Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Application No. | Application Title | Issue Date |
| 20120082667 | Antibodies That Specifically Bind To A Beta Oligomers And Use Thereof The present inventors successfully produced monoclonal antibodies that are specific to only soluble A beta oligomers, but do not recognize soluble A beta monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therap... | 04/05/2012 |
| 20120082676 | METHODS FOR PREVENTING AND TREATING ANGIOEDEMA One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R... | 04/05/2012 |
| 20120045782 | IMATINIB IMMUNOASSAY Novel conjugates and immunogens derived from imatinib and monoclonal antibodies generated by these immunogens are useful in immunoassays for the quantification and monitoring of imatinib or its pharmacologically active salts in biological fluids.... | 02/23/2012 |
| 20120034631 | ANTI-LYSOPHOSPHOLIPID ANTIBODY DESIGN USING ANTIBODY STRUCTURES The present invention provides crystalline forms of an anti-LPA antibody or fragment thereof, which may further comprise a lipid ligand of said antibody and/or salts, metals, or co-factors. Methods for making such crystals and co-crystals are provided, as are methods of... | 02/09/2012 |
| 20120034632 | TWO-PHASE OPTICAL ASSAYS FOR ANALYTES OF NO INTRINSIC OPITCAL CONTRAST Methods and kits for performing a two-phase optical assay for one or more than one analyte without intrinsic optical contrast in a sample are disclosed. The method requires use of a functionalized microparticle immobilized with two or more than functional components and... | 02/09/2012 |
| 20120034604 | USE OF BASIC PROLIN-RICH LACRIMAL GENE PRODUCTS, SUCH AS OPIORPHIN, AS A BIOMARKER The present invention relates to the use of Basic Prolin-rich Lacrimal protein (BPLP) gene products, such as Opiorphin, for establishing a prognosis, a diagnosis or the monitoring of a pathological state or of treatment efficacy in a subject and the related method of us... | 02/09/2012 |
| 20120009211 | BIMER OR AN OLIGOMER OF A DIMER, TRIMER, QUADROMER OR PENTAMER OF RECOMBINANT FUSION PROTEINS The invention relates to oligomers of a dimer, trimer, quatromer or pentamer of recombinant fusion proteins. Said oligomers are characterized in that the recombinant fusion proteins have at least one component A and at least one component B, whereby component A contains... | 01/12/2012 |
| 20120009608 | BIOMARKER FOR THE MONITORING AND PROGNOSIS OF CHRONIC MYELOPROLIFERATIVE DISORDERS The invention provides a method for monitoring the progression of a myeloproliferative disease, particularly Polycythemia Vera (PV) and Essential Thrombocythemia (ET), or the response to pharmacological treatment with JAK2 inhibitors in a patient diagnosed positive for ... | 01/12/2012 |
| 20110318765 | METHOD FOR PRE-TREATING SAMPLE CONTAINING GLYCATED HEMOGLOBIN There are provided a pre-treatment technique for a glycated hemoglobin-containing sample, which is a simple and convenient treatment, is free from problems in storage stability and environmental aspects, and is capable of exposing an epitope sufficiently in a short time... | 12/29/2011 |
| 20110311989 | ANTIBODY TO N-TERMINAL REGION OF HEMOGLOBIN BETA-CHAIN Provided is a general-purpose technique capable of measuring the HbA1c content, which is comparable to the IFCC reference method. An antibody which reacts with a peptide or a protein having an amino acid sequence of VHLTPE (SEQ ID NO: 1) at the N-terminus in which the N... | 12/22/2011 |
| 20110306070 | MAGNETIC BEADS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample with magnetic sacrificial beads opsonized to leukocytes, binding leukocytes... | 12/15/2011 |
| 20110275536 | BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF ACUTE HEART FAILURE AND USES THEREOF The application discloses Quiescin Q6 as a new biomarker for acute heart failure; methods for predicting, diagnosing and/or prognosticating acute heart failure based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said me... | 11/10/2011 |
| 20110269159 | REAGENTS FOR REDUCING LEUKOCYTE INTERFERENCE IN IMMUNOASSAYS Methods and devices for reducing interference from leukocytes in an analyte immunoassay are provided. In one embodiment, a method is provided comprising the steps of amending a biological sample such as a whole blood sample with one or more leukocidal reagents that redu... | 11/03/2011 |
| 20110256147 | DIAGNOSTIC AND TREATMENT METHODS FOR CANCER BASED ON IMMUNE INHIBITORS Methods of diagnosis and treatment of malignant tumors, in particular ovarian tumors, using GD3 and GD3 inhibitors. Also provided are methods of modulating the immune system of a mammal by the administration of a GD3 and GD3 inhibitors.... | 10/20/2011 |
| 20110245342 | 3,5,3'-TRIIODOTHYRONINE SULFATE AS THYROMIMETIC AGENT AND PHARMACEUTICAL FORMULATIONS THEREOF The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxin... | 10/06/2011 |
| 20110223624 | IMMUNOASSAY FOR DETECTION OF NEUROTOXIC AMINO ACID ASSOCIATED WITH NEUROLOGICAL DISORDERS An immunoassay for screening a sample to detect the presence of β-N-methylamino-L-alanine (BMAA) is disclosed. Antibodies specific for BMAA are disclosed. Antibodies that bind to BMAA on immunoblots are disclosed. Immunoassays and kits to detect the presence of BMAA in... | 09/15/2011 |
| 20110212853 | NOVEL DIAGNOSTIC METHOD A method of monitoring treatment of an inflammatory disease or an inflammatory associated disease with the use of the ratio of N-terminal pyroglutamate modified MCP-1 (MCP-1 N1pE):total concentration of MCP-1 within a biological sample as a biomarker, and a method for d... | 09/01/2011 |
| 20110177537 | Method and System for Measuring a Sample to Determine the Presence of and Optionally Treat a Pathologic Condition The present invention provides diagnostic in vitro methods as well as kits and devices to be used in the methods of the present invention for diagnosis or prognosis of a pathologic condition characterized by the presence/absence of an endogenous hormone and/or hormone a... | 07/21/2011 |
| 20110124020 | Methods for Detecting Antibodies Methods for detection of any antibody utilizing a standardized approach applicable to any antibody which provides highly specific assays specific for individual or multiple antibodies. The methods enable improved pharmacokinetic analysis during development and clinical ... | 05/26/2011 |
| 20110076702 | RECOMBINANT 12-KDA PROTEIN USEFUL FOR THE DETECTION OF RESPIRATORY ALLERGIES The present invention discloses the detection of an important 12K-Da protein having cross-reactivity amongst different prevalent allergenic grasses and fungi can be useful for detection of respiratory allergies. Conventionally, the whole extracts that are used for diagn... | 03/31/2011 |
| 20110076703 | CONCENTRATION ASSAY A method of determining the concentration of at least one analyte in a plurality of samples by sequentially subjecting each sample to an analysis cycle comprises contacting the sample or a sample-derived solution with a sensor surface supporting a species capable of spe... | 03/31/2011 |
| 20110065135 | LIPOSOME COMPOSITION, ITS PRODUCTION PROCESS, AND METHOD FOR ANALYZING ANALYTE USING THE SAME A liposome composition capable of including a chemical substance such as an electrochemiluminescent substance in an internal aqueous phase of the liposome at a higher concentration, and a production method thereof, as well as an analytical method of an analyte that enab... | 03/17/2011 |
| 20110059858 | NEW BIOMARKER FOR DIAGNOSIS, PREDICTION AND/OR PROGNOSIS OF SEPSIS AND USES THEREOF The present invention provides kits and methods for the diagnosis, prognosis and prediction of sepsis in a subject using the expression level of the TREML-1 biomarker as an indication of the condition of the patient, alone or in combination with further sepsis markers.... | 03/10/2011 |
| 20110015087 | DETECTION OF ENDOMETRIAL SECRETION MARKERS FOR ASSESSMENT OF ENDOMETRIOSIS The present invention refers to a group of biomarkers and to non-invasive in vitro methods for the diagnosis or prognosis of endometriosis, as well as to a kit to perform said methods.... | 01/20/2011 |
| 20100323377 | BIOCHEMICAL MARKERS FOR CVD RISK ASSESSMENT A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said... | 12/23/2010 |
| 20100267063 | METHODS AND APPARATUSES FOR CONDUCTING ASSAYS Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and sys... | 10/21/2010 |
| 20100248272 | Method for identifying Smk box riboswitch modulating compounds The invention is directed, inter alia, to a method for identifying a compound that modulates a gene expression of an mRNA molecule containing a SMK box riboswitch that contains a SAM binding pocket, wherein the mRNA molecule is produced by a lactic acid bacte... | 09/30/2010 |
| 20100190192 | METHOD OF DIAGNOSING PRE-ECLAMPSIA The present invention relates to a marker for the development of pre-eclampsia. In particular the invention provides a marker for the development of pre-eclampsia, which marker consists of a polypeptide of approximately 26.6 Kd as determined by 15-30% gradient SDS-PAGE ... | 07/29/2010 |
| 20100172833 | METHODS AND COMPOSITIONS FOR DIAGNOSING HEPATOCELLULAR CARCINOMA Methods for the diagnosis of hepatocellular carcinoma (HCC) are set forth. Improved assay methods and scanning methods are included that employ non-cell-associated and cell-associated HCC related proteins. Such methods are based upon the discovery of genes that were up-... | 07/08/2010 |
| 20100172837 | MN Gene and Protein A new gene—MN—and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and recombinant proteins are provided. Expression of the MN gene is disclosed as being associated with tumorigenicity,... | 07/08/2010 |
| 20100159491 | H-FABP AS EARLY PREDICTOR OF MYOCARDIAL INFARCTION The present invention relates to a method for diagnosing myocardial infarction in a subject who suffers from acute coronary syndrome and has a cardiac troponin level which is detectable but lower than the level that is considered as being indicative for a myocardial inf... | 06/24/2010 |
| 20100136590 | Method of Determining NT-proBNP The invention relates to a method of determining equine NT-proBNP, or fragments thereof, comprising the steps of: providing an equine sample, contacting the sample with at least one antibody which specifically binds to equine NT-proBNP, and determining the presence and/... | 06/03/2010 |
| 20100112610 | Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresis... | 05/06/2010 |
| 20100112609 | Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to botulinum toxin therapy in an individual, methods of treating immunoresis... | 05/06/2010 |
| 20100075348 | METHOD FOR DIAGNOSIS OF A DISEASE INVOLVING AN ANTI-ENDOTHELIN-RECEPTOR ANTIBODY The invention relates to a method for diagnosis of a disease, wherein presence or absence of an anti-endothelin-receptor antibody is determined in a sample from a patient to be diagnosed more in particular an anti-endothelin-receptor-A antibody. The disease according to... | 03/25/2010 |
| 20100047831 | DIAGNOSIS OF ANTHRAX INFECTION BY DETECTION OF CAPSULAR ANTIGEN IN URINE The present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum, urine, or other biological samples.... | 02/25/2010 |
| 20100035870 | Pyrimidin-4-yl-3, 4-Dihydro-2H-Pyrrolo[1,2A] Pyrazin-1-one Compounds The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein Z is NR11, NHCO, NHSO2, NHCH2, CH2, CH2CH2, or CH═CH; X is a hydrocarbyl group optionally... | 02/11/2010 |
| 20100021496 | METHODS, KITS, AND ANTIBODIES FOR QUANTITATIVE DETERMINATION OF PARATHYROID HORMONE MOLECULES WITH INTACT C-TERMINUS The present invention relates to novel methods and compositions useful for detecting whole parathyroid hormone at a physiological level and C-terminal parathyroid fragments in a mammalian sample. Such detections may be useful to different parathyroid diseases or disorde... | 01/28/2010 |
| 20100010009 | Furo[3,2-B] pyrrol -3-one derivatives and their use as cysteinyl porteinase inhibitors The present invention relates to compounds of formula (1), and pharmaceutically acceptable salts thereof, A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or pro-drug thereof (I), wherein: one of R1 and R2 is H, an... | 01/14/2010 |
| 20090317844 | DIAGNOSTIC TEST FOR HEPATOCELLULAR CARCINOMA A diagnostic test for hepatocellular carcinoma is based on increases in the concentration of two biochemical markers in a biological sample, alpha-1-acid glycoprotein (AAG) or isoforms thereof and alpha-fetoprotein (AFP) or glycoforms thereof. Levels of these markers ma... | 12/24/2009 |
