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| Application No. | Application Title | Issue Date |
| 20120108545 | Trioxane Monomers and Dimers Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases inc... | 05/03/2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120071489 | DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease o... | 03/22/2012 |
| 20120028920 | DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS A heterocyclic compound or a salt thereof represented by the formula (1):
| 02/02/2012 |
| 20120015925 | NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary scler... | 01/19/2012 |
| 20120015958 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C... | 01/19/2012 |
| 20110288052 | NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME The class compounds of the present invention may be represented by Formula (I), wherein X may be O, S, or N. R1 and R2 are independently either H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. R3 11/24/2011 | |
| 20110288104 | Beta-3 receptor ligands and their use in therapy The present invention relates to new compounds, ligands of the beta-3 adrenergic receptor, their preparation and their use in therapy or as research tools for said receptor; the invention also relates to a process for the preparation of the compounds of the invention an... | 11/24/2011 |
| 20110269747 | POLYARYLCARBOXAMIDES USEFUL AS LIPID LOWERING AGENTS Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.... | 11/03/2011 |
| 20110269717 | NEUROGENESIS BY MODULATING ANGIOTENSIN The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes compositions and methods based on modulating angiotensin activity to stimulate or ... | 11/03/2011 |
| 20110269815 | METHODS OF REDUCING CELLULAR PROLIFERATION BY INHIBITING ACSVL3 The present invention is directed to methods of reducing cancer cell proliferation and/or treating cancer by administering a therapeutically effective amount of a compound that inhibits the activity of ACSVL3.... | 11/03/2011 |
| 20110245265 | CXCR4 ANTAGONISTS FOR KIDNEY INJURY Methods to treat or prevent acute kidney injury and chronic kidney injury in subjects using CXCR4 antagonists are disclosed.... | 10/06/2011 |
| 20110245264 | Modulators of G Protein-Coupled Receptor 88 The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled receptor 88.... | 10/06/2011 |
| 20110212954 | ALPHA-LIPOIC ACID DERIVATIVES AND THEIR USE IN DRUG PREPARATION The present invention concerns an enantiomer R of a compound of Formula (I), wherein X is —NH—R1 or of Formula (V) or (VI), R1 is —(CH2)n—R2, R2 is a linear, branched or cyclic C1C... | 09/01/2011 |
| 20110200553 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS The present invention provides novel compounds represented by formula I: or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.... | 08/18/2011 |
| 20110201583 | GUANIDINE-CONTAINING COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS The invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein R1-3, R5-7, a, X, Y, Y′, Y″, and Z are as defined in the specification. These co... | 08/18/2011 |
| 20110190310 | Hypoxia Activated Drugs Of Nitrogen Mustard Alkylators Hypoxia activated drug compounds having a structure of formula (I) are useful in the treatment of cancer and other hyperproliferative diseases. ... | 08/04/2011 |
| 20110152234 | Novel Compounds The invention relates to thiophene carboxamides of formula (I), wherein A, R1, R2, R3, n and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and th... | 06/23/2011 |
| 20110136802 | SHIP1 MODULATORS AND METHODS RELATED THERETO Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5, R6 and R | |
| 20110130381 | SMALL MOLECULE INHIBITORS OF PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE Inhibitors of dihydroorotate dehydrogenase (DHODH) for the Plasmodium enzyme have been identified and characterized. The inhibitors have high specificity, submicromolar efficacy against cultured parasite strains, exhibit drug-like properties, and are not overtly ... | 06/02/2011 |
| 20110118263 | BENZOTHIOPHENE ALKANOL PIPERAZINE DERIVATIVES AND THEIR USE AS ANTIDEPRESSANT The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT, NA and DA. Compared with clinic... | 05/19/2011 |
| 20110112081 | INHIBITORS OF JANUS KINASES The instant invention provides for compounds that inhibit the four known mammalian JAK kinases (JAK1, JAK2, JAK3 and TYK2). The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting the activity of JAK1, JAK2, JAK3 and T... | 05/12/2011 |
| 20110104162 | Compounds which can be used for the Treatment of Cancers The present invention relates to a compound of general formula (I): and also to the pharmaceutically acceptable salts thereof, to the isomers or isomer mixtures thereof in all proportions, in particular to an enantiomer mixture, and especially to a racemic mixture. The ... | 05/05/2011 |
| 20110092496 | THIOPHENE COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS A compound represented by the formula (I) (wherein R1, R2, R3 and R4 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof. 04/21/2011 | |
| 20110053917 | Allosteric Modulators of the A1 Adenosine Receptor The present invention provides compounds of formula (I) wherein R1, R2, R3, R4 and Q have a meaning as defined herein in the specification. The compounds of formula... | 03/03/2011 |
| 20110046134 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.... | 02/24/2011 |
| 20110039858 | Novel Compounds The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R<... | 02/17/2011 |
| 20100324020 | Bicyclic [3.1.0] Heteroaryl Amides As Type 1 Glycine Transport Inhibitors The present invention relates to a series of substituted bicyclic[3.1.0]heteroaryl amides of the Formula I, wherein A, Q, X, Y, Z and R1-R5 groups are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pha... | 12/23/2010 |
| 20100324025 | Antibacterial Agents Antibacterial compounds of formula I are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of ... | 12/23/2010 |
| 20100317608 | Dithiol Compounds, Derivatives, and Uses Therefor Dithiol compounds and derivatives thereof are disclosed. The agents are useful for treating ocular disease, especially presbyopia and cataract.... | 12/16/2010 |
| 20100311694 | Set of Geldanamycin Derivatives and Their Preparation Methods A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90... | 12/09/2010 |
| 20100305088 | INHIBITORS OF THE CHEMOKINE RECEPTOR CxCR3 This invention is directed to a 3-(amido or sulphamido)-4-(4-substituted-azinyl)benzamide or benzsulphonamide compound as defined herein. The 3-(amido or sulphamido)-(4-substituted-azinyl)benzamide or benzsulphonamide compound is useful as a inhibitor of the chemokine r... | 12/02/2010 |
| 20100305103 | GENES DIFFERENTIALLY EXPRESSED IN BIPOLAR DISORDER AND/OR SCHIZOPHRENIA This invention provides molecular markers that are prognostic and/or diagnostic for a psychiatric disorder. In particular, genes are identified whose expression is altered in schizophrenia and/or bipolar disorder thereby providing prognostic and diagnostic markers for t... | 12/02/2010 |
| 20100291222 | ANTIOXIDANT NANOSPHERE COMPRISING [1,2]-DITHIOLANE MOIETIES The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS). Methods of synthesizing novel antioxidant mALAs, spontaneous emulsification o... | 11/18/2010 |
| 20100286162 | HUMAN PAPILLOMA VIRUS INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME HPV inhibitors of formula (I) in which G1 is —NHCO(CH2)n-, where n is an integer between 1 and 4, R3 is —CW(CH2)m—NR4R5 or —CW(CH2)mCH3 or —CN, where W is O, S or NH and m is an integ... | 11/11/2010 |
| 20100286152 | N-PHENYL HYDRAZIDES AS MODULATORS OF THE GHRELIN RECEPTOR The present invention relates to novel compounds of formula (I) or a pharmaceutically acceptable salt or solvate thereof, ... | 11/11/2010 |
| 20100280018 | Derivatives Of Hydroxamic Acid As Metalloproteinase Inhibitors A compound of formula (I), or an enantiomer or diastereoisomer thereof, or a salt, hydrate or solvate thereof: for the treatment or prophylaxis of arthritis in mammals.... | 11/04/2010 |
| 20100273750 | SEROTONIN RECEPTOR ANTAGONISTS FOR TREATING ARTHRITIS The present invention relates to serotonin receptor antagonists for treating inflammatory arthritis and related conditions. The present invention also relates to a kit comprising a pharmaceutical composition comprising a serotonin receptor antagonist and instructions in... | 10/28/2010 |
| 20100240638 | Organic Compounds and their uses The present application describes macrocyclic compounds of formula (I) with NS3 protease inhibitory activity for treating hepatitis C virus infection. ... | 09/23/2010 |
| 20100233232 | FATTY-ACID BASED PARTICLES The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a c... | 09/16/2010 |
