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| Application No. | Application Title | Issue Date |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120045509 | MODIFIED RELEASE COMPOSITIONS FOR DPP-IV INHIBITORS The present invention refers to pharmaceutical composition comprising a DPP-IV inhibitor.... | 02/23/2012 |
| 20120015972 | INDOLIZINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level and the like. That is, the present invention relates to indolizine derivatives represented by the following formula (I) ... | 01/19/2012 |
| 20120004233 | TRICYCLIC COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination... | 01/05/2012 |
| 20120004191 | Combinational Compositions And Methods For Treatment Of Cancer The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-... | 01/05/2012 |
| 20120003330 | BENZOQUINOLONE INHIBITORS OF VMAT2 The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof. ... | 01/05/2012 |
| 20110294800 | HYPOGLYCEMIC DIHYDROPYRIDONES The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical compositions comprising a compound of formula I, and methods of treatment or ... | 12/01/2011 |
| 20110268654 | COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.... | 11/03/2011 |
| 20110257220 | 3,11 b-cis-Dihydrotetrabenazine for the Treatment of Schizophrenia and Other Psychoses The invention provides the use of 3,11b-cis-dihydrotetrabenazine or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the prophylaxis or treatment of schizophrenia and other psychoses.... | 10/20/2011 |
| 20110212989 | THERAPEUTIC METHODS AND COMPOSITIONS INVOLVING ISOFLAVONES Therapeutic method of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H or RACO wherein R... | 09/01/2011 |
| 20110201641 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS The compound (+) {7R-[[(4-fluorophenyl)sulfonyl] (methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of C... | 08/18/2011 |
| 20110195961 | TRICYCLIC OXAZOLIDINONE ANTIBIOTIC COMPOUNDS The invention relates to antibacterial compounds of formula I wherein | |
| 20110190333 | DIHYDROTETRABENANZINE FOR THE TREATMENT OF ANXIETY The invention provides a 3,11b-cis-dihydrotetrabenazine of the formula (Ib): or a pharmaceutically acceptable salt thereof for use in the prophylaxis or treatment of anxiety. ... | 08/04/2011 |
| 20110172263 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma. ... | 07/14/2011 |
| 20110160242 | Purified Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same The present invention relates to a form 1 and form 2 polymorph of (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione. The present invention also relates to (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-<... | 06/30/2011 |
| 20110160243 | SUBSTITUTED TRICYCLIC ACID DERIVATIVES AS S1P1 RECEPTOR AGONISTS USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS The present invention relates to certain substituted tricyclic acid derivatives of Formula (I) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present inv... | 06/30/2011 |
| 20110160237 | Substituted Heterocyclic Compounds The present invention relates to substituted heterocyclic compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted heterocyclic compounds and methods of treating cell proliferative di... | 06/30/2011 |
| 20110118301 | Amino-Aza-Adamantane Derivatives and Methods of Use The invention relates to amine-substituted aza-adamantane derivatives, compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and compositions. Radiolabelled compounds useful for evalua... | 05/19/2011 |
| 20110118300 | GLUCOSE METABOLISM MODULATING COMPOUNDS The present invention provides, inter alia, dihydropyridone compounds and compositions, including analogs of a vesicular monoamine transporter type 2 (VMAT2) antagonist. The present invention also provides methods of using such compounds/analogs for modulating glucose l... | 05/19/2011 |
| 20110118241 | 6-Pyridin-3-YL-3,4-Dihydro-1H-Quinolin-2-One Derivatives and Related Compounds as Inhibitors of the Human Aldosterone Synthase CYP11B2 The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and the use of these compounds and other heteroaryl substituted quinolinone derivatives f... | 05/19/2011 |
| 20110112067 | Inhibitors of the Human Aldosterone Sythase CYP11B2 The invention provides compounds of the general formula (I) which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of... | 05/12/2011 |
| 20110092535 | Novel Epilepsy Treatment The present invention resides in the use of a 5-HT3 receptor antagonist as medicament for the treatment of temporal lobe epilepsy associated with hippocampal sclerosis (TLE-HS) in a human patient. Tropisetron or Dolasetro are the preferred compounds.... | 04/21/2011 |
| 20110053866 | PHARMACEUTICAL COMPOSITIONS The present invention provides for a pharmaceutical composition that includes tetrabenazine and a release-retarding agent; and a method of treating a hyperkinetic movement disorder (e.g., Huntington's disease, chorea associated with Huntington's disease, hemiballismus, ... | 03/03/2011 |
| 20110039832 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES The invention relates to 5,6-dihydropyrrolo[2,1-a]isoquinoline and pyrrolo[2,1-a]isoquinoline derivatives according to general formula (I) or a pharmaceutically acceptable salt thereof. The compounds can be used for the treatment of infertility. 02/17/2011 | |
| 20110039877 | USE OF 3, 11B-CIS-DIHYDROTETRABENAZINE IN THE TREATMENT OF MULTIPLE SCLEROSIS AND AUTOIMMUNE MYELITIS The invention provides a compound for use in treating multiple sclerosis wherein the compound is a 3, 11b-cis-dihydrotetrabenazine of the formula (Ia): or a pharmaceutically acceptable salt thereof. ... | 02/17/2011 |
| 20110003844 | REGULATION OF CARDIAC CONTRACTILITY AND HEART FAILURE PROPENSITY The methods and compositions of the present invention find use in altering expression of PKCα in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic a... | 01/06/2011 |
| 20110003824 | Caspase Inhibitors and Uses Thereof This invention provides novel caspase inhibitors of formula I: wherein R1 is hydrogen, CHN2, R, or —CH2Y; R is an aliphatic group, an aryl group, an aralkyl group, a heteroc... | 01/06/2011 |
| 20100322997 | METHOD FOR PRODUCING BIOLOGICALLY INGESTIBLE MICROPARTICLES, BIOLOGICALLY INGESTIBLE MICROPARTICLES, AND DISPERSION AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME A method of separating biologically ingestible microparticles is used to obtain biologically ingestible microparticles in a thin film fluid formed between two processing surfaces provided with a solution containing a first solvent in which an objective substance to be p... | 12/23/2010 |
| 20100323019 | Microparticles for the treatment of disease Microparticle-bioactive agent based treatments for local treatment of diseased tissues/organs are disclosed.... | 12/23/2010 |
| 20100298278 | INHIBITORS OF BETA-SECRETASE FOR THE TREATMENT OF ALZHEIMER'S DISEASE The invention relates to the substituted 1,2-ethylenediamines of general formula (I), wherein the groups R1 to R13, A, B, L and i are defined as in the description and the claims. The in... | 11/25/2010 |
| 20100297075 | COMBINATIONAL COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound or a pyrroloquinolinyl-pyrrolidine-2,5-... | 11/25/2010 |
| 20100273824 | SUBSTITUTED 1,3-DIOXANES AND THEIR USES The present invention relates to compounds containing 1,3-dioxane moiety, pharmaceutical compositions thereof, and the use of the compounds and compositions for the modulation of thromboxane A2 or a peroxisome proliferator-activated receptor. The compounds, analogs, and... | 10/28/2010 |
| 20100261710 | HDAC Inhibitors The present invention provides hydroxamic acid compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the hydroxamic acid compounds. The present invention provides methods of treating a cell... | 10/14/2010 |
| 20100261675 | FUNGICIDAL COMPOSITION CONTAINING ACID AMIDE DERIVATIVE Conventional many fungicidal compositions have had practical problems such that either a preventive effect or a curing effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upo... | 10/14/2010 |
| 20100256698 | Isoquinolinone Potassium Channel Inhibitors The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.... | 10/07/2010 |
| 20100240648 | HEXAHYDRO-PYRROLO-ISOQUINOLINE COMPOUNDS Certain hexahydro-pyrrolo-isoquinoline compounds are histamine H3 receptor and serotonin transporter modulators useful in the treatment of histamine H3 receptor- and serotonin-mediated diseases.... | 09/23/2010 |
| 20100234415 | INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS Compound of formula I are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-mediated diseases such as asthma.... | 09/16/2010 |
| 20100234411 | New Combination for the Treatment of Respiratory Diseases The present invention relates to novel pharmaceutical compositions based on telmisartan 1 and anticholinergics 2 processes for preparing them and their use for the treatment of respiratory diseases.... | 09/16/2010 |
| 20100222337 | FUNGICIDAL COMPOSITION CONTAINING CARBOXYLIC ACID AMIDE DERIVATIVE Conventional fungicidal compositions have had practical problems such that either a preventive effect or a curative effect is inadequate, the residual effect tends to be inadequate, or the controlling effect against plant diseases tends to be inadequate depending upon t... | 09/02/2010 |
| 20100221351 | Controlled Drug Delivery Using a Thermally Responsive Nanocapsule to Augment Cryoablation In accordance with certain embodiments of the present disclosure, A method for intracellular delivery of cytotoxin in combination with cyoablation is provided. The method includes encapsulation of one or more cytotoxins in a thermally responsive nanocapsule by decreasin... | 09/02/2010 |
