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| Application No. | Application Title | Issue Date |
| 20120129260 | METHOD FOR PRODUCING PLURIPOTENT STEM CELLS Methods are provided for producing a human embryo capable of developing to the blastocyst stage. The method includes transferring a human somatic cell genome into a mature human oocyte by nuclear transfer and activating the oocyte, without removing the oocyte genome. Pl... | 05/24/2012 |
| 20120107286 | PLURIPOTENT STEM CELLS Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided.... | 05/03/2012 |
| 20120040401 | Method For Producing Proteins The invention relates to a transcriptionally active recombinant linear polynucleotide encoding a multimeric protein comprising in the following order, a first promoter sequence, a first encoding polynucleotide sequence, a bidirectional regulatory sequence, a second enco... | 02/16/2012 |
| 20120015395 | Human Blood-Brain Barrier Endothelial Cells Derived From Pluripotent Stem Cells and Blood-Brain Barrier Model Thereof A model blood brain barrier obtained from hPSCs is disclosed.... | 01/19/2012 |
| 20120014931 | HUMAN LATE STAGE MOTOR NEURON PROGENITOR CELLS Motor neuron progenitor (MNP) cells and populations of MNP cells, are provided, in particular, populations of human late stage MNP cells having a purity of greater than about 65% late stage MNP cells and high-purity populations of MNP cells having greater than 95% viabl... | 01/19/2012 |
| 20120009157 | CULTURE METHOD OF EMBRYOID BODIES AND/OR NEURAL STEM CELLS DERIVED FROM HUMAN DIFFERENTIATED CELL-DERIVED PLURIPOTENT STEM CELLS A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid ... | 01/12/2012 |
| 20120003190 | LATERAL VENTRICLE CELL COMPOSITIONS AND USE FOR TREATING NEURAL DEGENERATIVE DISEASES A pluripotent stem cell isolated from the lateral ventrical of the brain or choroid plexus is provided. Compositions and methods of isolating and using the cell also is provided.... | 01/05/2012 |
| 20110312091 | PLURIPOTENT STEM CELLS, METHOD FOR PREPARATION THEREOF AND USES THEREOF Human pluripotent stem cells which are isolated from cut human umbilical cord or placenta and characteristic of cell surface marker CD151+, OCT4+ and CD184−, can adhere to tissue culture plastic and have the potential to differentiate ... | 12/22/2011 |
| 20110275152 | Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells A method of differentiating embryonic stem cells into neural and motor cells is disclosed. In one embodiment, the invention comprises culturing a population of cells comprising a majority of cells that are characterized by an early rosette morphology and are Sox1âˆ... | 11/10/2011 |
| 20110244470 | ISOLATED TRANSGENIC MAMMALIAN NEURAL CELL FOR DETECTION OF A SAMPLE CONTAINING A CHEMICAL SUBSTANCE DAMAGE TO NEUROLOGICAL SYSTEM OR SELECTION OF DRUGS FOR TREATING NEURODEGENERATIVE DISORDERS The invention is to provide an isolated transgenic mammalian neural cell, which comprises at least one heterologous vector expressing AhR/ARNT. Also provided is methods the detection of a sample containing a chemical substance damage to the nervous system and the select... | 10/06/2011 |
| 20110224145 | Neuromodulators and Methods of Use The present disclosure provides neuromodulators, nucleic acid encoding thereof, and compositions thereof for endowing visual processing abilities to neuronal cells. The present disclosure further provides a method of restoring light sensitivity to degenerate retinas.... | 09/15/2011 |
| 20110217774 | Efficient and Universal Method for Neural Differentiation of Pluripotent Stem Cells The present invention relates to a method for inducing neural differentiation of stem cells. In more detail, the present invention relates to a method for inducing neural differentiation of stem cells by inhibiting both BMP (bone morphogenetic protein) and Activin/Nodal... | 09/08/2011 |
| 20110217267 | GENE THERAPY VECTORS AND CYTOSINE DEAMINASES This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders.... | 09/08/2011 |
| 20110212541 | COMPOSITIONS AND METHODS TO PROTECT CELLS BY BLOCKING ENTRY OF PATHOGEN PROTEINS Pathogenic effector proteins include one or more virulence motifs of amino acid consensus sequence BXZ, where B=RK or H; X=any amino acid or is absent; Z=L, M, I, W, Y or F) which bind to target polar lipids on a host (plant or animal) cell as a prerequisite for translo... | 09/01/2011 |
| 20110207215 | CELL STORAGE METHOD AND CELL TRANSPORT METHOD To provide a cell storage method to store living cells while maintaining the functions of the living cells. An aspect of the cell storage method is a method to store living cells (40) by using a cell culture chamber (20) including a plurality of the microc... | 08/25/2011 |
| 20110189135 | HUMAN STEM CELL-DERIVED NEURAL PRECURSORS FOR TREATMENT OF AUTOIMMUNE DISEASES OF THE CENTRAL NERVOUS SYSTEM The present invention concerns the use of a population of cells comprising: (a) neural precursor cells committed to an oligodendroglial fate; (b) uncommitted neural precursor cells (c) differentiated oligodendrocytes; or (d) a combination of any one of (a) to (c) for th... | 08/04/2011 |
| 20110171731 | COMPOSITIONS CONTAINING PLATELET CONTENTS This document provides methods and materials relating to platelet lysates. For example, methods and materials for using platelet lysate compositions to grow adult stem cells, to differentiate adult stem cells, to grow primary cell cultures, to grow tumor stem cells, and... | 07/14/2011 |
| 20110165674 | NK-1 Receptor Mediated Delivery of Agents to Cells Provided herein are conjugates including a targeting vehicle coupled to an agent. The targeting vehicle includes a tachykinin receptor ligand and a reactive moiety. Conjugates including a tachykinin receptor ligand attached to an antibody or fragment thereof that is spe... | 07/07/2011 |
| 20110135696 | MULTIPOTENT NEURAL CELLS The inventions disclosed herein are based on the identification of novel cell populations derived from human embryonic stem cells and other pluripotent cells. The inventive cell populations may be used for cell therapies for the treatment of various neurological disease... | 06/09/2011 |
| 20110052500 | TAJ in Neuronal Function The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, including CNS disorders, stroke, or spinal injury, by administration of a TAJ antagonist.... | 03/03/2011 |
| 20110045500 | CELL CULTURE METHOD AND SCREENING METHOD Provided is a cell culture method whereby an in vivo function can be sustained over a long period of time and culture can be conducted using the minimum number of cells required. The cell culture method includes culturing undifferentiated cells in a layered state in a p... | 02/24/2011 |
| 20110034536 | CONTROLLING THE POTENTIAL OF PRIMATE NEURAL STEM CELLS BY REGULATING PAX6 A transcription factor both necessary and sufficient for human neuroectoderm specification, Pax6, as well as applications thereof, is disclosed.... | 02/10/2011 |
| 20110014695 | METHODS FOR OBTAINING ADULT HUMAN OLFACTORY PROGENITOR CELLS An isolated human olfactory stem cell can be prepared by culturing human tissue from olfactory neuroepithelium to form neurospheres.... | 01/20/2011 |
| 20110016547 | USE OF REGULATORY SEQUENCES FOR SPECIFIC, TRANSIENT EXPRESSION IN NEURONAL DETERMINED CELLS The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for m... | 01/20/2011 |
| 20110002897 | DIRECTED DIFFERENTIATION OF STEM CELLS Disclosed are compositions and methods for producing neural cells from stem cells and uses thereof.... | 01/06/2011 |
| 20110003358 | CULTURES OF GFAP+ NESTIN+ CELLS THAT DIFFERENTIATE TO NEURONS Cultures of cells immunoreactive for glial fibrillary acidic protein (GFAP), as well as for the intermediate filament marker nestin were grown in a medium including epidermal growth factor (EGF) and serum. The cultured cells had the morphology of astroglial cells. The c... | 01/06/2011 |
| 20110003003 | MAGNETIC CELLS FOR LOCALIZING DELIVERY AND TISSUE REPAIR Normal or genetically modified cell(s) having magnetic nanoparticle(s) bound (affixed) to their surfaces and methods of delivery to target tissues, e.g. for treatment of disease and or injury.... | 01/06/2011 |
| 20100330591 | GPCR Expressing Cell Lines and Antibodies The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines expressing GPCR proteins with the aid of the expression vectors of the inst... | 12/30/2010 |
| 20100330043 | GPR125 AS A MARKER FOR STEM AND PROGENITOR CELLS AND METHODS USE THEREOF The present invention relates to GPR1 25 as a marker of stem and progenitor cells, including multipotent adult spermatogonial-derived stem cells (MASCs), spermatogonial stem and progenitor cells, skin stem or progenitor cells, intestinal stem or progenitor cells, neural... | 12/30/2010 |
| 20100324697 | System and method for a piezoelectric scaffold for nerve growth and repair Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable... | 12/23/2010 |
| 20100323385 | NITROGEN INDEPENDENCE IDENTIFIES A HIGHLY MALIGNANT POPULATION OF TUMOR STEM CELLS The present invention is directed to a method for isolating and establishing Growth Factor-Independent (GF-I) Tumor Stem Cells (TSCs) from tumor biopsies or tumor cell lines consisting in culturing cells in serum-free mitogen-free culture medium. The method discloses ce... | 12/23/2010 |
| 20100287638 | NEURAL TUMOR STEM CELLS AND METHODS OF USE THEREOF The present invention relates to the discovery that renewable stem cell lines can be derived from tumor cells and can be cultured in vitro. Accordingly, the invention provides neural tumor stem cell lines and cells from such cell lines. Because the cell lines retain cha... | 11/11/2010 |
| 20100286248 | HUMAN FG01 GENE AND ITS APPLICATIONS A human gene, fg01, on chromosome 8, is identified. This gene, and its expression product, human fg01, shares a homology under 70% with the corresponding murine gene, which has been linked to presentation of the Alzheimer's phenotype of Aβ plaques and hyperphosphorylat... | 11/11/2010 |
| 20100257616 | DNA regulatory element for the expression of transgenes in neurons of a subject and uses thereof The present invention provides for a recombinant nucleic acid molecule comprising a region of a calcium-calmodulin dependent kinase IIα promoter operatively linked to a gene of interest. The region of a calcium-calmodulin dependent kinase IIα promoter may comprise an ... | 10/07/2010 |
| 20100212032 | Compositions and Methods for the Efficient and Reproducible Generation of Clone Animals of All Developmental Stages and Methods of Use Thereof Compositions and methods are provided for the efficient and reproducible generation of clone animals of all developmental stages. Also provided are methods of use of the same in reproductive and therapeutic cloning protocols.... | 08/19/2010 |
| 20100203570 | GENE SPECIFICALLY EXPRESSED IN POSTMITOTIC DOPAMINERGIC NEURON PRECURSOR CELLS A novel gene 65B13 expressed specifically and transiently in dopaminergic neuron precursor cells immediately after cell cycle exit was obtained by the present invention. The cellular expression of 65B13 can be used as an index to select cells that are suitable in terms ... | 08/12/2010 |
| 20100189712 | Preparation And Use Of Cell-Synthesized Threads The present technology provides for a cell-synthesized biological thread, processes for making a cell-synthesized thread, and an apparatus for carrying out a process used to engineer the cell-synthesized thread. The thread is produced from living cells in culture and ca... | 07/29/2010 |
| 20100184700 | PREPROCALCITONIN ANTIGEN T EPITOPES The present invention is related to Preprocalcitonin antigen T epitopes, presented by the Major Histocompatibility Complex I (MHC I). These peptides can be used in cancer immunotherapy.... | 07/22/2010 |
| 20100167330 | MICROMECHANICAL DEVICES FOR CONTROL OF CELL-CELL INTERACTION, AND METHODS OF USE THEREOF The development and function of living tissues depends largely on interactions between cells that can vary in both time and space; however, temporal control of cell-cell interaction is experimentally challenging. By employing a micromachined silicon substrate with movin... | 07/01/2010 |
| 20100168215 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF NEUROLOGICAL DISEASE The present invention relates to a method for delivering a nucleic acid sequence encoding neuropeptide Y, or a derivative or functional fragment thereof, to a mammalian nervous system target cell. The expression of exogenous NPY, or a derivative or a functional fragment... | 07/01/2010 |
