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| Application No. | Application Title | Issue Date |
| 20120129877 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention... | 05/24/2012 |
| 20120053052 | 3-Arylquinazolin-4-one compounds for combating invertebrate pests The present invention relates to the 3-arylquinazolin-4-one compounds of the formula I and the salts thereof, wherein
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| 20120015905 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASES The present disclosure relates to compounds, which are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders... | 01/19/2012 |
| 20110306612 | QUINAZOLINONE, QUINOLONE AND RELATED ANALOGS AS SIRTUIN MODULATORS Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, disease... | 12/15/2011 |
| 20110294818 | 1H-QUINAZOLINE-2,4-DIONES The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and phar... | 12/01/2011 |
| 20110294807 | COMPOUNDS FOR THE PREVENTION AND TREATMENT OF CARDIOVASCULAR DISEASE Disclosed are novel compounds that are useful for regulating the expression of apolipoprotein A-I (ApoA-I), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, f... | 12/01/2011 |
| 20110268679 | COMPOSITIONS AND METHODS TO TREAT SKIN DISEASES CHARACTERIZED BY CELLULAR PROLIFERATION AND ANGIOGENESIS Described herein are compositions and methods for preventing and/or treating skin diseases including, but not limited to, psoriasis and atopic dermatitis as well as providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved ski... | 11/03/2011 |
| 20110195965 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula (I) as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the ma... | 08/11/2011 |
| 20110195983 | QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R1, R2, R3, R4, R5 and m are as defined in the specification and in the claims, in free form or in salt form, and, wher... | 08/11/2011 |
| 20110195018 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.... | 08/11/2011 |
| 20110071148 | COMPOUNDS AS THE ESTROGEN RELATED RECEPTORS MODULATORS AND THE USES THEREOF The compounds according to formula VIII, their pharmaceutically acceptable acid or base addition salts, and the uses thereof is disclosed. These compounds and their pharmaceutically acceptable acid or base addition salts can be used for the preparing a medicament for mo... | 03/24/2011 |
| 20110046154 | USE OF AMINOPEPTIDASE INHIBITORS OR AZAINDOLE COMPOUNDS FOR PREVENTING OR TREATING CANCEROUS METASTASES FROM EPITHELIAL ORIGIN The invention relates to the use of a compound selected from an aminopeptidase-inhibiting compound and an azaindole compound for producing a drug for preventing or treating cancerous metastases in humans or animals.... | 02/24/2011 |
| 20100305109 | POTASSIUM CHANNEL MODULATORS Disclosed herein are KCNQ potassium channels modulators of formula (I) wherein ring G1, X, R1, and R2 are as defined in the specification. Compositions comprising such compoun... | 12/02/2010 |
| 20100278811 | VASCULOSTATIC AGENTS AND METHODS OF USE THEREOF Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusi... | 11/04/2010 |
| 20100273784 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods th... | 10/28/2010 |
| 20100261741 | Quinazolinone T-Type Calcium Channel Antagonists The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to ... | 10/14/2010 |
| 20100234404 | P-38 Kinase Inhibitors Compounds and compositions for modulating the activity of p38 kinases are provided, including p38α, and p38β kinase. Methods for treating, preventing or ameliorating one or more symptoms of a p38 kinase mediated disease or disorder are also provided.... | 09/16/2010 |
| 20100189648 | INHIBITORS FOR DISRUPTING THE INTERACTION OF UBIQUITINATION RELATED ENZYMES AND USES THEREOF A hydrophobic binding pocket on ubiquitin-protein ligase E3 is described, and used in designing the inhibitors disrupting ubiquitin conjugating enzyme E2 and E3 interaction. Four types of inhibitors designed by using the binding pocket are provided, which can be used fo... | 07/29/2010 |
| 20100179176 | V3 ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF CHRONIC PAIN The present invention relates to a V3 antagonist for use in the treatment of chronic pain, in particular neuropathic pain.... | 07/15/2010 |
| 20100160316 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in... | 06/24/2010 |
| 20100144740 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS A synergistic combination of a vanilloid receptor VR-1 antagonist and an NSAID or a pharmaceutically acceptable salt or solvate of either or both compounds thereof.... | 06/10/2010 |
| 20100144707 | Pharmacokinetically improved compounds The present invention relates to inhibitors of ROCK1 and ROCK2 and methods of modulating the pharmacokinetic and/or pharmacodynamic properties of such compounds. Also provided are methods of inhibiting ROCK1 and or ROCK2 that are useful for the treatment of disease.... | 06/10/2010 |
| 20100093768 | Agents for Reversing Epigenetic Silencing of Genes The present invention provides methods for discovering agents that are effective in reversing epigenetic silencing by inhibiting the interaction of methyl-binding (MBD) proteins with methylated genomic DNA. Also provided are methods for reactivating silenced genes havin... | 04/15/2010 |
| 20100063075 | Aryl-quinazoline/aryl-2amino-phenyl methanone derivatives A compound of formula (1): wherein R1, R2, R3 and Y are as defined herein, or a pharmaceutically-acceptable and -cleavable ester, or acid addition salt thereof, useful for promoting the release of parathyroid hormone, e.g. for preventing or treating bone conditions whic... | 03/11/2010 |
| 20100029658 | HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF The present invention relates to novel quinoxaline, quinazoline and phthalazine derivatives as well as multimeric derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds for the treatment and... | 02/04/2010 |
| 20090324495 | COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR IMAGING AND THERAPY The invention provides methods and compositions, e.g., for tumor imaging and therapy.... | 12/31/2009 |
| 20090318444 | TETRAHYDRO- AND DIHYDROQUINAZOLINONES The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manu... | 12/24/2009 |
| 20090233951 | Parenteral solutions containing metolazone Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and D5W useful in the treatment of hypertension, heart failure and renal disease leading to edematous ... | 09/17/2009 |
| 20090209562 | Fused ring 4-oxopyrimidine derivative The present invention provides a compound represented by formula (I) below, or a pharmaceutically acceptable salt thereof, which, having histamine H3 receptor antagonist or inverse agonist activity, is useful in the prophylaxis or therapy of metabolic diseases, circulat... | 08/20/2009 |
| 20090035306 | QUINAZOLINONE MODULATORS OF TGR5 The present invention relates to quinazolinone compounds useful as modulators of TGR5 and methods for the treatment or prevention of metabolic, cardiovascular, and inflammatory diseases.... | 02/05/2009 |
| 20080255111 | Tissue Factor Production Inhibitor A medicament which has an activity of inhibiting production of tissue factor and comprises an LXR ligand as an active ingredient; and a medicament for treatment and/or prophylaxis of vascular restenosis following angioplasty, endarterectomy, percutaneous transluminal co... | 10/16/2008 |
| 20080214553 | 2-(4-Oxo-4H-Quinazolin-3-Yl) Acetamides and Their Use as Vasopressin V3 Antagonists The present invention relates to 2-(4-oxo4H-quinazolin-3-yl)acetamicle derivatives of formula (I), and to their use as vasopressin V3 antagonists, particularly for the treatment of depression. ... | 09/04/2008 |
| 20080176830 | Compounds, Compositions, and Methods Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.... | 07/24/2008 |
| 20080167329 | Quinazolinone T-Type Calcium Channel Antagonists The present invention is directed to quinazolinone compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to ... | 07/10/2008 |
