Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Application No. | Application Title | Issue Date |
| 20120129209 | ALIGNING CELLS ON WRINKLED SURFACE A method is provided for preparing an aligned cell population comprising the culturing one or more cells on a surface having a texture, which texture has an average height of from about 100 nanometers to about 5 micrometers, thereby forming an aligned cell population on... | 05/24/2012 |
| 20120128689 | ANTI-IL-23 IMMUNOGLOBULINS The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).... | 05/24/2012 |
| 20120128639 | In Vitro Production Of Oligodendrocytes From Human Umbilical Cord Stem Cells The invention provides a method of producing oligodendrocytes by in vitro differentiation of human multi-potent progenitor cells (MLPCs). The method comprises culturing isolated MLPCs on a first surface in a serum-free defined culture medium; replacing the culture mediu... | 05/24/2012 |
| 20120128676 | MUC1 ANTIBODIES The present invention pertains to anti-mucin antibodies having improved antigen binding and/or recognition properties as well as a method for improving the antigen binding and/or recognition of an anti-mucin antibody. In particular, the present invention is directed to ... | 05/24/2012 |
| 20120129208 | HONEYCOMB SHRINK WELLS FOR STEM CELL CULTURE This invention provides a microwell array having a plurality of microwells on a hydrophobic surface wherein the microwells each is substantially proximate to each of its adjacent microwells, as well as methods to prepare arrays. Also provided is a plate that comprises a... | 05/24/2012 |
| 20120129260 | METHOD FOR PRODUCING PLURIPOTENT STEM CELLS Methods are provided for producing a human embryo capable of developing to the blastocyst stage. The method includes transferring a human somatic cell genome into a mature human oocyte by nuclear transfer and activating the oocyte, without removing the oocyte genome. Pl... | 05/24/2012 |
| 20120129261 | Transcriptome Transfer Produces Cellular Phenotype Conversion The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell. Preferably the phenotype-conve... | 05/24/2012 |
| 20120129254 | Inducible Expression System Transcription Modulators Comprising A Distributed Protein Transduction Domain And Methods For Using The Same Aspects of the invention include inducible expression systems in which a transcription modulator having a distributed protein transduction domain is employed. Aspects of the invention further include methods of using the systems to induce expression of a coding sequence... | 05/24/2012 |
| 20120128635 | METHODS AND COMPOSITIONS FOR TREATING HEMOPHILIA B Disclosed herein are methods and compositions for insertion of Factor IX (FIX) sequences into the genome of a cell for treating hemophilia B.... | 05/24/2012 |
| 20120128641 | METHODS AND COMPOSITIONS FOR IMPROVING THE VIABILITY OF CRYOPRESERVED CELLS The present invention provides polymers and methods for increasing the viability of cryopreserved cells after thawing. Thawing cryopreserved cells in the presence of a polymer such as poloxymer P1 88 or other non-ionic polymers is thought to stabilize the membranes of t... | 05/24/2012 |
| 20120131697 | GENE ENCODING AUXIN RECEPTOR PROTEIN DERIVED FROM RICE AND USE THEREOF The present invention pertains to an auxin receptor protein involved in activation of proton pump in plasma membrane of a plant derived from rice, a gene encoding the protein, a recombinant vector comprising the gene, a host cell transformed with the recombinant vector,... | 05/24/2012 |
| 20120129262 | Methods of Modifying Transcriptional Regulatory Networks in Stem Cells The vast differentiation potential of human embryonic and induced pluripotent stem cells, including their potential to cascade through all of the somatic cell lineages and to display the complete transcriptional regulatory network of human biology, has generated interes... | 05/24/2012 |
| 20120107413 | PRE-NATAL MESENCHYMAL STEM CELLS We describe an pre-natal mesenchymal stem cell obtainable from a pre-natal tissue such as a foetal tissue, a descendent of such a mesenchymal stem cell, a cell culture or a cell line comprising either. The pre-natal mesenchymal stem cell, cell culture or cell line may c... | 05/03/2012 |
| 20120107319 | Pharmaceutical compositions comprising antibodies binding to the intracellular domain of EBV (Epstein-Barr virus) latent membrane protein-1 (LMP1) The invention relates to pharmaceutical and vaccine compositions comprising an antibody binding specifically to the intracellular domain of EBV protein LMP1.... | 05/03/2012 |
| 20120107339 | Chimeric Factor H Binding Proteins (fHBP) Containing a Heterologous B Domain and Methods of Use Chimeric fHBPs that can elicit antibodies that are bactericidal for different fHBP variant strains of N. meningitidis, and methods of use, are provided.... | 05/03/2012 |
| 20120107929 | Variable Lymphocyte Receptors, Related Polypeptides and Nucleic Acids, and Uses Thereof Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs).... | 05/03/2012 |
| 20120107286 | PLURIPOTENT STEM CELLS Methods and compositions for the generation and use of footprint-free human induced pluripotent stem cells are provided.... | 05/03/2012 |
| 20120107281 | COMPOSITIONS AND METHODS FOR MODIFYING CELL SURFACE GLYCANS Methods and compositions for modifying glycans (e.g., glycans expressed on the surface of live cells or cell particles) are provided herein.... | 05/03/2012 |
| 20120109107 | Muscle Derived Cells for the Treatment of Urinary Tract Pathologies and Methods of Making and Using the Same The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft ti... | 05/03/2012 |
| 20120108790 | Truncated Somatostatin Receptors The present invention is directed to fusion proteins that can be used to assay gene transfer and expression both in vitro and in vivo. The fusion proteins contain a reporter protein, e.g. a somatostatin receptor, fused to a second protein, which may be a protein fusion ... | 05/03/2012 |
| 20120108464 | TEST SYSTEMS, METHODS AND USES INVOLVING AS160 PROTEIN The present invention relates to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-protein (AS160-protein) with a test substance, a... | 05/03/2012 |
| 20120108662 | COMPOSITIONS AND METHODS FOR TREATING SKIN DISORDERS The present application relates to compositions and the treatment of skin disorders, dry skin, protection of skin in inflammatory events and neurological disorders. The present application more particularly discloses the identification of new genes and metabolic pathway... | 05/03/2012 |
| 20120107898 | METHOD FOR OBTAINING HUMAN MICROGLIAL PRECURSOR CELLS FROM PLURIPOTENT STEM CELLS A method for obtaining human microglial precursor cells, comprising: (a) providing a cell population comprising neural precursor cells, wherein the cell population is obtainable from embryoid bodies differentiated from human pluripotent stem cells; (b) differentiating t... | 05/03/2012 |
| 20120107283 | HUMAN SKIN EQUIVALENTS EXPRESSING EXOGENOUS POLYPEPTIDES The present invention relates generally to compositions for wound closure. More specifically, the present invention provides human skin equivalents engineered to express exogenous polypeptides (e.g., antimicrobial polypeptides and keratinocyte growth factor 2) and compo... | 05/03/2012 |
| 20120107930 | METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELLS OR ARTIFICIAL PLURIPOTENT STEM CELLS Differentiation of a large number of embryonic stem cells or artificial pluripotent stem cells such as induced pluripotent stem cells can be readily induced by the following method. A substrate surface having a cell non-adhesive region on the periphery of a cell adhesiv... | 05/03/2012 |
| 20120083034 | EX HOST MATURATION OF GERMLINE STEM CELLS Methods are provided for the ex host maturation of immature germline cells into haploid gametes for restoration of fertility in patients in need thereof.... | 04/05/2012 |
| 20120083032 | EMBRYONIC STEM CELL LINE AND METHOD FOR PREPARING THE SAME An embryonic stem cell line derived from a nucleus-transferred oocyte prepared by transferring a nucleus of a human somatic cell into an enucleated human oocyte may differentiate into various desired cell types.... | 04/05/2012 |
| 20120084871 | NPC1L1 ORTHOLOGUES The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.... | 04/05/2012 |
| 20120070896 | METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS AND METHOD FOR CULTURING THE SAME [Object] To provide a technology for production of safer iPS cells and to provide a more efficient technology for culturing iPS cells. [Solving Means] Induced pluripotent stem cells are produced from human somatic cells by co-culturing huma... | 03/22/2012 |
| 20120071422 | Therapeutic application of isolated naturally-occuring soluble truncated forms of IL-23 receptor The present invention relates to an isolated naturally-occurring soluble truncated IL-23Rα protein, which is a translated protein resulting from a mRNA splice variant of IL-23Rα. The soluble IL-23Rα proteins (e.g., Δ9 and Δ8,9) represents a novel soluble IL-23Rα p... | 03/22/2012 |
| 20120070876 | VARIANT FORM OF URATE OXIDASE AND USE THEREOF The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxid... | 03/22/2012 |
| 20120070430 | IDENTIFICATION OF TUMOR-ASSOCIATED MARKERS FOR DIAGNOSIS AND THERAPY The invention relates to genetic products the expression of which is associated with cancer diseases. The invention also relates to the therapy and diagnosis of diseases in which the genetic products are expressed or aberrantly expressed, in particular cancer diseases.... | 03/22/2012 |
| 20120070857 | ELECTROPHYSIOLOGICAL ASSAYS USING OOCYTES THAT EXPRESS HUMAN ENaC AND THE USE OF PHENAMIL TO IMPROVE THE EFFECT OF ENaC ENHANCERS IN ASSAYS USING MEMBRANE POTENTIAL REPORTING DYES In one aspect, the present invention relates to a mammalian cell-based high-throughput assay for the profiling and screening of human epithelial sodium channel (hENaC) cloned from a human kidney c-DNA library and is also expressed in other tissues including human taste ... | 03/22/2012 |
| 20120071540 | Compositions and Methods Using siRNA Molecules and siRNA Cocktails for the Treatment of Breast Cancer The present invention provides small interfering RNA (siRNA) molecules, compositions containing the molecules, and methods of using the molecules and compositions to treat breast cancer. In one aspect, a multi-targeted siRNAi cocktail is disclosed. The siRNA molecules m... | 03/22/2012 |
| 20120070389 | METHODS FOR IDENTIFYING TREATMENTS THAT TREAT AND/OR PREVENT UV IRRADIATION INDUCING PHOTOAGING Methods are provided for ascertaining and measuring RPTP-κ activity in response to insults such as UV irradiation and with respect to administration of a treatment and/or composition. Attenuation of EGFR activity by RPTP-κ affects aspects of photoaging, including dama... | 03/22/2012 |
| 20120071859 | INDUCIBLE INTERLEUKIN-12 The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid compr... | 03/22/2012 |
| 20120052571 | Differentiation of Human Embryonic Stem Cells The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population... | 03/01/2012 |
| 20120052116 | IMMUNOGENIC EPITOPES OF NGEP ANTIGEN The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid... | 03/01/2012 |
| 20120052570 | METHOD FOR TEMPORALLY CONTROLLING THE BIOLOGICAL ACTIVITY OF PROTEINS IN VERTEBRATES, AND APPLICATIONS THEREOF The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a muta... | 03/01/2012 |
| 20120045795 | METHOD FOR PRODUCING A CELL CAPABLE OF HIGH-YIELD PRODUCTION OF HETEROPROTEINS The present invention provides a cell capable of high-yield production of polypeptides and a method for producing the same. The present invention relates to a method for producing a cell capable of high-yield production of a desired polypep... | 02/23/2012 |
