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| Application No. | Application Title | Issue Date |
| 20120129150 | PARTICLES EMBEDDED IN A POROUS SUBSTRATE FOR REMOVING TARGET ANALYTE FROM A SAMPLE The invention provides devices, test kits and methods for removing target agents from a sample. The device contains one or more porous matrices having pore sizes larger than 10 μm, and a plurality of particles impregnated therein. The target agents attach the de... | 05/24/2012 |
| 20120129764 | INFLUENZA A AND B VIRUS REPLICATION-INHIBITING PEPTIDES A synthesized or isolated influenza virus replication-inhibiting peptide that competitively inhibits protein-protein interaction of the PA and PB1 of both influenza Virus Types A and B and novel in vitro binding screen to identify peptides with antiviral activity agains... | 05/24/2012 |
| 20120107830 | REAGENTS FOR BIOMOLECULAR LABELING, DETECTION AND QUANTIFICATION EMPLOYING RAMAN SPECTROSCOPY The present disclosure provides isotopically substituted compounds of the formula (II): wherein T, U, V, W, X, Y, Z, R0, R3, R4, R5 and R6 are as defined... | 05/03/2012 |
| 20120107941 | REAL-TIME MONITOR SOLID PHASE PEPTIDE SYNTHESIS BY MASS SPECTROMETRY Provided are systems, apparatus, materials and methods for directly monitoring products and intermediates of solid phase chemical synthesis such as solid phase peptide synthesis.... | 05/03/2012 |
| 20120071356 | Variants in Complement Regulatory Genes Predict Age-Related Macular Degeneration Methods for identifying a subject at risk for developing AMD are disclosed, as are kits which can be used to practice the methods. The methods include identifying specific protective or risk polymorphisms or genotypes from the subject's genetic material, including polym... | 03/22/2012 |
| 20120071339 | BIOMARKERS The invention relates to a method of diagnosing or monitoring multiple sclerosis.... | 03/22/2012 |
| 20120070821 | Interference Control Panel for Evaluation of Analytical Assays For Samples Derived from Blood The invention relates to quality control of analytical assays, particularly NAT assays of blood samples containing nucleic acids. A control panel containing quantified amounts of substances known to interfere with an analytical assay is used and compared with a referenc... | 03/22/2012 |
| 20120071337 | METHODS The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the a... | 03/22/2012 |
| 20120052051 | METHOD OF TREATING DIABETES - RELATED VASCULAR COMPLICATIONS The method of treating diabetes-related vascular complications includes the treatment of diabetic patients with α-lipoic acid (LA) in order to mitigate the negative impact of diabetes-related vascular dysfunctions upon vascular homeostasis. The treatment method include... | 03/01/2012 |
| 20120045432 | B LYMPHOCYTE STIMULATOR ASSAYS The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host ... | 02/23/2012 |
| 20120045841 | SYSTEM AND METHOD FOR GENERATION OF AUTOMATED DENATURATION GRAPHS A system and method for creating a plurality of denaturation curves is disclosed. In accordance with certain embodiments, one variable, such as salt content, pH or another parameter, is varied to create a plurality of different buffer solutions. Each is then used to cre... | 02/23/2012 |
| 20120046639 | MICROFLUIDIC FREE INTERFACE DIFFUSION TECHNIQUES A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one embodiment of the present invention, the fluids are static and initially po... | 02/23/2012 |
| 20120045459 | Methods for Treating Autophagy-Related Disorders Methods for treating autophagy-related disorders with agents which modulate expression of the gene encoding tyrosine phosphatase receptor type sigma (PTPRS) or which modulate the biological activity of the PTPRS gene product (PTPsigma). Methods for modulating autophagy ... | 02/23/2012 |
| 20120045788 | Device for sample preparation A pipette tip or tube containing chromatographic media contained and held in place in said tube by using low melting point porous polymer particles. Such pipette tips or tubes can be used for sample preparation, filtration and synthesis of small molecules and biomolecul... | 02/23/2012 |
| 20120045785 | Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.... | 02/23/2012 |
| 20120040906 | PROTEIN TARGETS IN DISEASE MicroRNAs have been shown to be critically involved in control of cell survival and cell death decisions. By identifying microRNAs implicated in Endoplasmic Reticulum stress-induced cardiomyocyte apoptosis, it is envisaged that protein targets involved in same can be id... | 02/16/2012 |
| 20120027799 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY BOWEL DISEASE AND COLON CANCER The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention... | 02/02/2012 |
| 20120014998 | MODIFIED CHAPERONIN 10 The present invention relates to isolated Chaperonin 10 polypeptides possessing immunomodulatory activity, but lacking, or substantially lacking, protein folding activity.... | 01/19/2012 |
| 20120009685 | DESIGN OF A PEPTIDE PROBE FOR RAPID AND SPECIFIC DETECTION OF AMYLOID AGGREGATION A peptide probe that generates fluorescence signals rapidly upon recognition of various Aβ aggregates without significant perturbation of samples. The present peptide probes display an increase in fluorescence signals upon coincubation with Aβ oligomers, but neither m... | 01/12/2012 |
| 20120004185 | POLYPEPTIDE STRUCTURAL MOTIFS ASSOCIATED WITH CELL SIGNALING ACTIVITY Isolated polypeptides comprising or consisting essentially of specific structural motifs (e.g., three β-sheets and two α-helices) are provided, wherein the polypeptides exhibit at least one cell signaling and/or other non-canonical activity of biological relevance. Al... | 01/05/2012 |
| 20120003744 | DIAGNOSTIC METHODS The present invention provides a method for identifying a biomarker for diagnosis of lymphoma in a canine subject. The method comprises the following steps: (i) providing serum samples from canine subjects with lymphoma (lymphoma samples); (ii) providing serum samples f... | 01/05/2012 |
| 20110318771 | DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group—balancer groupâ... | 12/29/2011 |
| 20110318726 | PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the metabolite is indicative of the risk of cardiovascular disease in the subject. The ... | 12/29/2011 |
| 20110319436 | Methods and Compositions for Modulating IRE1, SRC, and ABL Activity Disclosed herein are, inter alia, compositions for modulating Ire1, Src, or Abl, methods for identifying modulating activity in test compounds, and methods for treating diseases caused by the activity or inactivity of Ire1, Src, or Abl.... | 12/29/2011 |
| 20110319334 | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF NEURODEGENERATIVE DISEASES Isolated peptides are provided, being less than 20 amino acids in length. The peptides comprising an amino acid sequence GVLYVGSKTREGV (SEQ ID NO: 12) AAATGLVKREE (SEQ ID NO: 13) or GVVAAAEKTKQG (SEQ ID NO: 14), mimetics and/or fragment thereof, the peptides being capab... | 12/29/2011 |
| 20110312099 | USE OF PSYCHROPHILIC ANAEROBIC DIGESTION IN SEQUENCING BATCH REACTOR FOR DEGRADATION OF PRIONS The present invention relates to the use or process of use of a sequencing batch reactor for eliminating prion in specified risk materials and for measuring the efficacy of a sequencing batch reactor to degrade prion proteins in specified risk materials.... | 12/22/2011 |
| 20110313276 | NON-INVASIVE IN VITRO METHOD FOR QUANTIFYING LIVER LESIONS An in-vitro non-invasive method for quantifying the lesions of the liver of the patient with metabolic steatosis addressing a diagnostic target, i.e. fibrosis, steatosis and/or steato-hepatitis (NASH) and measuring at least one marker selected from the group consisting ... | 12/22/2011 |
| 20110312011 | DIAGNOSTIC DEVICES AND METHODS OF USE The present invention relates to methods of diagnosing samples as well as various microfluidic, microcentrifuge and microfilter devices. In one embodiment, the present invention provides a method of diagnosing neurodegenerative diseases using mitochondrial and/or platel... | 12/22/2011 |
| 20110311505 | Photosensitive Aminoacid-Monomer Linkage and Bioconjugation Applications in Life Sciences and Biotechnology This invention is related to preparation of photosensitive ruthenium based aminoacid monomers and oligomers, aminoacid monomer-protein cross-linking using photo sensitat ion and conjugation on micro and nano-structures by ruthenium-chelate based monomers. Its vast range... | 12/22/2011 |
| 20110312009 | COMPOSITION FOR ASSAYING GLYCATED PROTEINS Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while... | 12/22/2011 |
| 20110301194 | Method for Determining Treatment Efficacy The present invention provides a method for determining the efficacy of a c-Met inhibitor in treating a cell proliferative disorder, comprising: a) administering to a subject in need thereof a therapeutically effective amount of the c-Met inhibitor, or a pharmaceuticall... | 12/08/2011 |
| 20110293599 | METHOD FOR MODULATING MUSCLE DIFFERENTIATION OR REGENERATION Present invention relates to method for promoting or inhibiting muscle differentiation or regeneration using an enhancer or an inhibitor capable of modulating the binding of TAZ polypeptide with MyoD polypeptide; method for screening a substance capable of up- or down-r... | 12/01/2011 |
| 20110294677 | MICROFLUIDIC SYSTEMS COMPRISING A RUBBER MATERIAL SUBSTRATE The invention relates to a novel microfluidic system having a substrate based on rubber material having polar side groups which are linked to the rubber polymer backbone via a spacer. By doing so, a transport of water-based fluids such as blood, saliva etc. will occur b... | 12/01/2011 |
| 20110286928 | Methods and compositions for inhibition of BCL6 repression Provided are peptides or mimetics that block corepressor binding to a BCL6 lateral groove. Also provided are methods or blocking corepressor binding to the BCL6 lateral groove. Additionally, methods of inhibiting BCL6 repression in a mammalian cell, and methods of treat... | 11/24/2011 |
| 20110287413 | MICROFLUIDIC SYSTEM A microfluidic system comprising a 1st reaction zone, a 2nd reaction zone, a reagent delivery channel configured to deliver one or more reagents to the 1st reaction zone, a waste channel to remove waste from the 2nd reaction z... | 11/24/2011 |
| 20110287414 | Systems and methods for identifying a portion of a molecule Techniques for identifying a portion of a molecule are described herein. In one example, multiple electrical measurements associated with a molecule are acquired, wherein each of the multiple electrical measurements corresponds to a discrete position of the molecule wit... | 11/24/2011 |
| 20110281374 | BIOMARKER A method of diagnosing or determining the degree of an arterial aneurysm, especially an abdominal aortic aneurysm, which comprises determining the presence or level of interleukin-1α (IL-1α) in a serum or plasma sample.... | 11/17/2011 |
| 20110280863 | METHODS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF PREECLAMPSIA Methods, kits and compounds are provided that relate to the diagnosis, treatment, and/or prevention of preeclampsia.... | 11/17/2011 |
| 20110281256 | Systems and Methods of Detecting and Demonstrating Hair Damage Via Evaluation of Protein Fragments Embodiments of a method for demonstrating type and/or source of hair damage comprises extracting protein fragments from a hair sample with an aqueous solution, testing the resulting protein fragments with the MALDI-MS test, and then either comparing the results between ... | 11/17/2011 |
| 20110281364 | METHOD AND MARKER FOR DIAGNOSING DIABETES MELLITUS A process for the diagnosis of diabetes mellitus comprising the step of determining the presence or absence or amplitude of at least three polypeptide markers in a urine sample, the polypeptide markers being selected from the markers characterized by the values for the ... | 11/17/2011 |
