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| Application No. | Application Title | Issue Date |
| 20120129886 | METALLOENZYME INHIBITOR COMPOUNDS The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.... | 05/24/2012 |
| 20120129861 | COMPOSITIONS OF DIBROMOMALONAMIDE AND THEIR USE AS BIOCIDES A biocidal composition comprising 2,2-dibromomalonamide and an aldehyde-based biocidal compound, and its use for the control of microorganisms in aqueous and water-containing systems.... | 05/24/2012 |
| 20120128657 | SYNTHETIC MACROCYCLIC COMPOUNDS AND METHODS FOR TREATING CANCER Disclosed herein are macrocyclic compounds that are effective to inhibit cell migration. In one embodiment, the compounds have the structure: or any pharmaceutically acceptable salt or solvate thereof, wherein: m is 0 or 1; R1, R2 and R3 05/24/2012 | |
| 20120129830 | 7-AZA-SPIRO[3.5]NONANE-7-CARBOXYLATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF The invention relates to compounds of the general formula (I) where: R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy, or NR8R9 group; m, n, o and p independently are ... | 05/24/2012 |
| 20120083513 | 3-Substituted-8-Substituted-3H-Imidazo[5,1-d][1,2,3,5]tetrazin-4-one Compounds and Their Use The present invention pertains generally to the field of therapeutic compounds, and more specifically to 3-substituted-8-substituted-3H-imidazo[5,1-d][1,2,3,5]tetrazin-4-one compounds of the following formula, wherein -A and —B are as defined herein (collectively refe... | 04/05/2012 |
| 20120071526 | COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. 03/22/2012 | |
| 20120071524 | COMPOUNDS FOR TREATMENT OF CANCER The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant ... | 03/22/2012 |
| 20120052118 | Apparatus and process for encapsulating capsules or other solid dosage forms within capsules The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate rel... | 03/01/2012 |
| 20120045509 | MODIFIED RELEASE COMPOSITIONS FOR DPP-IV INHIBITORS The present invention refers to pharmaceutical composition comprising a DPP-IV inhibitor.... | 02/23/2012 |
| 20120046303 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS Compounds which inhibit the activity of poly(ADP-ribose)polymerase (PARP), compositions containing the compounds and methods of treating diseases using them are disclosed.... | 02/23/2012 |
| 20120040033 | Anti-infective mangrove extract against viruses, bacteria and fungi The current invention discloses drug formulations of anti-infective mangrove extracts and their ability to block the reproductive capabilities of viruses, funguses, bacteria and tumors. Mangrove extracts can be ingested internally to prevent the proliferation of viruses... | 02/16/2012 |
| 20120034321 | NITRIC OXIDE ENHANCING PROSTAGLANDIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE The invention provides methods for treating ophthalmic disorders comprising at least one nitric oxide enhancing prostaglandin compound or a pharmaceutically acceptable salt thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therap... | 02/09/2012 |
| 20120035139 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.... | 02/09/2012 |
| 20120035198 | Antiviral Compounds and Methods of Using Thereof Disclosed herein are compounds which exhibit antiviral activity against a plurality of viruses belonging to different families such as Bornaviridae, Filoviridae, Paramyxoviridae, Rhabdoviridae, Arenaviridae, Bunyaviridae, Orthomyxoviridae, and Poxviridae. Thus, methods ... | 02/09/2012 |
| 20120022067 | THIAZOLE AND OXAZOLE-SUBSTITUTED ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is a group of formula A or formula B, and X, R | |
| 20120022075 | NOVEL PHENYLPYRROLE DERIVATIVE The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: ... | 01/26/2012 |
| 20120022096 | PRO-NEUROGENIC COMPOUNDS This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herei... | 01/26/2012 |
| 20120015932 | Pyrazole Derivatives Used as CCR4 Receptor Antagonists Indazole compounds, processes for their preparation, intermediates usable in these processes, pharmaceutical compositions containing such compounds and their use in therapy.... | 01/19/2012 |
| 20120015988 | Sulfone Compounds Which Modulate The CB2 Receptor Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | 01/19/2012 |
| 20120015933 | Spirocyclic nitriles as protease inhibitors The invention relates to substituted carbo- and heterocyclic spiro compounds of the formula Ia which inhibit thiol proteases, to processes for their preparation and to the use thereof as medicaments.... | 01/19/2012 |
| 20120009141 | FUNCTIONALIZED PYRROLIDINES AND USE THEREOF AS IAP INHIBITORS A compound of Formula 1: or a salt thereof, and methods for the use thereof, especially as an IAP inhibitor, as well as related compounds, compositions, and methods. ... | 01/12/2012 |
| 20120010219 | SALVINORIN DERIVATIVES AND USES THEREOF The invention features salvinorin compositions that are selective for kappa opioid receptors; methods of treating mania by using a selective kappa receptor agonist; and methods of treating mood disorders, such as depressive disorders and manic disorders, using salvinori... | 01/12/2012 |
| 20120003335 | CONSTITUTIVE ANDROSTANE RECEPTOR (CAR) AS A THERAPEUTIC TARGET FOR OBESITY AND TYPE TWO DIABETES The invention provides a method of controlling obesity or type two diabetes in a human. In accordance with the inventive method, the constitutive androstane receptor (CAR) is agonized within the human, which effectively controls obesity or type two diabetes.... | 01/05/2012 |
| 20120004196 | Anti-Viral Compounds Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.... | 01/05/2012 |
| 20110312953 | ANTHRANILIC ACID DERIVATIVES The present invention relates to novel anthranilic acid derivatives of the general formula (I) in which R1, R2, R3, R4, R5, Qx, A, Qy and n have the mean... | 12/22/2011 |
| 20110311594 | CONTROLLED RELEASE COMPOSITIONS WITH REDUCED FOOD EFFECT The present invention provides a controlled release pharmaceutical composition which exhibits reduced food effect.... | 12/22/2011 |
| 20110312989 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the ... | 12/22/2011 |
| 20110306542 | NOVEL GLP-1 RECEPTOR STABILIZERS AND MODULATORS Compounds that bind the glucagon-like peptide 1 receptor (GLP-1) receptor are provided including compounds which are modulators of the GLP-1 receptors and compounds which are capable of inducing a stabilizing effect on the receptor for use in structural analyses of the ... | 12/15/2011 |
| 20110306611 | Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing a... | 12/15/2011 |
| 20110301122 | HETEROAROMATIC COMPOUNDS FOR USE AS HIF INHIBITORS The present application relates to novel substituted aryl compounds, processes for their preparation, their use for treatment and/or prevention of diseases and their use for the preparation of medicaments for treatment and/or prevention of diseases, in particular for tr... | 12/08/2011 |
| 20110300104 | HEPATITIS C VIRUS INHIBITORS The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the Hepatitis C Virus (HCV). Conse... | 12/08/2011 |
| 20110301172 | COMBINATION OF DPP-IV INHIBITOR, PPAR ANTIDIABETIC AND METMORFORMIN The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises;
| |
| 20110294840 | HYDRAZIDE COMPOUND AND USE OF THE SAME IN PEST CONTROL There is provided a hydrazide compound having a controlling effect on pests represented by the formula (1): wherein, G is a 5-membered heterocyclic group, M is an oxygen atom or a sulfur atom, Q1, Q2, Q3 and Q4 is independentl... | 12/01/2011 |
| 20110294819 | Hepatitis C Virus Inhibitors The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the... | 12/01/2011 |
| 20110288053 | ANTIVIRAL PHOSPHONATE ANALOGS The invention is related to phosphorus substituted compounds with antiviral activity, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such c... | 11/24/2011 |
| 20110288089 | INSECTICIDAL COMPOUNDS A compound of Formula (I): wherein A1, A2, A3, A4, A5, G1, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the pr... | 11/24/2011 |
| 20110281875 | Inhibitors of IAP Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). ... | 11/17/2011 |
| 20110281910 | Hepatitis C Virus Inhibitors This disclosure concerns novel compounds of Formula (I) or as defined in the specification and compositions comprising such novel compounds. These compounds are useful antiviral agents, especially in inhibiting the function of the NS5A protein encoded by Hepatitis C vir... | 11/17/2011 |
| 20110275636 | DESAZADESFERROTHIOCIN AND DESAZADESFERROTHIOCIN POLYETHER ANALOGUES AS METAL CHELATION AGENTS Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals... | 11/10/2011 |
| 20110275677 | INDOLE COMPOUNDS BEARING ARYL OR HETEROARYL GROUPS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR BIOLOGICAL ACTIVITY The invention provides well-defined aryl and/or heteroaryl substituted indoles that are useful as sphingosine-1-phosphate agonists or antagonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with modulation of sp... | 11/10/2011 |
