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| Application No. | Application Title | Issue Date |
| 20120083509 | Synergistically active mixtures of alpha,omega-amino alcohol enantiomers, preparation thereof and use thereof in insect- and mite-repellent formulations What are described are insect- and mite-repellent compositions comprising at least 2 enantiomers selected from the group of 1-[(S)-sec-butyloxycarbonyl]-2-(S)-(2-hydroxyethyl)piperidine (referred to hereinafter as S,S), 1-[(R)-sec-butyloxycarbonyl]-2-(R)-(+)-(2-hydroxye... | 04/05/2012 |
| 20120053180 | CYCLOHEXANE ANALOGUES AS GPR119 AGONISTS This invention relates to a series of substituted cyclohexane containing analogues which are agonists of GPR119 intended to treat metabolic diseases mediated by GPR119 including Type I & II diabetes mellitus. Diabetes mellitus is an ever-increasing threat to human h... | 03/01/2012 |
| 20120046314 | NITROXIDES FOR USE IN TREATING OR PREVENTING NEOPLASTIC DISEASE Pharmaceutical compositions are provided that are useful in treating or preventing neoplastic disease, such as cancer. The compositions comprise a pharmaceutically acceptable carrier, and an effective therapeutic or prophylactic amount of a nitroxide antioxidant that al... | 02/23/2012 |
| 20120046317 | NOVEL HETEROCYCLIC COMPOUNDS The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation ... | 02/23/2012 |
| 20120040898 | PHARMACEUTICAL COMPOSITIONS A pharmaceutical composition comprising a combination of
| 02/16/2012 |
| 20120041025 | Dihydrolipoic Acid Derivatives Comprising Nitric Oxide and Therapeutic Uses Thereof Compounds are provided that comprise dinitroso-derivatives of dihydrolipoic acid. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating various diseases and disorders, including angina, hypertension, diabetes, dyslipidemia,... | 02/16/2012 |
| 20120035134 | CHEMICAL COMPOUNDS The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL ... | 02/09/2012 |
| 20120027723 | TAURINE OR TAURINE-LIKE SUBSTANCES FOR THE PREVENTION AND TREATMENT OF A DISEASE ASSOCIATED WITH RETINAL GANGLION CELL DEGENERATION The present invention relates to taurine or taurine-like substances for the prevention and treatment of a disease associated with retinal ganglion cell degeneration. More particularly the invention relates to a substance selected from the group consisting of taurine, a ... | 02/02/2012 |
| 20120015807 | Trifluromethoxyphenyl-Substituted Tetramic Acid Derivatives Pesticides and/or Herbicides The present invention relates to novel trifluoromethoxyphenyl-substituted tetramic acid derivatives of the formula (I), in which | 01/19/2012 |
| 20120015911 | METHOD AND COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.... | 01/19/2012 |
| 20120010161 | NOVEL AZAPEPTIDE OR AZAPEPTIDOMIMETIC COMPOUNDS INHIBITING BCRP AND/OR P-GP The present invention relates to compounds of azapeptide or azapeptidomimetic type of formula (I): in which R1, R2, R3, X1, X2, X3, X4 | |
| 20120004209 | 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Active Compounds A novel class of compounds of the general formula (I), their use in therapy, pharmaceutical compositions comprising the compounds, as well as their use in the manufacture of medicaments are described. The present compounds modulate the activity of 11β-hydroxy-steroid d... | 01/05/2012 |
| 20120004263 | Compounds for the treatment of pathologies associated with aging and degenerative disorders The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an effective amount of one or more of the compounds as set forth herein. ... | 01/05/2012 |
| 20120004165 | HETEROCYCLICALLY SUBSTITUTED METHOXYPHENYL DERIVATIVES WITH AN OXO GROUP, PROCESSES FOR PREPARATION THEREOF AND USE THEREOF AS MEDICAMENTS Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments The invention relates to heterocyclically substituted methoxyphenyl derivatives with an oxo group, an... | 01/05/2012 |
| 20120003291 | NANOBEAD RELEASING MEDICAL DEVICES Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.... | 01/05/2012 |
| 20110319448 | GUANIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These co... | 12/29/2011 |
| 20110311519 | METHODS OF TREATMENT OF BONE DEGENERATIVE DISEASES Methods of reducing bone loss and treating degenerative bone diseases such as osteoporosis are disclosed. The methods comprise administration of an agent that inhibits signaling through the IL-17 pathway, such as an antibody or a quinazoline analogue such as halofuginon... | 12/22/2011 |
| 20110311594 | CONTROLLED RELEASE COMPOSITIONS WITH REDUCED FOOD EFFECT The present invention provides a controlled release pharmaceutical composition which exhibits reduced food effect.... | 12/22/2011 |
| 20110312997 | Inhibition of WDR5 Interaction with Its Binding Partners Peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.... | 12/22/2011 |
| 20110294767 | BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.... | 12/01/2011 |
| 20110294793 | HYDROXYPHENYL SULFONAMIDES AS ANTIAPOPTOTIC BCL INHIBITORS The present invention provides compound of Formula (I): or a stereoisomer, tautomer, salt or solvate thereof, wherein the variables are defined herein. The compounds of formula (I) are inhibitors of Bcl-2 family antiapoptotic proteins, compositions containing the compou... | 12/01/2011 |
| 20110281795 | GLUCAGON RECEPTOR ANTAGONIST COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE Glucagon receptor antagonist compounds are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.... | 11/17/2011 |
| 20110274738 | FUNCTIONALIZED CHEMICALLY INERT POLYMERS FOR COATINGS Provided herein are methods for functionalizing a polymer for forming a coating and coatings and devices formed thereof or for functionalizing a coating or device surface including an polymer.... | 11/10/2011 |
| 20110275615 | NOVEL SUBSTITUTED AMIDES, THEIR PREPARATION AND USE An amide of the formula I and its tautomeric forms, possible enantiomeric and diastereomeric forms, E and Z forms, and possible physiologically tolerated salts, in which the variables have the following meani... | 11/10/2011 |
| 20110275616 | Combination Analgesic Employing Opioid and Neutral Antagonist Methods of utilizing an opioid agonist in a mammalian subject in a manner that inhibits peripheral effects of the opioid agonist are described. The methods comprise administering the opioid agonist in an amount sufficient to confer analgesia the subject and co-administe... | 11/10/2011 |
| 20110269722 | PRODRUGS CONTAINING NOVEL BIO-CLEAVABLE LINKERS The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable c... | 11/03/2011 |
| 20110269703 | METHOD FOR TREATING OR PREVENTING THROMBOSIS USING DABIGATRAN ETEXILATE OR A SALT THEREOF WITH IMPROVED SAFETY PROFILE OVER CONVENTIONAL WARFARIN THERAPY A method for preventing stroke in a patient suffering from atrial fibrillation, wherein the patient has at least one risk factor for major bleeding events, the method comprising administering to the patient 110 mg b.i.d. of dabigatran etexilate, optionally in the form o... | 11/03/2011 |
| 20110269795 | USE OF GLUCOSIDASE INHIBITORS FOR THERAPY OF MUCOVISIDOSIS A method provides for the use of glycosidase inhibitors selected from compounds of general formula (1), wherein R1 represents a CH3 group, or CH2OH, R2 represents H or an alkyl group having 1-5 carbon atoms, or R1 a... | 11/03/2011 |
| 20110257226 | HALOGEN-CONTAINING ORGANOSULFUR COMPOUND AND USE THEREOF There is provided a halogen-containing organosulfur compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 0, 1 or 2; n represents 0, 1 or 2; A represents an optionally substituted 3- to 8-membered saturated heterocy... | 10/20/2011 |
| 20110257085 | Crystal Forms of Saxagliptin and Processes for Preparing Same Physical crystal structures of a compound of the formula I: are provided including the free base monohydrate thereof (form H-1) and the hydrochloric acid salt thereof, including hydrochloric acid salt contain... | 10/20/2011 |
| 20110245188 | METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF INFLAMMATORY DISEASES OR CONDITIONS The present invention relates to methods and compositions of treating or preventing inflammatory diseases or conditions in a patient comprising administering to the patient a therapeutically effective amount of a composition comprising a glutathione donor, 5-amino 4-imi... | 10/06/2011 |
| 20110237538 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-gluc... | 09/29/2011 |
| 20110230437 | ORGANIC COMPOUNDS A composition comprising a compound of formula I CH3CH(OH)CC═O)NR1R2 (I) where R1 and R2 are each independently hydrogen; or C1-6 alkyl, C2-6 alkenyl or C3-6 cycloalkyl, each of wh... | 09/22/2011 |
| 20110224128 | METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY The invention features methods, compositions, and kits useful for the treatment of muscular dystrophy, e.g., Duchenne muscular dystrophy, in a patient.... | 09/15/2011 |
| 20110224213 | Use of Glutaric Acid Derivatives or the Pharmaceutically Acceptable Salts Thereof as Anti-Arrhythmic Agents The invention relates to the use of glutaric acid derivatives of general formula (I), which are disclosed in the invention description, as anti-arrhythmic agents.... | 09/15/2011 |
| 20110212080 | UREA DERIVATIVES AS ANTIBACTERIAL AGENTS This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which is useful for the treatment of diseases or conditions mediated by LpxC. ... | 09/01/2011 |
| 20110212996 | METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES The present invention provides methods to determine whether a patient with a lysosomal storage disorder will benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining α-galactosidase A respons... | 09/01/2011 |
| 20110207775 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT VESICLE-FUSING ATPASE ACTIVITY The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect vesicle-fusing ATPase; a method for assaying pesticidal activity of a test substance, which comprises measurin... | 08/25/2011 |
| 20110200660 | POLY(ESTER AMIDE)-BASED DRUG DELIVERY SYSTEMS WITH CONTROLLED RELEASE RATE AND MORPHOLOGY A method of forming a coating on a medical device having a controlled morphology is described. A medical device having a controlled morphology is described.... | 08/18/2011 |
| 20110200484 | DISINFECTING, NONBLEACHING N-HALAMINE FOR USE WITH CONTACT LENS A disinfecting, nonbleaching N-halamine for use in contact lens soaking solutions. The N-halamine compound is soluble in water and contact lens formulation solutions to the extent necessary to provide disinfection, but not to cause significant bleaching of dye materials... | 08/18/2011 |
