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| Application No. | Application Title | Issue Date |
| 20120129860 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative... | 05/24/2012 |
| 20120129906 | MODULATORS OF S1P RECEPTORS The present invention relates to novel diphenylethyne derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.... | 05/24/2012 |
| 20120046291 | Extended Triterpene Derivatives The present invention concerns novel pharmaceutically active triterpene derivatives, pharmaceutical compositions containing the same, their use as medicaments, and the use of the compounds for the manufacture of specific medicaments. The present invention also concerns ... | 02/23/2012 |
| 20120035154 | Modulators of Cellular Adhesion The present invention provides compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein R1-R4, n, p, A, B, D, E, L and AR1 are as described g... | 02/09/2012 |
| 20120027700 | SKIN CARE COMPOSITIONS COMPRISING SUBSTITUTED DIAMINES Skin care compositions comprising certain substituted diamines, which are particularly beneficial for skin lightening and achieving evenness of color, especially for face and underarm skin.... | 02/02/2012 |
| 20120022039 | NOVEL SUBSTITUTED INDANES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS The invention relates to substituted indanes and derivatives thereof, to physiologically acceptable salts and physiologically functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according to the invention or der... | 01/26/2012 |
| 20110294767 | BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.... | 12/01/2011 |
| 20110245244 | PHENOXY ACETIC ACIDS AS PPAR DELTA ACTIVATORS Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds are activators of PPARÎ... | 10/06/2011 |
| 20110237538 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-gluc... | 09/29/2011 |
| 20110172258 | INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS Compounds of formula (Ia):
| 07/14/2011 |
| 20110117219 | HAIR TREATMENT PRODUCT AND HAIR AFTER-TREATMENT PRODUCT CONTAINING ETHER GUANIDINES AS ACTIVE SUBSTANCES, FOR PROTECTING FROM DAMAGE CAUSED BY CHEMICAL TREATMENT AND FOR REPAIRING ALREADY DAMAGED HAIR The invention relates to ether guanidines of the general formulae (I) and/or salts or hydrates thereof, in which R1=—CH2—CH2—CH2—O—R3 where R | |
| 20110111068 | Inhibitors of cognitive decline Compounds that are central nervous system drug candidates for the treatment of cognitive decline and, more particularly, Alzheimer's disease are provided. Methods of treating, inhibiting, and/or abatement of cognitive decline and Alzheimer's disease with a derivative of... | 05/12/2011 |
| 20110098309 | METHODS OF INHIBITING THE FORMATION OF AMYLOID-BETA DIFFUSABLE LIGANDS USING ACYLHYDRAZIDE COMPOUNDS Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid β1-42 oligomers from amyloid β1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient sufferi... | 04/28/2011 |
| 20110071202 | ANTI-HEPATITIS C VIRUS AGENTS AND ANTI-HIV AGENTS An anti-hepatitis C virus agent or anti-HIV agent comprising, as an active ingredient, a fullerene derivative which has a nitrogen atom forming a ring together with adjacent bonded carbon atom pairs constituting the carbon cluster skeleton of the fullerene or a quaterna... | 03/24/2011 |
| 20100292279 | Bis-(Sulfonylamino) Derivatives in Therapy The invention provides compounds of formula wherein R1, R2, R3, A and m are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceu... | 11/18/2010 |
| 20100291069 | METHODS OF TREATING A DIABETIC EMBRYOPATHY Maternal diabetes can lead to a developmental malformation of an embryo. A developmental malformation caused by maternal diabetes is commonly referred to as a diabetic embryopathy. There is currently no effective treatment for reducing or inhibiting a diabetic embryopat... | 11/18/2010 |
| 20100292288 | CRYSTALLINE FORMS OF (R)-1-{2-[4`- (3-METHOXY-PROPANE-1- SULFONYL)-BIPHENYL-4-YL]-ETHYL}-2-METHYL-PYRROLIDINE, AND COMPOSITIONS, AND METHODS RELATED THERETO The present invention is directed to novel salts of (R)-1-{2-[4′-(3-methoxy-propane-1-sulfonyl)-biphenyl-4-yl]-ethyl}-2-methyl-pyrrolidine, and crystalline forms, and compositions thereof that modulate the activity of the histamine H3-receptor and are useful in the tr... | 11/18/2010 |
| 20100273778 | TREATMENT OF OSTEOARTHRITIS PAIN This invention discloses a method of treatment of osteoarthritis pain by administration of a histamine H3 receptor antagonist, described herein, a salt thereof, or a composition comprising such compound or salt.... | 10/28/2010 |
| 20100267690 | TRICYCLIC GUANIDINE DERIVATIVES AS SODIUM-PROTON EXCHANGE INHIBITORS Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or ... | 10/21/2010 |
| 20100260671 | COMPOUNDS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AMYLOID ASSOCIATED DISEASES The invention is in general directed to compounds, such as tannic acid, nicotine, nicotine derivatives and pyrrolid derivatives of nicotine, and methods for diagnosing, preventing or alleviating the symptoms of amyloid-associated diseases, for example, neuronal diseases... | 10/14/2010 |
| 20100256213 | Tosylate Salt Of Trans-N-Isobutyl-3-Fluoro-3- [3-Fluoro-4-(Pyrrolidin-1-YL-Methyl)-Phenyl] Cyclobut Anecarboxamide The present invention is directed to the tosylate salt of trans-N-isobutyl-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)-phenyl]-cyclobutanecarboxamide Formula (I): to solvates (e.g., hydrates) thereof, to p... | 10/07/2010 |
| 20100256214 | EPH RECEPTOR LIGANDS AND METHODS OF USE Disclosed are methods and compositions relating to binder, modulators and inhibitors of EphA4 and EphA2.... | 10/07/2010 |
| 20100240653 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds of the present invention and pharmaceutical compositions thereof are dire... | 09/23/2010 |
| 20100222406 | T Type Calcium Channel Blockers and the Treatment of Diseases The present invention provides a method for treating a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, which comprises administering to the mammal a therapeutically effective amount of a T type calcium channe... | 09/02/2010 |
| 20100210630 | Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c | |
| 20100204294 | Methods For Assessing, Improving, Or Maintaining Urogenital Health in Postmenopausal Woman This invention relates to methods and kits useful for improving or maintaining urogenital health using an estrogen agonist/antagonist. The methods of treatment are effective for improving or maintaining urogenital health while substantially reducing the concomitant liab... | 08/12/2010 |
| 20100197640 | NOVEL SULFAMOYL-PHENYL-UREIDO COMPOUNDS AND THEIR USE AS MEDICAMENT The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malar... | 08/05/2010 |
| 20100158818 | ANTIMICROBIAL N-CHLORINATED COMPOSITIONS The present application relates to N-chlorinated cationic compounds of Formula I or a salt thereof, and associated compositions and methods of use as antimicrobial agents.... | 06/24/2010 |
| 20100152220 | INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS Compounds of formula (Ia):
| 06/17/2010 |
| 20100152179 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), ... | 06/17/2010 |
| 20100130472 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES Provided herein are methods of utilizing bile acid transport inhibitors for the treatment of obesity and diabetes.... | 05/27/2010 |
| 20100120615 | 4-CYCLOALKYL OR 4-SUBSTITUTED PHENOXYPHENYLAMIDINES AND USE THEREOF AS FUNGICIDES The present invention relates to 4-cycloalkyl- or 4-aryl-substituted phenoxyphenylamidines of the general formula (I), to a process for their preparation, to the use of the amidines according to the invention for controlling unwanted microorganisms and also to a composi... | 05/13/2010 |
| 20100105753 | Inhibitors of Fibroblast Activation Protein, and Methods of Use Thereof One aspect of the present invention relates to synthetic peptide derivatives that inhibit fibroblast activation protein α (FAP) activity. Another aspect of the invention relates to methods for treating a mammal suffering from cancer by administering a therapeutically e... | 04/29/2010 |
| 20100093672 | USE OF S1P RECEPTOR MODULATOR Use of an S1P receptor modulator in the treatment or prevention of a disease or condition dependent on brain-derived neurotrophic factor (BDNF) expression.... | 04/15/2010 |
| 20100093673 | PAIN RELIEVING PATCH Described here are patches for the treatment of pain. The patches include a carrier material, which itself, in the absence of an active agent, is capable of relieving pain. Methods of treating pain using the patches are also described.... | 04/15/2010 |
| 20100076036 | HETEROCYCLYL-SUBSTITUTED SULFONAMIDES FOR THE TREATMENT OF COGNITIVE OR FOOD INGESTION RELATED DISORDERS The present invention relates to heterocyclyl-substituted sulfonamides with 5-HT6 receptor affinity, and compositions thereof, and the use of said compounds for the treatment or prophylaxis of various disorders.... | 03/25/2010 |
| 20100076034 | 2-ARYL-2-FLUOROPROPANOIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage... | 03/25/2010 |
| 20100076024 | Novel Compounds as Serine Protease Inhibitors The invention relates to compounds of formula (I) wherein the substituents are as defined in claim 1; to compositions comprising said compounds and to their use as pharmaceutical agents, in particular as inhibitors of serine proteases. 03/25/2010 | |
| 20100063090 | Composition for Repelling and Deterring Vermin The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known beta amino-alcohol derivatives of formula (I), as defined herein before. Furthermore, it describes the corresponding vermin-deterring c... | 03/11/2010 |
| 20100063135 | POLYETHYLENE GLYCOL LIPID CONJUGATES AND USES THEREOF Polyethylene glycol (PEG)-lipid conjugates, polyethylene glycol (PEG)-lipid conjugate based drug delivery systems, ways to make them and methods of treating diseases using them are disclosed.... | 03/11/2010 |
