Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Application No. | Application Title | Issue Date |
| 20100298277 | ANGIOTENSIN II RECEPTOR ANTAGONISTS A compound having the structure
| 11/25/2010 |
| 20090298795 | Thiol-Sensitive Positive Inotropes The present invention relates to methods for treating diastolic dysfunction or a disease, disorder or condition associated with diastolic dysfunction, methods for treating heart failure, methods for modulating SR Ca2+ release and/or uptake, methods for enhancing myocyte... | 12/03/2009 |
| 20090281067 | Nitroxyl progenitor compounds and methods of use Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.... | 11/12/2009 |
| 20090203653 | Compositions and Methods Using Apocynin Compounds and Nitric Oxide Donors The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprising at... | 08/13/2009 |
| 20090186859 | DIAZENIUMDIOLATED NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, COMPOSITIONS THEREOF, AND RELATED METHODS Disclosed are compounds that release nitric oxide, e.g., a compound of Formula (I) wherein R1-10, X, and n are as described herein, which are NSAID derivatives comprising a diazeniumdiolate moiety N2O2−. The compounds are ch... | 07/23/2009 |
| 20070270336 | Method for accelerating cutaneous barrier recovery A method for accelerating cutaneous barrier recovery by inducing efflux of potassium ion from an epidermal cell as well as a method for preventing epidermal hyperplasia induced by inducing efflux of potassium ion from an epidermal cell are provided. ... | 11/22/2007 |
| 20070207179 | Medical Device A medical device, such as a guide wire, an embolization device, or a guide shaft for a micro catheter, comprises a solid and/or non-expandable core member made from e.g. metal, such as tantalum, and an outer surface layer, which is formed by electrospun nanofibers. The ... | 09/06/2007 |
| 20070135391 | Microbicidal compositions and their use A composition comprising a copper salt of N′-hydroxy-N-cyclohexyldiazenium oxide (CuHDO) and a diluent is useful for combating and/or killing bacteria, mould, yeast and algae in industrial materials and or industrial processes. In a preferred embodiment CuHDO is gener... | 06/14/2007 |
| 20070060551 | Methods of using isothiazole derivatives to treat cancer or inflammation Methods of using substituted 3,5-dithio-, disulfinyl-or disulfonyl-isothiazole derivatives to treat cancer or inflammation in a mammal and pharmaceutical compositions containing such derivatives are disclosed. ... | 03/15/2007 |
| 20070059351 | Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods The present invention is drawn to a transdermal patch for the delivery of a nitric oxide-donor and a second active agent. The patch can comprise a backing layer and an active agent-containing composition which is supported at least in part by the backing layer. The acti... | 03/15/2007 |
| 20060293253 | INDOLE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ... | 12/28/2006 |
| 20060293288 | Use of resolvins to treat gastrointestinal diseases The present invention is generally drawn to novel isolated therapeutic agents, termed resolvins, generated from the interaction between a dietary omega-3 polyunsaturated fatty acid (PUFA) such as eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA), oxygenases and ... | 12/28/2006 |
| 20060247216 | Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments The present invention relates to multifunctional steroid compounds combining a steroid component with SOD mimic component and optionally also with NO donor component, and to their use in treating and preventing disorders associated with oxidative stress and free radical... | 11/02/2006 |
| 20060166894 | Ace-inhibitors having antioxidant and no-donor activity Multifonctional ACE inhibitor compounds are provided, that combine ACE-inhibiting activity with capability to scavenge superoxide and other reactive oxygen species, and that may further function as nitric oxide donors. The compounds are useful for preventing or treating... | 07/27/2006 |
| 20060135485 | Microbicidal compositions and their use A composition comprising a potassium salt of N′-hydroxy-N-cyclohexyldiazenium oxide (KHDO) and a diluent is useful for killing fungi. Such a composition but which additionally includes at least one of certain other fungicidally active components is useful for combatin... | 06/22/2006 |
| 20060128673 | Pharmaceutical compositions comprising CB1 cannabinoid receptor antagonists and potassium channel openers for the treatment of obesity and related conditions Described is a novel combination therapy for diabetes mellitus type I and/or for obesity and its concomitant and/or secondary diseases or conditions, in particular the metabolic syndrome and/or syndrome X, and/or diabetes mellitus type II, by administering a combination... | 06/15/2006 |
| 20060058316 | 4-Oxo-1-3-substituted phenyl-1,4-dihydro-1,8-naphthyridine-3-carboxamide phosphodiesterase-4 inhibitors Compounds represented by Formula (I): or a pharmaceutically acceptable salt thereof, are phosphodiesterase 4 inhibitors useful in the treatment of asthma and inflammation and useful for the enhancement of cognition. ... | 03/16/2006 |
| 20060051418 | Pharmaceutical formulations of potassium ATP channel openers and uses thereof Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or... | 03/09/2006 |
| 20060039950 | Multi-functional biocompatible coatings for intravascular devices A polymeric coating is adapted to substantially eliminate thrombus formation when in contact with blood. The polymeric coating includes a first polymeric layer and a second polymeric layer. Interposed between the first and second polymeric layers is a polymeric matrix l... | 02/23/2006 |
| 20060025386 | Method of treatment of retinal ischemia with diazoxide A composition including diazoxide (7-chloro-3-methyl-2H-1,2,4-benzothiadiazine-1,1-dioxide) for the treatment and/or prevention of retinal ischemia and of diseases associated with retinal ischemia. The composition can also contain riluzole, a derivative active in neurop... | 02/02/2006 |
| 20050288260 | Novel nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine diazeniundiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines. ... | 12/29/2005 |
| 20050239752 | Indole compounds useful for the treatment of cancer The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments. ... | 10/27/2005 |
| 20050214249 | O2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates Diazeniumdiolates, wherein the N1 position is substituted by an inorganic or organic moiety and the O2-oxygen is bound to a substituted or unsubstituted aromatic group, are provided. Also provided are O2-glycosylated 1-substituted diazen... | 09/29/2005 |
| 20050208088 | Pesticidal composition and method for pest control A method of protecting a plant against shoot or foliar insects and/or representatives of the order Acarina, which comprises treating the plant propagation material thereof with (a) a nematicidally effective amount of a nematicide and (b) at least one insecticidally effe... | 09/22/2005 |
| 20050203069 | Nitric oxide-releasing molecules This invention relates to compositions comprising carbon-based diazeniumdiolates that release nitric oxide (NO). The carbon-based diazeniumdiolated molecules release NO spontaneously under physiological conditions without subsequent nitrosamine formation. The present in... | 09/15/2005 |
| 20050203070 | Method of improving beta-adrenergic receptor function The present invention relates to a method of increasing the sensitivity of a hyperinsulinemic patient to the anti-obesity and antidiabetic effects of a β adrenergic receptor (βAR) agonist. The method comprises administering to the patient the βAR agonist and an agent... | 09/15/2005 |
| 20050202394 | Organ arrest, protection, preservation and recovery The present invention relates to a composition for controlling viability of a tissue including a potassium channel opener or adenosine receptor agonist, a compound for inducing local anaesthesia and a compound for reducing the uptake of water by a cell in the tissue. Th... | 09/15/2005 |
| 20050192254 | Nitroxyl progenitors in the treatment of heart failure Administration of an HNO/NO− donating compound, such as Angeli's salt, increases myocardial contractility while concomitantly lowering left ventricular preload in subjects experiencing heart failure. Moreover, administration of the HNO/NO− dona... | 09/01/2005 |
| 20050153940 | Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor Disclosed are methods of selectively delivering a medicant to an abnormal brain region and/or to a malignant tumor in a mammalian subject, including a human. A medicant is administered simultaneously or substantially simultaneously with a potassium channel activator (ot... | 07/14/2005 |
| 20050070509 | Antimycotic agent The present invention relates to a metal salt for use in pharmacy, to pharmaceutical compositions comprising it, and to the use for preparing a pharmaceutical composition for treating diseases associated with mycobionts. ... | 03/31/2005 |
| 20050009789 | Cyclooxygenase inhibition with nitroxyl Nitroxyl is used to inhibit COX-2 activity and particularly to selectively inhibit COX-2 activity. Nitroxyl also is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions. In some cases nitroxyl is used to trea... | 01/13/2005 |
