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| Application No. | Application Title | Issue Date |
| 20130053550 | YEAST STRAINS PRODUCING MAMMALIAN-LIKE COMPLEX N-GLYCANS Described herein are methods and genetically engineered fungal cells useful for producing target molecules containing mammalian-like complex N-glycans or containing intermediates in a mammalian glycosylation pathway.... | 02/28/2013 |
| 20130017574 | METHODS AND COMPOSITIONS FOR ENHANCED EXPRESSION AND SECRETION OF PROTEINS Optimized signal peptide coding sequences for enhanced expression and secretion of protein from a cell and related compositions and methods are described. The optimized signal peptide coding sequence encodes an mRNA that contains at least one hairpin structure immediate... | 01/17/2013 |
| 20120309057 | METHOD FOR PRODUCING INTERFERON ALPHA 5 A process for producing an interferon alpha 5 (IFNa5) protein by expression in an IFNa5 producing Escherichia coli host cell, wherein incorporation of an extra methionine residue in the N-terminal end of the polypeptide chain is minimized as well as the generatio... | 12/06/2012 |
| 20120308482 | Monkey Homolog of Human Interferon Omega Cytokine IFNω nucleic acids from the Cynomolgus monkey are useful for expression of IFNω proteins that are functional homologs of human IFNω. The nucleic acids and proteins produced therefrom are useful in screening and safety testing of IFNω, the generation and tes... | 12/06/2012 |
| 20120301922 | NOVEL P. PASTORIS PASTORIS PROMOTERS, AND THE USE THEREOF TO DIRECT EXPRESSION OF PROTEINS IN YEAST, PREFERABLY USING A HAPLOID MATING STRATEGY Novel promoters which are derived from P. pastoris pastoris which are inducible or repressible under specific growth conditions are provided. These promoters are useful for regulating the expression of a desired structural gene, e.g., a mammalian polypeptide. Par... | 11/29/2012 |
| 20120288477 | TYPE OF CONSENSUS INTERFERON AND PREPARATION METHOD THEREOF The invention relates to variants of consensus interferon protein with improved properties, such as improved anti-viral activity, and use thereof The variants are also easier to renature after denaturant treatment. The invention also relates to the preparation method of... | 11/15/2012 |
| 20120258494 | Retroviral Vector Particles and Methods for their Generation and Use The present invention relates to methods of host cell transduction utilising ecotropic retroviral vector particles. The retroviral vector particle may comprise an envelope of Friend murine leukaemia virus, in particular the envelope encoded by molecular clone PVC-211 an... | 10/11/2012 |
| 20120232007 | METHOD FOR PRODUCING PROTEINS IN PICHIA PASTORIS THAT LACK DETECTABLE CROSS BINDING ACTIVITY TO ANTIBODIES AGAINST HOST CELL ANTIGENS Methods for producing proteins and glycoproteins in Pichia pastoris that lack detectable cross binding activity to antibodies made against host cell antigens are described. In particular, methods are described wherein recombinant Pichia pastoris strains th... | 09/13/2012 |
| 20120230947 | BIOLOGICALLY ACTIVE PROTEINS HAVING INCREASED IN VIVO AND/OR IN VITRO STABILITY The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these enti... | 09/13/2012 |
| 20120231503 | Gene Expression Technique The present disclosure relates to a method for producing heterologous protein including:
| 09/13/2012 |
| 20120231505 | Gene Expression Technique The present invention provides a method for producing a desired protein (such as a desired heterologous protein) comprising:
| 09/13/2012 |
| 20120231504 | MULTIUSE REACTORS AND RELATED METHODS A septum is positioned within a disposable vessel and defines a lower chamber and an upper chamber. The septum includes a plurality of apertures that provide fluid communication between the upper chamber and lower chamber. Compressed gas is introduced in the lower chamb... | 09/13/2012 |
| 20120196326 | Mammalian Cell Lines for Increasing Longevity and Protein Yield from a Cell Culture Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and va... | 08/02/2012 |
| 20120190068 | DRAIN DOWN AND RE-FEED OF MICROCARRIER BIOREACTOR Disclosed is a method of increasing product yield per culture in a population of bound product-secreting cells in a bioreactor, the method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration; re-feed... | 07/26/2012 |
| 20120171722 | PERSONALIZED PRODUCTION OF BIOLOGICS AND METHOD FOR REPROGRAMMING SOMATIC CELLS The invention provides a method for producing polypeptide protein products and nucleic acid products having reduced levels of antigenicity in an animal being treated with a biologic product. Somatic cells are isolated from an animal, transformed into pluripotent stem ce... | 07/05/2012 |
| 20120142047 | Purification and Separation Treatment Assembly (PASTA) for Biological Products An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biologi... | 06/07/2012 |
| 20120142891 | FUSION PROTEIN SYSTEMS SUITABLE FOR HIGH EXPRESSION OF PEPTIDES The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system compr... | 06/07/2012 |
| 20120134961 | Interferon-alpha (IFN-alpha) Fused Protein Having IFN-alpha and Cytoplasmic Transduction Peptide (CTP) Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetic... | 05/31/2012 |
| 20120129218 | COFILIN KNOCKDOWN HOST CELLS AND USES THEREOF The present invention relates to a host cell comprising a cofilin-specific small interfering RNA (siRNA) sequence. The host cell may further comprise a nucleic acid encoding a recombinant protein. The present invention also relates to a method for producing a recombinan... | 05/24/2012 |
| 20120082644 | CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provide... | 04/05/2012 |
| 20120077228 | OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with ho... | 03/29/2012 |
| 20120064573 | METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifica... | 03/15/2012 |
| 20120023614 | ENVIRONMENTAL STRESS-INDUCIBLE 557 PROMOTER ISOLATED FROM RICE AND USES THEREOF The present invention relates to environmental stress-inducible 557 promoter isolated from rice, a recombinant plant expression vector comprising said promoter, a method of producing a target protein by using said recombinant plant expression vector, a method of produci... | 01/26/2012 |
| 20120003695 | METABOLIC ENGINEERING OF A GALACTOSE ASSIMILATION PATHWAY IN THE GLYCOENGINEERED YEAST PICHIA PASTORIS Lower eukaryotic cells such as Pichia pastoris that normally cannot use galactose as a carbon source but which have been genetically engineered according to the methods herein to use galactose as a sole source of carbon are described. The cells are genetically en... | 01/05/2012 |
| 20110305669 | PROCESS FOR THE PREPARATION OF GLYCOSYLATED INTERFERON BETA The present invention relates to a process for the production of interferon beta, and to an interferon beta composition having a unique glycosylation pattern.... | 12/15/2011 |
| 20110306753 | Method for Increasing Protein Expression in Cells The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermo... | 12/15/2011 |
| 20110288269 | Design of Spacers To Increase The Expression of Recombinant Fusion Proteins The present invention relates to fusion proteins. The invention specifically relates to compositions and methods of Tf-based fusion proteins that demonstrate a high-level expression of transferrin (Tf)-based fusion proteins by inserting a helical linker between two prot... | 11/24/2011 |
| 20110217784 | METHOD FOR PRODUCING SOLUBLE RECOMBINANT INTERFERON PROTEIN WITHOUT DENATURING The present invention relates to the field of recombinant protein production in bacterial hosts. It further relates to extraction of soluble, active recombinant protein from an insoluble fraction without the use of denaturation and without the need for a refolding step.... | 09/08/2011 |
| 20110189128 | RECOMBINANT SUPER-COMPOUND INTERFERON This invention provides a recombinant super-compound interferon or an equivalent thereof with changed spatial configuration. The super-compound interferon possesses anti-viral or anti-tumor activity and therefore is useful to prevent and treat viral diseases and cancers... | 08/04/2011 |
| 20110177555 | CHINESE HAMSTER OVARY CELL LINES We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis ag... | 07/21/2011 |
| 20110171687 | UNSTRUCTURED RECOMBINANT POLYMERS AND COMPOSITIONS COMPRISING SAME The present invention provides unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins and other related proteinaceous entities, as well as genetic packages displaying these enti... | 07/14/2011 |
| 20110159539 | METHOD FOR PRODUCING RECOMBINANT PROTEINS WITH A CONSTANT CONTENT OF PCO2 IN THE MEDIUM A method for the recombinant production of a polypeptide in a eukaryotic host cell modified in the citrate cycle is described, wherein the method comprises cultivating the eukaryotic host cell in a suitable medium under conditions which allow the expression of the polyp... | 06/30/2011 |
| 20110151515 | PRODUCTION OF FC-FUSION POLYPEPTIDES IN EUKARYOTIC ALGAE Methods and compositions are disclosed to engineer plastids comprising heterologous genes encoding immuno-activating domains fused to an extracellular domain (ECD) of a receptor or surface glycoprotein, a growth factor or an enzyme and produced within a subcellular orga... | 06/23/2011 |
| 20110135596 | FUSION PROTEIN COMPRISING UBIQUITIN OR UBIQUITIN-LIKE PROTEIN, MEMBRANE TRANSLOCATION SEQUENCE AND BIOLOGICALLY ACTIVE MOLECULE AND USE THEREOF A transmembrane fusion protein including ubiquitin or a ubiquitin-like protein, a membrane translocation sequence linked to the C-terminus of the ubiquitin or ubiquitin-like protein, and a biologically active molecule linked to the C-terminus of the membrane translocati... | 06/09/2011 |
| 20110112990 | Efficient Production of Peptides The present invention relates to processes for the production of peptides, and the peptides produced accordingly. Peptides produced according to the invention may be produced more efficiently than peptides produced according to prior art processes. The production proces... | 05/12/2011 |
| 20110091936 | PRODUCTION OF PROTEINS IN GLUTAMINE-FREE CELL CULTURE MEDIA The present invention relates generally to glutamine-free cell culture media supplemented with arginine. The invention further concerns the production of recombinant proteins, such as antibodies, in arginine-supplemented glutamine-free mammalian cell culture.... | 04/21/2011 |
| 20110070195 | USES OF SPATIAL CONFIGURATION TO MODULATE PROTEIN FUNCTION This invention provides a set of methods for modulating protein spatial configuration. First, select the amino-acid codon for encoding the target protein according to host codon usage. Second, choose combinations which can modulate the spatial configuration and construc... | 03/24/2011 |
| 20110053221 | RECOMBINANT PRODUCTION OF AUTHENTIC HUMAN PROTEINS USING HUMAN CELL EXPRESSION SYSTEMS The present invention relates to novel expression cassettes and vectors for efficiently producing authentic recombinant human proteins from stable cultures of novel human cell lines, the authentic recombinant proteins produced therefrom, and antibodies raised against th... | 03/03/2011 |
| 20110034672 | PURIFICATION OF NOT-GLYCOSYLATED POLYPEPTIDES The current invention reports a method for the purification of a not-glycosylated, heterologous polypeptide, which has been recombinantly produced in a prokaryotic cell, wherein the method comprises three chromatography steps of which the first chromatography step selec... | 02/10/2011 |
| 20110020870 | METHODS FOR PRODUCING MODIFIED GLYCOPROTEINS Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glyco... | 01/27/2011 |
