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| Application No. | Application Title | Issue Date |
| 20120128723 | CANCER SPECIFIC ANTIBODY AND CELL SURFACE PROTEINS The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention provides cancer specific antibodies and immunoconjugates comprising the ... | 05/24/2012 |
| 20120083033 | PRODUCTION OF TRANSGENIC AVIANS USING IMPROVED RETROVIRAL VECTORS A transgenic avian containing in its genome an exogenous nucleotide sequence which includes a promoter component and a vector with reduced promoter interference wherein the exogenous nucleotide sequence is integrated into the genome and the avian.... | 04/05/2012 |
| 20120084871 | NPC1L1 ORTHOLOGUES The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.... | 04/05/2012 |
| 20120070893 | METHODS FOR PRODUCING NONADHERENT AVIAN CELL LINES The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a ba... | 03/22/2012 |
| 20120053321 | ZCYTOR19 HETERODIMERIC CYTOKINE RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity i... | 03/01/2012 |
| 20120053232 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 4 (TSSC4) Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human and tumor suppressing subtransferable candidate 4 (TSSC4) and methods of use.... | 03/01/2012 |
| 20120052570 | METHOD FOR TEMPORALLY CONTROLLING THE BIOLOGICAL ACTIVITY OF PROTEINS IN VERTEBRATES, AND APPLICATIONS THEREOF The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a muta... | 03/01/2012 |
| 20120040456 | METHODS OF GENE THERAPY USING NUCLEIC ACID SEQUENCES FOR ATP-BINDING CASSETTE TRANSPORTER The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining ... | 02/16/2012 |
| 20120034160 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.... | 02/09/2012 |
| 20120028300 | Whitefly Ecdysone Receptor Nucleic Acids, Polypeptides, and Uses Thereof The present invention relates to a novel isolated whitefly ecdysone receptor polypeptide. The invention also relates to an isolated nucleic acid encoding the whitefly ecdysone receptor polypeptide, to vectors comprising them and to their uses, in particular in methods f... | 02/02/2012 |
| 20120028336 | Single Recombination System and Methods of Use The present invention is directed to a modified poxvirus vector that allows for the generation of recombinant poxviruses by a single recombination event. A modified poxvirus vector comprising at least one reporter gene located between two flanking sequences for homologo... | 02/02/2012 |
| 20120020934 | MATERIALS AND METHODS FOR CRYOPRESERVED BONE CONSTRUCTS The subject invention concern materials and methods for cryopreservation of HCG-cell constructs. In one embodiment, porous HCG scaffolds are provided in a perfusion bioreactor having perfusion chambers that can contain the HCG scaffolds, cells are then seeded in the HCG... | 01/26/2012 |
| 20120020940 | ANTIMICROBIAL PEPTIDES The present invention relates to a peptide comprising or consisting of the following amino acid sequence: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12 (formula II), wherein A0 is a hydrophobic amino acid residue or is absent; A1, A4, A7, A8, A12 each are a hydrophobic amin... | 01/26/2012 |
| 20120021491 | IDENTIFICATION OF ANTIGEN OR LIGAND-SPECIFIC BINDING PROTEINS The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-sp... | 01/26/2012 |
| 20120017290 | Genome editing of a Rosa locus using zinc-finger nucleases Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells c... | 01/19/2012 |
| 20120015840 | METHODS FOR GENERATION OF RNA AND (POLY)PEPTIDE LIBRARIES AND THEIR USE The present invention relates to a method for generating an RNA library or a (poly)peptide library comprising the steps of: (a) providing one or more nucleic acid molecules each comprising i) two or more coding elements (A) each giving rise to an RNA molecule upon trans... | 01/19/2012 |
| 20120016008 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN RIBOSOMAL PROTEIN L26 (RIBO26) Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human ribosomal protein L26 (RIBO26) and methods of use.... | 01/19/2012 |
| 20120010270 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN TUMOR SUPPRESSING SUBTRANSFERABLE CANDIDATE 6 (TSSC6) Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human tumor suppressing subtransferable candidate 6 and methods of use.... | 01/12/2012 |
| 20120010269 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN SMS3 Provided herein are isolated genomic polynucleotide fragments from the from the p15 region of chromosome 11 encoding human SMS3 (SMS3) and methods of use.... | 01/12/2012 |
| 20120010268 | ISOLATED GENOMIC POLYNUCLEOTIDE FRAGMENTS FROM THE p15 REGION OF CHROMOSOME 11 ENCODING HUMAN ACHAETE-SCUTE HOMOLOG 2 (HASH2) Provided herein are isolated genomic polynucleotide fragments from the p15 arm of chromosome 11 encoding HASH2 and methods of use.... | 01/12/2012 |
| 20120004178 | BIGLYCAN MUTANTS AND RELATED THERAPEUTICS AND METHODS OF USE The present disclosure provides compositions and methods for treating diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, for example, due to an unstable dystrophin associated prot... | 01/05/2012 |
| 20120003740 | ELECTROPORATION APPARATUS AND METHODS This document discloses electroporation vessels, electrocompetent cells that have been aliquoted and frozen in electroporation vessels, and a number of other apparatuses, kits, and methods for electroporation. Some embodiments of electroporation vessels described herein... | 01/05/2012 |
| 20110306126 | METHOD FOR PRODUCING ANTIBODY DIRECTED AGAINST PROTEIN EXPRESSED ON CELL SURFACE Disclosed is a method for producing an antibody directed against a protein, particularly a transmembrane protein, expressed on the surfaces of cells. Specifically disclosed is a means for obtaining a desired antibody by mixing cells capable... | 12/15/2011 |
| 20110293656 | RECOMBINANT MVA CAPABLE OF EXPRESSING STRUCTURAL HCV ANTIGENS The invention relates to recombinant MVA which is capable of expressing structural HCV antigens, functional parts of said structural antigens or epitopes of said structural antigens. The invention further relates to a pharmaceutical composition, especially in the form o... | 12/01/2011 |
| 20110294209 | METHODS FOR PRODUCING NONADHERENT AVIAN CELL LINES The present invention relates to a method for producing avian cell lines, comprising gradual or complete withdrawal of growth factors, serum and/or feeder layer so that the established lines are adherent or nonadherent cells capable of proliferating indefinitely in a ba... | 12/01/2011 |
| 20110281282 | SUBPOPULATIONS OF SPORE-LIKE CELLS AND USES THEREOF Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of Oct4, nanog, Zfp296, cripto, Gdf3... | 11/17/2011 |
| 20110269119 | ENCODING TEXT INTO NUCLEIC ACID SEQUENCES Methods and apparatus are disclosed herein for encoding human readable text conveying a non-genetic message into nucleic acid sequences with a substantially reduced probability of biological impact and decoding such text from nucleic acid sequences. In one embodiment, e... | 11/03/2011 |
| 20110265198 | Genome editing of a Rosa locus using nucleases Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprisin... | 10/27/2011 |
| 20110262902 | CIS-ACTING DIVERSIFICATION ACTIVATOR AND METHOD FOR SELECTIVE DIVERSIFICATION OF NUCLEIC ACIDS The invention relates to identification of a cis-acting diversification activator (DIVAC) that is necessary and sufficient for the activation of diversification in transcription units linked thereto. The invention provides a method for diversification of a target nuclei... | 10/27/2011 |
| 20110256622 | Novel Culture Systems for Ex Vivo Development The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.... | 10/20/2011 |
| 20110247091 | Transgenic Cells and Chickens Expressing RIG-I The present disclosure provides a transgenic cell or chicken having increased resistance to RNA viral infection, wherein the chicken cell expresses a foreign RIG-I gene. Also provided are methods for reducing RNA virus replication in a chicken cell and methods for produ... | 10/06/2011 |
| 20110229969 | Cell Line for Propagation of Highly Attenuated AlphaViruses The present invention provides an avian cell that is derived from an avian host cell and stably carries at least one DNA sequence in the cell nucleus encoding an alphavirus polypeptide, a method for preparing such an avian cell, and its use in preparing an alphavirus re... | 09/22/2011 |
| 20110217749 | METHOD FOR THE CULTIVATION OF PRIMARY CELLS AND FOR THE AMPLIFICATION OF VIRUSES UNDER SERUM FREE CONDITIONS The present invention relates to a method for the cultivation of primary cells. The primary cells are cultivated in a serum free medium comprising a factor selected from the group consisting of growth factors and attachment factors. The met... | 09/08/2011 |
| 20110212094 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.... | 09/01/2011 |
| 20110212488 | IMMORTALIZED AVIAN CELL LINES AND USE THEREOF The present invention relates to specific immortalized avian cell lines expressing telomerase reverse transcriptase (TERT), and exhibiting distinct biologics production patterns. More particularly, the present invention relates to immortalized avian cell line capable of... | 09/01/2011 |
| 20110189648 | POST-THAW SURVIVAL OF CRYOPRESERVED BIOLOGICAL MATERIAL BY HYDROSTATIC PRESSURE CHALLENGE The present invention relates to a method for improving post-thaw survival of cryopreserved biological material comprising applying hydrostatic pressure to said biological material; keeping the said biological material at the hydrostatic pressure for a predetermined tim... | 08/04/2011 |
| 20110189658 | CELL, METHOD AND KIT FOR CONDUCTING AN ASSAY FOR NEUTRALIZING ANTIBODIES The present invention provides a cell for use in a one-step cell-based assay for an extracellular ligand (e.g., I FNα) that initiates a ligand-specific signal at the nucleus of the cell and for neutralizing antibodies against the extracellular ligand. The cell-based on... | 08/04/2011 |
| 20110182931 | IMMORTAL AVIAN CELL LINE AND METHODS OF USE A avian cell line that supports replication of animal or human viruses, which cell line is adapted to animal-product free growth. The cell line is useful for propagating a virus suitable as a live or a killed vaccine and for virus isolation and diagnostic assays.... | 07/28/2011 |
| 20110183375 | METAL BINDING COMPOUNDS AND THEIR USE IN CELL CULTURE MEDIUM COMPOSITIONS The present invention is directed generally to metal binding compounds which may be added to cell culture media to replace factors required for cultivation of the cells (e.g. transferrin) which are of animal or human origin. More specifically, the invention is directed ... | 07/28/2011 |
| 20110179510 | METHOD FOR CULTURING AVIAN GONOCYTES A sustained culture of isolated avian gonocytes is provided, as well as a method of making and using the same. A chimeric avian containing an isolated gonocyte and a transgenic avian produced using the chimeric avian are also provided. The cell and method may be employe... | 07/21/2011 |
