|Application No.||Application Title||Issue Date|
|20140051683||7-SUBSTITUTED INDOLE MCL-1 INHIBITORS|
Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed....
|20140051682||NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS|
The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors....
|20140051660||CYCLOPENTYLPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS|
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows:
|20140051688||PYRROLOPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS|
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:
|20140045855||CHROMAN DERIVATIVES AS TRPM8 INHIBITORS|
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disor...
|20140045825||Inhibitors of PI3K-Delta and Methods of Their Use and Manufacture|
The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
Compounds of the general formula (I) wherein the substituents are as defined in claim 1, are useful as fungicides.
|20140045854||Methods and Compositions for the Treatment of Cancer and Related Hyperproliferative Disorders|
The present invention relates to methods of treating a disease related to cell hyper-proliferation via administration of a therapeutically effective amount of a compound having a general tripartite structure A-B-C. In the tripartite structure A, B, and C are identical o...
|20140038922||WNT PROTEIN SIGNALLING INHIBITORS|
The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment of Wnt protein signalling-related diseases and conditions such as cancer, d...
|20140038920||TFEB PHOSPHORYLATION INHIBITORS AND USES THEREOF|
The invention refers to TFEB phosphorylation inhibitors. Such molecules have a therapeutic applicability in all disorders that need induction of the cell authophagic/lysosomal system, such as lysosomal storage disorders, neurodegenerative diseases, hepatic diseases, mus...
The present invention relates to compounds according to Formula (I) or a pharmaceutically acceptable salt or solvate thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or condition.
|20140038962||Flavivirus Inhibitors and Methods of Their Use|
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine proteas...
|20140038821||ISOXAZOLINES FOR CONTROLLING INVERTEBRATE PESTS|
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof,
|20140038965||5- AND 6-MEMBERED HETEROCYCLIC COMPOUNDS|
5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for cen...
|20140031335||CYCLOALKENYL ARYL DERIVATIVES FOR CETP INHIBITOR|
The present invention relates to cycloalkenyl aryl derivatives, isomers thereof, pharmaceutically acceptable salts thereof, hydrates thereof, or solvates thereof; a method for preparing the derivatives; and pharmaceutical compositions containing the same. The compounds ...
|20140031338||INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES|
The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV....
|20140031391||Novel 5-aminotetrahydroquinoline-2-carboxylic acids and their use|
The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevent...
|20140024647||AROMATIC HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY|
A compound having TRPV4 inhibitory activity or a pharmaceutically acceptable salt thereof is provided. The present invention is related to a compound represented by the formula (I), wherein R1a is substituted or unsubstituted alkyl or the like; R1b
|20140024671||COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450|
Methods of inhibiting cytochrome P450 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450. Pharmaceutical compositions are provided that can act as boosters to improve the...
|20140018370||APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS|
The present invention relates to compounds of Formula (I):
|20140011840||Compounds of Modulating TRPV3 Function|
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3....
|20140011808||1,2-DISUBSTITUTED HETEROCYCLIC COMPOUNDS|
1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including hum...
|20140011836||METHOD OF TREATING NEUROPATHIC PAIN|
Provided are methods for using bis-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain....
The present invention relates to a compound that has URAT1 inhibitory action, and a URAT1 inhibitor, a blood uric acid level-reducing agent and a pharmaceutical composition comprising the compound. More specifically, the present invention relates to a compound represent...
|20140005194||BENZIMIDAZOLE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS|
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to benzimidazole containing compounds and methods for their preparation. These compounds may be useful as medicaments for...
|20140005190||COMPOUNDS AND METHODS OF USE|
In one aspect, the present invention provides for a compound of Formula I
in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the ...
|20140005195||BIPYRIDINE SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OR CONDITIONS|
The present invention relates to novel bipyridine sulfonamide derivatives of formula (I) and their use for the treatment and/or prophylaxis of a neurodegenerative disease or condition, particularly Alzheimers disease (AD), a cardiovascular disease or a pathology involvi...
|20140004203||COATED DRUG SPHEROIDS AND USES THEREOF FOR ELIMINATING OR REDUCING CONDITIONS SUCH AS EMESIS AND DIARRHEA|
The present invention provides an oral pharmaceutical formulation comprising coated spheroids of a kinase inhibitor such as neratinib, which formulation is designed to reduce or eliminate side effects associated with existing oral formulations of kinase inhibitors....
|20130345154||Gap Junction-Enhancing Agents for Treatment of Necrotizing Enterocolitis and Inflammatory Bowel Disease|
The present invention relates to methods of reducing the risk of occurrence of, and/or treating, necrotizing enterocolitis (“NEC”) or inflammatory bowel disease (“IBD”) comprising administering, to a subject in need of such treatment, an effective amount of a ga...
The present invention relates to 1-[m-Carboxamido(hetero)aryl-methyl]-piperidine-4-carboxamide derivatives of formula (I)
wherein X, Ar1, R1, R2, R3, R4,...
|20130345196||PHENOXY THIOPHENE SULFONAMIDES AND OTHER COMPOUNDS FOR USE AS INHIBITORS OF BACTERIAL GLUCURONIDASE|
This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene ca...
The invention relates to compounds of formula
wherein R1, R2, R3, R4, X, Ar, and
are defined herein
|20130345249||Formulations for the prevention and treatment of Wolbachia-related disease|
The invention encompasses pharmaceutical formulations for the prevention and treatment of Wolbachia-related disease wherein the formulations comprise a compound previously unknown and unused for such a purpose, the compound being one or more of: Pararosaniline Pa...
|20130338105||IMINIPYRIDINE DERIVATIVES AND THEIR USES AS MICROBIOCIDES|
Compounds of the formula I
in which the substituents are as defined in claim 1 are suitable for use as microbiocides....
|20130338112||COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS|
The invention relates to compounds of structural formula (I):
|20130338155||METHOD FOR TREATING INFECTIONS|
The present invention relates to compounds that inhibit the activity of Hsp90 and methods of using these compounds for treating or preventing infection....
|20130330284||NEUROPROTECTIVE AND NEURO-RESTORATIVE IRON CHELATORS AND MONOAMINE OXIDASE INHIBITORS AND USES THEREOF|
8-Hydroxy-quinoline derivatives and 8-ethers, 8-esters, 8-carbonates, 8-acyloxymethyl, 8-phosphates, (phosphoryloxy)methyl, and 8-carbamates derivatives thereof are described that exhibit iron chelation, neuroprotective, neurorestorative, apoptotic and/or selective MAO-...
|20130331414||Inhibitors of Retroviral Replication|
Methods for preventing or treating retroviral infection, such as human immunodeficiency virus, in vivo utilize transcriptional inhibitory compounds. These include cortistatin A and analogs of the cortistatin family....
|20130331389||Methods and Compositions for Cardiomyocyte Replenishment by Endogenous and Progenitor Stem Cells|
Disclosed herein are methods and compositions for replenishing injured and/or damaged cardiomyocytes in a subject by inducing, increasing, and/or enhancing the differentiation of endogenous stem and progenitor cells in the subject....
|20130331413||DEFENSIN-LIKE MOLECULES AS NOVEL ANTIMICROBIAL AGENTS|
Disclosed are compositions and methods for treating and/or preventing infections in mammals, by administering to a mammal a therapeutically effective amount of at least one defensin-like molecule, e.g., in a composition that includes such molecule. Also disclosed are ki...