Did You Know...
...that the Band-Aid Bandage was invented by a Johnson & Johnson employee whose wife had cut herself? Earl Dickson's wife was rather accident prone, so he set out to develop a bandage that she could apply without help. He placed a small piece of gauze in the center of a small piece of surgical tape, and what we know today as the Band Aid bandage was born!
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| Application No. | Application Title | Issue Date |
| 20120129869 | PHOSPHORYLATION AND MUTATIONS OF ANAPLASTIC LYMPHOMA KINASE AS A DIAGNOSTIC AND THERAPEUTIC TARGET IN LUNG CANCER The invention related to the use of high-density loss of heterozygosity (LOH) mapping in lung adenocarcinoma to identify intragenic LOH and driver mutations in different domains of ALK resulted in enhanced tumor growth in xenografted mouse. Mutant (H694R and E1384K) ALK... | 05/24/2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120107304 | Combination therapy in treatment of oncological and fibrotic diseases The invention relates to new methods for the treatment of oncological and fibrotic disease comprising the combined administration of a cell signalling and/or angiogenesis inhibitor in conjunction with an Aurora kinase inhibitor.... | 05/03/2012 |
| 20120083470 | INHIBITORS OF TYROSINE KINASES AND USES THEREOF Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alo... | 04/05/2012 |
| 20120071491 | Oligomer-Protein Tyrosine Kinase Inhibitor Conjugates The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water-soluble, n... | 03/22/2012 |
| 20120053164 | CYCLIC PYRIMIDIN-4-CARBOXAMIDES AS CCR2 RECEPTOR ANTAGONISTS FOR TREATMENT OF INFLAMMATION, ASTHMA AND COPD The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD. Formula (I), wherein A is selected from among a single... | 03/01/2012 |
| 20120053185 | METHOD TO TREAT MELANOMA IN BRAF INHIBITOR-RESISTANT SUBJECTS Methods to treat cancer patients, especially melanoma patients, who have BRAF mutations and have become resistant to BRAF mutant kinase inhibitors employ inhibitors of multiple receptor tyrosine kinases. In addition, methods are described for identifying pharmaceutical ... | 03/01/2012 |
| 20120045470 | IMATINIB IMMUNOASSAY Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.... | 02/23/2012 |
| 20120045519 | USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of deoxyelephantopin or an analogue thereof; and a pharmaceutically acceptable carrier... | 02/23/2012 |
| 20120045516 | COMPOSITION FOR PHOTODYNAMIC THERAPY COMPRISING A MACROMOLECULAR CAPSULE A composition for photodynamic therapy including a polymer capsule having a diameter of about 10 nm to about 2000 nm synthesized by copolymerization of a flat aromatic compound represented by Formula 1 (see the specification) and an organic compound represented by Formu... | 02/23/2012 |
| 20120034216 | SPIROKETALS The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative disorders and anti inflammatory disorders. The spiroketal compounds are also u... | 02/09/2012 |
| 20120028958 | 5-ALKYNYL-PYRIMIDINES The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the trea... | 02/02/2012 |
| 20120028952 | 5-ALKYNYL-PYRIMIDINES The present invention encompasses compounds of general formula (1)
| 02/02/2012 |
| 20120028924 | CHEMICAL COMPOUNDS The present invention relates to compounds of Formula (I) and/or Formula (Ia): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit ALK k... | 02/02/2012 |
| 20120022077 | NOVEL CYANOPYRIMIDINE DERIVATIVE The present invention relates to a novel cyanopyrimidine compound and a pharmaceutical composition which have a safe and potent adenosine A2a receptor agonistic activity.... | 01/26/2012 |
| 20120015027 | F, G, H, I and K Crystal Forms of Imatinib Mesylate The invention relates to the F-crystal form, G-crystal form, H-crystal form, I-crystal form and K-crystal form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide, cert... | 01/19/2012 |
| 20120015955 | F, G, H, I and K Crystal Forms of Imatinib Mesylate The invention relates to the F-crystal form, G-crystal form, H-crystal form, I-crystal form and K-crystal form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide, certain pro... | 01/19/2012 |
| 20120010182 | Chemical Compounds The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulf... | 01/12/2012 |
| 20120010161 | NOVEL AZAPEPTIDE OR AZAPEPTIDOMIMETIC COMPOUNDS INHIBITING BCRP AND/OR P-GP The present invention relates to compounds of azapeptide or azapeptidomimetic type of formula (I): in which R1, R2, R3, X1, X2, X3, X4 | |
| 20120003291 | NANOBEAD RELEASING MEDICAL DEVICES Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.... | 01/05/2012 |
| 20120003319 | COMPOSITIONS FOR SITE-SPECIFIC DELIVERY OF IMATINIB AND METHODS OF USE The invention provides an oral formulation for administering to a subject comprising an imatinib compound and an enteric matrix or enteric coating or a combination thereof, whereby at least 80% of the imatinib compound is released in the small intestine of the subject. ... | 01/05/2012 |
| 20110319392 | Thiazole Sulfonamide And Oxazole Sulfonamide Kinase Inhibitors The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.... | 12/29/2011 |
| 20110319420 | PREPARATION METHOD OF DIHYDROINDENE AMIDE COMPOUNDS, THEIR PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS THEREOF AND USE AS PROTEIN KINASES INHIBITOR The invention provides a new kind of dihydroindene amide compounds of general formula I or their pharmaceutically acceptable salts or prodrug thereof which can be used as protein kinase inhibitor. The invention provides a preparation method of the kind of compounds, the... | 12/29/2011 |
| 20110318336 | Identification and Treatment of Aggressive Lung Cancer Tumors This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a like... | 12/29/2011 |
| 20110318393 | Substituted Pyrazole Compounds Provided are substituted pyrazole compounds which are useful as protein kinase inhibitors, compositions comprising the compounds, and methods of use thereof. The protein kinase inhibitors are particularly for inhibition of Aurora A (Aurora-2) protein kinase and are usef... | 12/29/2011 |
| 20110312959 | Derivatives of Azaindoles as Inhibitors of Protein Kinases ABL and SRC The present invention relates to compounds of general formula I and use thereof as inhibitors of protein kinases AbI and Src and the method of production thereof. The present invention also relates to pharmaceutical compositions and medici-nal products comprising these ... | 12/22/2011 |
| 20110312968 | METHOD FOR OPTIMIZING THE TREATMENT OF CHRONIC MYELOID LEUKEMIA WITH ABL TYROSINE KINASE INHIBITORS The present invention relates to a method tor evaluating patterns to help-optimizing the treatment of chronic myeloid leukemia (CML) in a human patient population. Specifically, present invention relates to SHP1 and/or SHP2 as a biomarker for CML patients.... | 12/22/2011 |
| 20110312939 | NEW CHEMICAL COMPOUNDS The present invention relates to new compounds of general formula (I), wherein the groups R1 to R3, X1, X2, X3 and L1 are defined as in claim 1, which are suitable for the treatment of diseases cha... | 12/22/2011 |
| 20110306618 | JNK Modulators Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH—R2 Or N—SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radic... | 12/15/2011 |
| 20110306589 | NITROGEN CONTAINING HETEROARYL COMPOUNDS The invention is concerned with novel nitrogen-containing heteroaryl compounds of formula (I) wherein A1, A2, R1,... | 12/15/2011 |
| 20110300137 | Use of lumefantrine and related compounds in the treatment of cancer The present application discloses the use of the anti-malarial drug lumefantrine and related compounds in the treatment of cancer.... | 12/08/2011 |
| 20110301157 | BICYCLIC AMIDES AS KINASE INHIBITORS The invention relates to compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula I and to the use of a compound of formula I for the preparation of pharmaceutical compositions f... | 12/08/2011 |
| 20110301175 | 5- (4- (HALOALKOXY) PHENYL) PYRIMIDINE-2-AMINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS The invention provides compounds of formula (1) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase... | 12/08/2011 |
| 20110294820 | N-Oxides of n-Phenyl-2-pyrimidine-amine Derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compound... | 12/01/2011 |
| 20110293575 | PHOTOCHEMICAL INTERNALISATION OF KINASE INHIBITORS The present invention relates to a method for enhancing the activity of kinase inhibitors in target cells, and more specifically for enhancing the activity of tyrosine kinase inhibitors (TKIs), said method comprising contacting a cell with a kinase inhibitor and a photo... | 12/01/2011 |
| 20110294810 | SUBSTITUTED (PYRIDYL)-AZINYLAMINE DERIVATIVES AS PLANT PROTECTION AGENTS The present invention relates (pyridyl)-azinylamino derivatives of formula (I) wherein Q1 and p, Ra to Rc, X, Y, Z, L2 and Q2 represent various substituents, their process of preparation, preparation intermediate co... | 12/01/2011 |
| 20110293615 | Use of Combination of Anti-Angiogenic Substance and c-kit Kinase Inhibitor The object of the present invention is to find a pharmaceutical composition and a method for treating cancer that show an excellent antitumor effect. Combinational use of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7-methoxy-6-quinolinecarboxamide and analogue... | 12/01/2011 |
| 20110288091 | SOLUBLE MTOR COMPLEXES AND MODULATORS THEREOF The present invention relates to small molecule modulators of mTORC1 and mTORC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, a... | 11/24/2011 |
| 20110288102 | IL-8 BIOMARKER FOR MONITORING CANCER TREATMENT The present application includes methods for using IL-8 as a biomarker for, e.g., tumor size, for example, during course of treatment with an anti-cancer agent such as an ERK inhibitor.... | 11/24/2011 |
| 20110281867 | COMPOSITIONS AND METHODS OF USE FOR TYROSINE KINASE INHIBITORS TO TREAT PATHOGENIC INFECTION Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic infection are provided. Infections to be treated according to the present... | 11/17/2011 |
