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| Application No. | Application Title | Issue Date |
| 20120128778 | COMPOSITIONS AND METHODS FOR ONCE-DAILY ADMINISTRATION OF A TRILAYER OSMOTIC TABLET A trilayer osmotic tablet is described. The tablet includes a core, a semi-permeable membrane disposed generally around the core, and an orifice in the semi-permeable membrane in fluid communication with the core. The core includes first, second, and third layers. The f... | 05/24/2012 |
| 20120129836 | Imidazole derivatives as PDE10A enzyme inhibitors This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention... | 05/24/2012 |
| 20120129835 | SCHIZOPHRENIA METHODS AND COMPOSITIONS Methods of preparing and using neural cells derived from human induced pluripotent stem cell (hiPSCs), particularly hiPSCs derived from subjects with schizophrenia are provided. The hiPSC-derived neural cells can be used to screen test compounds and to identify schizoph... | 05/24/2012 |
| 20120108570 | Pharmacological Treatment for Sleep Apnea The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.... | 05/03/2012 |
| 20120107269 | THIOPHENE DERIVATIVES Disclosed is a compound of formula (I), wherein
| |
| 20120108545 | Trioxane Monomers and Dimers Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases inc... | 05/03/2012 |
| 20120082640 | Small molecule apoptosis promoters The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions compri... | 04/05/2012 |
| 20120071432 | CENTRAL ADMINISTRATION OF STABLE FORMULATIONS OF THERAPEUTIC AGENTS FOR CNS CONDITIONS The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-ac-Live agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasi... | 03/22/2012 |
| 20120040961 | PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1, 2, 3, or 4, Ack1, Ack2, AbI, DCAMKL1, ABL1, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ... | 02/16/2012 |
| 20120035156 | COMBINATION OF GLYT1 COMPOUND WITH ANTIPSYCHOTICS The present invention relates to a pharmaceutical combination of a glycine transporter inhibitor (GlyT1) and an atypical antipsychotic drug which may be used for the treatment of positive and negative symptoms of schizophrenia.... | 02/09/2012 |
| 20120027879 | BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING METABOLIC DISORDERS Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention compri... | 02/02/2012 |
| 20120028964 | PHARMACEUTICAL COMBINATION The present invention relates to a pharmaceutical combination for the treatment of schizophrenia and acute manic episodes associated with bipolar disorders, which comprises a compound which is active on a trace amine-associated receptor 1 (TAAR1 agonist) and an antipsyc... | 02/02/2012 |
| 20120022051 | RAPID ONSET LIQUID MIDAZOLAM COMPOSITION FOR BUCCAL ADMINISTRATION This application discloses liquid compositions for administration to a patient comprising midazolam and a pharmaceutically acceptable carrier, wherein the pH of the composition is about 6 or higher, the composition comprises less than about 200 mg/ml cyclodextrin, and a... | 01/26/2012 |
| 20120015035 | Implantable Delivery Vehicle for Ocular Delivery of Muscarinic Antagonists The present invention provides compositions and methods for treating ocular disorders such as myopia.... | 01/19/2012 |
| 20120010127 | Compositions Comprising Multiple Bioactive Agents, and Methods of Using the Same In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other... | 01/12/2012 |
| 20120003330 | BENZOQUINOLONE INHIBITORS OF VMAT2 The present invention relates to new benzoquinolone inhibitors of VMAT2, pharmaceutical compositions thereof, and methods of use thereof. ... | 01/05/2012 |
| 20110319394 | FUSED HETEROCYCLIC COMPOUNDS The present invention provides a compound which has the effect of PDE inhibition, and which is useful as an agent for preventing or treating schizophrenia. The compound is represented by the formula (I): wher... | 12/29/2011 |
| 20110319395 | Pharmaceutical Formulation of Olanzapine A pharmaceutical formulation comprising a homogeneous mixture of (a) olanzapine or a pharmaceutically acceptable salt thereof as an active ingredient, (b) a monosaccharide and/or oligosaccharide, (c) a polysaccharide and, optionally, further ingredients.... | 12/29/2011 |
| 20110312938 | Pyrrolopyridine Carboxylic Acid Derivatives Disclosed are compounds and pharmaceutically acceptable salts of Formula (I) wherein R1, R2, R3, and RN are as defined herein. Compounds of Formula (I) are useful in the prevention and/or treatment of neurological and psychiatric disorde... | 12/22/2011 |
| 20110312946 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES The present invention provides methods of treating, reducing, preventing, or inhibiting symptoms of diabetes and/or lowering plasma levels of HbA1c by co-administration of therapeutic or subtherapeutic doses of telenzepine and sertraline to a subject in need thereof.... | 12/22/2011 |
| 20110312941 | 1,4-DISUBSTITUTED PIPERIDINES AS VASOPRESSIN RECEPTOR VIA ANTAGONISTS The present invention provides compounds of formula (1) compositions comprising such compounds; the use of such compounds in therapy (such as in the treatment of dysmenorrhoea); and methods of treating patients with such compounds; wherein A and G are as defined herein.... | 12/22/2011 |
| 20110306552 | PYRIMIDINONE INHIBITORS OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 The present invention relates to new pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 activity, pharmaceutical compositions thereof, and methods of use thereof ... | 12/15/2011 |
| 20110301152 | NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES Nicotine receptor agonists or analogs or derivatives thereof for treating inflammatory pulmonary diseases, and pharmaceutical compositions including nicotine receptor agonists or analogs or derivatives thereof. Compounds of formula wherein R1, R2, Xa and Ya are as defin... | 12/08/2011 |
| 20110300210 | CONTROLLED RELEASE NANOPARTICULATE CLOZAPINE COMPOSITIONS Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel compositions release the agent foll... | 12/08/2011 |
| 20110294791 | PIRENZEPINE AS AN AGENT IN CANCER TREATMENT The present invention generally relates to the neuroprotective activity of condensed diazepinones, e.g. condensed benzodiazepinones such as pirenzepine or compounds which are metabolized to condensed benzodiazepinones such as olanzapine. These compounds are suitable as ... | 12/01/2011 |
| 20110294792 | PURINE DERIVATIVES AS KINASE INHIBITORS The present invention provides kinase inhibitors of Formula I. ... | 12/01/2011 |
| 20110294737 | TERMINALLY-DIFFERENTIATED ANUCLEATE PLATELET PROGENY GENERATION Platelets are induced to proliferate, form extensions and produce daughter cells by various methods, including culturing platelets under thrombocytopenic conditions. Expansion of platelet cell numbers increases the storage life of platelets. Modulation of RT activity ca... | 12/01/2011 |
| 20110288069 | Benzodiazepine and Pyridodiazepine Derivatives The present application relates to benzodiazepine and pyridodiazepine derivatives of formula (I) wherein R1, R2, R3, R4, X1, Y1, Y2... | 11/24/2011 |
| 20110288070 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE This disclosure relates to compounds for the inhibition of histone deacetylase and treatment of a cognitive disorder or deficit. More particularly, the disclosure provides for compounds of formula (I) wherein (I), Q, J, L and Z are as defined in the specification.... | 11/24/2011 |
| 20110281853 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING ATRIAL FIBRILLATION The present invention provides compositions and methods for treating or preventing atrial fibrillation (AF). In particular, the present invention provides administration of muscarinic receptor antagonists (e.g., M2-selective muscarinic receptor blockers), administered a... | 11/17/2011 |
| 20110281852 | Pharmaceutical compositions containing berberine for treatment or prevention of weight gain and obesity associated with anti-psychotic drugs The compositions and methods disclosed herein are of use for the treatment and prevention of weight gain and obesity. In particular, the compositions and methods include treatment of weight gain and obesity with berberine and/or berberine analogs alone or in combination... | 11/17/2011 |
| 20110280808 | Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and of diseases or conditions associated with amyloid-like proteins. The compou... | 11/17/2011 |
| 20110275588 | Fused Diimidazodiazepine Compounds and Methods of Use and Manufacture Thereof The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceutically acceptable salts thereof. The invention also encompasses method... | 11/10/2011 |
| 20110275616 | Combination Analgesic Employing Opioid and Neutral Antagonist Methods of utilizing an opioid agonist in a mammalian subject in a manner that inhibits peripheral effects of the opioid agonist are described. The methods comprise administering the opioid agonist in an amount sufficient to confer analgesia the subject and co-administe... | 11/10/2011 |
| 20110269675 | STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS A method for the treatment and/or prophylaxis of an osteonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and ... | 11/03/2011 |
| 20110263545 | HEPATOPROTECTANT ACETAMINOPHEN MUTUAL PRODRUGS The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs ma... | 10/27/2011 |
| 20110263573 | HETEROBIARYL-CYCLOHEXYL-TETRAAZABENZO[E]AZULENES The present invention relates to heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The compounds according to the in... | 10/27/2011 |
| 20110263574 | PIRENZEPINE AS OTOPROTECTIVE AGENT The present invention generally relates to the otoprotective activity of condensed diazepinones, e.g. condensed benzodiazepines such as pirenzepine or compounds which are metabolized to condensed benzodiazepinones such as olanzapine. These compounds are suitable as medi... | 10/27/2011 |
| 20110251183 | ARYL-/HETEROARYL-CYCLOHEXENYL-TETRAAZABENZO[E]AZULENES The present invention is concerned with aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes of formula I wherein R1, R2 and R3 are as described herein. The invention furthe... | 10/13/2011 |
| 20110244020 | DRUG CONDENSATION AEROSOLS AND KITS The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. ... | 10/06/2011 |
