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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Application No. | Application Title | Issue Date |
| 20120131697 | GENE ENCODING AUXIN RECEPTOR PROTEIN DERIVED FROM RICE AND USE THEREOF The present invention pertains to an auxin receptor protein involved in activation of proton pump in plasma membrane of a plant derived from rice, a gene encoding the protein, a recombinant vector comprising the gene, a host cell transformed with the recombinant vector,... | 05/24/2012 |
| 20120129260 | METHOD FOR PRODUCING PLURIPOTENT STEM CELLS Methods are provided for producing a human embryo capable of developing to the blastocyst stage. The method includes transferring a human somatic cell genome into a mature human oocyte by nuclear transfer and activating the oocyte, without removing the oocyte genome. Pl... | 05/24/2012 |
| 20120083442 | MYOSTATIN BINDING AGENTS The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such ... | 04/05/2012 |
| 20120045764 | METHOD OF EXPANDING HUMAN HEPATOCYTES IN VIVO Described herein is a method of expanding human hepatocytes in vivo using an immunodeficient mouse which is further deficient in fumarylacetoacetate hydrolase (Fah). The method comprises transplanting human hepatocytes into the immunodeficient and Fah-deficient mice, ad... | 02/23/2012 |
| 20120034642 | METHOD FOR OBTAINING A SINGULAR CELL MODEL CAPABLE OF REPRODUCING IN VITRO THE METABOLIC IDIOSYNCRASY OF HUMANS The method is based on the use of expression vectors coding for the sense and anti-sense mRNA of the Phase I and Phase II drug biotransformation enzymes showing a greatest variability in humans for transforming cells expressing reductase activity. Such vectors can modul... | 02/09/2012 |
| 20120027788 | SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF The present invention relates to novel adenovirus strains with an improved sero-prevalence. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleoti... | 02/02/2012 |
| 20120028353 | HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+ 02/02/2012 | |
| 20120009672 | Methods for Differentiating Cells into Hepatic Stellate Cells and Hepatic Sinusoidal Endothelial Cells, Cells Produced by the Methods, and Methods for Using the Cells The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype and cells that express a hepatic sinusoidal endothelial phenotype. The invention is also directed to cells produc... | 01/12/2012 |
| 20120003719 | INFECTIOUS GENOTYPE 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a HEPATITIS C VIRUS LACKING THE HYPERVARIABLE REGION 1 (HVR1) The present inventors used the previously developed H77/JFH1T27OOC,A4O8OT (1a/2a), J4/JFH1T2996C,A4827T,ΔHVRI (1b/2a), J6/JFH1ΔHVRI (2a/2a), J8/JFH1ΔHVRI (2b/2a), S52/JFH1T27i8G,τ7i6oc (3a/2a), SA13/JFH1C34... | 01/05/2012 |
| 20120003720 | NUCLEIC ACID DERIVED FROM HEPATITIS C VIRUS AND EXPRESSION VECTOR, TRANSFORMED CELL, AND HEPATITIS C VIRUS PARTICLES EACH PREPARED BY USING THE SAME The present invention provides a nucleic acid comprises a 5′ untranslated region, an NS3 protein coding region, an NS4A protein coding region, an NS4B protein coding region, an NS5A protein coding region, an NS5B protein coding region, and a 3′ untranslated region o... | 01/05/2012 |
| 20120003741 | HEPATITIS C VIRUS EXPRESSING REPORTER TAGGED NS5A PROTEIN The present inventors developed hepatitis C reporter viruses containing Core through NS2 of prototype isolates of all major HCV genotypes and the remaining genes of isolate JFH1, by insertion of reporter genes in domain III of HCV NS5A. The inventors have identified a d... | 01/05/2012 |
| 20110318367 | NOVEL TARGETS FOR TREATMENT OF HYPERCHOLESTEROLEMIA In certain embodiments this invention this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of hypercholesterolemia. Methods of treating hypercholesterolemia and methods of screening ... | 12/29/2011 |
| 20110318730 | MICROPATTERNED CO-CULTURE SYSTEMS AS INFECTIOUS DISEASE ANALYSIS PLATFORMS Cell cultures are provided that include a population of micropatterened hepatocytes and one or more non-parenchymal cell populations, where the hepatocytes are infected with a virus or parasite and include a reporter of virus or parasite infection. Methods of making and... | 12/29/2011 |
| 20110319337 | Dominant Negative WNT2 Compositions and Methods of Use The present disclosure provides compositions, pharmaceutical preparations, kits and methods for inhibiting cell proliferation by contacting a cell expressing Fzd8 with a truncated Wnt2 polypeptide which acts as a dominant negative inhibitor of Fzd8 signaling. The presen... | 12/29/2011 |
| 20110313540 | IN OR RELATING TO GROWING CELLS The present invention relates to a method of growing a plurality of cells (110) to performance competence in a matrix forming agent (120) containing one or more density modifiers (130), characterized in that the cells are grown in a culture media su... | 12/22/2011 |
| 20110311977 | In Vitro Generation of Hepatocytes from Human Embryonic Stem Cells Differentiation of human pluripotent stem cells, such as human embryonic stem cells (hESC), into hepatocytes by in vitro methods is disclosed. The pluripotent stem cells are cultured in conditioned medium from the hepatocarcinoma cell line, HepG2. Specific growth factor... | 12/22/2011 |
| 20110312091 | PLURIPOTENT STEM CELLS, METHOD FOR PREPARATION THEREOF AND USES THEREOF Human pluripotent stem cells which are isolated from cut human umbilical cord or placenta and characteristic of cell surface marker CD151+, OCT4+ and CD184−, can adhere to tissue culture plastic and have the potential to differentiate ... | 12/22/2011 |
| 20110306127 | ENHANCING IRON UPTAKE IN PROTEIN-FREE MEDIA Methods for enhancing iron uptake in cell culture are described. The methods include using a NTBI uptake activator and non-protein bound iron source. Suitable NTBI activators are delineated. Also described are serum-free culture media which can be used in the present me... | 12/15/2011 |
| 20110306753 | Method for Increasing Protein Expression in Cells The present invention relates to a method for increasing the expression of a protein in cells, preferably in eukaryotic cells, by reducing the number of RNase L cleavage sites in the coding and/or non-coding region of the nucleic acid sequence of said protein. Furthermo... | 12/15/2011 |
| 20110306090 | Mammalian Expression Vector The present invention describes new mammalian expression vectors comprising a novel combination of regulatory elements and one or more selection marker gene(s). The vector allows for incorporation of at least one, preferably two or more genes of interest, its/their subs... | 12/15/2011 |
| 20110301073 | Novel DNA-binding proteins and uses thereof Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomi... | 12/08/2011 |
| 20110301092 | THE USE OF A NON-GLYCANATED POLYPEPTIDE FOR TREATING A CANCER The use of a non-glycanated form of a polypeptide including an amino acid sequence having at least 90% amino acid identity with an amino acid sequence selected from the group consisting of SEQ ID No 1 and SEQ ID No 2 for manufacturing a medicament for preventing or trea... | 12/08/2011 |
| 20110294195 | EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 7a Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the compl... | 12/01/2011 |
| 20110294194 | EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recove... | 12/01/2011 |
| 20110294211 | HEPATOCYTE LINEAGE CELLS Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further discl... | 12/01/2011 |
| 20110287483 | PRODUCTION OF GLYCOPROTEINS USING MANGANESE Culture media comprising manganese and methods of culturing cells to improve sialylation and glycosylation of glycoproteins are provided.... | 11/24/2011 |
| 20110289610 | HCV/GBV-B CHIMERIC VIRUS An HCV/GBV-B chimeric virus which maintains the replication function of HCV and is capable of infecting tamarin is disclosed in order to construct an HCV animal model which can be used as a development or evaluation system for therapeutic agents for HCV. The HCV/GBV-B c... | 11/24/2011 |
| 20110281349 | Insect Desiccation Resistance Genes and Uses Thereof An objective of the present invention is to provide polynucleotides encoding insect desiccation resistance proteins, and uses thereof cDNA libraries were produced from Polypedilum vanderplanki larvae in a desiccated state, a P. vanderplanki EST database wa... | 11/17/2011 |
| 20110275569 | PROTEASES TARGETING AGENTS A protein inhibitor from Sulfolobulus Solfataricus and peptides thereof, which both have the ability to inhibit AARE and elastase. Similarly to the eukaryotic counterparts, the recombinant protein is able to inhibit in vitro the bovine alfa-chymotrypsin with a hi... | 11/10/2011 |
| 20110274623 | Stabilized Fibronectin Domain Compositions, Methods and Uses A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and... | 11/10/2011 |
| 20110256625 | Liver Engrafting Cells, Assays, and Uses Thereof A substantially enriched mammalian hepatic liver engrafting cell population is provided. Methods are provided for the isolation and culture of this liver engrafting cell. The progenitor cells are obtained from a variety of sources, including fetal and adult tissues. The... | 10/20/2011 |
| 20110250684 | METHOD FOR PRODUCING NEURAL STEM CELLS In order to provide a method for producing neural stem cells easily and quickly by inducing differentiation of somatic cells directly into neurospheres, dedifferentiation factors are introduced into somatic cells, which are then cultured in suspension in the presence of... | 10/13/2011 |
| 20110229874 | COMPOSITIONS AND METHODS USEFUL FOR HCV INFECTION The present invention provides compositions comprising cells that can effectively produce HCV after HCV infection, compositions for culturing the cells, methods for making the composition and methods for infecting the cells in the composition with HCV. The present inven... | 09/22/2011 |
| 20110223659 | Compositions And Methods For Detecting Severe Acute Respiratory Syndrome Coronavirus The invention provides compositions and methods for detecting the presence of SARS-coronavirus, for screening anti-SARS coronavirus agents and vaccines, and for reducing infection with plus-strand RNA viruses such as SARS-coronavirus.... | 09/15/2011 |
| 20110217725 | CELL CULTURE KIT, SCREENING METHOD, AND METHOD OF MANUFACTURING CELL CULTURE KIT To provide a cell culture kit including cultured living cells of various donors, and a manufacturing method thereof. The cell culture kit includes a culture plate and living cells cultured thereon. The culture plate includes a plurality of microchambers (33) and ... | 09/08/2011 |
| 20110212541 | COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target polar lipids on a host (plant or animal) cell as a prerequisite for translo... | 09/01/2011 |
| 20110212061 | Mesoderm and Definitive Endoderm Cell Populations The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention... | 09/01/2011 |
| 20110207215 | CELL STORAGE METHOD AND CELL TRANSPORT METHOD To provide a cell storage method to store living cells while maintaining the functions of the living cells. An aspect of the cell storage method is a method to store living cells (40) by using a cell culture chamber (20) including a plurality of the microc... | 08/25/2011 |
| 20110136101 | Immortalized Human Fetal Liver Cells The present invention provides immortalized fetal liver cells that express the oncogene Simian virus (SV 40) large T-antigen and specific hepatocyte markers and a method for producing same.... | 06/09/2011 |
| 20110117061 | Ex Vivo Expansion of Human Hematopoietic Stem Cells Methods and kits for expanding the number of hematopoietic stem cells are provided. The methods comprise incubating cells in medium comprising isolated IGFBP-2 and an angiopoietin-like protein (Angptl). Expanded HSCs are provided as well as culture media and kits for th... | 05/19/2011 |
