Did You Know...
...that a workman who left the soap mixing machine on too long was responsible for making Ivory Soap? He was so embarrassed by his mistake that he threw the mess in a stream. Imagine his dismay when the evidence of his error floated to the surface! Result: Ivory soap, the soap that floats.
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| Application No. | Application Title | Issue Date |
| 20120129265 | NEW BIOMARKERS FOR ASSESSING KIDNEY DISEASES The present invention relates to a metabolic biomarker set for assessing kidney disease comprising at least two amino acids, at least two acylcarnitines and at least two biogenic amines. Moreover, the present invention relates to a method for assessing kidney disease in... | 05/24/2012 |
| 20120028285 | Clickable cross-linker A clickable cross-linker compound provides an easily scanned reporter ion for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins and peptides.... | 02/02/2012 |
| 20110312505 | Rapid Isolation of Monoclonal Antibodies from Animals Methods and compositions for identification of candidate antigen-specific variable regions as well as generation of antibodies or antigen-binding fragments that could have desired antigen specificity are provided. For example, in certain aspects methods for determining ... | 12/22/2011 |
| 20110281256 | Systems and Methods of Detecting and Demonstrating Hair Damage Via Evaluation of Protein Fragments Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between ... | 11/17/2011 |
| 20110281293 | PREPARATION AND ITS USE OF DERIVATIZATION REAGENT FOR DETECTING L-CARNITINE OR D-CARNITINE A preparation method and its use of derivatisation reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to... | 11/17/2011 |
| 20110275985 | MAGNETIC NANOSENSOR COMPOSITIONS AND BIOANALYTICAL ASSAYS THEREFOR Disclosed are magnetic nanosensors or transducers that permit measurement of a physical parameter in an analyte via magnetic reasonance measurements, in particular of non-agglomerative assays. More particularly, in certain embodiments, the invention relates to designs o... | 11/10/2011 |
| 20110212531 | Mass Spectrometry-Based Protein Identification Method A method of detection of amino acid sequences and/or identification of proteins and peptides is based on derivatization of peptides or proteins using compounds comprising two or more sulfonyl groups, and subsequent analysis of the derivatized analytes using a mass spect... | 09/01/2011 |
| 20110207616 | SOLID STATE SYNTHESIS HYDROXYL RADICALS FOR HIGH THROUGHPUT STRUCTURE DETERMINATION OF PROTEINS AND NUCLEIC ACIDS BY OXIDATIVE FOOTPRINTING The present invention generally relates to an apparatus for structural mapping of a macromolecule comprising an amount of persulfide effective to generate hydroxyl radicals upon contact with an aqueous solution. The present invention further relates to methods for struc... | 08/25/2011 |
| 20110201539 | DETECTING SUCCINYLACETONE This invention relates, inter alia, to detecting and/or measuring succinylacetone and one or more additional biological analytes using mass spectrometry.... | 08/18/2011 |
| 20110183428 | METHOD FOR ANALYZING C-TERMINAL AMINO ACID SEQUENCE OF PEPTIDE USING MASS SPECTROMETRY The present invention provides a method for analyzing the C-terminal amino acid sequence of a peptide by using a reaction for successively releasing the C-terminal amino acids of the peptide, which method can suppress, when successively releasing the C-terminal amino ac... | 07/28/2011 |
| 20110135575 | METALLOPROTEIN MRI CONTRAST AGENTS AND RELATED METHODS The present invention generally relates to Magnetic Resonance Imaging (MRI) analysis of the location, presence, and/or quantity of a particular molecule or material. In some embodiments, the invention relates to compositions and methods for determination of an analyte, ... | 06/09/2011 |
| 20110136241 | TYPE II DIABETES MOLECULAR BIOPROFILE AND METHOD AND SYSTEM OF USING THE SAME Molecular bioprofiles comprising biologically correlated and relevant analytes that impact the biological state of a human health condition compared to a control population are provided. These molecular bioprofiles are useful in several ways including but not limited to... | 06/09/2011 |
| 20110129933 | MEANS AND METHODS FOR ASSESSING INCREASED PEROXISOMAL PROLIFERATION The present invention pertains to the field of toxicological as for risk stratification of chemical compounds. Specifically, it relates to methods for (i) diagnosing, (ii) determining whether a compound is capable of inducing, (iii) identifying a drug for treating incre... | 06/02/2011 |
| 20110123999 | Novel Polymorphism in Bovine Prion Protein Gene Sequence A specific, non-synonymous SNP in the Prnp gene encoding the bovine prion protein affects the susceptibility of bovine animals to bovine spongiform encephalopathy (BSE). Depending on the number of octapeptide repeat units present in the Prnp gene, the position of the SN... | 05/26/2011 |
| 20110111513 | MASS SPECTROMETRIC ANALYSIS The disclosure provides a method for assaying for a target analyte, comprising providing a plurality of samples which may comprise the target analyte, wherein each sample is differentially labelled with a mass label or a combination of mass labels, wherein the mass labe... | 05/12/2011 |
| 20110085983 | Liquid Chromatography-Mass Spectrometry Methods For Multiplexed Detection and Quantitation of Free Amino Acids The present invention provides liquid chromatography-mass spectrometry methods and kits for the specific, sensitive and rapid detection as well as quantitation of free amino acids in samples following High Pressure Liquid Chromatography (HPLC) separation.... | 04/14/2011 |
| 20110045598 | METHODS FOR DETERMINING ENANTIOMERIC PURITY WITH IMPROVED CHIRAL SELECTORS A strategy, or method, for the quantitative determination of enantiomeric purity that combines lin situ enantiomer diastereomerization', spectroscopy, and chemometric modeling. Spectral data for samples of known enantiomeric composition is subjected to a type of multiva... | 02/24/2011 |
| 20100311175 | MASS TAGS FOR QUANTITATIVE ANALYSES This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mix... | 12/09/2010 |
| 20100291066 | DONOR SPECIFIC ANTIBODY LIBRARIES The present application concerns donor-specific antibody libraries derived from a patient donor who has suffered from, or is suffering from one or more diseases discussed herein. The present application also concerns the method of making and using the donor-specific ant... | 11/18/2010 |
| 20100285597 | DETECTION OF FRAGMENTS OF NECTIN-1 FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE Methods for diagnosing Alzheimer's Disease by detection of fragments of nectin-1 are described. Nectin-1 is shown to be a substrate for proteases associated with the onset of Alzheimer's Disease, including α-secretase, γ-secretase and BACE1 or a BACE1-like protease. T... | 11/11/2010 |
| 20100278860 | SYSTEM AND METHOD FOR IDENTIFYING COMPLEX PATTERNS OF AMINO ACIDS A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For p... | 11/04/2010 |
| 20100273661 | Methods and Kits for Predicting Treatment Response in Type II Diabetes Mellitus Patients A method for predicting treatment response of a type II diabetes patient to rosiglitazone is provided. The method involves at least one sample from a patient having type II diabetes and analyzing biomarkers predictive of a patient who will respond to treatment with rosi... | 10/28/2010 |
| 20100240139 | FREE RADICAL INITIATOR AND METHOD FOR PEPTIDE SEQUENCING USING THE SAME The present invention relates to a free radical initiator and a method for peptide sequencing using the same. Compared with diazo or peroxy functionalized precursors, the precursors using the present compounds are chemically more robust and can generate radical species ... | 09/23/2010 |
| 20100227827 | METHOD OF INCREASING TRYPTOPHAN AND NICOTINAMIDE LEVELS IN VIVO Novel methods of increasing the biosynthesis of aromatic amino acids and compositions containing the precursors of said aromatic amino acids or nicotinamide and methods of use thereof. In addition, methods of monitoring the therapeutic effects of an anti-oxidant therapy... | 09/09/2010 |
| 20100209927 | PROCESSING DEVICE TABLET A microfluidic processing device includes a tablet comprising a reagent, where the tablet is configured to fit within at least one chamber of the processing device. In addition, in some embodiments, at least two tablets are disposed within a single process chamber of th... | 08/19/2010 |
| 20100210582 | METHOD AND COMPOSITION FOR TREATING PATIENTS WITH A HIGH RISK OF DEVELOPING NEURO-IMMUNE DISORDERS OR DEVELOPMENTAL DELAYS, IDENTIFIED THROUGH THE UTILIZATION OF LOW HOMOCYSTEINE OR ITS PRECURSORS/METABOLITES, AS THE PREDICTOR OF SUCH RISK A method for predicting the likelihood of developing ASD and ASD-related diseases in a subject is disclosed. The method includes the steps of measuring the level of homocysteine, a homocysteine precursor or a homocysteine metabolite in the subject and evaluating the lik... | 08/19/2010 |
| 20100167326 | METHOD FOR CLEAVAGE OF PEPTIDIC BOND AT C TERMINAL OF PEPTIDE AND A METHOD FOR DETERMINATION OF C TERMINAL AMINO ACID SEQUENCE OF PEPTIDE The present invention is to provide a method for cleavage of peptidic bond at C terminal of peptide and a method for determination of C terminal amino acid sequence of peptide without the decrease of the sensitivity and with preventing the subsidiary reaction. The metho... | 07/01/2010 |
| 20100159486 | BIOMARKERS FOR NEUROLOGICAL CONDITIONS Low molecular weight (LMW) peptides have been discovered that are indicative of neurological conditions, such as Alzheimer's Disease (AD), cognitive impairment and brain microhemmorhages. Evaluating patient samples for the presence of such LMW peptides is an effective m... | 06/24/2010 |
| 20100144047 | ELECTRODE FOR MOLECULAR SENSING AND METHOD FOR MOLECULAR SENSING Molecular sensing of target molecules is performed by using an electrode for molecular sensing in which detecting molecules which can shift a surface potential of the electrode by an interaction with the target molecules are bound directly or via coupling molecules to s... | 06/10/2010 |
| 20100130431 | DISCORDANT HELIX STABILIZATION FOR PREVENTION OF AMYLOID FORMATION The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compo... | 05/27/2010 |
| 20100125092 | 4-[2-(2-FLUOROPHENOXYMETHYL)PHENYL]PIPERIDINE COMPOUNDS The invention relates to compounds of formula I: where a, R1, and R3-6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds of formula I are ... | 05/20/2010 |
| 20100099120 | Method for staining substances having a phosphate group It is intended to provide a method by which a substance having a phosphate group can be easily detected from a biological sample or the like, a method by which a phosphorylated amino acid residue is easily identified and a compound which can be used in the methods becau... | 04/22/2010 |
| 20100093011 | AMINE-CONTAINING COMPOUND ANALYSIS METHODS The present teachings provide methods for analyzing one or more amine-containing compounds in one or more samples using isobaric labels and parent-daughter ion transition monitoring (PDITM). In various embodiments, the methods comprise the steps of: (a) labeling one or ... | 04/15/2010 |
| 20100055729 | SENSOR DEVICE Sensor devices and compositions can be used for detecting the presence of a target substance in a medium. The sensor devices and compositions can be configured to include at least one nanosensor through a high concentration of nanosensors that interact with the target s... | 03/04/2010 |
| 20090318556 | BIOMARKERS FOR DETECTING RADIATION EXPOSURE: METHODS AND USES THEREOF Disclosed herein are biomarkers for determining gamma radiation exposure by an animal or human. The biomarkers include 3-hydroxy-2-methylbenzoic acid 3-O-sulfate, N-hexanoylglycine, β-thymidine, taurine, xanthine, xanthosine, 2′-deoxyuridine, 2′-deoxycytidine, 2′... | 12/24/2009 |
| 20090311696 | POLYMORPHISMS IN THE HUMAN CYP2B6 GENE AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the CYP2B6 genes. In particular, polynucleotides of mole... | 12/17/2009 |
| 20090305321 | Assays for Allosteric Modulators of G-Protein Coupled Receptors (GPCRs) The present invention relates to G protein-coupled receptors (GPCRs) and allosteric modulators thereof. More specifically, the invention relates to allosteric modulators of GPCRs that interact at an intracellular binding site. It also relates to methods for designing or... | 12/10/2009 |
| 20090297494 | Diagnostic and treatment of a mental disorder The present invention generally relates to the field of neurological, physiological and psychotic dysfunctions associated with a mental disorder such as schizophrenia, or a predisposition therefor. The invention further relates to genes and proteins, which, when varied ... | 12/03/2009 |
| 20090270268 | Methods for Obtaining Immortalized Antibody Secreting Cells The present Invention provides novel methods for immortalizing cells that secrete antibodies of one or more specific isotypes. Polyclonal, oligoclonal, and monoclonal populations of cells obtained using the methods of the Invention can be screened on the basis of the fu... | 10/29/2009 |
| 20090246879 | Materials and Methods Relating to Nano-Tags and Nano-Brands The invention relates to novel methods and materials for encoding and decoding information on individual molecules through the use of nano-tags, nano-barcodes, or modifications of a native molecule.... | 10/01/2009 |
