Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Application No. | Application Title | Issue Date |
| 20120129217 | POLYPEPTIDE EXPRESSION IN CILIATES This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production of recombinant polypeptides in ciliates.... | 05/24/2012 |
| 20120107915 | METHOD FOR HIGH-THROUGHPUT IDENTIFICATION OF MICROBIAL ANTAGONISTS AGAINST PATHOGENS The present invention relates to high-throughput methods of screening biological samples to identify microorganisms having potential utilities as biocontrol agents. The methods include, for example, the use of multitest platforms for the simultaneous identification of m... | 05/03/2012 |
| 20120107343 | PRODUCTION OF RECOMBINANT PROTEINS IN CILIATES AND USES THEREOF This invention is directed to methods for recombinant polypeptide production and, in particular, methods and products for the production and purification of recombinant proteins in ciliates.... | 05/03/2012 |
| 20120071859 | INDUCIBLE INTERLEUKIN-12 The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid compr... | 03/22/2012 |
| 20120052542 | Reducing Carbon Dioxide Production and Increasing Ethanol Yield During Microbial Ethanol Fermentation The present invention provides compositions and methods for producing ethanol wherein the amount of CO2 by-product is reduced during the fermentation process. The invention includes the use of oxidized lignin during the fermentation process.... | 03/01/2012 |
| 20120045836 | Enzyme-Based Fed-Batch Technique In Liquid Cultures The present invention is generally in the field of continuous and high-cell-density cultivation in laboratory- or large-scale liquid shaken cultures. More particularly it relates to a method of enzyme-based fed-batch (EnBase) for liquid microbial prokaryotic or eukaryot... | 02/23/2012 |
| 20120034621 | MICROORGANISM CONCENTRATION PROCESS AND DEVICE A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has ... | 02/09/2012 |
| 20120034160 | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.... | 02/09/2012 |
| 20120030842 | METHODS OF PRODUCING GABA The present invention describes an alternative approach to increase GABA production in prokaryotes or eukaryotes, namely by the insertion of the putrescine catabolic pathway in organisms where the pathway does not exist or has not clearly been identified. The invention ... | 02/02/2012 |
| 20120021470 | Chimeric PUFA Polyketide Synthase Systems and Uses Thereof Disclosed are chimeric polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) proteins and chimeric PUFA PKS systems, including chimeric PUFA PKS proteins and systems derived from Schizochytrium and Thraustochytrium. Disclosed are nucleic acids and pr... | 01/26/2012 |
| 20120009190 | IDENTIFICATION AND METHOD FOR USING THE PRE-LIGAND ASSEMBLY DOMAIN OF THE IL-17 RECEPTOR The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides comprising an amino acid sequence of a domain (e.g., a Fibronectin Ill-like domain) of an IL-17 Receptor (IL-17R) family member, wherein the PLAD polypeptide inhibits multimerization of a rec... | 01/12/2012 |
| 20120009569 | MICROORGANISM CONCENTRATION PROCESS AND DEVICE A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises diatomaceous earth bearing, on at least a... | 01/12/2012 |
| 20120003626 | SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration ag... | 01/05/2012 |
| 20110318814 | METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a co... | 12/29/2011 |
| 20110313029 | DIAGNOSTIC AND THERAPEUTIC USES OF GNPTAB, GNPTG, AND NAGPA IN STUTTERING The allelic variants or mutations in three genes: GNPTAB, GNPTG and NAGPA, that correlate with stuttering in humans, as well as the encoded mutated polypeptides and related vectors, host cells, antibodies, antibody-producing cell lines and methods of diagnosing, prognos... | 12/22/2011 |
| 20110305749 | HIV-1 Envelope Polypeptides for HIV Vaccine Immunogenic HIV-1 envelope polypeptides are provided, wherein specific amino acid residues are mutated to repress immunosuppression in GP41, thereby boosting the immune response against HIV-1. Specifically, mutation of those specific residues does not affect the fusogen... | 12/15/2011 |
| 20110306611 | Transcription factor modulating compounds and methods of use thereof Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing a... | 12/15/2011 |
| 20110301073 | Novel DNA-binding proteins and uses thereof Disclosed herein are polypeptides, polynucleotides encoding, cells and organisms comprising novel DNA-binding domains, including TALE DNA-binding domains. Also disclosed are methods of using these novel DNA-binding domains for modulation of gene expression and/or genomi... | 12/08/2011 |
| 20110293587 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such meth... | 12/01/2011 |
| 20110293586 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such metho... | 12/01/2011 |
| 20110286981 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such meth... | 11/24/2011 |
| 20110286982 | GLUCAGON ANALOGUES The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such metho... | 11/24/2011 |
| 20110289607 | METHOD OF INHIBITING GENE EXPRESSION The present invention relates to a method for inhibiting expression of a target gene, which comprises introducing a cell, tissue, or individual organism with a double-stranded polynucleotide comprising DNA and RNA having a substantially identical nucleotide sequence wit... | 11/24/2011 |
| 20110275116 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS THROUGH ENZYME RELOCATION Genetically manipulated cells, lysates of such cells, systems, and methods of use thereof are provided, where one or more enzymes in a pathway of interest are genetically modified to incorporate a peptide sequence that provides for relocation of the protein, e.g., to th... | 11/10/2011 |
| 20110269198 | METHODS FOR CONTROL OF FLUX IN METABOLIC PATHWAYS The invention pertains to a method for preparing cells that can be used as biocatalysts by inducing in them a growth-decoupled state, in which interferase inhibits the expression of genes except the ones that code for the pathway enzymes of interest. mRNAs that code for... | 11/03/2011 |
| 20110256576 | RECOVERY AND DETECTION OF MICROORGANISMS FROM MIXED CELLULOSE ESTER FILTRATION SUPPORTS BY SEQUENTIAL TREATMENT WITH METHANOL AND ACETONE The present invention is directed to the recovery of bacteria and microparasites, particularly Cryptosporidium and Giardia, from water samples by filtration through a mixed cellulose ester membrane, partial dissolution of said membrane with methanol follow... | 10/20/2011 |
| 20110250130 | TNF-ALPHA BINDING PROTEINS Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions c... | 10/13/2011 |
| 20110212058 | TARGETED MODULATION OF GENE EXPRESSION The present invention relates to a method of modulating gene expression using snoRNA molecules or snoRNA like molecules or fragments, designed to target specific nucleic acid sequences.... | 09/01/2011 |
| 20110207702 | BORON-CONTAINING SMALL MOLECULES AS ANTI-PROTOZOAL AGENTS This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as well as combinations of these compounds with at least one additional therapeutically effective agent.... | 08/25/2011 |
| 20110207218 | MIXING SYSTEM WITH CONDENSER A system for mixing a liquid solution or suspension includes a support housing bounding a compartment and a collapsible bag disposed within the compartment. A mixer is disposed within the collapsible bag while a sparger delivers a gas to the lower end of the collapsible... | 08/25/2011 |
| 20110183347 | Compositions and methods for therapeutic delivery with microorganisms Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.... | 07/28/2011 |
| 20110165066 | INTERLEUKIN-13 BINDING PROTEINS The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. A... | 07/07/2011 |
| 20110150861 | SORF CONSTRUCTS AND MULTIPLE GENE EXPRESSION Embodiments of the invention relate to vector constructs and methods for expression of polypeptides including multimeric products such as therapeutic antibodies. Particular constructs allow for the generation of expression products from a single open reading frame (sORF... | 06/23/2011 |
| 20110142761 | IL-1 BINDING PROTEINS The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be... | 06/16/2011 |
| 20110142845 | NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST THE NOGO-66 RECEPTOR (NgR) AND USES THEREOF The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind to the Nogo-66 receptor. Specifically, these antibodies have the ability to inhibit the binding of the natural ligand of the Nogo-66 receptor and neutralize the Nogo-66 re... | 06/16/2011 |
| 20110091372 | Dual Variable Domain Immunoglobulins and Uses Thereof The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.... | 04/21/2011 |
| 20110059042 | SUBSTITUTED IL-15 The invention provides IL-15 amino acid sequences with amino acid substitutions that reduce or eliminate deamidation of IL-15 and degradation by-products. The invention also provides DNA sequences that encode the substituted amino acid sequences, a pharmaceutical compos... | 03/10/2011 |
| 20110003367 | Material For Capturing Microbes, Device For Capturing Microbes, Method Of Capturing Microbes, And Method Of Producing Material For Capturing Microbes The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pulveri... | 01/06/2011 |
| 20100322957 | SECRETION-RELATED BACTERIAL PROTEINS FOR NLRC4 STIMULATION Introduction of immunomodulatory T3SS polypeptides (IT3SSP's) into cells stimulates a response mediated by NLRC4 intracellularly. Introduction of said IT3SSP into the cells of a subject evoke an innate immune response in the subject.... | 12/23/2010 |
| 20100261220 | Biological system and assay for identifying modulators of tubulin ligases Tetrahymena is used as a host cell in a biological assay for identification of modulators of tubulin ligases.... | 10/14/2010 |
