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| Application No. | Application Title | Issue Date |
| 20110269151 | CENTRIFUGAL MICRO-FLUIDIC DEVICE AND METHOD FOR IMMUNOASSAY A centrifugal micro-fluidic device and an immunoassay method using the same are provided. The micro-fluidic device includes at least one micro-fluidic structure, the micro-fluidic structure including: a sample chamber receiving a fluid sample; a first reaction chamber w... | 11/03/2011 |
| 20110104826 | CALIBRATION OF FLUIDIC DEVICES The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic... | 05/05/2011 |
| 20100297672 | HIGHLY SENSITIVE SYSTEM AND METHODS FOR ANALYSIS OF TROPONIN The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve releas... | 11/25/2010 |
| 20100292152 | Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases Isolated polynucleotides encoding novel galectin-8 variants polypeptides are provided. Also provided are methods and kits using same for diagnosing prognosing and treating rheumatoid arthritis (RA) and other joint/chronic inflammatory diseases.... | 11/18/2010 |
| 20100209937 | FLUORESCENCE MICROSCOPE IN A MICROWAVE CAVITY The present invention relates to an optical imaging system communicatively connected to a microwave energy producing source wherein the combination provides for increases in chemical reaction times and the ability to monitor the reactions in real time with sufficient re... | 08/19/2010 |
| 20100196360 | NEUTROKINE-ALPHA AND NEUTROKINE-ALPHA SPLICE VARIANT The present invention relates to nucleic acid molecules encoding Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host ... | 08/05/2010 |
| 20100151495 | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective ... | 06/17/2010 |
| 20100136526 | Therapeutic Agent for Neuroblastoma Targeting ARID3b It is intended to provide a therapeutic agent for neuroblastoma. More particularly, it is intended to provide the therapeutic agent for neuroblastoma containing an ARID3b inhibitor.... | 06/03/2010 |
| 20100120018 | Integrated Active Flux Microfluidic Devices and Methods The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting mole... | 05/13/2010 |
| 20100112727 | SINGLE MOLECULE ASSAYS The present invention provides single molecule analyses of species of use in analytical, diagnostic or prognostic assays. In exemplary embodiments, the assays utilize samples prepared by novel methods, affording assays of unexpected sensitivity and robustness. The metho... | 05/06/2010 |
| 20100068827 | Stabilized Standards for Busulfan Immunoassay Use of busulfan amide as stabilized standards in immunoassays for quantifying the amount of busulfan in samples of human biological fluids, methods for carrying out said immunoassay and kits for use in said immunoassay.... | 03/18/2010 |
| 20100055668 | Fluid-Transfer Collection Assembly Including Breakable Vial and Method of Using Same A method of using a fluid transfer and mixing collection assembly includes depressing a flexible member to cause a force to be imparted to a breakable vial to break the vial, releasing the second fluid therein into an interior of the flexible member; releasing the flexi... | 03/04/2010 |
| 20100055130 | STAPHYLOCOCCUS AUREUS PROTEINS AND NUCLEIC ACIDS The invention provides proteins from Staphylococcus aureus, including amino acid sequences and corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies, and as targets for antibiotics.... | 03/04/2010 |
| 20100035758 | METHOD FOR DETECTING ORAL SQUAMOUS-CELL CARCINOMA It is an object to be achieved by the present invention to provide a method for detecting cancer and a cell growth inhibiting agent by the identification of genes exhibiting characteristic behavior in cancers such as oral squamous-cell carcinoma. The present invention p... | 02/11/2010 |
| 20100029017 | Mono-chlorinated hydroxycoumarin conjugates The present invention provides fluorescent biopolymers that are amino acid polymers conjugated to multiple mono-chlorinated 3-carbonyl-7-hydroxy-coumarin dyes, and methods of their use. The fluorescent biopolymers containing multiple mono-chlorinated 3-carbonyl-7-hydrox... | 02/04/2010 |
| 20100015728 | Assay Device and Method A method for detecting an analyte can include binding an analyte with a first reagent which is associated with a magnetic particle, allowing analyte to interact with an excess amount of a second reagent capable of interacting with the analyte, and magnetically separatin... | 01/21/2010 |
| 20100009389 | Method of Making and Using Versatile Positive Controls and Antibody Detection Assays The present invention is in the technical field of ligand-binding assays for detection of antigen-specific antibodies. Specifically a method for preparation of a versatile positive control, components of which can be mixed and matched in numerous combinations to render ... | 01/14/2010 |
| 20090317406 | Phosphorylation of tau by abl Methods of diagnosing a tauopathy and predicting whether a subject will develop a tauopathy are provided. Also provided are antibody preparations that specifically bind to tau phosphorylated at tyr394 and/or tyr310. Methods of inhibiting tau phosphorylation in a cell an... | 12/24/2009 |
| 20090317805 | Proteolytic Markers as Diagnostic Biomarkers for Cancer, Organ Injury and Muscle Rehabilitation/Exercise Overtraining The present invention identifies biomarkers that are diagnostic of nerve cell injury, organ injury, and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the i... | 12/24/2009 |
| 20090297546 | AVIAN-DERIVED ANTIBODY CAPABLE OF BINDING SPECIFICALLY TO HUMAN HMGB1, IMMUNOLOGICAL DETERMINATION METHOD FOR HUMAN HMGB1, AND IMMUNOLOGICAL DETERMINATION REAGENT FOR HUMAN HMGB1 An object of the present invention is to provide an anti-human HMGB1 antibody having high capability of binding to human high mobility group box protein-1 (HMGB1) with a high probability. According to the present invention, a highly sensitive immunoassay method a... | 12/03/2009 |
| 20090280507 | METHOD FOR MEASUREMENT OF SARS VIRUS NUCLEOCAPSID PROTEIN, REAGENT KIT FOR THE MEASUREMENT, TEST DEVICE, MONOCLONAL ANTIBODY DIRECTED AGAINST SARS VIRUS NUCLEOCAPSID PROTEIN, AND HYBRIDOMA CAPABLE OF PRODUCING THE MONOCLONAL ANTIBODY The present invention provides a method for measuring SARS virus nucleocapsid protein (SARS-NP) using first and second antibodies both binding specifically to SARS-NP, wherein the first or second antibody is an antibody recognizing an epitope located in a region (Region... | 11/12/2009 |
| 20090275050 | 14273 receptor, a novel G-protein coupled receptor The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and po... | 11/05/2009 |
| 20090275124 | Methods and Compositions Comprising Anti-Idiotypic Antibodies to Anti-MMP-14 Antibodies Provided are anti-idiotypic antibodies specific for a CDR of an anti-MMP-14 antibody for use as reagents in novel assays for anti-MMP-14 antibodies, pharmaceutical compositions and vaccines.... | 11/05/2009 |
| 20090274699 | UL16 BINDING PROTEIN 4 ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.... | 11/05/2009 |
| 20090274688 | Antibodies to OPGL Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibo... | 11/05/2009 |
| 20090269791 | NON-PROTEOLYTIC METHOD FOR THE DETERMINATION OF ANALYTES IN KERATINIZED STRUCTURES Methods that permit the rapid release of one or more analytes from head or body hair or other keratinized structures of an individual (who may previously have ingested one or more of the analytes) are provided. The methods can include contacting the keratinized structur... | 10/29/2009 |
| 20090269783 | B7-H2 molecules, novel members of the B7 family and uses thereof Novel B7-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length B7-like proteins, the invention further provides isolated B7-like fusion proteins, antigenic peptides, and anti-B7-like antibodies. The invention also pr... | 10/29/2009 |
| 20090258435 | BIOTIN-RECEPTOR REAGENTS FOR SENSITIVITY MODULATION IN ASSAYS Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for... | 10/15/2009 |
| 20090258442 | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective ... | 10/15/2009 |
| 20090238832 | Novel compositions and method for the treatment of psoriasis The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of psoriasis.... | 09/24/2009 |
| 20090232797 | PLASMODIUM MALARIAE AND PLASMODIUM OVALE GENES AND USES THEREOF The subject invention relates to nucleic acid sequences and amino acid sequences encoded thereby, derived from the Merozoite Surface Protein (MSP1) gene of the Plasmodium species P. malariae and P. ovale. Such genes and proteins have many beneficial... | 09/17/2009 |
| 20090226416 | Human G-Protein Chemokine Receptor (CCR5) HDGNR10 The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HD... | 09/10/2009 |
| 20090227692 | Biomarkers for breast cancer The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as breast cancer or non-breast can... | 09/10/2009 |
| 20090221481 | STIMULATORY AUTO-ANTIBODIES TO THE PDGF RECEPTORS AS PATHOLOGY MARKER AND THERAPEUTIC TARGET An in vitro method for detecting the presence in a body sample of auto-antibodies for the PDGF receptor suitable for the diagnosis and prognosis of autoimmune diseases, in particular the systemic sclero-is and related diagnostic kits. Use of an inhibitor of ROS and/or R... | 09/03/2009 |
| 20090220991 | Reagents for the detection of protein phosphorylation in leukemia signaling pathways The invention discloses nearly 480 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective d... | 09/03/2009 |
| 20090221478 | Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases Isolated polynucleotides encoding novel galectin-8 variants polypeptides are provided. Also provided are methods and kits using same for diagnosing prognosing and treating rheumatoid arthritis (RA) and other joint/chronic inflammatory diseases.... | 09/03/2009 |
| 20090221430 | Proteomic Methods For The Identification And Use Of Putative Biomarkers Associated With The Dysplastic State In Cervical Cells Or Other Cell Types The invention relates to methods for detecting and identifying potential biomarkers of high-grade cervical dysplasia in an individual human subject. The invention also relates to newly discovered biomarkers, as set forth in Tables 1-4 herein, which are associated with t... | 09/03/2009 |
| 20090214535 | Pharmaceutical Compositions Containing sc(Fv)2 The present inventor discovered stabilizing agents/stabilizing conditions for suppressing isomerization reactions of sc(Fv)2. It was also discovered that the above-mentioned isomerization reactions can be suppressed through use of freeze-dried formulations. As disclosed... | 08/27/2009 |
| 20090214536 | CACNA1E in Cancer Diagnosis, Detection and Treatment This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the CACNA1E gene or proteins encoded by this gene. The invention also provides meth... | 08/27/2009 |
| 20090208510 | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins A method of producing a metalloprotein inhibitor, the method comprising generating antibodies directed at a composition including a metal ion-bound chelator, wherein the composition is selected having structural and electronic properties similar to a functional domain o... | 08/20/2009 |
