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| Application No. | Application Title | Issue Date |
| 20120128718 | ATTENUATED FNR DEFICIENT ENTEROBACTERIA The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated ent... | 05/24/2012 |
| 20120128669 | MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid seque... | 05/24/2012 |
| 20120129227 | THERMOSTABLE CELLULASES, AND MUTANTS THEREOF, CAPABLE OF HYDROLYZING CELLULOSE IN IONIC LIQUID The present invention provides for a composition comprising an ionic liquid and a thermostable cellulose, and a method of hydrolyzing a cellulose, comprising: (a) providing a composition comprising a solution comprising an ionic liquid and a cellulose, and (b) introduci... | 05/24/2012 |
| 20120128709 | EXPRESSION OF RECOMBINANT PROTEINS The invention provides auto-inducible systems for expressing recombinant proteins of interest which take advantage of elements of quorum sensing (QS) systems of certain bacteria. These systems can be used to produce commercial quantities of proteins such as antigens, wh... | 05/24/2012 |
| 20120129232 | POLYHYDROXYALKANOATE PRODUCTION FROM POLYOLS Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are usef... | 05/24/2012 |
| 20120131687 | AGENT THAT MODULATES PHYSIOLOGICAL CONDITION OF PESTS, INVOLVED IN INSECT VOLTAGE-GATED POTASSIUM CHANNEL ACTIVITY The present invention provides an agent that modulates physiological condition of pests, wherein the agent has an ability to modulate the activity of an insect voltage-gated potassium channel; a method for assaying pesticidal activity of a test substance, which comprise... | 05/24/2012 |
| 20120128689 | ANTI-IL-23 IMMUNOGLOBULINS The present invention relates to antigen binding proteins to human IL-23, pharmaceutical formulations containing them and to the use of such antigen binding proteins in the treatment and/or prophylaxis of inflammatory diseases such as Rheumatoid Arthritis (RA).... | 05/24/2012 |
| 20120128676 | MUC1 ANTIBODIES The present invention pertains to anti-mucin antibodies having improved antigen binding and/or recognition properties as well as a method for improving the antigen binding and/or recognition of an anti-mucin antibody. In particular, the present invention is directed to ... | 05/24/2012 |
| 20120128677 | PANCREATIC CANCER TARGETS AND USES THEREOF The present invention provides a method for diagnosing and detecting diseases associated with pancreas. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in pancreatic diseases (PCAT) an... | 05/24/2012 |
| 20120125355 | Transgenic Plants Comprising Constructs Encoding Phosphoenolpyruvate Carboxykinase and/or Pyruvate Orthophosphate Dikinase The invention provides genetic constructs which comprise a senescence-specific promoter operably linked to at least one coding sequence, which encodes at least one polypeptide having phosphoenolpyruvate carboxykinase (PCK) activity and/or pyruvate orthophosphate dikinas... | 05/24/2012 |
| 20120129219 | Antibody Molecules Which Bind Human IL-17 The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods of producing the antibody molecules.... | 05/24/2012 |
| 20120129778 | LIGAND THAT BIND TGF-BETA RECEPTOR RII The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue f... | 05/24/2012 |
| 20120131697 | GENE ENCODING AUXIN RECEPTOR PROTEIN DERIVED FROM RICE AND USE THEREOF The present invention pertains to an auxin receptor protein involved in activation of proton pump in plasma membrane of a plant derived from rice, a gene encoding the protein, a recombinant vector comprising the gene, a host cell transformed with the recombinant vector,... | 05/24/2012 |
| 20120128723 | CANCER SPECIFIC ANTIBODY AND CELL SURFACE PROTEINS The present invention provides the amino acid and nucleic acid sequences of heavy chain and light chain complementarity determining regions of a cancer specific antibody. In addition, the invention provides cancer specific antibodies and immunoconjugates comprising the ... | 05/24/2012 |
| 20120128727 | BACTERIAL EXPRESSION OF AN ARTIFICIAL GENE FOR THE PRODUCTION OF CRM197 AND ITS DERIVATIVES The present invention relates to polynucleotide sequences comprising the SEQ ID N° 1 encoding CRM197 and optimised for its expression in E. coli. The invention consequently concerns a method for the production of CRM197 in E. coli via a fusion protein CRM... | 05/24/2012 |
| 20120128695 | TENEURIN C-TERMINAL ASSOCIATED PEPTIDES (TCAP) AND METHODS AND USES THEREOF The invention provides a novel family of biologically active neuropeptides and the nucleic aid molecules coding for same. The peptides are derived for the C-terminus of the teneurin family peptides (Ten M1-4). These novel peptides, referred to as teneurin C-terminal ass... | 05/24/2012 |
| 20120107325 | IL-17 Antagonistic Antibodies An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-17 m... | 05/03/2012 |
| 20120107339 | Chimeric Factor H Binding Proteins (fHBP) Containing a Heterologous B Domain and Methods of Use Chimeric fHBPs that can elicit antibodies that are bactericidal for different fHBP variant strains of N. meningitidis, and methods of use, are provided.... | 05/03/2012 |
| 20120110697 | METHOD OF CONSTRUCTING NOVEL HIGHER PLANT AND METHOD OF PROMOTING THE GROWTH OF HIGHER PLANT The present invention provides a method of producing a higher plant having cytochrome c6 in the thylakoid space of chloroplast, which is characterized in that it comprises introducing a gene encoding a fused protein formed by adding a signal peptide consistin... | 05/03/2012 |
| 20120107234 | Pan-HER Antibody Composition The present invention is directed to improved therapeutics against receptors within the EGFR/ErbB/HER family that more broadly interfere with multiple members of the HER family (pan-HER inhibition). More particularly, the invention is directed to the use of antibody com... | 05/03/2012 |
| 20120108662 | COMPOSITIONS AND METHODS FOR TREATING SKIN DISORDERS The present application relates to compositions and the treatment of skin disorders, dry skin, protection of skin in inflammatory events and neurological disorders. The present application more particularly discloses the identification of new genes and metabolic pathway... | 05/03/2012 |
| 20120108493 | Polypeptide Fragments Comprising Endonuclease Activity and Their Use The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or variants thereof possessing endonuclease activity, wherein said PA subunit is from a virus belonging to the Orthomyx... | 05/03/2012 |
| 20120108521 | IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREOF The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.... | 05/03/2012 |
| 20120108795 | Antibodies Binding Human Collagen II The present invention relates to antibodies against human collagen II, polypeptides and polynucleotides encoding human collagen II antibodies or fragments thereof, and methods of making and using the foregoing.... | 05/03/2012 |
| 20120107333 | VANGL1 PEPTIDES AND VACCINES INCLUDING THE SAME The present invention provides isolated peptides or the fragments derived from SEQ ID NO: 35, which bind to an HLA antigen and induce cytotoxic T lymphocytes (CTL). The peptides may include one of the above mentioned amino acid sequences with substitution, deletion, or ... | 05/03/2012 |
| 20120107894 | Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.... | 05/03/2012 |
| 20120107899 | Heat-Stable Carbonic Anhydrases and Their Use The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their ex... | 05/03/2012 |
| 20120108855 | INCREASED EXPRESSION OF TRANSHYDROGENASE GENES AND THEIR USE IN ETHANOL PRODUCTION The invention provides isolated or recombinant ethanologenic bacteria that have increased expression of transhydrogenase genes and methods of preparation. The invention also provides methods of producing ethanol using the bacterium and corresponding kits.... | 05/03/2012 |
| 20120107350 | VIRUS-LIKE PARTICLES OF CAPSID PROTEINS FROM HUMAN PAPILLOMAVIRUS TYPE 16/58/18/6/11 AND THE METHOD FOR PREPARATION AND THE USES THEREOF Five optimized genes of capsid L1 protein from human papillomavirus type 16, 58, 18, 6 and 11, which are modified by using insect's preferred codons and so on. Method for modifying those genes to express more highly in insect cells. Virus-like particle's vaccine composi... | 05/03/2012 |
| 20120107330 | ANTAGONISTS, USES & METHODS FOR PARTIALLY INHIBITING TNFR1 The present invention relates to anti-Tumor Necrosis Factor 1 (TNFR1, p55, CD120a, P60, TNF receptor superfamily member 1A, TNFRSF1A) antagonists for partially inhibiting TNFR1 useful for the treatment and/or prevention of TNFR1-mediated diseases or conditions such as a... | 05/03/2012 |
| 20120107362 | NEUROTOXINS EXHIBITING SHORTENED BIOLOGICAL ACTIVITY The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation si... | 05/03/2012 |
| 20120107882 | Recombinant Microorganism And Method For Producing L-Lysine The present invention provides methods of producing L-lysine at a high yield using an Escherichia bacterium, especially E. coli, comprising a wild type or variant dapA gene of B. subtilis. The invention also provides related recombinant Escherich... | 05/03/2012 |
| 20120107875 | Expression Cassette, Recombinant Host Cell and Process for Producing a Target Protein Disclosed herein is a process for producing a target protein, in which a recombinant polynucleotide is constructed to encode a fusion protein including: (i) an anchoring protein that includes a N-terminal amino acid sequence of an ice nucleation protein, so that the fus... | 05/03/2012 |
| 20120107906 | NOVEL LIPOLYTIC ENZYME LIP1 The present invention provides a novel nucleic acid sequence, designated LIP1, encoding a lipolytic enzyme and the corresponding encoded amino acid sequences. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding at le... | 05/03/2012 |
| 20120082648 | Colonization factor (CF) antigens of enterotoxigenic escherichia coli in recombinant bacteria Escherichia coli strains, such as enterotoxigenic E. coli strains, genetically engineered to express from recombinant plasmids one or more colonization factors (CFs) associated with enterotoxigenic Escherichia coli bacteria (ETEC) in an increased am... | 04/05/2012 |
| 20120082662 | ANTI-CMET ANTAGONISTS The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.... | 04/05/2012 |
| 20120082663 | ANTI-CMET ANTAGONISTS The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.... | 04/05/2012 |
| 20120082644 | CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provide... | 04/05/2012 |
| 20120083020 | MANIPULATION OF GENES OF THE MEVALONATE AND ISOPRENOID PATHWAYS TO CREATE NOVEL TRAITS IN TRANSGENIC ORGANISMS Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the ... | 04/05/2012 |
| 20120083442 | MYOSTATIN BINDING AGENTS The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such ... | 04/05/2012 |
