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| Application No. | Application Title | Issue Date |
| 20120129847 | COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES Disclosed are methods for the treatment of diseases or conditions of the eye, especially retinopathies, ocular edema and ocular neovascularization. Non-limiting examples of these diseases or conditions include diabetic macular edema, age-related macular degeneration (we... | 05/24/2012 |
| 20120129843 | PYRIDYL-THIAZOLYL INHIBITORS OF PRO-MATRIX METALLOPROTEINASE ACTIVATION This invention relates to thiazole I and its therapeutic and prophylactic uses, wherein the variables Rz, Q, J, R1, R3, R5, and R6 are defined in the specification. Disorders treated and/or prevented include rheumat... | 05/24/2012 |
| 20120128625 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR PREVENTING METASTASIS OF CANCER CELLS Disclosed are methods for preventing metastasis of cancer cells. The disclosed compounds can be used to prevent the spread of tumor or other types of cancer cells.... | 05/24/2012 |
| 20120108423 | Novel Heterocyclic Alkanol Derivatives The present invention relates to novel heterocyclic alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in cro... | 05/03/2012 |
| 20120108591 | ALKYLSULFINYL-SUBSTITUTED THIAZOLIDE COMPOUNDS A new class of alkylsulfinyl thiazolides is described. These compounds show strong activity against hepatitis viruses.... | 05/03/2012 |
| 20120110702 | Pesticidal Compositions and Processes Related Thereto This document discloses molecules having the following formula (“Formula One”): and processes related thereto.... | 05/03/2012 |
| 20120107398 | PHARMACEUTICAL COMPOSITIONS The present invention relates to pharmaceutical compositions comprising fixed dose combinations of a DPP-4 inhibitor drug and pioglitazone, processes for the preparation thereof, and their use to treat certain diseases.... | 05/03/2012 |
| 20120108576 | THIAZOLE COMPOUNDS AND METHODS OF USE The present invention provides compounds, salts and hydrates of Formula I, wherein the variables Ar1, R2, R3, R4, r, q, and t are defined herein. Certain compounds ... | 05/03/2012 |
| 20120083463 | Insecticidal and Fungicidal Active Compound Combinations The present invention relates to active compound combinations consisting, firstly, of a known halogen-substituted derivative (component A) and, secondly, of further known pesticidally active compounds (component B), which active compound combinations are suitable for co... | 04/05/2012 |
| 20120083490 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. T... | 04/05/2012 |
| 20120071516 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other co... | 03/22/2012 |
| 20120053051 | 5-ARYL ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2 and A3 are independently selected from the group consisting of CR3 and N; B1 B2 03/01/2012 | |
| 20120053146 | PESTICIDAL COMPOSITIONS Molecules according to Formula One: and their uses are disclosed herein.... | 03/01/2012 |
| 20120053200 | BACE 2 INHIBITORS The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalamides of formula I having BACE2 inhibitory activity and their use as therapeutically active substances, their manufa... | 03/01/2012 |
| 20120046232 | COMPOSITIONS AND METHODS FOR REDUCING RELAPSE OF ADDICTIVE BEHAVIOR Disclosed are methods and compositions comprising mGluR modulators and procysteine drugs. The methods and compositions can be used to treat subjects with prior addiction in order to reduce drug use, drug seeking or relapse.... | 02/23/2012 |
| 20120046273 | COMPOUNDS AND COMPOSITIONS FOR COGNITION-ENHANCEMENT, METHODS OF MAKING, AND METHODS OF TREATING Muscarinic agonists, which are useful for stimulating muscarinic receptors and treating cognitive disorders, are provided. Methods of synthesizing such agonists also are provided. Also provided are compositions for enhancing cognitive function in subjects such as humans... | 02/23/2012 |
| 20120040999 | P38 KINASE INHIBITING AGENTS Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: Formula (I); are inhibitors of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, COPD, ARDS, rheumatoid arthritis, rheumatoid spondylitis,... | 02/16/2012 |
| 20120040898 | PHARMACEUTICAL COMPOSITIONS A pharmaceutical composition comprising a combination of
| 02/16/2012 |
| 20120040937 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS The invention relates to compounds of structural formula (I): or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein Ra, Rb, and R2 are define... | 02/16/2012 |
| 20120040997 | VINYL-ARYL DERIVATIVES FOR INFLAMMATION AND IMMUNE-RELATED USES The invention relates to compounds that are useful as immunosuppressive agents and for treating and preventing inflammatory conditions, allergic disorders, and immune disorders.... | 02/16/2012 |
| 20120040984 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method for preparing same and to the therapeutic applications thereof. 02/16/2012 | |
| 20120035163 | NOVEL FUSED RING COMPOUND AND USE THEREOF The present invention provides an agent for the prophylaxis or treatment of diabetes, obesity and the like, a glucokinase activator, containing a compound represented by the formula (I): wherein each symbol i... | 02/09/2012 |
| 20120035157 | 2-PYRIDONE DERIVATIVES AS NEUTROPHIL ELASTASE INHIBITORS AND THEIR USE There are provided novel compounds of formula (I), wherein R1, R2, R4, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racema... | 02/09/2012 |
| 20120029029 | SUBSTITUTED THIAZOL-2-YLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE AS 11-BETA HSD1 MODULATORS The present invention is directed to substituted thiazol-2-ylamine derivatives and pharmaceutically acceptable salts thereof that inhibit 11βHSD1 and that may be useful in the treatment of diseases in which modulation or inhibition of 11βHSD1 is beneficial or where a ... | 02/02/2012 |
| 20120029028 | Compositions and methods for treating hyperlipidemias The present invention is directed to a composition and method for the treatment of hyperlipidemias by targeting Microsomal triglyceride transfer protein (MTP). In particular, the present invention is directed to a combination of at least one MTP inhibitor and at least o... | 02/02/2012 |
| 20120028892 | INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The invention is also directed to a pharmaceutical composition comprising ... | 02/02/2012 |
| 20120029030 | METHOD FOR CUSTOMIZED DISPENSING OF VARIABLE DOSE DRUG COMBINATION PRODUCTS FOR INDIVIDUALIZING OF THERAPIES Generally the method involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable co... | 02/02/2012 |
| 20120022113 | METHODS FOR SUPPRESSING TIPDC TRAFFICKING OR ACCUMULATION AND PREVENTING HYPERCYTOKINEMIA The present invention features methods for preventing or ameliorating hypercytokinemia or preventing lethality-associated with infection by highly pathogenic strains of influenza virus by suppressing TNF-α/Inducible nitric oxide synthase-Producing dendritic cell traffi... | 01/26/2012 |
| 20120015929 | NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions c... | 01/19/2012 |
| 20120015941 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.... | 01/19/2012 |
| 20120015982 | Thiazolidinedione analogues The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.... | 01/19/2012 |
| 20120015001 | METHODS OF TREATING THYROID EYE DISEASE The present invention relates to a methods and compositions for the treatment of and management of symptoms for thyroid eye disease. The methods include administering to a patient having thyroid eye disease an agent that interferes with hyaluronan synthesis in an amount... | 01/19/2012 |
| 20120014906 | ORGANIC COMPOUNDS The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also enco... | 01/19/2012 |
| 20120010179 | Methods of using a thiazole derivative This invention relates to a method of treating a disease, disorder, or condition in a patient comprising administering to a patient a therapeutically effective amount of a thiazole derivative, tetomilast. The invention further relates to the administration of at least o... | 01/12/2012 |
| 20120010187 | BROAD SPECTRUM BENZOTHIOPHENE-NITROTHIAZOLIDE AND OTHER ANTIMICROBIALS The invention provides FIG. 1 novel antimicrobial chemical entities based on a nitrothiazolide backbone that exhibit antibacterial and antiparasitic action against a wide range of human pathogens. The new classes of compounds show extended action against Gram pos... | 01/12/2012 |
| 20120004216 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating A... | 01/05/2012 |
| 20120004103 | Insecticidal Compositions Suitable for Use in Preparation of Insecticidal Liquid Fertilizers Insecticidal compositions suitable for use in preparation of insecticidal liquid fertilizers comprising a pyrethroid, a hydrated aluminum-magnesium silicate, and at least one dispersant selected from the group consisting of a sucrose ester, a lignosulfonate, an alkylpol... | 01/05/2012 |
| 20120004166 | ARYLOXYALKYLENE-SUBSTITUTED HYDROXYPHENYLHEXYNOIC ACIDS, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS A MEDICAMENT The invention relates to aryloxyalkylene-substituted hydroxyphenylhexynoic acid derivatives, and to physiologically compatible salts thereof. The invention relates to compounds of the formula I 01/05/2012 | |
| 20120004104 | OIL DISPERSIONS OF nAChR BINDING NEONICOTINOIDS Selective insect neonicotinoids is a class of pesticide active ingredients that share some characteristics in their chemical structures and bind to the nAChR acetylcholine receptors. Formulation of such compounds in oil suspension or oil dispersion is challenging due to... | 01/05/2012 |
| 20120004165 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments The invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, an... | 01/05/2012 |
