Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Application No. | Application Title | Issue Date |
| 20120128680 | BIOMARKER ANTIBODY AND DIAGNOSIS DEVICE FOR DETECTING CERTAIN AUTOIMMUNE DISEASES Antibodies which specifically bind to a peptide having the sequence Ala-Ala-Ala-Pro-Ala-Lys-Ala-Ala-Ala-Ala-Pro-Ala-Lys-Thr-Ala-Ala-Ala-Pro-Val (SEQ ID No1), and which are not induced in a host following an infection of the host with T. cruzi. ... | 05/24/2012 |
| 20120129157 | Methods and Devices for Rapid Detection and Identification of Live Microorganisms by Aptamers and/or Antibodies Immobilized on Permeable Membranes The invention provides methods, devices and kits for rapid detection and identification of one or more live target microorganisms in a liquid sample or grown on plates containing nutrient media. The invention includes mixing one or more target microorganisms with one or... | 05/24/2012 |
| 20120129194 | Visible Detection of Microorganisms Methods of detecting very low levels of targets, such as cells, are provided. In some embodiments, for example, the methods can detect bacteria present in a sample at concentrations less than 25 cells/mL. The method involves detecting nanoparticle aggregation in the abs... | 05/24/2012 |
| 20120107839 | NMR DEVICE FOR DETECTION OF ANALYTES This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a tar... | 05/03/2012 |
| 20120070846 | METHODS FOR DETECTING MOLECULE-MOLECULE INTERACTIONS WITH A SINGLE DETECTION CHANNEL A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels.... | 03/22/2012 |
| 20120070850 | Method for detecting microorganisms and microorganism detecting apparatus It is possible to determine the presence of bacteria in a sample solution in a shorter period of time without changing a conventional incubating method. Bacteria in a sample solution are incubated in, for example, a sterilized agar medium 10 having a layer thickn... | 03/22/2012 |
| 20120046191 | AUTOMATED DETECTION AND COUNTING OF BIOMOLECULES USING NANOPARTICLE PROBES An apparatus and method for counting nanoparticle probes is disclosed. In one embodiment, quantum dot-tagged proteins on optically transparent membranes or slides are counted. The transparent membranes or slides are loaded onto a stage (e.g., an X-Y stage or X-Y-Z stage... | 02/23/2012 |
| 20120040370 | SYSTEMS AND METHODS FOR RAPIDLY CHANGING THE SOLUTION ENVIRONMENT AROUND SENSORS The invention provides microfluidic systems for altering the solution environment around a nanoscopic or microscopic object, such as a sensor, and methods for using the same. The invention also provides a system and methods for modulating, controlling, preparing, and st... | 02/16/2012 |
| 20120039806 | Compounds and Methods for Modulating an Immune Response The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulati... | 02/16/2012 |
| 20120034623 | UP-CONCENTRATION OF ORGANIZ MICROOBJECTS FOR MICROSCOPIC IMAGING A method of analyzing a sample fluid containing organic microobjects is proposed. The method comprises the steps of: up-concentrating (S1) the microobjects by removing, in a total time T1, a volume V1 of the sample fluid from the upconcentra... | 02/09/2012 |
| 20120034622 | ACTIVATION AND MONITORING OF CELLULAR TRANSMEMBRANE POTENTIALS The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.... | 02/09/2012 |
| 20120028879 | HIGHLY SENSITIVE DETECTION METHOD FOR HIGHLY VIRULENT ORAL CAVITY BACTERIA Provided is a method that involves the detection of protein antigen (PA) and/or collagen-binding protein (CBP) of oral cavity bacteria in a sample, and in which oral cavity bacteria that exacerbate hemolysis are detected for and/or subjects at high-risk for hemolysis ag... | 02/02/2012 |
| 20120028280 | XANTHURENIC ACID DERIVATIVE PHARMACEUTICAL COMPOSITIONS AND METHODS RELATED THERETO The present invention relates to diuretic pharmaceutical compositions and methods and in particular to certain derivatives of the formula I:
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| 20120020878 | FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR APPLICATION TO TRANSMEMBRANE DRUG DELIVERY SYSTEMS The present invention comprises a method for delivering pharmaceutical and/or imaging agents within and/or through the dermal, mucosal and other cellular membranes, and across the blood-brain barrier, utilizing a fusogenic protein. The fusogenic protein is associated wi... | 01/26/2012 |
| 20120015376 | Free Solution Measurement Of Molecular Interactions By Backscattering Interferometry Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry (BSI). Molecular interaction can be detected between analytes in free-solution wherein at least one of the analytes is label-free... | 01/19/2012 |
| 20120014957 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF Engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease are provided.... | 01/19/2012 |
| 20120009569 | MICROORGANISM CONCENTRATION PROCESS AND DEVICE A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a... | 01/12/2012 |
| 20120003628 | Methods for Diagnosing Pervasive Development Disorders, Dysautonomia and Other Neurological Conditions Methods for aiding in the diagnosis of disorders including, but not limited to, PDDs (Pervasive Development Disorders), Dysautonomic disorders, Parkinson's disease and SIDS (Sudden Infant Death Syndrome). In one aspect, a diagnosis method comprises analyzing a stool sam... | 01/05/2012 |
| 20110311585 | Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity Therapeutic compositions and methods for treating HIV including identification and manipulation of particular domains associated with immunogenicity.... | 12/22/2011 |
| 20110300531 | METHOD AND DEVICE TO DETECT THE PRESENCE OF ANALYTES IN A SAMPLE Disclosed are methods and apparatus useful for determining the presence or absence of one or more analytes in a liquid sample, such as a biological or environmental sample. In some embodiments, the method can use an indirect competitive immunochromatographic test strip.... | 12/08/2011 |
| 20110301442 | DIAGNOSTIC ANALYTE COLLECTION DEVICE BASED ON FLEXIBLE POLYMERS WITH BIOLOGICAL SURFACE MODIFICATION AND MICROFLUIDIC FUNCTIONALITY The invention relates to a device for detecting analytes. In order to supply a need in alternative prenatal diagnostic methods which do not include the risks known in the state of art, the present invention provides a device for detecting analytes, including a polymer f... | 12/08/2011 |
| 20110300116 | Method for Generating a Recombinant Clonal Cell Line and Novel Reagents for Use in the Method A method for generating a recombinant clonal cell line expressing a target cell surface receptor at a specific level of expression from a cell population comprising cells transfected with a plasmid encoding the cDNA sequence of the target receptor and expressing the tar... | 12/08/2011 |
| 20110300076 | METHODS FOR PREPARATION OF ZnTe NANOCRYSTALS Nanocrystals having a ZnTe core and methods for making and using them to construct core-shell nanocrystals are described. These core-shell nanocrystals are highly stable and provide quantum yields and stability suitable for applications such as flow cytometry, cellular ... | 12/08/2011 |
| 20110294142 | Multiply Fluorescently Labeled Calcium Phosphate-Protein Surfaces Described herein are multiply-fluorescently-labeled calcium phosphate protein substrates composed of a base coated with a fluorophore-labeled calcium phosphate coating and further having a fluorescently-labeled protein. The multiply-fluorescently-labeled substrate may b... | 12/01/2011 |
| 20110287420 | Compositions for diagnosis and therapy of diseases associated with aberrant expression of kremen and/or WNT The present invention relates to a composition useful for the diagnosis and therapy of diseases associated with aberrant expression of the gene encoding the receptor Kremen 1 and/or Kremen 2 e.g. tumors or diseases of the kidneys, bones and eyes, lipid and glucose metab... | 11/24/2011 |
| 20110286973 | METHODS FOR INTRODUCING HETEROLOGOUS CELLS INTO FISH The invention provides methods of introducing heterologous cells into fish. After introduction cells remain viable, and in some instances proliferate, for sufficient time to conduct a variety of analyses on the heterologous cells or the fish or both. Such methods are us... | 11/24/2011 |
| 20110287979 | Methods for Identifying and Isolating Cells Expressing a Polypeptide The invention relates to novel polypeptides and cells comprising the polypeptides. The polypeptides and cells are used in methods to identify and/or isolate cells producing a protein with specific biological functions. In particular, the methods may be used for identify... | 11/24/2011 |
| 20110281757 | Methods and Compositions for Detection of Complement Fixing Antibodies The invention provides methods for sensitive and specific detection of complement fixing antibodies in a biological sample using complement factor C1q, including autologous complement factor C1q present in the biological sample and a detectably labeled antibody that bin... | 11/17/2011 |
| 20110280859 | PREVENTING AND TREATING SEPSIS Provided are polypeptides comprising a variant activated protein C comprising one or more amino acid substitutions selected from the group consisting of K146R, D172N, C212R, K146G, R147G, R177G and combinations thereof. Also provided are nucleic acids encoding the polyp... | 11/17/2011 |
| 20110274692 | Screening Methods The present invention provides polypeptide binding agents, e.g. antibodies, that exhibit the ability to kinetically modulate the binding and signaling of biological signaling complexes, e.g., receptor-ligand complexes; methods of identifying such polypeptide binding age... | 11/10/2011 |
| 20110268661 | FLUORESCENT FUSION POLYPEPTIDES AND METHODS OF USE Embodiments of the present invention provide for the facile generation of a stable recombinant fusion polypeptides with intrinsic fluorescent properties. The recombinant antibodies may be suitable for qualitative and/or quantitative immunofluorescence analysis. Generall... | 11/03/2011 |
| 20110262925 | METHODS FOR ISOLATING A TARGET ANALYTE FROM A HETEROGENEOUS SAMPLE The invention generally relates to methods of using compositions that include sets of magnetic particles, members of each set being conjugated to an antibody specific for a pathogen, and magnets to isolate a pathogen from a body fluid sample.... | 10/27/2011 |
| 20110262897 | IMAGING TECHNIQUES USING A TRIDENTATE LIGAND The present invention relates to microscopy and, in particular, Time-resolved Emission Imaging Microscopy (TREM). The Invention relates to the use of a transition metal complex having a tridentate ligand in an imaging technique. The transition metal is preferably platin... | 10/27/2011 |
| 20110256552 | METHOD FOR PREPARING A SUBSTRATE FOR IMMOBILIZING A CELL, SAID SUBSTRATE AND USES THEREOF The present invention relates to a method of preparation of a solid substrate capable of immobilizing at least one cell and/or at least one part of a cell, said method comprising a step consisting of fixing, to said solid substrate, a fusogenic compound capable of being... | 10/20/2011 |
| 20110250616 | ELECTROACTIVE SURFACE-CONFINABLE MOLECULES The invention provides compositions, kits, methods, and species that include electroactive entities which can serve as signaling entities in chemical and/or biochemical assays. The electroactive species can be metallocenes, such as ferrocenes, including substituents tha... | 10/13/2011 |
| 20110250617 | DEVICE AND ANALYZING SYSTEM FOR CONDUCTING AGGLUTINATION ASSAYS A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and a lower chamber comprising an end in communication with the upper chamber ... | 10/13/2011 |
| 20110236884 | MICROBUBBLES FOR AFFINITY SEPARATION The present invention relates to methods, compositions and kits for affinity isolation, affinity purification and affinity assay based on microbubbles coated with an affinity molecule. Particularly, the invention provides protein microbubbles coated with an affinity mol... | 09/29/2011 |
| 20110236907 | RADIOLABLED CYCLOPAMINE ASSAY FOR THE SMOOTHENED RECEPTOR The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.... | 09/29/2011 |
| 20110229485 | INHIBITION OF THE NT-3:TRKC BOUND AND ITS APPLICATION TO THE TREATMENT OF CANCER SUCH AS NEUROBLASTOMA The subject matter of the present disclosure relates to an in vitro method for the screening of anti-cancer compounds based on the capacity for these compounds to interact with neurotrophin 3 (NT-3 or NT3), to the extracellular domain, or TrkC receptor and/or to inhibit... | 09/22/2011 |
| 20110229910 | Fluorescent Substrates for Neurotransmitter Transporters The invention is based on the finding that IDT307 and analogs thereof are fluorescent substrates transported by several neurotransmitter transporters. Provided are methods for the analysis of neurotransmitter transport and binding using IDT307 and its analogs. The inven... | 09/22/2011 |
