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3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Application No. | Application Title | Issue Date |
| 20120130199 | Methods for Treating Chronic or Unresolvable Pain and/or Increasing the Pain Threshold in a Subject and Pharmaceutical Compositions for Use Therein The invention relates to a method of reducing chronic inflammatory pain in a human subject with androgen deficiency symptoms comprising transdermally administering a pain-reducing amount of a composition comprising a bioactive androgen to the subject on a daily basis. T... | 05/24/2012 |
| 20120128662 | SUBSTITUTED IMIDAZOQUINOXALINES The present invention relates to substituted imidazoquinoxaline compounds of general formula (I) as inhibitors of Mps-1 Kinase or TTK, and being active against inflammation and cancer. ... | 05/24/2012 |
| 20120129819 | GEL COMPOSITIONS FOR ADMINISTRATION OF PHARMACEUTICALLY ACTIVE COMPOUNDS The present invention provides a pharmaceutical composition in the form of a water-based gel comprising: at least one pharmaceutically active compound; at least one gelling agent; a solubilising agent; and water, wherein said composition is free or substantially free of... | 05/24/2012 |
| 20120128657 | SYNTHETIC MACROCYCLIC COMPOUNDS AND METHODS FOR TREATING CANCER Disclosed herein are macrocyclic compounds that are effective to inhibit cell migration. In one embodiment, the compounds have the structure: or any pharmaceutically acceptable salt or solvate thereof, wherein: m is 0 or 1; R1, R2 and R3 05/24/2012 | |
| 20120128733 | PHARMACEUTICAL COMPOSITIONS COMPRISING ACTIVE DRUGS, CONTRACEPTIVE KITS COMPRISING ACTIVE DRUGS, AND METHODS OF ADMINISTERING THE SAME The present invention relates to pharmaceutical compositions and kits comprising pharmaceutical compositions, and methods for administering pharmaceutical compositions comprising active contraceptive drugs in a patient. Specifically, the pharmaceutical compositions may ... | 05/24/2012 |
| 20120129821 | INHIBITORS OF BRUTON'S TYROSINE KINASE Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible inhibitors of Btk. Methods for the preparation of the compounds are disclosed. Also disclosed are pharmaceutical compositions that include the co... | 05/24/2012 |
| 20120128654 | Allantoin Administration for the Treatment of Neurodegenerative Disease and Neurotrauma Methods for inhibiting the progression of neurodegenerative diseases and treating neurotrauma-induced damage and cerebrovascular disease are provided herein, the methods including the administration of a safe and effective amount of allantoin to a patient in need thereo... | 05/24/2012 |
| 20120128612 | AZOLE ANTIFUNGAL COMPOSITIONS The present invention relates generally to antifugal compositions. In an embodiment, the antifungal compositions are effective for application to nails and surrounding skin, and comprise at least one volatile solvent, at least one film forming substance, and at least on... | 05/24/2012 |
| 20120128793 | IMPLANTABLE OR INSERTABLE MEDICAL DEVICE RESISTANT TO MICROBIAL GROWTH AND BIOFILM FORMATION Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or in... | 05/24/2012 |
| 20120128778 | COMPOSITIONS AND METHODS FOR ONCE-DAILY ADMINISTRATION OF A TRILAYER OSMOTIC TABLET A trilayer osmotic tablet is described. The tablet includes a core, a semi-permeable membrane disposed generally around the core, and an orifice in the semi-permeable membrane in fluid communication with the core. The core includes first, second, and third layers. The f... | 05/24/2012 |
| 20120128762 | Sphingomyelin Liposomes for the Treatment of Hyperactive Bladder Disorders The present invention provides pharmaceutical compositions and methods for the instillation of lipid vehicles comprised of liposomes containing sphingomyelin or sphingomyelin metabolites to prevent, manage, ameliorate and/or treat disorders involving neuropathic pain an... | 05/24/2012 |
| 20120129820 | NEW PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF RESPIRATORY AND GASTROINTESTINAL DISORDERS The present invention provides pharmaceutical compositions comprising one or more CRTH2 antagonists 1 and one or more further active compounds 2.... | 05/24/2012 |
| 20120128686 | THIENOPYRIMIDINES FOR PHARMACEUTICAL COMPOSITIONS The present invention relates to novel pharmaceutical compositions comprising thienopyrimidine compounds. Moreover, the present invention relates to the use of the thienopyrimidine compounds of the invention for the production of pharmaceutical compositions for the prop... | 05/24/2012 |
| 20120130144 | TREATMENT OF LUNG CANCER WITH A NITROBENZAMIDE COMPOUND IN COMBINATION WITH A GROWTH FACTOR INHIBITOR In one aspect, the present invention provides a method of treating lung cancer, comprising administering to a subject at least one PARP inhibitor in combination with at least one growth factor inhibitor. In another aspect, the present invention provides a method of trea... | 05/24/2012 |
| 20120107417 | Effective Antitumor Treatments ET-743 is used in the preparation of a medicament for an effective treatment of a tumour by combination therapy employing ET-743 with another drug.... | 05/03/2012 |
| 20120108522 | HDAC INHIBITORS AND HORMONE TARGETED DRUGS FOR THE TREATMENT OF CANCER The present invention relates to the methods of treating endocrine-regulated cancers, including hormone resistant cancers, for example. More specifically, the present invention relates to a method of increasing the sensitivity of hormone resistant cancers to hormonal th... | 05/03/2012 |
| 20120107404 | Crystalline Pharmaceutical and Methods of Preparation and Use Thereof Novel crystalline polymorphic forms, Forms A, B, C, D, and E of a compound of Formula I, which has been found to be a potent inhibitor of LFA-1, are disclosed. Methods of preparation and uses thereof in the treatment of LFA-1 mediated diseases are also disclosed in this... | 05/03/2012 |
| 20120108527 | POLYMERIC TOPICAL COMPOSITIONS The present invention relates to topical antibacterial compositions. The compositions comprise an antibacterial agent such as mupirocin, water, a polymer and a volatile solvent present in an amount of less than about 40%. The invention also relates to methods of treatme... | 05/03/2012 |
| 20120107307 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS This invention concerns N-(ortho phenylamino dihydropyridyl)sulfonamides and N-(ortho phenylamino dihydropyridyl), N′-alkyl sulfamides which are inhibitors of MEK and are useful in the treatment of cancer and other hyperproliferative diseases.... | 05/03/2012 |
| 20120108556 | METHODS AND DOSAGE FORMS FOR THE TREATMENT OF HUMAN CANCERS Methods for the treatment of human cancers, daily dosage forms for cancer patients, and methods of formulating the dosage forms are provided wherein the daily dosage form contains from about 10-6,000 mg of each of β-sitosterol, isovanillin, and linolenic acid. Preferab... | 05/03/2012 |
| 20120107269 | THIOPHENE DERIVATIVES Disclosed is a compound of formula (I), wherein
| |
| 20120108557 | FLUOROQUINOLONE DERIVATIVES FOR OPHTHALMIC APPLICATIONS The present invention relates to fluoroquinolone derivatives having enhanced ocular penetration characteristics and/or antimicrobial activity, and to compositions comprising such derivatives. The derivatives and compositions are particularly well suited for treating oph... | 05/03/2012 |
| 20120108555 | Mixtures or Organic Compounds for the Treatment of Airway Diseases A medicament comprising, separately or together, (A) a compound of formula (I) in free or pharmaceutically acceptable salt or solvate form and (B) a corticosteroid, for simultaneous, sequential or separate administration in the treatment of an inflammatory or obstructiv... | 05/03/2012 |
| 20120082658 | Methods for the Treatment of Allergic Diseases The present invention is directed generally to a TLR8 agonist VTX-378, for use in the treatment or prevention of allergic diseases, including allergic rhinitis.... | 04/05/2012 |
| 20120082626 | USE OF R-BAMBUTEROL AS INHALED MEDICAMENT AND COMBINATION THERAPIES FOR TREATMENT OF RESPIRATORY DISORDERS The present invention concerns with a new use of R-Bambuterol or Bambuterol as inhaled medicament for treatment of asthma, COPD and other respiratory disorders, and a new use of R-bambuterol or bambuterol and corticosteroids or other therapeutically active medicament as... | 04/05/2012 |
| 20120083478 | CRYSTALLINE OXALATE SALTS OF A DIAMIDE COMPOUND The invention relates to crystalline oxalate salts of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-methyl}phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester. This invention also relates to c... | 04/05/2012 |
| 20120083479 | Compositions Comprising Azelastine and Methods of Use Thereof The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise... | 04/05/2012 |
| 20120071451 | METHOD OF TREATING NONALCOHOLIC STEATOHEPATITIS WITH ELEVATED DOSES OF URSODEOXYCHOLIC ACID The present invention is directed to a method for the treatment of nonalcoholic steatohepatitis (NASH) by administering an elevated dose of ursodeoxycholic acid (UDCA), or a pharmaceutically acceptable salt thereof, to a patient in need of such treatment, wherein the pa... | 03/22/2012 |
| 20120071452 | COMBINATIONS COMPRISING ANTIMUSCARINIC AGENTS AND CORTICOSTERIODS Combinations comprising (a) a corticosteroid and (b) an antagonist of M3 muscarinic receptors which is 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane, in the form of a salt having an anion X, which is a pharmaceutically accepta... | 03/22/2012 |
| 20120071450 | ORGANIC COMPOUNDS Optionally substituted 4,5,7,8-tetrahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-imidazo[1,2-a]pyrazolo[4,3-e]pyrimidine or 4,5,7,8,9-pentahydro-(optionally 4-thioxo or 4-imino)-(1H or 2H)-pyrimido[1,2-a]pyrazolo[4,3-e]pyrimidine compounds or Compounds of Formula (... | 03/22/2012 |
| 20120070410 | IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by receptor kinases.... | 03/22/2012 |
| 20120073001 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.... | 03/22/2012 |
| 20120071449 | PHARMACEUTICAL COMPOSITION FOR INHALATION The present invention relates to a pharmaceutical composition for inhalation. The invention is further directed to a method for setting the performance characteristics of such a pharmaceutical composition and the use of such a composition in the treatment of asthma, COP... | 03/22/2012 |
| 20120053159 | ISOTOPOLOGUES OF LENALIDOMIDE Provided herein are lenalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are also provided.... | 03/01/2012 |
| 20120053160 | Dosage Form for Hormonal Contraception A dosage form for hormonal contraception containing a specific number of gestagen-containing daily units A and a specific number of gestagen-containing daily units B for uninterrupted, daily, oral administration of daily units A and then immediately subsequently of dail... | 03/01/2012 |
| 20120053161 | TOPICAL SOLUTION FORMULATIONS CONTAINING A CORTICOSTEROID AND A CYCLODEXTRIN Solution formulations containing a corticosteroid, cyclodextrin, and xanthan gum are disclosed. The formulations are intended for topical application to the eye, ear, or nose.... | 03/01/2012 |
| 20120052130 | GPR 119 MODULATORS Compounds of Formula (I) that modulate the activity of the G-protein-coupled receptor GPFM 19 and their uses in the treatment of diseases linked to the modulation of the G-protein-coupled receptor GPR119 in animals are described herein. ... | 03/01/2012 |
| 20120052005 | COMBINATION THERAPY TO IMPROVE DRUG EFFICIENCY Compositions and methods for increasing drug bioavailability and/or preventing multi-drug resistance through inhibition of ABCG2 by xanthine compounds are disclosed.... | 03/01/2012 |
| 20120053239 | TREATMENT FOR INTESTINAL GAS, BLOATING, MICROSCOPIC COLITIS, INFLAMMATORY BOWEL DISEASE AND TRAVELER'S DIARRHEA USING COLLOIDAL BISMUTH SUBCITRATE A method of treatment for intestinal gas bloating, microscopic colitis, traveler's diarrhea and inflammatory bowel disease, said method comprising ingesting an effective quantity of a composition comprising colloidal bismuth subcitrate to eliminate gastrointestinal disc... | 03/01/2012 |
| 20120052061 | THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND ANTI-HER2(ERBB2) ANTIBODIES OR COMBINATIONS OF COX-2 INHIBITORS AND HER2(ERBB2) RECEPTOR TYROSINE KINASE INHIBITORS Described herein are compositions and methods for using these compositions in the treatment of cancer, tumors, and tumor-related disorders in a subject.... | 03/01/2012 |
