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| Application No. | Application Title | Issue Date |
| 20110294787 | SUBSTITUTED THIOMORPHOLINE DERIVATIVES The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.... | 12/01/2011 |
| 20110281850 | INTRACELLULAR KINASE INHIBITORS Intracellular kinase inhibitors and their therapeutic uses for patients with T cell malignancies, B cell malignancies, autoimmune disorders, and transplanted organs.... | 11/17/2011 |
| 20110275619 | INHIBITORS OF BACE1 AND METHODS FOR TREATING ALZHEIMER'S DISEASE Inhibitors of BACE1 and compositions containing them are described. Use of the inhibitors and compositions containing them to treat Alzheimer's disease are described.... | 11/10/2011 |
| 20110237525 | METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure: 09/29/2011 | |
| 20110207739 | Novel 1, 2-Disubstituted Amido-anthraquinone Derivatives, Preparation Method and application thereof A series of novel 1,2-disubstituted amido-anthraquinone derivatives, and the preparation method and application of said derivatives. Said application includes said derivatives with therapeutically effective amount being prepared into pharmaceutical compositions for inhi... | 08/25/2011 |
| 20110195962 | USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or more pro-inflammatory cytokines (for instance IL-1 and TNFα) and inhibit p... | 08/11/2011 |
| 20110172195 | AQUAPORIN MODULATORS AND METHODS OF USING THEM FOR THE TREATMENT OF EDEMA AND FLUID IMBALANCE Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.... | 07/14/2011 |
| 20110135650 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions compri... | 06/09/2011 |
| 20110136735 | CYCLOHEXANE DERIVATIVES AND USES THEREOF The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacolog... | 06/09/2011 |
| 20110112076 | SELECTIVE HYDROXAMIC ACID BASED MMP-12 AND MMP-13 INHIBITORS The present invention provides a compound of formula (I) said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP-13. Accordingly, the compound of form... | 05/12/2011 |
| 20110105482 | COMPOSITIONS OF DUAL THYROINTEGRIN ANTAGONISTS AND USE IN VASCULAR-ASSOCIATED DISORDERS A dual thyrointegrin antagonist and a method for treating an angiogenesis-mediated disorder and/or a hyperthyroidism disorders by introducing the dual thyrointegrin antagonist into animals (e.g., mammals, human beings). The dual thyrointegrin antagonist includes a chemi... | 05/05/2011 |
| 20110105485 | Alpha-(N-Sulfonamido)Acetamide Derivatives as Beta-Amyloid Inhibitors There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid pe... | 05/05/2011 |
| 20110021505 | Use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides in the treatment of pain The present invention relates to the use of sulfonyl-substituted 2-sulfonylaminobenzoic acid N-phenylamides of the formula I, wherein A and R1 to R6 have the meanings indicated in the cl... | 01/27/2011 |
| 20100317653 | OXADIAZOLE DERIVATIVES AS DGAT INHIBITORS Compounds of formula (I), and salts and pro-drugs thereof:
| |
| 20100311734 | Spiro Compounds Useful as Antagonists of the H1 Receptor The invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, for treating diseases and conditions of the central nervous system (CNS), in particular sleep disorders. ... | 12/09/2010 |
| 20100297077 | NOVEL ARYL POTASSIUM CHANNEL BLOCKERS AND USES THEREOF The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmu... | 11/25/2010 |
| 20100298299 | NON-PEPTIDE DERIVATIVES AS BRADYKININ B1 ANTAGONISTS The present invention relates to new non-peptide derivatives of formula (I), wherein R1-R5, Q and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonis... | 11/25/2010 |
| 20100291003 | HISTONE DEACETYLASE INHIBITORS Novel compounds of the general formula (I), having histone deacetylase (HDAC) inhibiting enzymatic activity, their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical com... | 11/18/2010 |
| 20100279997 | ANALGESIC THAT BINDS FILAMIN A A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula A, wherein A, B, X, R1, R2, R7 and R8, and the dashed lines are defined within. | 11/04/2010 |
| 20100280018 | Derivatives Of Hydroxamic Acid As Metalloproteinase Inhibitors A compound of formula (I), or an enantiomer or diastereoisomer thereof, or a salt, hydrate or solvate thereof: for the treatment or prophylaxis of arthritis in mammals.... | 11/04/2010 |
| 20100279996 | NOVEL ANALGESIC THAT BINDS FILAMIN A A compound, composition and method are disclosed that can provide analgesia. A contemplated compound has a structure that corresponds to Formula I, wherein R1 and R2 are substituents, and W is a ring structure that are defined within. 11/04/2010 | |
| 20100273785 | 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS Provided herein are 2,5-disubstituted arylsulfonamide CCR3 antagonists of Formula I or II, and pharmaceutical compositions thereof: wherein X, Y, Z, and R1-R5 are as defined herein. Also... | 10/28/2010 |
| 20100273782 | 2,5-DISUBSTITUTED ARYLSULFONAMIDE CCR3 ANTAGONISTS Provided herein are 2,5-disubstituted arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a CCR3-mediated ... | 10/28/2010 |
| 20100267801 | CYCLOHEXYL SULPHONES FOR TREATMENT OF CANCER Sulphones of formula (I) are disclosed for use in treatment of cancer. ... | 10/21/2010 |
| 20100256122 | BUTYL AND BUTYNYL BENZYL AMINE COMPOUNDS Certain substituted butyl and butynyl benzyl amine compounds are histamine H3 receptor and/or serotonin transporter modulators useful in the treatment of histamine H3 receptor- and/or serotonin-mediated diseases.... | 10/07/2010 |
| 20100234364 | CCR2 INHIBITORS AND METHODS OF USE THEREOF Compounds are provided that act as potent antagonists of the CCR2 or CCR9 receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR2 and CCR9. The compounds are generally aryl sulfonamide derivatives and ... | 09/16/2010 |
| 20100197640 | NOVEL SULFAMOYL-PHENYL-UREIDO COMPOUNDS AND THEIR USE AS MEDICAMENT The present invention relates to novel sulfamoyl-phenyl-ureido compounds having the formula (I) or a physiologically acceptable salt or derivative thereof which are suitable for the therapy of infections caused by protozoa and in particular uncomplicated or severe malar... | 08/05/2010 |
| 20100190766 | ANTIBACTERIAL AGENTS Antibacterial compounds of formula (I) are provided: as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods o... | 07/29/2010 |
| 20100179136 | N-AMINO TETRAHYDROTHIAZINE DERIVATIVES, METHOD OF MANUFACTURE AND USE This invention comprises the innovative synthesis of N-amino tetrahydrothiazine free bases and their salts. This invention further comprises the use of the derivatives and their therapeutic application as anticancer agents. Further this invention comprises their manufac... | 07/15/2010 |
| 20100160289 | SULFONAMIDES AS TRPM8 MODULATORS Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) and Formula (II) as follows: | 06/24/2010 |
| 20100144720 | INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2 Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation... | 06/10/2010 |
| 20100137293 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES AND CONDITIONS RELATED THERETO AND FOR THE TREATMENT OF CONDITIONS AMELIORATED BY INCREASING A BLOOD GLP-1 LEVEL The present invention concerns combination of an amount of a GPR119 agonist with an amount of a dipeptidyl peptidase IV (DPP-IV) inhibitor such that the combination provides an effect in lowering a blood glucose level or in increasing a blood GLP-1 level in a subject ov... | 06/03/2010 |
| 20100113433 | N-Substituted Thiomorpholine Derivatives as the Inhibitors of Dipeptidyl Peptidase IV and the Pharmaceutical Uses Thereof The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for p... | 05/06/2010 |
| 20100092469 | ANTAGONISTS OF A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS The present invention is directed to a combination of therapeutic compounds and treatment methods and kits using the combination. In particular, one of the combination affects the NCca-ATP channel of neural tissue, including neurons, glia and blood vessels within the ne... | 04/15/2010 |
| 20100093673 | PAIN RELIEVING PATCH Described here are patches for the treatment of pain. The patches include a carrier material, which itself, in the absence of an active agent, is capable of relieving pain. Methods of treating pain using the patches are also described.... | 04/15/2010 |
| 20100063036 | Substituted morpholine and thiomorpholine derivatives The present invention relates to morpholine and thiomorpholine derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.... | 03/11/2010 |
| 20100022520 | MALONYL-COA ACETYLTRANSFERASE INHIBITORS AGAINST ANTIBIOTIC RESISTANT BACTERTIA Compounds characterized by thiolactone or thiomorpholino cores display useful antibiotic and radioprotective properties. The latter properties are believed to arise from an ability of the compounds to inhibit proteins involved in apoptosis.... | 01/28/2010 |
| 20100016295 | Preparation and Use of Biphenyl Amino Acid Derivatives for the Treatment of Obesity This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.... | 01/21/2010 |
| 20090306040 | Mono and Combination Therapy of M1/M4 Agonist (Sabcomeline) for Treatment of Negative Symptoms of Schizophrenia The invention relates to the use of a functional muscarinic M1/M4 receptor agonist or a pharmaceutically acceptable salt thereof for the treatment of negative symptoms of schizophrenia. It also relates to adjunctive and simultaneous combination therapies for the treatme... | 12/10/2009 |
| 20090291944 | Antimicrobial compositions and methods of use In one aspect, compositions provide antimicrobial therapy as topical disinfectants. Particularly, one aspect relates to an alcohol containing antimicrobial composition that includes at least one paraben, a redox compound and an organic acid at a concentration of from ab... | 11/26/2009 |
