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| Application No. | Application Title | Issue Date |
| 20100278895 | ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include... | 11/04/2010 |
| 20100278894 | ANTIOXIDANTS AND ANTIMICROBIAL ACCESSORIES INCLUDING ANTIOXIDANTS An antimicrobial accessory may include a polymer an antimicrobial mixed in the polymer, and an antioxidant. The antioxidant may include, for example, at least one of citric acid, maltol, kojic acid, malic acid, or vitamin A. In some examples, the antioxidant may include... | 11/04/2010 |
| 20100260709 | ORGANIC COMPOUNDS AND THEIR USES The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.... | 10/14/2010 |
| 20100234285 | Benzofuranyl Derivatives The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokin... | 09/16/2010 |
| 20100233262 | COATED TABLET A main object of the present invention is to provide a novel coated tablet which contains a drug having a guanidino group and does not suffer an obvious color change even when packed in a one-dose pack together with a drug having a (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl... | 09/16/2010 |
| 20100233241 | OPHTHALMIC DRUG DELIVERY SYSTEM AND APPLICATIONS An ocular device for insertion into an eye is provided and includes a body having an anterior surface and a posterior surface for placement on one of superior sclera and inferior sclera of the eye. The posterior surface is defined by a base curve that is substantially i... | 09/16/2010 |
| 20100233231 | USE OF CRYOGENIC PROCESSING TO OBTAIN A SUBSTANTIALLY-THICKENED FORMULATION The present invention related to substantially-thickened therapeutic formulation comprising an oil-based composition and a therapeutic agent, wherein the therapeutic agent is of a reduced particle size.... | 09/16/2010 |
| 20100233194 | TREATMENT OF NEOVASCULAR OCULAR DISEASE STATES Compositions and regime or regimen for inhibiting unwanted ocular angiogenesis include the treatment of ocular neovascularization by administration of anti-angiogenesis agents, e.g., agents that inhibit VEGF, in combination with a second ocular therapy.... | 09/16/2010 |
| 20100226918 | PYRROLE DERIVATIVES AS P2Y12 ANTAGONISTS The present invention relates to compounds of the formula I, in which R1; R2; R3; R4; R5; R6; R7; R8; R9; R10; R11; R12; R13; A; B, D and E have the meanings indicated in the claims. The compounds of the form... | 09/09/2010 |
| 20100227800 | TRIAZOLE DERIVATIVES AS KINASE INHIBITORS The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment o... | 09/09/2010 |
| 20100227801 | PHARMACEUTICAL COMPOSITIONS This invention relates to combinations comprising 3-[(R)-2-(N,N-dimethylamino)ethylthio-Sar]-4-(gammahydroxymethylleucine)cyclosporine, or a pharmaceutically acceptable salt, solvate or hydrate thereof; and certain nucleoside analogues, and their use in the treatment of... | 09/09/2010 |
| 20100222257 | SUBSTITUTED PHENETHYLAMINES Disclosed herein are substituted phenethylamine alpha adrenergic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. ... | 09/02/2010 |
| 20100221343 | COMPOSITIONS AND METHODS OF MAKING BRITTLE-MATRIX PARTICLES THROUGH BLISTER PACK FREEZING The present invention includes compositions and methods for treating and delivering medicinal formulations using an inhaler. The composition includes a space filled flocculated suspension having one or more flocculated particles of one or more active agents and a hydrof... | 09/02/2010 |
| 20100222256 | Novel polypeptide anti-HIV agent containing the same The present invention provides novel polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 ... | 09/02/2010 |
| 20100221299 | THERAPEUTIC STEM CELL NUTRIENT COMPOSITION AND USES THEREOF The present invention relates to a composition and uses thereof for treatment of damaged tissue comprising at least one essential amino acid in L form and at least one essential lipid; wherein the composition is administered to a mammal suffering from severe tissue dama... | 09/02/2010 |
| 20100216697 | PHARMACEUTICAL COMPOSITION, SUBSTRATE COMPRISING A PHARMACEUTICAL COMPOSITION, AND USE OF A PHARMACEUTICAL COMPOSITION The invention relates to the use of a pharmaceutical composition for the local treatment or prevention of a tissue infection at an infection site, the pharmaceutical composition comprising at least two different antibiotics of group A or pharmaceutically acceptable deri... | 08/26/2010 |
| 20100215614 | Enterostatin as Inhibitor of Angiogenesis It has been discovered that enterostatin inhibits angiogenesis in an in vitro adipose tissue angiogenesis model. In concentrations from about 10−6 to about 10−9 M, enterostatin effectively blocked the angiogenic response. Enterostatin will be e... | 08/26/2010 |
| 20100215652 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.... | 08/26/2010 |
| 20100215661 | NICOTINAMIDE DERIVATES USEFUL AS P38 INHIBITORS Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.... | 08/26/2010 |
| 20100216700 | METHODS OF TREATING OCULAR DISORDERS This invention is directed to treatments of ocular disorders using emulsions and molecular dispersions in the form of a gel comprising a hydrophobic ocular agent.... | 08/26/2010 |
| 20100209499 | Solid Oral Dosage Form Containing an Enhancer The invention relates to a solid oral dosage form comprising a pharmaceutically active ingredient in combination with an enhancer which enhances the bioavailability and/or the absorption of the active ingredient. Accordingly, a solid oral dosage form comprises a drug an... | 08/19/2010 |
| 20100210518 | Peg-lipid conjugates for increasing the solubility of drug compounds Diacyl lipid-polymer conjugates are used to enhance the solubility of lipophilic drugs in aqueous solution. The conjugates comprise a backbone, two lipophilic acyl groups and a hydrophilic polymer.... | 08/19/2010 |
| 20100209445 | MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING BETA1-ADRENOCEPTOR ANTIBODIES The present invention relates to novel β-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopepti... | 08/19/2010 |
| 20100209541 | BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING METABOLIC DISORDERS Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention compri... | 08/19/2010 |
| 20100209467 | TDF-RELATED COMPOUNDS AND ANALOGS THEREOF, ANALOGS AND BIOACTIVE FRAGMENTS The present invention relates generally to tissue differentiation factor (TDF) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of ... | 08/19/2010 |
| 20100210519 | PEPTIDE SLOW-RELEASE FORMULATIONS A composition for the delayed delivery of a peptide active agent comprising; i) a salt of said peptide active agent comprising at least one positively charged peptide ion and at least one negatively charged counter-ion ii) a sustained-release delivery vehicle. Wherein s... | 08/19/2010 |
| 20100210517 | CYCLIC RECEPTOR-ASSOCIATED PROTEIN (RAP) PEPTIDES The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions fo... | 08/19/2010 |
| 20100209390 | CYCLOSPORIN ANALOGUES The present invention provides cyclosporin analogues of formula I, and compositions comprising these compounds, as well as processes for their preparation, intermediates in their synthesis, and methods of use... | 08/19/2010 |
| 20100203103 | THERAPEUTIC COMPOSITIONS FOR TREATMENT OF INFLAMMATION OF OCULAR AND ADNEXAL TISSUES The present invention comprises a composition with means to inhibit the function of the inflammatory cytokine IL-1 and methods for using this composition to treat inflammatory disease of ocular and adnexal tissues by topical administration. The present invention also di... | 08/12/2010 |
| 20100203119 | PHARMACEUTICAL TREATMENT PROCESS USING CHITOSAN OR DERIVATIVE THEREOF The present invention provides a solid composition for oral administration comprising:
| 08/12/2010 |
| 20100203120 | PHARMACEUTICAL CYCLOSPORIN COMPOSITIONS An oral cyclosporin composition comprises minicapsules having a core containing a cyclosporin, especially cyclosporin A in a solubilised liquid form. The minicapsules have a release profile to release the pre-solubilised cyclosporin, at least in the colon. The compositi... | 08/12/2010 |
| 20100204090 | USE OF A PEPTIDE AS A THERAPEUTIC AGENT The present invention is directed to the use of the peptide compound Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammato... | 08/12/2010 |
| 20100197572 | USE OF SOMATOSTATIN-14 AS A THERAPEUTIC AGENT The present invention is directed to the use of the peptide compound Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodeg... | 08/05/2010 |
| 20100197571 | EXTRUDATES WITH IMPROVED TASTE MASKING The invention relates to extrudates comprising one or more pharmaceutically active substances, where the extrudates have a strand diameter of 0.5 mm or less, and to the use of these extrudates for the manufacture of medicaments.... | 08/05/2010 |
| 20100197570 | Cyclodepsipeptides with Antineoplastic Activity and Methods of Using to Inhibit Cancer and Microbial Growth The present invention is directed to cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity, preferably Kitastatin 1. The present invention is further directed to methods of inhibiting cancer cell growth and/or microbial growth in a host inflict... | 08/05/2010 |
| 20100196317 | CYCLIC UNDECAPEPTIDES AND DERIVATIVES AS MULTIPLE SCLEROSIS THERAPIES A method for treating a subject with multiple sclerosis is disclosed herein. In one embodiment, a method is provided for treating a subject with multiple sclerosis that includes administering to the subject a therapeutically effective amount of a cyclosporin compound.... | 08/05/2010 |
| 20100189802 | Method for treatment of vascular hyperpermeability A method comprising preparing a vascular hyperpermeability treatment composition comprising an apoptosis regulating protein, a antioxidant, a mitochondrial modulator, a biological effector molecule, or combinations thereof in a form deliverable to a mammal; whereby an e... | 07/29/2010 |
| 20100190693 | METHOD FOR SCREENING COMPOUNDS & USES THEREFOR In accordance with the present invention, it has been discovered that glucose and incretin hormones promote pancreatic islet cell survival via the calcium and cAMP dependent induction, respectively, of the transcription factor CREB. Specifically, a signaling module has ... | 07/29/2010 |
| 20100190694 | Methods for identifying patients who will respond well to cancer treatment The invention provides methods for identifying patients who will respond well to cancer treatment with a therapeutic regimen that comprises the use of a histone deacetylase inhibitor (HDACi) and one or more further chemotherapeutic agents. The invention also relates to ... | 07/29/2010 |
| 20100190696 | TREATMENT OF T-CELL MEDIATED DISEASES The invention provides a method of treating T-cell mediated diseases and a method of inhibiting the activation of T-cells using certain diketopiperazines. The invention also provides methods of synthesizing diketopiperazines and pharmaceutical compositions comprising ce... | 07/29/2010 |
