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| Application No. | Application Title | Issue Date |
| 20120129194 | Visible Detection of Microorganisms Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the abs... | 05/24/2012 |
| 20120070382 | FLUORESCENT CONJUGATED POLYMERS WITH A BODIPY-BASED BACKBONE AND USES THEREOF The present invention provides various fluorescent conjugated polymers with a BODIPY-based backbone. The invention also provides methods of using the polymers of the invention, such as for imaging and detection of cells, tumors, bacteria and viruses.... | 03/22/2012 |
| 20120034617 | ASSAYS FOR BACTERIAL DETECTION AND IDENTIFICATION The invention herein generally relates to kits and methods for detecting the presence of a bacterium in a subject, for example, methicillin resistant S. aureus. In certain embodiments, the invention provides a method of detecting presence of a bacterium in a samp... | 02/09/2012 |
| 20120003661 | METHODS AND DEVICES FOR THE SELECTIVE DETECTION OF MICROORGANISMS Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabiliz... | 01/05/2012 |
| 20110311993 | DEVICE FOR DETECTION OF ANTIGENS AND USES THEREOF Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.... | 12/22/2011 |
| 20110306574 | INHIBITORS OF F18+ E COLI BINDING The present invention relates to blood group A/B/H determinant on Type 1 Core glycosphingolipids chains as recognition point for the FedF protein of F18-fimbriated Enterotoxigenic and verotoxinogenic Escherichia coli and the use of compounds comprising such deter... | 12/15/2011 |
| 20110183316 | METHODS FOR DETECTING ORGANISMS AND ENZYMATIC REACTIONS USING RAMAN SPECTROSCOPY The present disclosure provides systems for the rapid and sensitive detection of organisms and molecules in samples. Reactants that produce Raman-active products are used in combination with Raman light scattering. The present disclosure can also be used to measure enzy... | 07/28/2011 |
| 20110165555 | Capillary-Column-Based Bioseparator/Bioreactor with an Optical/Electrochemical Detector for Detection of Microbial Pathogens The present invention is directed to satisfying the need to detect microbial contamination of food products. The described bioseparator/bioreactor coupled with an optical/electrochemical biosensor was able to specifically detect E. coli O157:H7 from 8.8×101... | 07/07/2011 |
| 20110097745 | Method For Detecting Microbes The invention provides means and methods for determining the presence of infecting microbes in a liquid. The method comprises steps of introducing the liquid to the sample container of a microbial analyzer, the sample container further containing nutrients. Other steps ... | 04/28/2011 |
| 20110039267 | Sample Preparation And Detection Of Analytes Using Silica Beads This invention provides methods for concentration of analyte from biological sample, or various liquid samples and methods for identification of the analyte. The method includes providing silica beads conjugated with analyte recognition element for concentration of anal... | 02/17/2011 |
| 20110020240 | Use of bacterial beta-lactamase for in vitro diagnostics and in vivo imaging, diagnostics and therapeutics Provided herein are imaging methods for detecting, diagnosing and imaging pathogenic bacteria or a pathophysiological condition associated therewith using fluorogenic substrates for bacterial enzymes. Fluorescent, luminescent or colorimetric signals emitted by substrate... | 01/27/2011 |
| 20110008801 | METHODS FOR MEASURING CELL-CELL OR CELL-MATRIX ADHESIVE FORCES AND COMPOUNDS FOR DISRUPTING ADHESIVE FORCES IN BIOLOGICAL SYSTEMS The invention provides an atomic force microscope-based bioassay, assisted by thermodynamic characterizations to quickly and accurately screen for compounds that disrupt cell-cell or cell-substrate interactions.... | 01/13/2011 |
| 20110008449 | Human Specific Escherichia Coli Strains The present invention relates to human specific Escherichia coli strains.... | 01/13/2011 |
| 20100297677 | CYCOCHROME C SYNTHESIS INHIBITORS The invention provides methods for identifying a compound that inhibits cytochrome c synthesis. This invention further provides a method for the high throughput screening of compounds that inhibit cytochrome c synthesis.... | 11/25/2010 |
| 20100279322 | Direct detection of intracellular fluorescently tagged cells in solution A method of detecting target cells and pathogens in a test sample concentrates to target cells in solution by filtering or capturing the target cells on a solid support. The target cells are tagged with a fluorescent dye and dispersed in a solution or suspension. The re... | 11/04/2010 |
| 20100222268 | ANTIBIOTIC PEPTIDES This invention concerns novel antibiotic peptide and peptide derivates, especially for use in medicine. Further, the invention relates to compositions and methods for killing microbes, like bacteria or fungus, and methods to treat microbial infections. The invention fur... | 09/02/2010 |
| 20100120073 | METHODS AND DEVICES FOR DETECTING ORGANISMS CAUSING URINARY TRACT INFECTIONS The invention provides for devices and methods for detecting an organism causing a urinary tract infection. In a preferred embodiment, detecting the organism causing a urinary tract infection follows a preliminary indication of a urinary tract infection by a urinary mon... | 05/13/2010 |
| 20100105082 | RAPID DETECTION NANOSENSORS FOR BIOLOGICAL PATHOGENS An assay test solution, a method for using, and an apparatus for the rapid detection of multiple pathogens using a FRET-based phenomenon. A volume of fluid, possibly containing pathogens, is passed through an intake and combined with an assay solution of quantum dot/ant... | 04/29/2010 |
| 20100055721 | Surface Enhanced Raman Scattering and Multiplexed Diagnostic Assays Multiplexed lateral flow assays, related methods, and devices are disclosed which are capable of simultaneously detecting multiple analytes. The assays are preferably immunoassays and can be multiplexed spatially, spectrally, and both spatially and spectrally. Multiplex... | 03/04/2010 |
| 20100035234 | VACCINE ASSAYS The present invention is directed to methods, assays and compositions for implementing such methods and assays for assessing efficacy of individual components in multi-component vaccines and for assessing efficacy of a vaccine against a pathogen. In one aspect, the meth... | 02/11/2010 |
| 20090269788 | METHOD FOR DETECTING MICROORGANISM A method for detecting a microorganism in a sample containing or suspected of containing said microorganism, said method comprising: i) contacting said sample with a binding agent for said microorganism, wherein the binding agent is immobilised on a support, and allowin... | 10/29/2009 |
| 20090232852 | USE OF OUTER MEMBRANE PROTEIN A (OMPA) IN TREATMENT/PREVENTION/DIAGNOSIS OF INFECTIONS CAUSED BY KLEBSIELLA PNEUMONIAE AND OTHER GRAM-NEGATIVE BACTERIA The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effectiv... | 09/17/2009 |
| 20090226890 | ASSAYS AND SYSTEMS FOR RAPID DETECTION OF PATHOGENS Assay systems and methods are provided for detecting a target pathogen, such as a microorganism (e.g., bacterium, bacterial toxin) which may be present in a fluid or other location. The method can include linking a magnetic microparticle to a first epitope of the target... | 09/10/2009 |
| 20090220952 | Compositions And Methods For Analyzing Protein Interactions The present invention relates to compositions and methods for analyzing and modulating (e.g., enhancing or inhibiting) protein-protein interactions. In particular, compositions and methods of the present invention find use in identifying, reconstituting and characterizi... | 09/03/2009 |
| 20090208501 | Anti-Pathogen Immunoadhesins Chimeric molecules that include a pathogen recognition module derived from a pathogen binding domain of a pathogen recognition protein, e.g., a toll-like receptor (TLR), CD14, BPI, MD-2, scavenger receptors (SRs), surfactant proteins (SP), C-reactive protein (CRP), Mann... | 08/20/2009 |
| 20090162833 | TEST DEVICE FOR RAPID DIAGNOSTICS Devices for detecting analytes or analogues thereof in a biological sample are disclosed. The device includes a solid support. The solid support has several juxtaposed zones. The sample is able to migrate from a sample receiving zone towards a detection zone. The analyt... | 06/25/2009 |
| 20090136936 | IMMUNOGLOBULIN FC LIBRARIES Methods and composition for the screening and isolation of aglycosylated antibody Fc domain polypeptides. For example, in certain aspects methods for identifying aglycosylated Fc domains that bind to Fc receptors or preferentially bind to particular Fc receptors are des... | 05/28/2009 |
| 20090123921 | IMMUNOGLOBULIN LIBRARIES Methods and compositions for the screening and isolation of ligand-binding polypeptides, such as antibodies. In some aspects, methods of the invention enable the isolation of intact soluble antibodies comprising a constant domain. Screening methods that employ genetic p... | 05/14/2009 |
| 20080293080 | ACTIVE IMMUNIZATION USING A SIDEROPHORE RECEPTOR PROTEIN The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain o... | 11/27/2008 |
| 20080279874 | COMPOSITIONS AND METHODS FOR MODULATION OF PLK1 KINASE ACTIVITY Described are compositions and methods for activating a Plk1 protein as well as phospho-specific anti-Myt1 antibodies that can be used to detect phosphorylation of Myt1. Activated Plk1 protein, phospho-specific anti-Myt1 antibodies, and/or Plk1 substrates can be used in... | 11/13/2008 |
| 20070275397 | Detection of molecular interactions using a reduced affinity enzyme complementation reporter system Methods and compositions for detecting molecular interactions are provided. Aspects of the invention include the use of a reduced affinity enzyme complementation reporter system. Also provided are systems and kits for use in practicing embodiments of the methods. ... | 11/29/2007 |
| 20070218518 | Host Receptor for Pathogenic Bacteria A polypeptide, called Tir (for translocated intimin receptor, which is secreted by attaching and effacing pathogens, such as the enteropathogenic (EPEC) and enterohemorrhagic (EHEC) E. coli. These bacterial pathogens inserts their own receptors into mammalian cel... | 09/20/2007 |