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| Application No. | Application Title | Issue Date |
| 20120129901 | TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS Formula (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydrolysable ester thereof, for preventing and/or inhibiting tumor growth ... | 05/24/2012 |
| 20120108527 | POLYMERIC TOPICAL COMPOSITIONS The present invention relates to topical antibacterial compositions. The compositions comprise an antibacterial agent such as mupirocin, water, a polymer and a volatile solvent present in an amount of less than about 40%. The invention also relates to methods of treatme... | 05/03/2012 |
| 20120071506 | METHODS FOR TREATING CNS DISORDERS WITH BICYCLO-SUBSTITUTED 2-IMIDAZOLINE AND 2-IMIDAZOLES The present invention relates to a method for treating a disorder selected from depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as ... | 03/22/2012 |
| 20120054920 | Hyperbranched Polycarbonates for Solubilizing Poorly Soluble Active Substances The present invention provides a composition comprising an amphiphile and an active ingredient whose solubility in water at 20° C. is not more than 10 g/L. Likewise provided is an amphiphile comprising a hyperbranched polycarbonate which is joined to at least one linea... | 03/01/2012 |
| 20120041031 | METHOD OF ACTIVATING REGULATORY T CELLS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS Disclosed herein is a method of upregulating regulatory T-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.... | 02/16/2012 |
| 20120041042 | Scent Ectoparasiticidal Formulation The present invention provides an improved-scent composition comprising metaflumizone, as well as a method for protecting against ectoparasite infestations in a warm-blooded animal.... | 02/16/2012 |
| 20120035176 | ANALOGS OF 3-O-ACETYL-11-KETO-BETA-BOSWELLIC ACID Analogs of 3-O-acetyl-11-keto-beta-boswellic acid and their method of preparation are presented. The analogs may be used as anti-inflammatory and anti-cancer agents. The compounds inhibit 5-lipoxygenase enzyme and various cell lines related to inflammation as well as to... | 02/09/2012 |
| 20120024743 | TRANSDERMAL PHARMACEUTICAL PREPARATIONS The present invention relates to semisolid transdermal pharmaceutical preparation having enhanced stability and bioavailability, wherein the particles are coated by a volatile silicon oil component and the thus obtained suspension is dispersed in a gel or cream base.... | 02/02/2012 |
| 20120022079 | Method For Producing Preparations Of Substances Poorly Soluble In Water The invention relates to a process for producing formulations of sparingly water-soluble substances, said sparingly soluble substances being present in amorphous embedded form in a copolymer, and said copolymer being obtained by free-radically initiated polymerization o... | 01/26/2012 |
| 20120022083 | SMALL MOLECULE MODULATORS OF CELL ADHESION Compounds, particularly compounds having activity as modulators of cadherin-mediated cell adhesion having the following structure: or a pharmaceutically acceptable salt, stereoisomer or prodrug thereof, 01/26/2012 | |
| 20120015017 | Slow releasing microcapsules containing an active substance A production method is provided for the preparation of small polymer microcapsules with an oil core and solid microspheres, containing high amounts of biocide by internal phase separation from emulsion droplets with ethyl acetate as a solvent. The size of the microcapsu... | 01/19/2012 |
| 20120004230 | IMIDAZOLE DERIVATIVES The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compo... | 01/05/2012 |
| 20110319459 | Compounds and Methods for Treating Cancer and Diseases of the Central Nervous System Disclosed are compounds of the general formula (I):
compositions comprising an effective amount of said compounds either alone or in combin... | 12/29/2011 |
| 20110312997 | Inhibition of WDR5 Interaction with Its Binding Partners Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.... | 12/22/2011 |
| 20110300152 | COMPOSITIONS AND METHODS FOR MODULATING CELL-CELL FUSION VIA INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS Compositions and methods are provided for modulating cell-cell fusion by using agents that modulate expression, activity, or function of intermediate-conductance calcium-activated potassium (SK4) channel. In some embodiments, the compositions and methods of the inventio... | 12/08/2011 |
| 20110301099 | Method for enhancing penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeability as carrier molecules A method and composition that allows for the penetration of lipid insoluble medicaments through cell membranes using small S-Allyl-containing molecules with phospholipid permeable molecules as carrier molecules. S-Allyl-containing compounds can include alliin, allicin, ... | 12/08/2011 |
| 20110274763 | Slow releasing microcapsules and microspheres containing an active substance A production method is provided for the preparation of small polymer microcapsules with an oil core and solid microspheres, containing high amounts of biocide by internal phase separation from emulsion droplets with ethyl acetate as a solvent. The size of the microcapsu... | 11/10/2011 |
| 20110269666 | METHOD AND DRUG COMPOSITION FOR TREATING SEPTIC SHOCK HYPOTENSION A method for treating septic hypotension, including administering at least one alpha-2 agonist or other sympatholytic, and at least one vasopressor. The alpha-2 agonist may be clonidine or dexmedetomidine, and the sympaholytic may be rilmelidine, monoxidine, alpha-methy... | 11/03/2011 |
| 20110269704 | METHOD FOR DEVELOPING A LIQUID COMPOSITION TO BE APPLIED TO THE SKIN AS A FOAM AND A COMPOSITION THAT CAN BE APPLIED TOPICALLY A liquid pharmaceutical composition to be applied to the skin as a foam and that has at least one solvent, at least one active pharmaceutical ingredient, and at least one foaming agent. The foam volume and the foam stability are determined according to a standardized SI... | 11/03/2011 |
| 20110268684 | HAIR CONDITIONERS COMPRISING IMIDAZOLINES AND ESTER OILS Cosmetic preparations, in particular hair conditioners, contain at least one imidazoline derivative including at least two long fat groups, and at least two ester oils.... | 11/03/2011 |
| 20110257235 | TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF The present disclosure relates to certain new and known triazolium and/or imidazolium salts and to their therapeutic use, for example in methods of treating or preventing an infection by a Plasmodium or Babesia parasite in a subject in need thereof. The tr... | 10/20/2011 |
| 20110244058 | Compositions and methods for treatment of pulmonary diseases and conditions The invention provides compositions and methods for treating pulmonary diseases and conditions. The provided compositions and methods utilize either low concentrations of selective α-2 adrenergic receptor agonists having a binding affinity of 300 fold or greater for α... | 10/06/2011 |
| 20110237528 | COMPOSITIONS AND METHODS COMPRISING IMIDAZOLE AND TRIAZOLE DERIVATIVES The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an ... | 09/29/2011 |
| 20110237633 | SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY The present invention provides compounds and pharmaceutically acceptable compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which hepatocyte growth factor/scatter factor (HGF/SF) or the activities ther... | 09/29/2011 |
| 20110230534 | Composition For Local Anesthesia An object of the present invention is to provide a composition for local anesthesia to be added to a local anesthetic drug, the composition showing a sustained local anesthetic effect and having high safety. The object is achieved by a composition for local anesthesia i... | 09/22/2011 |
| 20110224252 | NOVEL IMIDAZOLE DERIVATIVES The present invention relates to novel imidazole derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is halogen, C1-C4alkyl or C1-C4haloa... | 09/15/2011 |
| 20110224723 | CYANOACRYLATE TISSUE ADHESIVES A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic... | 09/15/2011 |
| 20110224196 | TREATMENT OF OBSTRUCTIVE SLEEP APNEA SYNDROME WITH A COMBINATION OF A CARBONIC ANHYDRASE INHIBITOR AND AN ADDITIONAL ACTIVE AGENT This invention relates generally to methods and pharmaceutical formulations useful in treating patients suffering from obstructive sleep apnea syndrome (OSAS). Treatment of OSAS is effected by administering a carbonic anhydrase inhibitor to the patient in combination wi... | 09/15/2011 |
| 20110224179 | MEDICAMENT AND METHOD OF DIAGNOSIS We disclose a diagnostic test to determine suitable therapeutic intervention of subjects suffering from subclinical Cushing's syndrome [SCS] and also agents that antagonise the action of cortisol or inhibit excess cortisol production in the treatment of conditions such ... | 09/15/2011 |
| 20110217289 | Melt-Coated Dosage Forms Formulations of sparingly water-soluble active ingredientscomprising carrier particles provided with active ingredient-containing coatings, the sparingly soluble active ingredients being embedded in coatings composed of amphiphilic copolymers, and the coatings being app... | 09/08/2011 |
| 20110218214 | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insul... | 09/08/2011 |
| 20110195944 | MODIFIED RELEASE EMULSIONS FOR APPLICATION TO SKIN OR VAGINAL MUCOSA Modified release oil in water emulsions that delivers drugs to a target tissue. The emulsions according to the present invention contain the lipophilic active ingredient completely dissolved into the hydrophobic internal phase stabilised by a polymeric surfactant. The p... | 08/11/2011 |
| 20110183942 | Methods and Compositions for Treating Alzheimer's Disease A method is disclosed for inhibiting the build-up of amyloid plaques in the brain of a patient with at least one risk factor for, or a diagnosis of, Alzheimer's Disease by administering to the patient an amount of one or more compounds effective to inhibit the phosphory... | 07/28/2011 |
| 20110178040 | METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium compounds as described herein, including imidazolium and imidazolinium sa... | 07/21/2011 |
| 20110172258 | INDENE DERIVATIVES AS PHARMACEUTICAL AGENTS Compounds of formula (Ia):
| 07/14/2011 |
| 20110171310 | HYDROGEL COMPOSITIONS COMPRISING VASOCONSTRICTING AND ANTI-HEMORRHAGIC AGENTS FOR DERMATOLOGICAL USE The present specification generally relates to hydrogel compositions and methods of treating a soft tissue condition using such hydrogel compositions.... | 07/14/2011 |
| 20110159091 | RAPIDLY DISPERSIBLE VAGINAL TABLET THAT PROVIDES A BIOADHESIVE GEL A tablet for insertion into a vagina including 0.01 to 500 mg of a vaginal medication, such as a microbicide, such as cellulose acetate 1,2-benzenedicarboxylate (CAP); 100 to 500 mg of mannitol powder; 50 to 300 mg of inert microcrystalline cellulose; 10 to 80 mg of hyd... | 06/30/2011 |
| 20110160265 | METHOD OF TREATING MOTOR DISORDERS WITH ALPHA-2B ADRENERGIC RECEPTOR AGONISTS Disclosed herein is a method of treating motor disorders comprising administering to a subject in need of such treatment an alpha-2 receptor agonist lacking significant alpha-2A receptor activity.... | 06/30/2011 |
| 20110152271 | Compositions and methods for ophthalmic delivery of nasal decongestants The invention provides compositions and methods for treating nasal congestion through ophthalmic delivery. The provided compositions and methods utilize low concentrations of selective α-2 adrenergic receptor agonists. The compositions preferably include brimonidine.... | 06/23/2011 |
| 20110150775 | GENOMIC APPROACHES TO FETAL TREATMENT AND DIAGNOSIS The present invention provides systems for developing and/or testing therapies for prenatal diseases and conditions including Down Syndrome. The present invention also provides diagnostic methods for Down Syndrome involving, in some embodiments, gene expression analyses... | 06/23/2011 |
