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| Application No. | Application Title | Issue Date |
| 20120129810 | COMBINATION ANTINEOPLASTIC THERAPY The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.... | 05/24/2012 |
| 20120125325 | THE USE OF AMLEXANOX IN THE THERAPY OF NEUTROPHIL-DRIVEN DISEASES An agent, which is amlexanox, is useful in the therapy of a disease associated with neutrophilia.... | 05/24/2012 |
| 20120128665 | PRESELECTION OF SUBJECTS FOR THERAPEUTIC TREATMENT BASED ON HYPOXIC STATUS The present invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of hypoxia in cancerous cells in the subject. In one embodiment, the invention provides methods for the preselection of a subject f... | 05/24/2012 |
| 20120108529 | PROTEASE INHIBITORS Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing... | 05/03/2012 |
| 20120108581 | FUSED PIPERIDINE COMPOUND AND PHARMACEUTICAL CONTAINING SAME The present invention provides a low molecular weight compound having EPO production-promoting action and/or hemoglobin production-promoting action. The present invention relates to a fused piperidine compound represented by the following general formula (1): | 05/03/2012 |
| 20120108625 | NOVEL FORMS OF TIOTROPIUM BROMIDE AND PROCESSES FOR PREPARATION THEREOF This invention relates to novel crystalline forms of tiotropium bromide, processes for preparing them, and their use in pharmaceutical formulations.... | 05/03/2012 |
| 20120082626 | USE OF R-BAMBUTEROL AS INHALED MEDICAMENT AND COMBINATION THERAPIES FOR TREATMENT OF RESPIRATORY DISORDERS The present invention concerns with a new use of R-Bambuterol or Bambuterol as inhaled medicament for treatment of asthma, COPD and other respiratory disorders, and a new use of R-bambuterol or bambuterol and corticosteroids or other therapeutically active medicament as... | 04/05/2012 |
| 20120071449 | PHARMACEUTICAL COMPOSITION FOR INHALATION The present invention relates to a pharmaceutical composition for inhalation. The invention is further directed to a method for setting the performance characteristics of such a pharmaceutical composition and the use of such a composition in the treatment of asthma, COP... | 03/22/2012 |
| 20120071500 | MACROCYCLIC LACTONE COMPOUNDS AND METHODS FOR THEIR USE The present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5... | 03/22/2012 |
| 20120071435 | PHARMACEUTICAL COMBINATIONS COMPRISING FOR THE TREATMENT OF SPECIFIC CANCERS The present invention relates to the field of oncology and provides compositions and methods for treating specific cancers, including non small cell lung cancer, breast cancer, thyroid cancer, pancreatic cancer, colon cancer, melanoma, hepatoma and adenocarcinoma. Parti... | 03/22/2012 |
| 20120071967 | ONE-STEP PHOSPHORYLCHOLINE-LINKED POLYMER COATING AND DRUG LOADING OF STENT A one step method for drug coating an interventional device is disclosed by mixing a drug with a phosphorylcholine-linked methacrylate polymer in a liquid and applying the mixture to an interventional device, such as a stent, in a single step.... | 03/22/2012 |
| 20120053198 | WATER-SOLUBLE SOLID PHARMACEUTICAL INCLUSION COMPLEXES AND THEIR AQUEOUS SOLUTIONS FOR ORAL, OPHTHALMIC, TOPICAL OR PARENTERAL USE CONTAINING A MACROLIDE AND CERTAIN CYCLODEXTRINS This invention relates to new water-soluble solid pharmaceutical inclusion complexes and their aqueous solutions for oral, ophthalmic, topical or parenteral use containing a macrolide and certain cyclodextrins. More particularly the inventi... | 03/01/2012 |
| 20120053199 | NOSCAPINE AND ANALOGS AND METHODS RELATED THERETO The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical compositions and methods of using the compounds and compositions to treat inflammat... | 03/01/2012 |
| 20120053197 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly,... | 03/01/2012 |
| 20120052118 | Apparatus and process for encapsulating capsules or other solid dosage forms within capsules The present invention provides an apparatus and process for making softgel capsules having incorporated therein other solid dosage forms selected from the group consisting of pellets, smaller capsules, smaller tablets, sustained release solid dosage forms, immediate rel... | 03/01/2012 |
| 20120046304 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly,... | 02/23/2012 |
| 20120046311 | CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREOF Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: | 02/23/2012 |
| 20120046467 | QUATERNARY AMMONIUM SALT COMPOUNDS [Problem] The object of the present invention is to provide a novel compound having 132 adrenergic receptor agonist activity and muscarinic receptor antagonist activity. [Means for Solving the Problem] | 02/23/2012 |
| 20120045519 | USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of deoxyelephantopin or an analogue thereof; and a pharmaceutically acceptable carrier... | 02/23/2012 |
| 20120041019 | PROTEASE INHIBITORS Compounds useful as protease inhibitors are provided, as are methods of use and preparation of such compounds and compositions containing such compounds. In one embodiment, the compounds are useful for inhibiting HIV protease enzymes, and are therefore useful in slowing... | 02/16/2012 |
| 20120039868 | Biomarkers for Graft Rejection Methods are disclosed for diagnosing rejection in a transplanted subject, monitoring rejection in a transplanted subject at risk thereof, preventing, inhibiting, reducing or treating rejection in a transplanted subject, or identifying agents for use in the prevention, i... | 02/16/2012 |
| 20120035409 | BI- AND TRICYCLIC INDAZOLE-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES AND USES THEREOF This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof and to the use thereof for the treatment of c-Met-mediated diseases or c-M... | 02/09/2012 |
| 20120034279 | TRANSSCLERAL DELIVERY Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera an... | 02/09/2012 |
| 20120029009 | Tacrolimus For Improved Treatment Of Transplant Patients An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form relea... | 02/02/2012 |
| 20120028908 | Methods of Manufacturing Crystalline Forms of Rapamycin Analogs A process for preparing a crystalline rapamycin analog includes: combining the rapamycin analog with an organic medium to form a mixture; incubating the mixture until the rapamycin analog crystallizes; and recovering the crystalline rapamycin analog. The organic medium ... | 02/02/2012 |
| 20120028977 | Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive disorders, depression, neuropathic pain, stroke, traumatic brain injury, e... | 02/02/2012 |
| 20120027859 | Biodegradable Proline-Based Polymers The invention provides sequential poly(ester amide)s derived from Proline and that are synthesized by a two-step method, involving a final thermal polyesterification reaction. Molecular weights of polymers prepared by this method are from 14,000 Da to about 77,000 Da.1 ... | 02/02/2012 |
| 20120021021 | METHOD FOR PREPARING PHARMACEUTICAL COMPOSITIONS COMPRISING FINE PARTICLES OF ACTIVE SUBSTANCE The present invention relates to a method for preparing solid pharmaceutical compositions comprising fine particles of at least one active substance, dispersed on and (or) within a divided solid. This method is characterized in that a solution is formed which comprises ... | 01/26/2012 |
| 20120022095 | TOPICAL RAPAMYCIN FOR TREATMENT OF FACIAL ANGIOFIBROMAS IN TUBEROUS SCLEROSIS The present disclosure provides for a method and a topical composition to treat facial angiofibromas in Tuberous Sclerosis by applying from about 0.25% to about 2% rapamycin to a small body surface area.... | 01/26/2012 |
| 20120022046 | Thienopyridine Derivatives for the Treatment and Prevention of Dengue Virus Infections Methods and pharmaceutical compositions for treating viral infections, by administering certain thienopyridine derivative compounds in therapeutically effective amounts are disclosed. Methods of using the compounds and pharmaceutical compositions thereof are also disclo... | 01/26/2012 |
| 20120022001 | METHOD OF MITIGATING ADVERSE DRUG EVENTS USING OMEGA-3 FATTY ACIDS AS A PARENTERAL THERAPEUTIC DRUG VEHICLE A method of parenterally administering a composition, the method including parenterally administering to a person a composition including at least one omega-3 fatty acid and at least one drug, wherein the at least one omega-3 fatty acid source and the at least one drug ... | 01/26/2012 |
| 20120015908 | SYNTHESIS AND ANTICANCER ACTIVITY OF ARYL AND HETEROARYL-QUINOLIN DERIVATIVES A compound of Formula I is disclosed as follows:
| 01/19/2012 |
| 20120015971 | OPHTHALMIC COMPOSITION COMPRISING ASCOMYCIN This invention relates to topical ophthalmic compositions comprising an ascomycin e.g. for the treatment of inflammatory diseases such as blepharitis.... | 01/19/2012 |
| 20120014949 | Serum Biomarkers For Early Detection Of Acute Cellular Rejection The present invention provides an improved method of diagnosing a subject having received an organ transplant with Acute Cellular Rejection (ACR). The method comprises obtaining a biological sample from the subject, detecting an amount of at least one protein indicative... | 01/19/2012 |
| 20120015035 | Implantable Delivery Vehicle for Ocular Delivery of Muscarinic Antagonists The present invention provides compositions and methods for treating ocular disorders such as myopia.... | 01/19/2012 |
| 20120015901 | METHODS AND PREPARATIONS FOR PROTECTING CRITICALLY ILL PATIENTS The present invention relates to a method of treating a life threatening condition in a critically ill human patient with a non-infectuous disorder, wherein the critically ill patient is a patient receiving enteral or parenteral nutrition, the method comprising the step... | 01/19/2012 |
| 20120015019 | Drug Coated Balloon With In-Situ Formed Drug Containing Microspheres The current invention relates to methods of forming a coating that involves the in-situ formation of drug microspheres. The coating may be applied to a medical device, such as a catheter balloon or a stent. Coated devices and methods of treatment therewith are also enco... | 01/19/2012 |
| 20120010234 | USE OF VEGF-D IN THE DIAGNOSIS OF LYMPHANGIOLEIOMYOMATOSIS (LAM) DISEASE Described herein are methods of diagnosing lymphangioleiomyomatosis (LAM) that permits differentiating LAM from another lung disorder. Methods of treatment are also provided.... | 01/12/2012 |
| 20120009236 | Formable Aquatic Coverings For Preventing Biofouling The instant invention describes an anti-biofouling structure for placement onto structures or surfaces that are exposed to aquatic environments. Embedded within the anti-biofouling structure are agents that can diffuse out of the structure and prevent the formation and/... | 01/12/2012 |
| 20120010181 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditio... | 01/12/2012 |
