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| Application No. | Application Title | Issue Date |
| 20130060208 | WOUND CARE PRODUCTS The present invention relates to wound care products, devices and methods incorporating acetic acid for the treatment of bacterial infections, in particular bacterial biofilm infections. In particular it relates to a wound care product comprising acetic acid, wherein th... | 03/07/2013 |
| 20130005712 | COMPOSITION FOR NOXIOUS ORGANISMS-CONTROLLING AGENT AND METHOD FOR USING THE SAME The present invention relates to a composition for noxious organisms-controlling agent having a synergistic effect and a method for using said composition, which comprises, as active ingredients thereof, one or more compounds selected from the phthalamide derivatives re... | 01/03/2013 |
| 20120322823 | HETEROCYCLIC SULFONAMIDES, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also d... | 12/20/2012 |
| 20120316198 | HYDRAZONE AND DIACYL HYDRAZINE COMPOUNDS AND METHODS OF USE Disclosed herein are novel hydrazone and diacyl hydrazine derivatives that are inhibitors of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Also disclosed are hydrazone and diacyl hydrazine derivatives as potent and selective inhibitors of the ... | 12/13/2012 |
| 20120316171 | Tryptophan Hydroxylase Inhibitors for the Treatment of Cancer Methods and compositions for the treatment and/or management of cancer are disclosed, which comprise the use of tryptophan hydroxylase inhibitors.... | 12/13/2012 |
| 20120232028 | Bicyclic Compound, Production and Use Thereof The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: | 09/13/2012 |
| 20120202738 | THERAPY FOR ENTERIC INFECTIONS There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhoea, chronic idiopathic nausea, IBD-associated constipation and diarrhoea, p... | 08/09/2012 |
| 20120189614 | INHIBITORS OF FILOVIRUS ENTRY INTO HOST CELLS Organic compounds showing the ability to inhibit viral glycoprotein (GP)-mediated entry of a filovirus into a host cell are disclosed. The disclosed filovirus entry inhibitor compounds are useful for treating, preventing, or reducing the spread of infections by filoviru... | 07/26/2012 |
| 20120184608 | N alkylcarbonyl amino lactone compounds and their use The present invention generally relates to refreshing, soothing, and cooling compounds that affect sensory processes. More particularly, the present invention pertains to certain N-alkylcarbonyl-amino lactone compounds as described herein; compositions and articles comp... | 07/19/2012 |
| 20120178780 | RAF KINASE INHIBITORS Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.... | 07/12/2012 |
| 20120148651 | Articles Having Antimicrobial Properties And Methods of Manufacturing the Same According to one embodiment, a coagulant comprising calcium nitrate and an antimicrobial agent is disclosed. The coagulant may be used in the molding process to releasably bond the substrate material to the mold and to bond to the antimicrobial to the substrate material... | 06/14/2012 |
| 20120135925 | Covalent Inhibition of Bacterial Quorum Sensing Inhibitors of bacterial communication, such as quorum sensing, and method of use and manufacture thereof.... | 05/31/2012 |
| 20120122877 | Compositions for Treating Bacterial Infections The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are useful as antibiotic compounds.... | 05/17/2012 |
| 20120071430 | SYNTHETIC ANALOGS OF BACTERIAL QUORUM SENSORS Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produc... | 03/22/2012 |
| 20120022100 | ORGANIC COMPOUNDS Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising thes... | 01/26/2012 |
| 20120022116 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PATHOLOGICAL CONDITION(S) RELATED TO GPR35 AND/OR GPR35-HERG COMPLEX Disclosed are compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically related to GPR35, and/or GPR35-hERG signaling complex. For example, disclosed are compounds for preventing and/or treating diseases which are pathophysi... | 01/26/2012 |
| 20110319455 | Antifungal Treatment A method of treating or preventing fungal infection, which includes identifying a plant or animal having a fungal infection and administering an effective amount of an anti-fungal composition to the plant or animal to reduce the fungal infection. In a preferred form of ... | 12/29/2011 |
| 20110245262 | COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS Disclosed are compounds and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also, disclosed are pharmaceut... | 10/06/2011 |
| 20110245204 | CYCLOALKANE-CONTAINING SPHINGOSINE 1-PHOSPHATE AGONISTS The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention include compounds having a phosphate moiety as well as compounds ... | 10/06/2011 |
| 20110178108 | Group of amino substituted benzoyl derivatives and their preparation and their use A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also ... | 07/21/2011 |
| 20110144043 | Stat modulators The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for treating and/or preventing disorders characterized by Stat dysregulation, such... | 06/16/2011 |
| 20110105533 | Heterocyclic Sulfonamides, Uses and Pharmaceutical Compositions Thereof The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula I: as defined in the specification. The invention is also d... | 05/05/2011 |
| 20110092564 | CYCLIC AMINO ACIDS FOR THE TREATMENT OF PAIN Compositions comprising cyclic amino acids or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier. Said composition are for use in the treatment of pain. Pain includes both acute and chronic forms of pain. The preferred cyclic amino acid ... | 04/21/2011 |
| 20110053890 | SYNTHETIC ANALOGS OF BACTERIAL QUORUM SENSORS Bacterial quorum-sensing molecule analogs having the following structures: and methods of reducing bacterial pathogenicity, comprising providing a biological system comprising pathogenic bacteria which produc... | 03/03/2011 |
| 20110046142 | ANTIBIOTIC COMPOUNDS Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these compounds.... | 02/24/2011 |
| 20110027356 | Combination of Oral Medicaments Bonded by a Wrapping Oral pharmaceutical dosage form containing at least two medicaments, in which form the medicaments on the one hand are brought together in a leakproof and in-vivo water soluble wrapping and on the other hand are separated so that the active principle of the combined med... | 02/03/2011 |
| 20100305182 | COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA The present invention provides compositions and methods for modulating the communication and virulence of quorum sensing bacteria. In various exemplary embodiments, the invention provides a combinatorial library of quorum sensing compounds including synthetic analogs of... | 12/02/2010 |
| 20100292261 | QUORUM SENSING ANTAGONIST, METHOD OF PREVENTING A BIOFILM FORMATION USING THE QUORUM SENSING ANTAGONIST AND METHOD OF REDUCING A BACTERIAL CONTAMINATION USING THE QUORUM SENSING ANTAGONIST In the quorum sensing antagonist blocking the communication in bacteria, the method for preventing biofilm formation using this quorum sensing antagonist and the method for reducing the bacterial contamination, the quorum sensing antagonist contains the homoserine lacto... | 11/18/2010 |
| 20100292321 | BIOFILM CONTROL Compositions and methods suitable for killing bacteria and controlling biofilms comprising one or more microorganisms are provided wherein molecules capable of emulating cell-to-cell signal molecules of the microorganisms are utilized.... | 11/18/2010 |
| 20100286261 | SUBSTITUTED N-ACYL HOMOSERINE LACTONES The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 11/11/2010 | |
| 20100160423 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The ... | 06/24/2010 |
| 20100160371 | INHIBITION OF P38 KINASE ACTIVITY BY ARYL UREAS This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases other than cancer and proteolytic enzyme mediated diseases other than cancer, and pharmaceutical compositions for use in such therapy.... | 06/24/2010 |
| 20100137401 | 2-METHYLPROP ANAMIDES AND THEIR USE AS PHARMACEUTICALS The present invention relates to inhibitors of 11-β hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases ass... | 06/03/2010 |
| 20100069484 | SIGMA(s)-RECEPTOR LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES OVER CELLULAR BIOCHEMICAL MECHANISMS, WITH NEUROPROTECTIVE, ANTI-CANCER, ANTI-METASTATIC AND ANTI-(CHRONIC) INFLAMMATORY ACTION The present invention involves new and original sigma receptors ligands : (Mono- or di-alkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydrofuranes, the (1-adamantyl)phenyl(s) alkylamines, the N,N Dialkyl α-[(adamantyl-1)benzyloxy-2] alkylamines and the 3... | 03/18/2010 |
| 20100063088 | Raf Kinase Inhibitors Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.... | 03/11/2010 |
| 20100048545 | Compounds and Compositions for Use in the Prevention and Treatment of Disorders of Fat Metabolism and Obesity The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in t... | 02/25/2010 |
| 20100016424 | PRODUCTION AND USE OF DERIVATIZED HOMOSERINE LACTONES The present invention provides analogues of autoinducer molecules that are derivatized to allow their attachment to other molecules and surfaces. Libraries of the autoinducer analogues are also contemplated. Also provided are methods for using the compounds of the inven... | 01/21/2010 |
| 20090221643 | 4-PHENYL-3-(2-PROPYLSULFONYLAMINO) TETRAHYDROFURAN DERIVATIVES WHICH POTENTIATE GLUTAMATE RECEPTORS AND ARE USEFUL IN THE TREATMENT OF SCHIZOPHRENIA Compounds of formula (I), salts and solvates thereof are provided: wherein Ar is selected from phenyl, pyridyl and thienyl optionally substituted with one or more groups Y; and each Y group is independently s... | 09/03/2009 |
| 20090203641 | ANTIBIOTIC COMPOSITIONS AND RELATED SCREENING METHODS Moenomycin inhibits bacterial growth by clocking the transglycosylase activity of class A penicillin-binding proteins (PBPs), which are key enzymes in bacterial cell wall synthesis. The binding affinities of moenomycin A with various truncated PBPs were compared showing... | 08/13/2009 |
| 20090176836 | Cyclic Ketal Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease The present invention is directed to cyclic ketal compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme... | 07/09/2009 |
