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| Application No. | Application Title | Issue Date |
| 20120129888 | LIBRARIES OF N-(2-OXO-1-PHENYLPIPERIDIN-3-YL)SULFONAMIDES FOR DRUG DISCOVERY Novel compounds are continually sought after to treat and prevent disorders. The invention relates to N-(2-oxo-1-phenylpiperidin-3-yl)sulfonamides useful for contributing to the search and identification of new lead compounds which can modulate the functional activity o... | 05/24/2012 |
| 20120130147 | METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours. ... | 05/24/2012 |
| 20120128654 | Allantoin Administration for the Treatment of Neurodegenerative Disease and Neurotrauma Methods for inhibiting the progression of neurodegenerative diseases and treating neurotrauma-induced damage and cerebrovascular disease are provided herein, the methods including the administration of a safe and effective amount of allantoin to a patient in need thereo... | 05/24/2012 |
| 20120129889 | Non-competitive NMDA receptor antagonists Disclosed herein are non-competitive NMDA receptor antagonists having chemical structures similar to that of phencyclidine (PCP). These antagonists contain a polycyclic ring structure in place of the cycloalkyl ring of PCP. The antagonists also differ from PCP in that t... | 05/24/2012 |
| 20120070421 | Synergistic Fungicidal Mixtures The present invention relates to fungicidal mixtures, comprising a compound of formula I and one fungicidal component II selected from groups A′) to C′) as defined in the description, and to compositions comprising these mixtures.... | 03/22/2012 |
| 20120045508 | METHOD AND COMPOSITION FOR ADMINISTERING AN NMDA RECEPTOR ANTAGONIST TO A SUBJECT The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.... | 02/23/2012 |
| 20120041001 | CARBONYLAMINO-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, R5, L, Q, X, Y and | 02/16/2012 |
| 20120029017 | PECTIN-CONTAINING JELLY FORMULATION There is disclosed a technique for making a jelly formulation comprising pectin slide out of a container easily (improving the slidability of the jelly formulation) when taking the formulation out of the container to prevent the formulation from remaining in the contain... | 02/02/2012 |
| 20120022039 | NOVEL SUBSTITUTED INDANES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS The invention relates to substituted indanes and derivatives thereof, to physiologically acceptable salts and physiologically functional derivatives thereof, to the production thereof, to drugs containing at least one substituted indane according to the invention or der... | 01/26/2012 |
| 20120022070 | Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of tr... | 01/26/2012 |
| 20120015960 | CHEMICAL INHIBITOR OF P53-SNAIL BINDING AND PHARMACEUTICAL COMPOSITION FOR TREATING CANCER DISEASE CONTAINING SAME AS ITS ACTIVE INGREDIENT Provided are compounds for inhibiting Snail-p53 binding and therapeutic agents for cancer including the compounds as an effective component. The Snail-p53 binding inhibitors induce expression of p53 in K-Ras mutant cell lines, thereby enabling effective treatment or pre... | 01/19/2012 |
| 20120015942 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 01/19/2012 |
| 20120015943 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF This invention provides compounds of formula (I):
| 01/19/2012 |
| 20120010243 | METHODS FOR TREATING DISORDERS OR DISEASES ASSOCIATED WITH HYPERLIPIDEMIA AND HYPERCHOLESTEROLEMIA WHILE MINIMIZING SIDE EFFECTS The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein... | 01/12/2012 |
| 20110319387 | INDOLE DERIVATIVES FOR TREATING NEURODEGENERATIVE DISEASES The invention relates to a compound of the following formula (I),
| 12/29/2011 |
| 20110319416 | Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, e... | 12/29/2011 |
| 20110319386 | NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via in... | 12/29/2011 |
| 20110311466 | NOVEL 4-(AZACYCLOALKYL)BENZENE-1,3-DIOL COMPOUNDS AS TYROSINASE INHIBITORS, PROCESS FOR THE PREPARATION THEREOF AND USE THEREOF IN HUMAN MEDICINE AND IN COSMETICS 4-(azacycloalkyl)benzene-1,3-diol compounds are described corresponding to general formula (I) below: Also described, are compositions including the same, processes for preparation thereof and uses thereof in... | 12/22/2011 |
| 20110301197 | Bis(difluoromethyl)pyrazoles as Fungicides Bis(difluoromethyl)pyrazole derivatives of the formula (I) in which the symbols R1, X, Y and Q are each as defined in the description, and agrochemically active salts thereof, and use thereof for c... | 12/08/2011 |
| 20110293673 | ORAL FILM-FORM BASE AND ORAL FILM-FORM PREPARATION The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a ... | 12/01/2011 |
| 20110293640 | Cholinesterase Inhibitors for Treating Inflammation A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor, provided that the inhibitor is not galantamine.... | 12/01/2011 |
| 20110281850 | INTRACELLULAR KINASE INHIBITORS Intracellular kinase inhibitors and their therapeutic uses for patients with T cell malignancies, B cell malignancies, autoimmune disorders, and transplanted organs.... | 11/17/2011 |
| 20110281847 | SELECTIVE ESTROGEN RECEPTOR MODULATORS FOR THE TREATMENT OF VASOMOTOR SYMPTOMS The present invention relates to a selective estrogen receptor modulator of formula I or Ia: (I) (Ia); or a pharmaceutical acid addition salt thereof; useful for treating vasomotor symptoms, in particular hot flashes, night sweats and other symptoms that affect women ar... | 11/17/2011 |
| 20110280808 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compou... | 11/17/2011 |
| 20110281912 | ORAL DISPERSIBLE TABLET The present invention relates to an oral dispersible tablet comprising at least one filler selected from sugars and sugar alcohols, and microcrystalline cellulose.... | 11/17/2011 |
| 20110275670 | New Compounds VII The present invention relates to new compounds of formula (I), to pharmaceutical compositions comprising these compounds and to the use of these compounds as leptin receptor modulator mimetics in the preparation of medicaments against conditions associated with weight g... | 11/10/2011 |
| 20110269747 | POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.... | 11/03/2011 |
| 20110269717 | NEUROGENESIS BY MODULATING ANGIOTENSIN The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulating angiotensin activity to stimulate or ... | 11/03/2011 |
| 20110251239 | COMBINATION THERAPY FOR THE TREATMENT OF DEMENTIA Provided herein is a combination therapy useful for the treatment of Alzheimer's disease and Alzheimer's disease related dementia. The combination comprises memantine in an immediate or sustained release form and donepezil in a sustained release form.... | 10/13/2011 |
| 20110250272 | SOLID, ORODISPERSIBLE AND/OR DISPERSIBLE COMPOSITION, WITHOUT AN EXCIPIENT OF KNOWN EFFECT AND ITS PROCESS OF PREPARATION The present invention relates to a solid, orodispersible and/or dispersible composition comprising (a) from 0.1 to 59% by weight of at least one active substance with particle size no exceeding 50 μm; (b) from 40 to 99% by weight of at least one diluent without known e... | 10/13/2011 |
| 20110243998 | PATCH PREPARATION AND PRODUCTION METHOD THEREOF The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the adhesive layer immediately after application of a physical stimulation to the ad... | 10/06/2011 |
| 20110237563 | FAST DISSOLVING DRUG DELIVERY SYSTEMS The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition, leading to difficulties in swallowing oral medicine forms and thus difficu... | 09/29/2011 |
| 20110237623 | SUSTAINED-RELEASE DONEPEZIL FORMULATION A sustained-release formulation for an acetylcholinesterase inhibitor, comprising an acetylcholinesterase inhibitor and at least two gel-forming polymers, and methods of manufacture thereof. The acetylcholinesterase inhibitor preferably comprises donepezil.... | 09/29/2011 |
| 20110218218 | Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain Internal-dermal formulations of RS—, S—, or R-2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine causing intradermal accumulation of said piperidine and intended for the treatment of neuropathic pain are provided, as well as a method of inducing the relief of pain usi... | 09/08/2011 |
| 20110218216 | EXTENDED RELEASE PHARMACEUTICAL COMPOSITION OF DONEPEZIL The present invention relates to an extended release pharmaceutical composition for oral administration comprising donepezil or pharmaceutically acceptable salt thereof and a release-controlling agent. Further, it relates to process for preparation of said compositions.... | 09/08/2011 |
| 20110218204 | PHARMACEUTICALLY ACCEPTABLE SALTS OF NOVEL BETULINIC ACID DERIVATIVES The present invention relates to certain novel salts of Betulinic acid derivatives, to process for preparing such compounds, to use the compounds in treating diseases or disorders mediated by HIV infection, to methods for their therapeutic use and to pharmaceutical comp... | 09/08/2011 |
| 20110218217 | PIPERIDYLPROPIONAMIDE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS INCLUDING DEPRESSION AND PANIC DISORDER This invention relates to novel piperidine-4-propionamide derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising th... | 09/08/2011 |
| 20110218160 | ARYLALKYLAMINE COMPOUND AND PROCESS FOR PREPARING THE SAME The present invention relates to an arylalkylamine compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof, a process for preparing the same, and use of the above-mentioned compound as an activating compound (CaSR agonist) of a Ca... | 09/08/2011 |
| 20110212928 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor (AChEI) or their pharmaceutically acceptable salts, hydrates, solvates, poly... | 09/01/2011 |
| 20110201597 | METHOD AND COMPOSITION FOR TREATING ALZHEIMER-TYPE DEMENTIA There is described a method for increasing the maximal tolerated dose and thus the efficacy of an acetylcholinesterase inhibitor (AChEI) in a patient suffering from an Alzheimer type dementia by decreasing concomitant adverse effects by administration of said AChEI in c... | 08/18/2011 |
