User-operated amusement apparatus for kicking the user's buttocks
An apparatus including a user-operated and controlled apparatus for self-infliction of repetitive blows to the user's buttocks by a plurality of elongated arms bearing flexible extensions that rotate under the user's control.
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| Application No. | Application Title | Issue Date |
| 20120129895 | METHODS OF TREATMENT The invention relates to combinations comprising a vascular disrupting agent (VDA) with IAP antagonists, for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases.... | 05/24/2012 |
| 20120128778 | COMPOSITIONS AND METHODS FOR ONCE-DAILY ADMINISTRATION OF A TRILAYER OSMOTIC TABLET A trilayer osmotic tablet is described. The tablet includes a core, a semi-permeable membrane disposed generally around the core, and an orifice in the semi-permeable membrane in fluid communication with the core. The core includes first, second, and third layers. The f... | 05/24/2012 |
| 20120071539 | COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decreas... | 03/22/2012 |
| 20120045531 | METHODS OF TREATING CELLULITE Provided are methods of treating cellulite, the methods comprising applying to skin in need of cellulite treatment a composition comprising paulownin or an extract of Paulownia wood.... | 02/23/2012 |
| 20120046238 | COUMARIN COMPOUNDS AND THEIR USE FOR TREATING VIRAL INFECTION A method for treating an infection with a virus. The method includes administering to a subject in need thereof an effective amount of one or more coumarin compounds of formula (I): wherein R1, R | |
| 20120042398 | COMPOSITIONS FOR LABELING AND IDENTIFYING AUTOPHAGOSOMES AND METHODS FOR MAKING AND USING THEM The invention provides methods and compositions for detecting and measuring the amount of autophagosomes in cells or tissues, including biopsy samples, in vitro, in situ and/or in vivo. By detecting and measuring the amount of autophagosomes in cells or tissues, the met... | 02/16/2012 |
| 20120039796 | Novel method for creating, suspending and stabilizing electronically modified oxygen derivatives, along with creating, suspending and stabilizing electronically modified reaction intermediates, in a bio compatible fluorocarbon suspension, for the purpose of inducing a cascading immune response in mammalian patients A bio compatible free radical suspension, comprising of oxygen and electronically modified reaction intermediates, where a fluorocarbon is used as an inert medium for stabilization of reaction intermediates. A stabilized bio compatible electronically modified derivative... | 02/16/2012 |
| 20120034216 | SPIROKETALS The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also u... | 02/09/2012 |
| 20120010213 | ORAL CONTROLLED RELEASE DOSAGE FORMS FOR WATER SOLUBLE DRUGS Disclosed herein is an oral controlled release pharmaceutical formulation comprising water-soluble drug or pharmaceutically acceptable salts thereof, in a hydrophilic matrix system, further comprising pH independent polymers present in an amount of 5% to 90% w/w in comb... | 01/12/2012 |
| 20120010219 | SALVINORIN DERIVATIVES AND USES THEREOF The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinori... | 01/12/2012 |
| 20120003312 | Multilayer Minitablets with Different Release Rates Multilayer minitablets for oral administration of a combination of active pharmaceutical ingredients which release the active pharmaceutical ingredient at different release rates are described.... | 01/05/2012 |
| 20110319389 | METHODS AND COMPOSITIONS FOR TREATING FATIGUE ASSOCIATED WITH DISORDERED SLEEP USING VERY LOW DOSE CYCLOBENZAPRINE The present invention relates to methods for the treatment or prevention of fatigue associated with disordered sleep, for example, in multiple sclerosis, fibromyalgia, Fabry's disease, Parkinson's disease, or traumatic brain injury, using cyclobenzaprine The present inv... | 12/29/2011 |
| 20110318425 | TREATMENT OF INTERSTITIAL CYSTITIS USING (6aR, 10aR)- DELTA-8-TETRAHDRAOCANNABINOL-11-OIC ACIDS The present invention relates to non-psychoactive derivatives of tetrahydrocannabinol, which are useful in treating interstitial cystitis and relieving symptoms thereof. The invention uses (6aR,10aR)-Δ8-tetrahydrocannabinol-11-oic acids (hereinafter referred... | 12/29/2011 |
| 20110280909 | METHOD AND SYSTEM FOR EFFECTING CHANGES IN PIGMENTED TISSUE Methods and systems are described for a rapid and sustainable change in the pigment melanin content of melanocytes of the iris stroma, thereby to change the color of the eye. Also described are nanoparticle compositions for lightening the pigmented tissues or treating a... | 11/17/2011 |
| 20110275571 | KV1.3 CHANNEL BLOCKING SUBSTANCES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH INTIMAL HYPERPLASIA The present invention provides a therapeutic tool against intimal hyperplasia consisting of the use of Kv1.3 channel blocking substances, able to selectively stop cell migration and multiplication of VSMCs.... | 11/10/2011 |
| 20110275703 | SUBSTITUTED SPIROKETAL DERIVATIVES AND USE THEREOF AS THERAPEUTIC DRUG FOR DIABETES The present invention provides a compound represented by Formula (II):
| |
| 20110268679 | COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved ski... | 11/03/2011 |
| 20110263694 | Use of Xanthone Derivatives as a Medicament for Cancer The invention relates to xanthone derivatives of formula (IA) or (IB) and their use for manufacturing a medicament for cancer, and in particular for chemotherapeutic resistant cancer. More particularly, the invention relates to compounds and compositions comprising such... | 10/27/2011 |
| 20110262362 | METHODS FOR TREATING OBESITY The present invention provides methods to reduce or inhibit weight gain by administering inhibitors of the SirT1 protein to a subject. Methods to identify such inhibitors are also disclosed.... | 10/27/2011 |
| 20110262457 | MODULATION OF THE IMMUNE RESPONSE Methods for increasing the generation of IL-17-producing T cells (TH17) in vivo and in vitro, and enriched populations of TH17 cells for the treatment of diseases benefiting from an induced or enhanced immune response, e.g., infection and cancer.... | 10/27/2011 |
| 20110262535 | Low Dose Topiramate / Phentermine Composition and Methods of Use Thereof A method for effecting weight loss by administering a combination of topiramate and phentermine is provided. The phentermine is generally administered in immediate release form, in a daily dose in the range of 2 mg to 8 mg, in combination with a daily dose of topiramate... | 10/27/2011 |
| 20110263695 | NFAT Signal Inhibitor and Hair-Growing Agent An NFAT signal inhibitor and the like are provided. An NFAT signal inhibitor and the like, containing, as an active ingredient, at least one compound selected from the group consisting of a coumarin derivative represented by formula [where ... | 10/27/2011 |
| 20110263920 | ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of activation by a simultaneous two photon absorption event and of effecting a pr... | 10/27/2011 |
| 20110250296 | REVERSE VITAMIN K EFFECT VIA PHOTODYNAMIC OXIDATION TARGETED AT VASCULAR ENDOTHELIUM, FIBRIN AND BLOOD PLATELETS A formulation or preparation for treating and preventing arterial and venous thrombi is provided. This preparation includes a non-metal containing photodynamic dye and a fat soluble vitamin. A method of administration for treatment and prophylaxis of arterial and venous... | 10/13/2011 |
| 20110243917 | COMPOSITION FOR THE PREVENTION AND TREATMENT OF ABSENCE SEIZURES COMPRISING PKC AGONIST AS AN EFFECTIVE INGREDIENT The present invention relates to a composition comprising PKC agonist as an active ingredient. More precisely, the present inventors confirmed that absence seizure specific SWD was reduced by administrating PKC agonist into an animal model. Therefore, the composition of... | 10/06/2011 |
| 20110236400 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in on... | 09/29/2011 |
| 20110229495 | METHODS FOR PREDICTING DEVELOPMENT OF AUTO-IMMUNE DISEASES AND TREATMENT OF SAME The present invention provides a new method for the prediction of, or diagnosis of, auto-immune diseases, thereby alerting the subject to the presence of, or propensity to develop, an auto-immune disease so that preventative or therapeutic regiments may be initiated or ... | 09/22/2011 |
| 20110224146 | AUGMENTED COGNITIVE TRAINING The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity... | 09/15/2011 |
| 20110224170 | Pyranopyranone derivatives as antimicrobial agents Disclosed is the use of pyranopyranone derivatives of formula wherein
| |
| 20110218239 | Use of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antiviral Agent The invention relates to the areas of therapeutics, pharmaceuticals, drug discovery, and immunotherapy. More specifically, the present invention relates to methods of stimulating the immune system through the administration of flavone acetic acid [FAA] analogues, and in... | 09/08/2011 |
| 20110217202 | ACTIVE OXYGEN DISINFECTION SYSTEM AND USE THEREOF The present invention provides a lens care kit for disinfecting and/or cleaning contact lenses. The lens care kit of the invention comprising: (1) a lens care solution; (2) a lens case for holding the lens care solution and a contact lens immersed in the lens care solut... | 09/08/2011 |
| 20110201678 | Xanthenone-4-Acetic Acid Derivatives This invention relates to novel compounds that are xanthenone-4-acetic acid derivatives and pharmaceutically acceptable salts thereof. More specifically, this invention relates to novel xanthenone-4-acetic acid derivatives that are derivatives of AS 1404. This invention... | 08/18/2011 |
| 20110190244 | METHOD OF TREATMENT OF EGFR INHIBITOR TOXICITY The invention provides a method of treating and/or preventing a toxicity associated with epidermal growth factor receptor (EGFR) inhibitor therapy in a subject, the method comprising administering to the subject an effective amount of a steroid sulfatase (STS) inhibitor... | 08/04/2011 |
| 20110190229 | COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING A method for preventing hyperpigmented skin, undesired pigmentation disorder of skin, or undesired darkening of skin using coumarin compounds, the use of such compounds, and compositions and formulations thereof are disclosed. In a particular embodiment, the coumarin co... | 08/04/2011 |
| 20110178153 | METHODS OF TREATING CHEMORESISTANCE AND RELAPSE IN CANCER CELLS Methods of treating or preventing chemoresistance or relapse growth of cancer cells are provided. Methods of treating or preventing resistance to tyrosine kinase based chemotherapeutic treatment in hematologic and solid tumors are provided. BCR-ABL drug resistance in ch... | 07/21/2011 |
| 20110171300 | DELTA 9 TETRAHYDROCANNABINOL DERIVATIVES A compound of formula (I) wherein R is selected from
| 07/14/2011 |
| 20110172185 | THERAPEUTIC DRUG FOR ADULT T-CELL LEUKEMIA An object is to provide a novel therapeutic drug for adult T-cell leukemia having an ATL cell specific antitumor effect. The therapeutic drug for adult T-cell leukemia according to the invention is characterized by containing a compound represented by the formula I or a... | 07/14/2011 |
| 20110171195 | METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog the... | 07/14/2011 |
| 20110165125 | METHODS FOR ENHANCING ENERGY METABOLISM The invention provides methods for one or more of enhancing energy metabolism, promoting healthy energy metabolism, maintaining healthy energy metabolism, preventing conditions that result in a decline or deficiency in energy metabolism, treating conditions that result ... | 07/07/2011 |
| 20110166217 | PHARMACEUTICAL COMPOSITION FOR PREVENTION AND/OR TREATMENT OF BONE LOSS A pharmaceutical composition for preventing and/or treating bone loss is disclosed. The pharmaceutical composition includes an effective amount of a licorice, black bean, Cnidi Fructus, and buckhorn.... | 07/07/2011 |