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| Application No. | Application Title | Issue Date |
| 20100234274 | Use of Nestafin-1 in the Treatment for Diabetes The present invention provides a method of treating diabetes by increasing peripheral nesfatin-1. Peripheral nesfatin-1 can be increased by administration of nesfatin-1, conjugated nesfatin-1 that would not penetrate the blood-brain barrier, or plasmin inhibitors. The p... | 09/16/2010 |
| 20100233116 | ORGANIC COMPOUNDS The present invention provides heterocyclic derivatives hat modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encom... | 09/16/2010 |
| 20100235935 | PLASMA ANTI-DIABETIC NUCB2 PEPTIDE (PLADIN) AND USES THEREOF The present invention provides pladin (plasma anti-diabetic nucb2 peptide) polypeptide and functional equivalent thereof that are useful for treating diabetes. The present invention provides a method of treating diabetes by administering to a subject nesfatin-1, pladin,... | 09/16/2010 |
| 20100227797 | USE OF CYCLOLIGNANS FOR THE TREATMENT OF TYPE 2 DIABETES AND AS CONTRACEPTIVES There is disclosed use of certain cyclolignans for prophylaxis or treatment of diabetes mellitus type 2, nephropathy, retinopathy, macular degeneration, retinopathy of prematurity, central retinal vein occlusion, branch retinal vein occlusion, rubeotic glaucoma, thyroid... | 09/09/2010 |
| 20100221240 | Chemically Modified Peptide Analogs The present invention relates to improved agents and methods for treating diabetes and Alzheimer's disease by use of IAPP peptide derivatives.... | 09/02/2010 |
| 20100221343 | COMPOSITIONS AND METHODS OF MAKING BRITTLE-MATRIX PARTICLES THROUGH BLISTER PACK FREEZING The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrof... | 09/02/2010 |
| 20100222251 | MIXTURE COMPRISING AN AMYLIN PEPTIDE AND A PROTRACTED INSULIN The invention relates to a soluble pharmaceutical composition for parenteral administration, which comprises an amylin peptide and a protracted insulin peptide.... | 09/02/2010 |
| 20100216694 | ANTIDIABETIC TRICYCLIC COMPOUNDS Tricyclic compounds containing a cyclopropanecarboxylic acid fused to a bicyclic ring, including pharmaceutically acceptable salts, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 dia... | 08/26/2010 |
| 20100215689 | Soluble Fiber Combinations for Weight Control and Improving Parameters of Cardiovascular Health A food or pharmaceutical agent is provided for treating or offsetting the risks of a disease or disorder such as a cardiovascular disease, a hypercholesterolemia disorder, a low serum high density lipid (HDL)/low density lipid (LDL) ratio, a hypertriglyceridemia disorde... | 08/26/2010 |
| 20100216693 | COMPOSITIONS AND METHODS OF TREATING DIABETES The invention features compositions comprising insulin and C-peptide and methods for treating diabetes, using such compositions. The invention further features compositions comprising insulin analogues and C-peptide and the uses thereof for treating diabetes.... | 08/26/2010 |
| 20100209532 | TARGETED OXYGEN DELIVERY VIA INTRAVENOUS OR INTRA-ARTERIAL INFUSION OF OXYGENATED POLYMERIZED HEMOGLOBIN SOLUTIONS A method of delivering oxygen to a tissue, a blood vessel, an organ, or a region of an organ, under an ischemic condition, or prophylactically preventing occurrence of an ischemic condition, of a subject, comprising the step of administering to the subject an oxygenated... | 08/19/2010 |
| 20100210506 | INTRANASAL ADMINISTRATION OF RAPID ACTING INSULIN What is described are pharmaceutical compositions, formulations, and uses thereof, for medicaments for intranasal delivery of insulin to a patient, comprising an aqueous mixture of human insulin, a solubilizing agent, and a surface active agent, wherein the human insuli... | 08/19/2010 |
| 20100210505 | POLYMER CONJUGATES OF GLP-1 Conjugates of a GLP-I moiety may be covalently attached to one or more water-soluble polymers. For instance, a GLP-I polymer conjugate may include a GLP-I moiety releasably attached at its N-terminus to a water-soluble polymer. The GLP-I polymer conjugate may include a ... | 08/19/2010 |
| 20100209350 | Biomarkers for Adipose Tissue Activity The invention provides compositions and methods for determining a subject's adipose tissue activity. In one embodiment, the composition comprises a solid support comprising probes for measuring a biomarker panel comprising, for example, adiponectin, resistin, PAI-1, opt... | 08/19/2010 |
| 20100211015 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally activ... | 08/19/2010 |
| 20100203119 | PHARMACEUTICAL TREATMENT PROCESS USING CHITOSAN OR DERIVATIVE THEREOF The present invention provides a solid composition for oral administration comprising:
| 08/12/2010 |
| 20100190687 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder rel... | 07/29/2010 |
| 20100173825 | HETEROARYL BENZAMIDE DERIVATIVES The invention relates to a novel group of compounds of Formula (I) or a salt thereof: wherein R1, R2, R3, n, A and HET-1 are as described in the specification, which may be us... | 07/08/2010 |
| 20100174222 | METHOD AND APPARATUS FOR ACNE TREATMENT USING LOW INTENSITY LIGHT THERAPY Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteri... | 07/08/2010 |
| 20100167990 | Pharmaceutical Formulations Comprising an Insulin Derivative The invention concerns a soluble pharmaceutical formulation comprising an insulin derivative wherein the formulation further comprises more than 4 zinc atoms per 6 molecules of the insulin derivative, and a citric acid monohydrate and/or a histidine compound used in an ... | 07/01/2010 |
| 20100167987 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of at least one agent for modulating PKC production... | 07/01/2010 |
| 20100167986 | Cholesteryl Ester Transfer Protein Inhibitors Compounds of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), A1 07/01/2010 | |
| 20100166843 | PHARMACEUTICAL COMPOSITION COMPRISING A CAMPOTHECIN DERIVATIVE The present invention relates to pharmaceutical compositions comprising a topoisomerase I inhibitor including, but not limited to, a camptothecin derivative.... | 07/01/2010 |
| 20100167988 | ETHOXYPHENYLMETHYL INHIBITORS OF SGLT2 The present invention relates to new ethoxyphenylmethyl modulators of SGLT2, pharmaceutical compositions thereof, and methods of use thereof. ... | 07/01/2010 |
| 20100167989 | ISOPROPOXYPHENYLMETHYL INHIBITORS OF SGLT2 The present invention relates to new isopropoxyphenylmethyl inhibitors of SGLT2, pharmaceutical compositions thereof, and methods of use thereof. ... | 07/01/2010 |
| 20100144594 | 2-HETEROARYL-PYRROLO[3,4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS The invention relates to heterocyclic derivatives of formula I wherein R, R1, A, B, D, M, L and n are as defined herein, or their physiologically compatible salts, their pharmaceutical compositions and their ... | 06/10/2010 |
| 20100143341 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS The present invention relates to novel pharmaceutical compositions of general formula (I) comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical co... | 06/10/2010 |
| 20100136133 | NUTRITIVE COMPOSITIONS AND METHODS OF USING SAME The invention provides intradialytic parenteral nutrition (IDPN) solutions with low carbohydrate for the treatment of malnutrition in dialysis patients. The IDPN solutions of the invention are particularly advantageous for the treatment of malnutrition in patients who a... | 06/03/2010 |
| 20100130403 | Biomarkers for insulin efficacy The invention provides compositions and methods for determining insulin efficacy in a subject. The invention also provides compositions and methods for treating a subject according to the efficacy of insulin in the subject.... | 05/27/2010 |
| 20100129332 | METHODS AND PHARMACEUTICAL COMPOSITIONS FOR HEALING WOUNDS A pharmaceutical composition and method for inducing or accelerating a healing process of a skin wound are described. The pharmaceutical composition contains, as an active ingredient, a therapeutically effective amount of at least one agent for modulating PKC production... | 05/27/2010 |
| 20100129311 | PHENYLALANINE AMIDE INHIBITORS OF ATP-SENSITIVE POTASSIUM CHANNELS The present invention relates to new phenylalanine amide inhibitors of ATP-sensitive potassium channels, pharmaceutical compositions thereof, and methods of use thereof. ... | 05/27/2010 |
| 20100130404 | Biomarkers for cardiodiabetes The invention provides compositions and methods for determining cardiodiabetes status in a subject. The invention also provides compositions and methods for treating a subject experiencing cardiodiabetes.... | 05/27/2010 |
| 20100124541 | HYDROXYADAMANTYL INHIBITORS OF DIPEPTIDYLPEPTIDASE IV The present invention relates to new hydroxyadamantyl inhibitors of dipeptidylpeptidase IV activity, pharmaceutical compositions thereof, and methods of use thereof. ... | 05/20/2010 |
| 20100120662 | Glucose uptake modulator and method for treating diabetes or diabetic complications The present invention relates to an glucose uptake modulator, a pharmaceutical composition comprising the glucose uptake modulator, and a method of treating a diabetes or diabetic complications in a mammal in need thereof, which comprises administering to said mammal an... | 05/13/2010 |
| 20100113330 | TETRAHYDROPYRIDO[4,3-D]PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF The present invention relates to methods of using Tetrahydropyrido[4,3-d]Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disorder, a cardiovascular disease or a disorder related to the activity of GPR119 in a patient.... | 05/06/2010 |
| 20100113331 | Substituted Imidazole Derivatives, Compositions, and Methods of Use as PtPase Inhibitors The present invention provides imidazole derivatives of Formula (I-IV), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I-IV), and their use in treating human or animal disorders. The compounds of the invention inhibit prot... | 05/06/2010 |
| 20100113487 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF The present invention relates to Pyrimidinone Derivatives, compositions comprising a Pyrimidinone Derivative, and methods of using the Pyrimidinone Derivatives for treating or preventing obesity, diabetes, a metabolic disease, a cardiovascular disease or a disorder rela... | 05/06/2010 |
| 20100104549 | GLUFOSFAMIDE COMBINATION THERAPY The co-administration of glufosfamide and a glucose lowering drug other than insulin is efficacious in cancer treatment.... | 04/29/2010 |
| 20100105605 | FATTY ACID FORMULATIONS AND ORAL DELIVERY OF PROTEINS AND PEPTIDES, AND USES THEREOF Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated for ... | 04/29/2010 |
| 20100105604 | ALLYLOXY AND ALKYLOXY BENZOIC ACID DELIVERY AGENTS The present invention relates to pharmaceutical compounds for delivering active agents, such as biologically or chemically active agents, to a target. The invention also relates to pharmaceutical compositions comprising at least one delivery agent compound of the presen... | 04/29/2010 |
