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| Application No. | Application Title | Issue Date |
| 20110269791 | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use The present invention relates to compounds defined by Formula (I), wherein the groups A, B, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD)... | 11/03/2011 |
| 20110245272 | PYRIDO[4,3-B]INDOLES AND METHODS OF USE This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of t... | 10/06/2011 |
| 20110237582 | PYRIDO[3,4-B]INDOLES AND METHODS OF USE This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of t... | 09/29/2011 |
| 20110218143 | COMPOSITIONS AND METHODS FOR TISSUE REPAIR The invention generally provides compositions and methods for the repair or regeneration of a tissue or organ in need thereof.... | 09/08/2011 |
| 20110190262 | Aryl-and Heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use The present invention relates to compounds defined by formula I wherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity.... | 08/04/2011 |
| 20110152306 | AZA-BRIDGED RING-FUSED INDOLES AND INDOLINES The present application relates to indole and indoline derivatives of formula (I) wherein a, R1, R2, R3, h, i, j, m, n, L, Q, and X are as defined in the specification. The pr... | 06/23/2011 |
| 20110152248 | BRIDGEHEAD AMINE RING-FUSED INDOLES AND INDOLINES The present application relates to indole and indoline derivatives of formula (I), formula (II), formula (III), or formula (IV) wherein a, R2, R3, h, k, m, n, L, Q, X, and Z are as defin... | 06/23/2011 |
| 20110112122 | EPIMINOCYCLOALKYL[b] INDOLE DERIVATIVES AS SEROTONIN SUB-TYPE 6 (5-HT6) MODULATORS AND USES THEREOF The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT6) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment ... | 05/12/2011 |
| 20110104275 | METHODS AND KITS FOR TREATING CLUSTER HEADACHE DISORDERS The invention features methods and kits employing bromolysergide in therapies for the treatment of cluster headache disorders.... | 05/05/2011 |
| 20110038936 | SYSTEM AND METHOD FOR ELECTROSPUN DRUG LOADED BIODEGRADABLE CHEMOTHERAPY APPLICATIONS Biodegradable resorbable drug delivery systems characterized by an electrospun biodegradable resorbable polymeric fiber matrix with at least one therapeutic agent incorporated into the fibers of the matrix, wherein the fiber matrix has an interfibrillar space of at leas... | 02/17/2011 |
| 20110028494 | HCV NS3 Protease Inhibitors The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. ... | 02/03/2011 |
| 20110003737 | AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in ... | 01/06/2011 |
| 20100285020 | LEUKEMIC CELL CNS INFILTRATION CONTROLLED BY NOTCH-INDUCED CHEMOTAXIS The present invention is directed to methods of preventing central nervous system leukemia, treating T-cell acute lymphoblastic leukemia, and treating immune system disorders associated with CCR7-CCL19 mediated signaling. Suitable therapeutic agents for inhibiting CCR7-... | 11/11/2010 |
| 20100256178 | SUPER-OXIDE DISMUTASE MIMETICS The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 16-membered macrocyclic complexes that catalytically dismutate superox... | 10/07/2010 |
| 20100130512 | FUSED-RING HETEROCYCLE OPIOIDS Compounds of formula: are disclosed. In these compounds is a heterocyclic ring. The compounds are useful as analgesics, anti-pruritics, anti-diarr... | 05/27/2010 |
| 20100104567 | PHARMACEUTICAL COMPOSITION The present invention provides a pharmaceutical composition comprising a combination of an Flt-3 inhibitor and at least one compound, the said pharmaceutical composition wherein an Flt-3 inhibitor is an indazole derivative represented by Formula (I) | 04/29/2010 |
| 20100099667 | BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical composit... | 04/22/2010 |
| 20100099695 | HCV NS3 Protease Inhibitors The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. ... | 04/22/2010 |
| 20100093779 | HCV NS3 PROTEASE INHIBITORS The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections. ... | 04/15/2010 |
| 20100069424 | 3-CYANO-QUINOLINE DERIVATIVES WITH ANTIPROLIFERATIVE ACTIVITY The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein
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| 20100068285 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same The present disclosure generally relates to nanoparticles having about 0.2 to about 35 weight percent of a therapeutic agent; and about 10 to about 99 weight percent of biocompatible polymer such as a diblock poly(lactic) acid-poly(ethylene)glycol. Other aspects of the ... | 03/18/2010 |
| 20100069423 | Use of Chk2 Kinase Inhibitors for Cancer Treatment Described herein are Chk2-inhibitor compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.... | 03/18/2010 |
| 20090318490 | COMPOUNDS AND METHODS FOR PROMOTING SMOKING CESSATION Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.... | 12/24/2009 |
| 20090306085 | HCV PROTEASE INHIBITORS AND USES THEREOF The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.... | 12/10/2009 |
| 20090137598 | METHOD OF TREATING METABOLIC DISORDERS AND DEPRESSION WITH DOPAMINE RECEPTOR AGONISTS This invention relates to methods and formulations for treating metabolic disorders and depression. In some embodiments, the methods comprise administering a dopamine receptor agonist and an anti-depressant.... | 05/28/2009 |
| 20090088448 | Rapamycin Derivatives and the Uses Thereof in the Treatment of Neurological Disorders Provided is a method of treating neurodegenerative disorders comprising administering to a subject in need thereof a compound of formula I: ... | 04/02/2009 |
| 20090076059 | DEUTERIUM-ENRICHED DIANICLINE The present application describes deuterium-enriched dianicline, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.... | 03/19/2009 |
| 20080318966 | Sinomenine Derivatives and Preparation and Uses Thereof The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I. The approach disclosed herein is the modification of D ring by-substituting for R. Additional substitutions in the other rings are also provided herein. Seve... | 12/25/2008 |
| 20080275075 | Medicine Comprising a Combination of an Acetylcholinesterase Inhibitor and a 5-Substituted-3-Oxadiazolyl-1,6-Naphthyridin-2(1H)-One Derivative The invention provides a medicine comprising a combination of an acetylcholinesterase inhibitor and a 5-substituted-3-oxadiazolyl-1,6-naphthyridin-2(1H)-one derivative of the formula (I): wherein Het is oxadi... | 11/06/2008 |
| 20080242657 | Treatment of Tremor with Histamine H3 Inverse Agonists or Hist Amine H3 Antagonists Histamine H3 inverse agonists or histamine H3 antagonists are useful, alone or in combination with a neuroleptic agent, for treating or preventing movement disorders, including tremor, such as essential tremor, and tremor associated with Parkinson's disease, cranofacial... | 10/02/2008 |
| 20080176873 | Novel Pharmaceutical Compositions for Treating Acquired Chronic Pain and Associated Dysphoria Chronic pain is alleviated in a mammal suffering there from by administering to the mammal a chronic pain alleviating amount of a nontoxic N-methyl-D-aspartate receptor antagonist such as dextromethorphan, dextrorphan, ketamine or pharmaceutically acceptable salt thereo... | 07/24/2008 |
| 20080139587 | Combinations Comprising Epothilones and Protein Tyrosine Kinase Inhibitors and Pharmaceutical Uses Thereof The invention relates to a combination which comprises: (a) an epothilone; and (b) a protein tyrosine kinase inhibitor; and optionally (c) a derivative of rapamycin; for simultaneous, separate or sequential use, in particular, for the delay of progression or treatment o... | 06/12/2008 |
| 20080027089 | Rapamycin derivatives and the uses thereof in the treatment of neurological disorders Pharmaceutical composition containing compounds of the following structure, wherein R1-R9, R15, and n are defined herein, are provided. These compositions are useful in treating neurological disorders or complications due to stroke or... | 01/31/2008 |
| 20080015211 | TREATMENT OF INFLAMMATORY AND ULCERATIVE DISEASES OF THE BOWEL WITH OPIOID ANTAGONISTS Methods for the treatment of inflammatory and ulcerative diseases of the bowel (e.g., Crohn's disease and ulcerative colitis) with low dose opioid antagonists (e.g., naltrexone, nalmefene or naloxone), pharmaceutical compositions for use in such methods, and methods for... | 01/17/2008 |
| 20070275973 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS Compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, R3 and n are defined as in the specification, intermediates in the synthesis of such compounds, pharmaceutical compositions containing such c... | 11/29/2007 |
| 20060094741 | Remedies for neuropathic pain and model animals of neuropathic pain The present invention relates to a therapeutic agent for neuropathic pain containing, as an active ingredient, a compound represented by general formula (I) or a pharmacologically acceptable acid addition salt thereof: (wherein R1, R2, R<... | 05/04/2006 |
| 20060009480 | Sinomenine and sinomenine compounds, synthesis and use The invention relates to sinomenine and compounds thereof and also to compounds of formula (I): wherein
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| 20050182083 | Heterocyclic modulators of the glucocorticoid receptor, AP-1, and/or NF-kB activity and use thereof Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I)... | 08/18/2005 |
| 20050101623 | Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors The present invention provides novel bridged beta-carboline compounds that are capable of inhibiting mitogen activated protein kinase-activated protein kinase-2 and analogues thereof and pharmaceutical compositions and kits that include these compounds. ... | 05/12/2005 |
| 20050000390 | Low-viscosity opacifiers free from anionic surface-active agents The invention relates to wax-based opacifier preparations containing (a) at least one amphoteric surfactant, (b) at least one fatty acid partial glyceride, (c) at least one fatty acid polyglycol ester and optionally (d) a polyol, with the proviso that the ratio by weigh... | 01/06/2005 |
