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| Application No. | Application Title | Issue Date |
| 20120129272 | LATERAL FLOW ASSAY SYSTEMS AND METHODS In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed f... | 05/24/2012 |
| 20120107954 | PHYSIOLOGIC SAMPLE PREPARATION FOR NANOSENSORS The present invention provides a microfluidic purification chip for capturing a biomarker from a physiological solution. The present invention also provides a method of capturing and releasing a biomarker, wherein the biomarker is originally in a physiological solution.... | 05/03/2012 |
| 20120108461 | HIGH-THROUGHPUT SLIDE PROCESSING APPARATUS An assay device and method of use thereof includes a sample tray comprising a plurality of sample wells having a first volume, and a slide tray comprising a slide, and a liquid dispenser. The slide comprises a plurality of reaction sites on a bottom surface of the slide... | 05/03/2012 |
| 20120052597 | RECOGNIZABLE CARRIER FOR OPTICAL MEASUREMENT METHODS The invention relates to a recognizable carrier for determining physical, chemical or biochemical interactions by means of optical measurement methods. The carrier comprises a surface that defines a substrate surface and that has a base layer coated with reactive elemen... | 03/01/2012 |
| 20120040373 | Integrated Diagnosis of Heparin-Induced Thrombocytopenia Disclosed are methods for the early detection of heparin-induced thrombocytopenia comprising the quantitative detection of chemokine platelet factor-heparin complexes, autoantibodies to such complexes, and platelet activation. Also disclosed are assays to detect the pro... | 02/16/2012 |
| 20120021443 | DIRECTIONAL SURFACE PLASMON COUPLED FLUORESCENCE AND CHEMILUMINESCENCE FROM THIN FILMS OF NICKEL, IRON OR PALLADIUM AND USES THEREOF Nickel, iron and palladium thin films thermally evaporated onto glass supports are used to demonstrate surface plasmon coupled fluorescence (SPCF) and surface plasmon couple chemiluminescence (SPCC) over a broad wavelength range (400-800 nm) for potential assays or othe... | 01/26/2012 |
| 20120015451 | FLUID SENSOR PREVENTING GENERATION OF AIR BUBBLES Provided herein is a fluid sensor, which includes a closed reaction unit in which reaction of a fluid sample takes place. The reaction unit is tapered on a side through which the fluid is injected so as to prevent generation of air bubbles during the injection of the fl... | 01/19/2012 |
| 20120003756 | CHROMATOGRAPHIC ASSAY SYSTEM The present application discloses an analyte detection apparatus having at least one reservoir area and a wicking membrane, wherein a labeled specific binding partner is impregnated on the reservoir area; and a region on the wicking membrane where at least one chemical ... | 01/05/2012 |
| 20110262919 | METHOD FOR PRETREATING SPECIMEN AND METHOD FOR ASSAYING BIOLOGICAL SUBSTANCE On magnetic particles serving as a first support, an antibody against a nonspecific reaction factor is immobilized. These magnetic particles are mixed with a specimen and suspended therein. After suspending, the suspension is sucked up into a pipette chip and a magnet c... | 10/27/2011 |
| 20110263048 | INSOLUBLE CARRIER FOR USE IN ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, ANTI-PHOSPHOLIPID ANTIBODY MEASUREMENT REAGENT, AND METHOD FOR MEASURING ANTI-PHOSPHOLIPID ANTIBODY The present invention has an object to provide an insoluble carrier for an antiphospholipid antibody detection reagent having a high reactivity. The present invention also has an object to provide an antiphospholipid antibody detection reagent, and a method of detecting... | 10/27/2011 |
| 20110250616 | ELECTROACTIVE SURFACE-CONFINABLE MOLECULES The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents tha... | 10/13/2011 |
| 20110250705 | NANOPORE CAPTURE SYSTEM A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture me... | 10/13/2011 |
| 20110244598 | Test Element Having Combined Control and Calibration Zone A test element, for example in the form of an immunological test strip functioning according to the sandwich principle, for the fluorophoric detection of one or more analytes in a sample comprising an analyte detection zone and a combined control and calibration zone. T... | 10/06/2011 |
| 20110244597 | IMMUNOCHROMATOGRAPHIC MEDIUM AND IMMUNOCHROMATOGRAPHIC METHOD Disclosed are an immunochromatographic medium and an immunochromatographic method in which, even when plural items exceeding four items are detected which are the number of colors that can be detected by colored latex particles, the plural items can be detected and quan... | 10/06/2011 |
| 20110244596 | PULSED MAGNETIC ACTUATION FOR SENSITIVE ASSAYS A method for controlling the movement of magnetic or magnetizable objects (10) in a biosensor cartridge. The method comprises the step of providing a biosensor cartridge with a laterally extending sensor surface (A) and at least a magnetic field generating means ... | 10/06/2011 |
| 20110244494 | REAGENTS, METHODS AND KITS FOR THE UNIVERSAL RAPID IMMUNO-DETECTION Novel immuno-detection methods, kits and reagents are provided. The Combination of this invention, combining at least two of the following reagents of a Non-specific Competitor, a Specific Indicator, a primary antibody and an antigen, provides a faster and easier method... | 10/06/2011 |
| 20110236999 | Hydrogel Nanoparticle Based Immunoassay An immunoassay device incorporating porous polymeric capture nanoparticles within either the sample collection vessel or pre-impregnated into a porous substratum within fluid flow path of the analytical device is presented. This incorporation of capture particles within... | 09/29/2011 |
| 20110236879 | METHODS AND COMPOSITIONS FOR ANALYTE DETECTION The present invention is directed to methods and apparatus for detection of one or more analytes. Analytes include agents or components of infectious agents such as pathogenic virus, as well as enzymes, proteins and biomarkers.... | 09/29/2011 |
| 20110236998 | METHODS AND DEVICES FOR DETECTION OF ANALYTES USING BLOCH SURFACE WAVE-ENHANCED DIFFRACTION-BASED SENSORS The invention features methods and diffraction-based devices for the detection of specific analytes. The devices of the invention contain a periodic dielectric multilayer, which allows for the propagation of Bloch surface waves (BSWs) at the surface of the multilayer, t... | 09/29/2011 |
| 20110236884 | MICROBUBBLES FOR AFFINITY SEPARATION The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity mol... | 09/29/2011 |
| 20110237000 | Method for detecting an analyte molecule The invention relates to a method for detecting the presence or amount of an analyte, said method comprising (a) coupling the analyte to a carrier molecule, wherein the carrier molecule is larger in size, electrically charged and/or polar, to form an analyte:carrier mol... | 09/29/2011 |
| 20110229887 | DETECTION OF NUCLEIC ACID AMPLIFICATION PRODUCTS IN THE PRESENCE OF AN INTERNAL CONTROL SEQUENCE ON AN IMMUNOCHROMATOGRAPHIC STRIP Compositions and methods useful in nucleic acid assays are provided. The invention permits detection of test and control nucleic acids. Test nucleic acids can be immobilized at multiple locations, such that amplification of either a test nucleic acid or a control nuclei... | 09/22/2011 |
| 20110223690 | ASSAY The present invention provides an assay kit for detecting an analyte of interest in a sample. The kit comprises a) a reporter species; b) a labelled species having first and second binding regions, wherein the first binding region is capable of binding to the analyte of... | 09/15/2011 |
| 20110207233 | METHOD FOR MEASURING INHIBITORY ACTIVITY ON LIGAND-RECEPTOR BINDING A method for measuring the presence or absence and/or strength of the inhibitory activity of a test substance on binding between a ligand and a receptor thereof, which comprises the following steps (1) to (3): (1) immobilizing either of the... | 08/25/2011 |
| 20110207237 | OPTICAL FIBER PROBE A biosensor having an optical fiber having at least one curved portion configured to enhance penetration of evanescent waves; and one or more nanoparticles associated with the optical fiber, and configured to enhance localized surface plasmon resonance.... | 08/25/2011 |
| 20110207238 | BIOLOGICAL SUBSTANCE ANALYZING METHOD, AND BIOLOGICAL SUBSTANCE ANALYZING CELL, BIOLOGICAL SUBSTANCE ANALYZING CHIP, AND BIOLOGICAL SUBSTANCE ANALYZING APPARATUS EMPLOYED IN THE BIOLOGICAL SUBSTANCE ANALYZING METHOD Detection of detection target substances at a sensor portion is expedited and the efficiency thereof is improved in biological substance analysis, to enable accelerated analysis with high sensitivity. A biological substance analyzing cell equipped with a reaction chambe... | 08/25/2011 |
| 20110201132 | Optical Detection of Label-Free Biomolecular Interactions using Microreplicated Plastic Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.... | 08/18/2011 |
| 20110200986 | BIO-ASSAY USING LIQUID CRYSTALS There is provided a method, an in vitro method and a detection system for detecting the presence of at least one biological molecule in at least one sample. The method can include, for example, providing a sample and/or a binding agent to a contact portion of a surface ... | 08/18/2011 |
| 20110195526 | Thermo-probes, methods of making thermo-probes, and methods of detection using thermo-probes Embodiments of the present disclosure provide for thermo-probes (also referred to herein as “probes”), particles including a plurality of probes, methods of making thermo-probes or particles, thermo-probe complexes, method of making thermo-probe complexes, methods o... | 08/11/2011 |
| 20110195527 | METHODS AND DEVICES FOR ANALYTE DETECTION Methods and apparatus are provided to resolve analytes within a fluid path using isoelectric focusing, gel electrophoresis, or other separation means. Materials within the fluid path that are compatible with these separation means are used to attach resolved analytes to... | 08/11/2011 |
| 20110195126 | PEPTIDE-COATED NANOPARTICLES WITH GRADED SHELL COMPOSITIONS A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The n... | 08/11/2011 |
| 20110183439 | STRUCTURES INCORPORATING CONFORMATIONALLY FLEXIBLE CONJUGATED POLYMERS AND METHODS OF USE Methods, compositions and articles of manufacture involving conformationally flexible conjugated polymers are provided. A structure is provided comprising the conformationally flexible conjugated polymer bound to or associated with at least one member of a binding pair ... | 07/28/2011 |
| 20110183357 | DEVICE AND METHODS FOR LIQUID CRYSTAL-BASED BIOAGENT DETECTION The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presen... | 07/28/2011 |
| 20110177619 | IN VITRO DIAGNOSTIC MARKERS COMPRISING CARBON NANOPARTICLES AND KITS This invention relates to luminescent markers for in vitro diagnostic applications, and kits using those markers. In some embodiments, those markers comprise luminescent carbon nanoparticles. Some embodiments provide a method for investigating an analyte comprising corr... | 07/21/2011 |
| 20110177620 | BIOANALYTICAL ASSAY A nanoparticle having a detectible feature and whose diameter is less than 200 nm, and which is coated with multiple specific binding reactants such that the affinity constant of the nanoparticle towards an analyte exceeds that of free binding reactant towards the analy... | 07/21/2011 |
| 20110171754 | ANALYSIS SYSTEM An analysis system comprises a sampling cartridge (11) comprising a housing (21, 22) having an inlet (23) for receiving a fluid sample, a sensor (26, 45), and a guide (40, 42) extending between the inlet and the sensor for guiding samp... | 07/14/2011 |
| 20110160074 | Capture Ligand Controls, Blocking Probes, Masking Probes and Methods of Using the Same The invention, depending on aspect and embodiment, relates to capture probe controls, and capture and signal probe configurations and combinations of configurations that can facilitate accurate and efficient multiplex analyte detection, especially in electrochemical det... | 06/30/2011 |
| 20110151585 | DUAL INLET MICROCHANNEL DEVICE AND METHOD FOR USING SAME A dual inlet microchannel device and a method for using the device to perform a flow-through kinetic assay are described. A microplate having an array of the dual inlet microchannel devices and in particular their specially configured flow chambers is also described. Se... | 06/23/2011 |
| 20110151584 | Dual Path Immunoassay Device The systems of the invention include test cells with a first sorbent material defining a first flow path for a solution, a second sorbent material defining a second flow path distinct from the first flow path for a sample, and a test site with immobilized antigens or an... | 06/23/2011 |
| 20110151481 | BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.... | 06/23/2011 |
