|Application No.||Application Title||Issue Date|
The invention relates to fungicidal compositions comprising as active ingredient a combination of components A) and B) as defined in the patent claims, to a method of controlling phytopathogenic diseases on crop plants using such a composition and to a method of protect...
|20140051729||COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS|
Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent. Embodiments of the methods disclosed herein include administering therapeuticall...
|20140051735||USE OF N-PHENYLETHYLPYRAZOLE CARBOXAMIDE DERIVATIVES OR SALTS THEREOF FOR CONTROLLING POWDERY MILDEW PRIMARY INFECTIONS|
The present invention relates to the use of N-phenylethylpyrazole carboxamide derivatives, in particular 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethyl]-amide for controlling powdery mildew primary infections in ...
|20140050772||METHODS FOR TREATING CONDITIONS OF THE NAIL UNIT|
The biodegradable drug delivery systems described here are formulated for implantation into the nail unit and its surrounding tissues for the treatment of various nail unit conditions. The systems include non-temperature dependent phase change compositions that may be f...
|20140051709||Compositions and Methods for Treating Myotonic Dystrophy Type 1|
Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula:
|20140044799||MOLECULAR SIGNATURE OF CUTANEOUS PIGMENTARY SPOTS, ASSOCIATED WITH THE ORGANIZATION OF THE EXTRACELLULAR MATRIX|
The present invention concerns a molecular signature of cutaneous pigmentary spots, comprising the genes MXRA5, LYZ, CTSL2, PLAU, TIMP1, EFEMP1, ECM1, ASPN, HS3ST6, PAPLN, CHSY1 and FLRT2, and various applications of this signature. In particular, the invention concerns...
|20140039018||MYCOTOXIN ACCUMULATION INHIBITION METHOD AND MYCOTOXIN ACCUMULATION INHIBITOR|
An fungicide capable of inhibiting the accumulation of the mycotoxin in a crop effectively and a mycotoxin accumulation inhibition method using said fungicide are provided. The mycotoxin accumulation inhibition method according to the invention is a mycotoxin accumulati...
|20140037622||HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS|
Methods of treating a head and neck cancer are disclosed....
|20140038944||FURO[3, 2-B] PYRR0L-3-ONES AS CATHESPIN S INHIBITORS|
A first aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof,
|20140038823||ACTIVE COMPOUND COMBINATIONS COMPRISING A (THIO)CARBOXAMIDE DERIVATIVE AND A FUNGIDICAL COMPOUND|
The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and a fur...
|20140024641||TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TRIPTANS|
A method of treating exposure to organophosphate agents and preventing morbidity due to such exposure through the administration of a triptan compound to a subject....
A composition suitable for control of diseases caused by phytopathogens comprising (A) a compound of formula I
wherein R1 is difluoromethyl or trifluoromethyl and X is chloro, fluoro or bromo; and ...
The invention relates to novel arylpyrroline compounds of formula (I)
which have excellent insecticidal activity and which can thus be used as an insecticide....
The present invention discloses compounds of Formula I:
wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods...
|20140011772||COMPOSITIONS AND METHODS FOR TREATING CONDITIONS ASSOCIATED WITH NEURONAL DYSFUNCTION|
The present invention relates to compositions and methods for the treating and empirically investigating conditions associated with neuronal dysfunction (e.g., chronic pain, epileptic neuronal activity). In particular, the present invention provides compositions and met...
|20140010866||METHODS AND SYSTEMS FOR TREATMENT OF MIGRAINES AND OTHER INDICATIONS|
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery compris...
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also rel...
|20140005135||STABLE FORMULATIONS FOR PARENTERAL INJECTION OF SMALL MOLECULE DRUGS|
Disclosed is a stable liquid formulation for parenteral injection comprising a biocompatible non-aqueous solvent and a small molecule drug, or a salt thereof, solubilized within the non-aqueous solvent, wherein the liquid formulation comprises less than 10% by weight re...
|20140005240||COMPOUNDS AND COMPOSITIONS FOR USE AS MODULATORS OF TAU AGGREGATION AND ALLEVIATION OF TAUOPATHIES|
This invention relates to the use of bis- and tris-dihydroxyaryl compounds as well as sulfonamides, heteroaryls, tricycloalkyl and their analogs and pharmaceutically acceptable salts, for modulating tau aggregation and alleviating tauopathies, such as Alzheimer's diseas...
The disclosure provides bisindole suitable for inhibiting lipoxygenases or Aβ-formation, and treating associated diseases, such as Alzheimer's disease. The bisindoles are indolo[2,3-b]carbazole derivatives, and may be administered to a patient as part of a pharmaceutic...
|20130338165||Use of Compounds Elevating Glutathione Levels for the Treatment of Parkinson's Disease|
Methods of treating Parkinson's Disease comprising administering compounds that up-regulate cystine-glutamate exchange (system Xc−) and/or increase glutathione levels in the brain cells. Preferred compounds are cysteine/cystine prodrugs or N-acet...
|20130331419||MINERALOCORTICOID RECEPTOR ANTAGONISTS|
Disclosed are the compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, which are useful for treating aldosterone-mediated diseases. The processes for preparing compounds of the Formula (I), the use for the therapy and prophylaxis of the abo...
|20130331357||COMBINATION THERAPY OF HSP90 INHIBITORY COMPOUNDS WITH PROTEASOME INHIBITORS|
A composition comprising a proteasome inhibitor, and an Hsp90 inhibitor according to the following formulae (I) or (Ia), a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables in the structural formulae are defined herein. Also provided are met...
|20130324481||SUSTAINED RELEASE EYE DROP FORMULATIONS|
This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for...
The present invention relates to compounds of general formula I,
wherein the groups R1, R2, R3, m and n are defined as in claim 1, which have valuable pharmacological p...
|20130324560||ANTHRANILIC ACID DIAMIDE DERIVATIVE WITH HETERO-AROMATIC AND HETERO-CYCLIC SUBSTITUENTS|
The present invention relates to new insecticides of the formula (I)
in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stat...
|20130317014||INHIBITORS OF BETA-SECRETASE|
The present invention is directed to a compound represented by the following structural formula:
or a pharmaceutically acceptable salt thereof. Pharmaceutical composition comprising a compound represented by ...
|20130317068||SUBSTITUTED 1,2,4-TRIAZOLE COMPOUNDS AS A SEED TREATMENT TO CONTROL PESTS|
Methods of using substituted 1,2,4-triazole compounds as a seed treatment to control pests, such as insects and mites....
|20130317031||Nuclear Transport Modulators And Uses Thereof|
The present invention relates to compounds of formula I:
and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said compounds, ...
|20130310433||THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES|
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various disease, c...
|20130303493||Triazole Compounds that Modulate HSP90 Activity|
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for treating hyperproliferat...
|20130302305||Methods for Treating Gout in Patients Subpopulations|
The present application discloses a method of lowering serum uric acid level in a subject with impaired renal function, comprising administering to the subject a compound of Formula (I), as disclosed herein....
|20130303579||HYBRID MOLECULES CONTAINING PHARMACOPHORES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND THEIR PREPARATION|
Disclosed herein are novel antifungal compounds of Formula 1, containing fluconazole pharmacophore moieties coupled with other moieties including aryl enones and chalcones and pharmaceutically acceptable salts thereof, methods for preparing these compounds and pharmaceu...
|20130303378||Biocide Compositions Comprising Esters Of Ethoxylated Alcohols|
Suggested are biocide compositions, comprising (a) Esters of ethoxylated alcohols according to formula (I) R1CO(OCH2CH2)nOR2 (I) In which R1CO stands for a saturated or unsaturated acyl radical having 8 t...
|20130296388||PHENOL-CONTAINING AZOLE COMPOSITIONS FOR THE PROTECTION OF INDUSTRIAL MATERIALS|
A process for the protection of industrial materials in which a composition, comprising at least one azole and at least one phenol, is employed so as to treat the industrial material....
|20130296355||GLUCAGON RECEPTOR MODULATORS|
The present invention provides a compound of Formula (I)
or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4...
|20130296387||TOPICAL NON-AQUEOUS PHARMACEUTICAL FORMULATIONS|
The present application relates to non-aqueous pharmaceutical formulations containing an anti-microbial agent....
|20130281502||POST-TREATMENT BREAST CANCER PROGNOSIS|
The disclosure includes the identification and use of gene expression profiles, or patterns, with clinical relevance to extended treatment and cancer-free survival in a patient. In particular, the disclosure includes the identities of genes that are expressed in correla...
|20130281300||Biocide Compositions Comprising Amides Based On 2-Furoic Acid And Its Derivatives|
Suggested are biocide compositions, comprising (a) 2-Furoic and/or Tetrahydro-2-furoic acid amides; (b) Biocides and optionally (c) Oil components or co-solvents and/or (d) Emulsifiers. The compositions show high solubility for biocides and improved emulsification prope...
|20130274110||HYDROPHOBICALLY MODIFIED POLYSACCHARIDE ETHERS AS DEPOSITION ENHANCERS FOR AGRICULTURAL ACTIVE INGREDIENTS|
A composition is provided, comprising a non-ionic, water-soluble, hydrophobically modified lower alkyl hydroxyalkyl linear polysaccharide ether, wherein the hydrophobic group comprises a long-chain C10-C18 alkyl or alkenyl group, the lower alkyl group has 1-4 carbon ato...