Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Application No. | Application Title | Issue Date |
| 20120108501 | Protease Inhibitors The invention relates to (among other things) protease inhibitors containing both a water-soluble, non-peptidic oligomer and a lipophilic moiety-containing residue. A compound of the invention, when administered by any of a number of administration routes, exhibits adva... | 05/03/2012 |
| 20120108580 | Use of Fungicidal Active Substances For Controlling Mycoses on Plants of the Palm Family The present invention relates to the use of specific fungicidal active substances, alone or in combination, for controlling mycoses in plants of the palm family and to a method for using said specific fungicidal active substances for controlling said mycoses in the fiel... | 05/03/2012 |
| 20120108592 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.... | 05/03/2012 |
| 20120108642 | TRPV1 ANTAGONISTS The present invention relates to compounds of formula (I) wherein X, R1, R2, R3, R4, R5, m, and n are defined in the specification are TRPV1 antagonists.... | 05/03/2012 |
| 20120108522 | HDAC INHIBITORS AND HORMONE TARGETED DRUGS FOR THE TREATMENT OF CANCER The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method of increasing the sensitivity of hormone resistant cancers to hormonal th... | 05/03/2012 |
| 20120082626 | USE OF R-BAMBUTEROL AS INHALED MEDICAMENT AND COMBINATION THERAPIES FOR TREATMENT OF RESPIRATORY DISORDERS The present invention concerns with a new use of R-Bambuterol or Bambuterol as inhaled medicament for treatment of asthma, COPD and other respiratory disorders, and a new use of R-bambuterol or bambuterol and corticosteroids or other therapeutically active medicament as... | 04/05/2012 |
| 20120082623 | SHH Regulation and Methods Thereof The invention provides for methods of upregulating endogenous GDNF by inhibiting Shh signaling. The invention further provides a method for increasing the production of cholinergic neurons and dopamine neurons by subventricular zone (SVZ) neurogenesis in a subject. The ... | 04/05/2012 |
| 20120083471 | Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same The present invention relates to novel pharmaceutical compositions containing the same, and methods of use for a variety of therapeutically valuable uses including, but not limited to, treating obesity by inhibiting the activity of Glycerol 3-phosphate acyltransferase (... | 04/05/2012 |
| 20120083463 | Insecticidal and Fungicidal Active Compound Combinations The present invention relates to active compound combinations consisting, firstly, of a known halogen-substituted derivative (component A) and, secondly, of further known pesticidally active compounds (component B), which active compound combinations are suitable for co... | 04/05/2012 |
| 20120070467 | Ophthalmic Drug Delivery The present invention includes and provides a method of delivering a medicament to an eye of a subject in need thereof a solution, the method comprising: (a) providing droplets containing the medicament with a specified average size and average initial ejecting velocity... | 03/22/2012 |
| 20120071448 | S1P3 Receptor Inhibitors for Treating Conditions of the Eye Disclosed herein are compositions and methods for treating conditions of the eye using S1P3 receptor inhibitors.... | 03/22/2012 |
| 20120071520 | CRYSTALLINE PHASES OF 2'--BIPHENYL-2-CARBOXYLIC ACID (2-PYRIDIN-3-YL-ETHYL)-AMIDE The present invention relates to polymorphic forms and solvates of 2′-{[2-(4-methoxy-phenyl)-acetylamino]-methyl]}-biphenyl-2-carboxylic acid (2-pyhdin-3-yl-ethyl)-amide, processes for their preparation and their use, in particular for the preparation of medicaments.... | 03/22/2012 |
| 20120052118 | Apparatus and process for encapsulating capsules or other solid dosage forms within capsules The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate rel... | 03/01/2012 |
| 20120053200 | BACE 2 INHIBITORS The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalamides of formula I having BACE2 inhibitory activity and their use as therapeutically active substances, their manufa... | 03/01/2012 |
| 20120053051 | 5-ARYL ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 03/01/2012 | |
| 20120046242 | MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/β-catenin signaling and administering to the selected subject a compou... | 02/23/2012 |
| 20120046293 | RENIN INHIBITORS The present invention relates to renin inhibitor compounds having the structure and their use in treating cardiovascular events and renal insufficiency.... | 02/23/2012 |
| 20120046323 | Use of Succinate Dehydrogenase Inhibitors and/or Respiratory Chain Complex III Inhibitors for Improving the Ratio of Harmful to Beneficial Microorganisms The present invention relates to the use of succinate dehydrogenase inhibitors and/or complex III inhibitors for controlling undesired fungal pathogens and simultaneously improving the ratio of harmful to beneficial microorganisms in crops and to a method for treating c... | 02/23/2012 |
| 20120041033 | HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxy... | 02/16/2012 |
| 20120039823 | PREPARATIONS FOR REDUCING ITCHING AND OTHER PARAESTHESIAS WITH (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYLCYCLOHEXANECARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-(CYANOMETHYL)-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANECARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-(CYANOMETHYL)-PHENYL)-2ISOPROPYL-5-METHYLCYCLOHEXANECARBOXAMIDE Use of topical, cosmetic or dermatological preparations with a content of (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethylcyclohexanecarboxamide and/or (1R,2S,5R)-N-(4-(cyanomethyl)-phenyl)-2-isopropyl-5-methylcyclohexyl carboxamide for reducing itching.... | 02/16/2012 |
| 20120039909 | EPIGENETIC MECHANISMS RE-ESTABLISH ACCESS TO LONG-TERM MEMORY AFTER NEURONAL LOSS The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.... | 02/16/2012 |
| 20120041037 | COMPOSITION THAT COMPRISES AT LEAST ONE OXIME AND ITS USE IN THERAPEUTICS A medication, a pharmaceutical composition, and method for the treatment of respiratory poisoning in animals and humans caused by organophosphorus compounds, whereby said medication and said pharmaceutical composition comprise at least one oxime and one blocker of organ... | 02/16/2012 |
| 20120041038 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.... | 02/16/2012 |
| 20120040021 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer pati... | 02/16/2012 |
| 20120041036 | SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED) An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on serotonin 5-HT5A receptor modulating action. It was discovered that acylguanidine derivatives, in whi... | 02/16/2012 |
| 20120041039 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS Provided are amine derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.... | 02/16/2012 |
| 20120031403 | DRY POWDER FORMULATION COMPRISING A PHOSPHODIESTERASE INHIBITOR Pharmaceutical formulations in the form of inhalable dry powder comprising particles of a phosphodiesterase-4 inhibitor as active ingredient are useful for the prevention and/or treatment of respiratory diseases, such as asthma and COPD.... | 02/09/2012 |
| 20120034172 | PHARMACEUTICAL FORMULATION COMPRISING A PHOSPHODIESTERASE INHIBITOR Pharmaceutical formulations to be administered by pressurized metered dose inhalers (pMDIs), comprising a compound of general formula (I) may be used for the treatment and/or prevention of inflammatory or obstructive airway diseases.... | 02/09/2012 |
| 20120035135 | Treatment of Transgenic Crops with Mixtures of Fiproles and Chloronicotinyls The Invention relates to methods for increasing the production potential of plants and/or controlling pests in plants with at least one transgenic modification related to yield increase as compared to a corresponding wild-type plant, comprising treating the location whe... | 02/09/2012 |
| 20120035187 | ANTI-NEURODEGENERATIVE DISEASE AGENT The present invention has an object to provide a novel agent for anti-neurodegenerative diseases and solves the object by providing an agent for anti-neurodegenerative diseases containing, as an effective ingredient, the compound(s) represented by the following General ... | 02/09/2012 |
| 20120035139 | GAMMA-AMINO-BUTYRIC ACID DERIVATIVES AS GABAB RECEPTOR LIGANDS Gamma-amino-butyric acid derivatives that are GABAB receptor ligands, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives and pharmaceutical compositions thereof for treating diseases are disclosed.... | 02/09/2012 |
| 20120027871 | METHOD OF TREATMENT BASED ON POLYMORPHISMS OF THE KCNQ1 GENE The invention provides methods for the administration of compounds capable of prolonging a QTc interval and methods for predicting whether an individual is predisposed to such QTc prolongation.... | 02/02/2012 |
| 20120028995 | NOVEL COMPOUNDS FOR MEDICAL USE AS PEPTIDASE EFFECTORS The invention relates to compounds of general formula (I) as set forth in the claims as well as to the use of the compounds of the general formula (1) in the medical field, specifically for use in the suppression of DNA synthesis and inflammatory cytokine production as ... | 02/02/2012 |
| 20120022076 | DERIVATIVES OF N-(ARYLAMINO)SULFONAMIDES AS INHIBITORS OF MEK This invention concerns N-(2-arylamino)aryl sulfonamides, which are inhibitors of MEK and are useful in treatment of cancer and other hyperproliferative diseases.... | 01/26/2012 |
| 20120022080 | Plasminogen Activator Inhibitor-1 Inhibitor The present invention provides a novel compound having plasminogen activator inhibitor-1 inhibitory activity, and an inhibitor of PAI-1 comprising the compound as an active ingredient. The present invention also provides a pharmaceutical composition having an inhibitory... | 01/26/2012 |
| 20120020876 | HEDGEHOG PATHWAY INHIBITORS This disclosure generally relates to methods useful for improving, for example, blood vessel density and/or blood vessel patency to a tissue by administration of a hedgehog pathway inhibitor. In certain embodiments, the hedgehog pathway inhibitor is administered with an... | 01/26/2012 |
| 20120015987 | NOVEL POLYMORPH OF ATAZANAVIR SULFATE The present invention provides a novel crystalline form of atazanavir sulfate, process for its preparation and to pharmaceutical composition containing it. In accordance with the present invention atazanavir sulfate was dissolved in methanol, to the solution was added e... | 01/19/2012 |
| 20120010072 | DIMETHOMORPH AS SAFENER FOR PESTICIDES WITH PHYTOTOXIC EFFECTS The present invention relates to a method for reducing or preventing damage caused by pesticides to plants treated therewith and/or to plant propagation material treated therewith and/or to plants growing from this plant propagation material and/or to plants which grow ... | 01/12/2012 |
| 20120010253 | Fungicidal compositions comprising Fluopyram and Metrafenone Fungicidal compositions comprising as active components Fluopyram and Metrafenone in a synergistically effective amount, methods for controlling phytopathogenic harmful fungi using mixtures of Fluopyram and Metrafenone, the use of Fluopyram and Metrafenone for preparing... | 01/12/2012 |
| 20120010172 | NOVEL UREA AND THIOUREA DERIVATIVES The present application discloses compounds of formula (I) wherein X is ═O, ═S, ═NH, ═NOH and ═NO-Me; A is —C(═O)—, —S(═O)2—, —C(═S)— and P(═O)(R5)—; B is, —O—, —(CH2)3-6—, and O—(CH 01/12/2012 | |
