising a fixed dose combination of a first solid pharmaceutical composition containing fenofibrate as the active substance and second solid pharmaceutical composition containing an HMG-CoA reductase inhibitor such... | 06/05/2008 |
| 20080058412 | 1,3-Diphenylprop-2-En-1-One Derivative Compounds, Preparation Method Thereof and Uses of Same The invention relates to substituted 1,3-diphenylprop-2-en-1-one derivative compounds, pharmaceutical and/or cosmetic compositions containing same, and the applications thereof in therapeutics and cosmetics. The invention also relates to a ... | 03/06/2008 |
| 20080039524 | Methoxypolyethylene glycol thioester chelate and uses thereof The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the produ... | 02/14/2008 |
| 20070259943 | ORTHO-SUBSTITUTED PENTAFLUOROSULFANYL BENZENES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS SYNTHESIS INTERMEDIATES This invention relates to novel substituted pentafluorosulfanylbenzenes of the formula I: and/or salts thereof as claimed, for use as a synthetic intermediates for preparing medicaments, diagnostic aids, liquid crystals, pesticides, herbicides, fungicides, nematicid... | 11/08/2007 |
| 20070037869 | Histone deacetylase inhibitors Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, such as, for example, a hydroxamic acid group or a carboxylic acid group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expre... | 02/15/2007 |
| 20070032476 | Aminothiolester compounds, pharmaceutical and cosmetic compositions containing same and uses thereof The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (cancers and precancers, dermatological, rhe... | 02/08/2007 |
| 20070015827 | Methods and compositions for treating ophthalmic conditions via serum retinol, serum retinol binding protein (RBP), and/or serum retinol-RBP modulation Compounds that reduce serum retinol, serum RBP, and/or serum retinol-RBP levels may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions us... | 01/18/2007 |
| 20060270705 | Method for inhibiting lipid absorption and lipid absorption inhibitor The present invention relates to a method of inhibiting lipid absorption through the small intestine, which comprises administering a compound having a CETP inhibitory activity to an administration subject, and an inhibitor of lipid absorption through the small intestin... | 11/30/2006 |
| 20060252827 | Therapeutic use of of acyglycerols and the nitrogen-and sulphur-containing analogues thereof The invention relates to the use of acylglycerols and the nitrogen- and sulfur-containing analogues thereof in therapy, particularly for the treatment of cerebral ischemia. The invention further relates to methods for preparing said derivatives, novel compounds, in part... | 11/09/2006 |
| 20060211654 | Pharmaceutical Compositions of Cholesteryl Ester Transfer Protein Inhibitor A pharmaceutical composition comprises a solid amorphous dispersion of a cholesteryl ester transfer protein inhibitor and a concentration-enhancing polymer. ... | 09/21/2006 |
| 20060167088 | Methods and compositions for treating ophthalmic conditions with retinyl derivatives Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their der... | 07/27/2006 |
| 20060154984 | Therapeutic use of acyl glycerols and the nitrogen- and sulphur- containing analogues thereof The invention relates to the use of acyl glycerols and the nitrogen- and sulfur-containing analogues thereof in the therapeutic field, particularly in human health. The inventive compounds have advantageous pharmacological properties and are particularly of use for the ... | 07/13/2006 |
| 20060142383 | 3D-Structure model of SARS coronavirus 3CL protease and anti-SARS drugs The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.)... | 06/29/2006 |
| 20060030554 | Novel sulfonamides as inhibitors of histone deacetylase for the treatment of disease Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune di... | 02/09/2006 |
| 20050261255 | Use of docosatrienes, resolvins and their stable analogs in the treatment of airway diseases and asthma The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), cyclooxygenase-... | 11/24/2005 |
| 20050239833 | Compositions and methods for modulating interaction between polypeptides The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another. ... | 10/27/2005 |
| 20050203177 | Methods for selectively inhibiting janus tyrosine kinase 3 (JAK3) Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a derivat... | 09/15/2005 |
| 20050197390 | Thiol ester compositions and processes for making and using same Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cross-linked thiol esters. The thio... | 09/08/2005 |
| 20050197391 | Thiol ester compositions and processes for making and using same Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cross-linked thiol esters. The thio... | 09/08/2005 |
| 20050170015 | Antiproliferative colchicine compositions and uses thereof A method of treatment of a host with a cellular proliferative disease, including contacting the host with a colchicine family member such as thiocolchicine and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease. Anti... | 08/04/2005 |
| 20050107468 | Process for the preparation of an enantiomerically enriched thio compound The invention relates to a process for the preparation of an enantiomerically enriched compound of formula (1) or a salt thereof, in which R1 and R2 each independently represent an (hetero)alkyl or (hetero)aryl group, wherein R1—C(O)â€... | 05/19/2005 |
| 20050085448 | Production of pure stereoisomers of tricyclo[5.2.1.0 2.6]-dec-9-yl-xanthogenate and medicaments therefrom The invention relates to pharmaceutical formulations containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate, drugs containing exo/exo-tricyclo[5.2.1.02.6]-dec-9-yl-xanthogenate as active ingredient for the treatment of genital herpes, labial... | 04/21/2005 |
