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| Application No. | Application Title | Issue Date |
| 20120129778 | LIGAND THAT BIND TGF-BETA RECEPTOR RII The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue f... | 05/24/2012 |
| 20120129254 | Inducible Expression System Transcription Modulators Comprising A Distributed Protein Transduction Domain And Methods For Using The Same Aspects of the invention include inducible expression systems in which a transcription modulator having a distributed protein transduction domain is employed. Aspects of the invention further include methods of using the systems to induce expression of a coding sequence... | 05/24/2012 |
| 20120129231 | ENGINEERING OF THERMOTOLERANT BACILLUS COAGULANS FOR PRODUCTION OF D(-)-LACTIC ACID Genetically modified microorganisms having the ability to produce D(−)-lactic acid at temperatures between 30° C. and 55° C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal ace... | 05/24/2012 |
| 20120128624 | Recombinant Human Albumin-Granulocyte Macrophage Colony Stimulating Factor Fusion Protein With Long-Lasting Biological Effects Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and bioactive molecules. The bioactive molecules may be a protein or peptide havin... | 05/24/2012 |
| 20120131699 | METHODS AND COMPOSITIONS FOR OBTAINING MARKER-FREE TRANSGENIC PLANTS The invention provides methods and compositions for identifying transgenic seed that contain a transgene of interest, but lack a marker gene. Use of an identification sequence that results in a detectable phenotype increases the efficiency of screening for seed and plan... | 05/24/2012 |
| 20120128669 | MONOVALENT, BIVALENT AND TRIVALENT ANTI HUMAN RESPIRATORY SYNCYTIAL VIRUS (HRSV) NANOBODY CONSTRUCTS FOR THE PREVENTION AND/OR TREATMENT OF RESPIRATORY TRACT INFECTIONS Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid seque... | 05/24/2012 |
| 20120131697 | GENE ENCODING AUXIN RECEPTOR PROTEIN DERIVED FROM RICE AND USE THEREOF The present invention pertains to an auxin receptor protein involved in activation of proton pump in plasma membrane of a plant derived from rice, a gene encoding the protein, a recombinant vector comprising the gene, a host cell transformed with the recombinant vector,... | 05/24/2012 |
| 20120128718 | ATTENUATED FNR DEFICIENT ENTEROBACTERIA The invention provides an attenuated enterobacterium comprising an attenuating mutation in the fnr gene, and optionally further comprising a heterologous nucleic acid encoding a foreign antigen. Also provided are pharmaceutical formulations comprising the attenuated ent... | 05/24/2012 |
| 20120107357 | NOVEL DIVERGENT PICORNAVIRUS: COSAVIRUS Presented herein is the discovery of a new human picornavirus, Cosavirus (previously termed Dekavirus), methods of detecting the Cosavirus and diagnosing Cosavirus infection, methods of treating or preventing Cosavirus infection, and methods for identifying anti-Cosavir... | 05/03/2012 |
| 20120110686 | Cand45 tRNA-Derived Expression System for Gene Modulation The present invention relates to systems and methods for modulating gene expression and applications thereof. Provided is a novel expression system to generate RNaseZ and RNA polymerase III dependent RNAs to regulate genes and control the timing and the location of the ... | 05/03/2012 |
| 20120107362 | NEUROTOXINS EXHIBITING SHORTENED BIOLOGICAL ACTIVITY The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation si... | 05/03/2012 |
| 20120110685 | MODULAR DNA-BINDING DOMAINS AND METHODS OF USE The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specificall... | 05/03/2012 |
| 20120107894 | Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.... | 05/03/2012 |
| 20120107360 | GAMMA-GLUTAMYL TRANSPEPTIDASE ATTENUATED FRANCISELLA The present invention relates to a mutated Francisella bacterium, wherein the ggt gene is silenced or deleted; pharmaceutical compositions comprising the same, in particular, vaccine compositions, and use of the bacterium and compositions for treatment and/or pro... | 05/03/2012 |
| 20120107320 | ANTIBODIES SPECIFICALLY DIRECTED TO THE SOLUBLE FORM OF CTLA-4 The invention provides materials and methods relating to antibodies specific for the soluble form of CTLA-4 (sCT-LA-4). Such antibodies have been shown to have a strong boosting effect on antigen-specific human immune responses.... | 05/03/2012 |
| 20120107244 | MONOMERIC VARIANTS OF THE TETRAMERIC eqFP611 Monomeric eqFP611 variants exhibit red fluorescent properties and DNA encoding monomeric eqFP611 variants.... | 05/03/2012 |
| 20120108662 | COMPOSITIONS AND METHODS FOR TREATING SKIN DISORDERS The present application relates to compositions and the treatment of skin disorders, dry skin, protection of skin in inflammatory events and neurological disorders. The present application more particularly discloses the identification of new genes and metabolic pathway... | 05/03/2012 |
| 20120107888 | MODULATION OF FERMENTATION PRODUCTS THROUGH VITAMIN SUPPLEMENTATION Improved yields of biofuels and other chemicals are obtained by culturing a cellulolytic microorganism, such as Clostridium phytofermentans, Clostridium sp. Q.D, or Clostridium biocatalysts thereof in modulated amounts of vitamins, such as thiamine or nico... | 05/03/2012 |
| 20120107330 | ANTAGONISTS, USES & METHODS FOR PARTIALLY INHIBITING TNFR1 The present invention relates to anti-Tumor Necrosis Factor 1 (TNFR1, p55, CD120a, P60, TNF receptor superfamily member 1A, TNFRSF1A) antagonists for partially inhibiting TNFR1 useful for the treatment and/or prevention of TNFR1-mediated diseases or conditions such as a... | 05/03/2012 |
| 20120107325 | IL-17 Antagonistic Antibodies An IL-17 binding molecule, in particular an antibody to human IL-17, more preferably a human antibody to human IL-17 is provided, wherein the hypervariable regions of the heavy and light chains have amino acid sequences as defined, for use in the treatment of an IL-17 m... | 05/03/2012 |
| 20120108855 | INCREASED EXPRESSION OF TRANSHYDROGENASE GENES AND THEIR USE IN ETHANOL PRODUCTION The invention provides isolated or recombinant ethanologenic bacteria that have increased expression of transhydrogenase genes and methods of preparation. The invention also provides methods of producing ethanol using the bacterium and corresponding kits.... | 05/03/2012 |
| 20120108521 | IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREOF The present invention provides novel immune-stimulatory polypeptides, and methods for their use and identification.... | 05/03/2012 |
| 20120107899 | Heat-Stable Carbonic Anhydrases and Their Use The present invention relates to use of Caminibacter carbonic anhydrase in CO2 extraction, e.g., from flue gas, natural gas, biogas or ambient air. The Caminibacter carbonic anhydrases are especially well suited for these purpose due to their ex... | 05/03/2012 |
| 20120107904 | CARBOXY TERMINAL RESIDUES AS PREDICTORS AND REGULATORS OF PROTEIN STABILITY Compositions and methods are provided that are useful for predicting and controlling the stability of expressed polypeptides. The compositions and methods may be used to predict and as desired, increase or decrease the stability of proteins recombinantly expressed in my... | 05/03/2012 |
| 20120107339 | Chimeric Factor H Binding Proteins (fHBP) Containing a Heterologous B Domain and Methods of Use Chimeric fHBPs that can elicit antibodies that are bactericidal for different fHBP variant strains of N. meningitidis, and methods of use, are provided.... | 05/03/2012 |
| 20120082622 | Macaca fascicularis CCL17 Isolated polynucleotides encoding Macaca fascicularis CCL17 (CynoCCL17), polypeptides obtainable from expression of these polynucleotides, recombinant cells, and methods of use are disclosed.... | 04/05/2012 |
| 20120082644 | CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provide... | 04/05/2012 |
| 20120083020 | MANIPULATION OF GENES OF THE MEVALONATE AND ISOPRENOID PATHWAYS TO CREATE NOVEL TRAITS IN TRANSGENIC ORGANISMS Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate, dimethylallyl diphosphate and isoprenoid pathway derived products in the ... | 04/05/2012 |
| 20120082662 | ANTI-CMET ANTAGONISTS The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.... | 04/05/2012 |
| 20120083442 | MYOSTATIN BINDING AGENTS The present invention provides binding agents comprising peptides capable of binding myostatin and inhibiting its activity. In one embodiment the binding agent comprises at least one myostatin-binding peptide attached directly or indirectly to at least one vehicle such ... | 04/05/2012 |
| 20120083012 | Expression System for Producing Multi-Enzyme Complexes and Uses Thereof An expression system for producing a multi-enzyme complex, the system including a nucleic acid molecule containing a promoter operatively linked to a nucleotide sequence including multiple genes encoding multiple enzymes that are components of the multi-enzyme complex.... | 04/05/2012 |
| 20120083587 | BIOLOGICALLY ACTIVE POLYPEPTIDES DERIVED FROM A NOVEL EARLY STAGE PREGNANCY FACTOR DESIGNATED MATERNIN (MA) The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful ... | 04/05/2012 |
| 20120084889 | Novel Fatty Acid Elongation Components and Uses Thereof The invention provides isolated nucleic acid molecules which encodes a novel fatty acid nECR. The invention also provides recombinant expression vectors containing nECR nucleic acid molecules, host cells into which the expression vectors have been introduced, and method... | 04/05/2012 |
| 20120082663 | ANTI-CMET ANTAGONISTS The invention provides therapeutic anti-c-met antibodies, and compositions comprising and methods of using these antibodies.... | 04/05/2012 |
| 20120082670 | CD33 BINDING AGENTS The present invention relates to immunotherapies that are based on myeloid cell depletion. In particular, the present invention relates to CD33 binding agents for use in such therapies, e.g. in the treatment of myeloid cell malignancies and myelodysplastic syndrome (MDS... | 04/05/2012 |
| 20120082693 | USE OF PROTEINS AND PEPTIDES ENCODED BY THE GENOME OF A NOVEL SARS-ASSOCIATED CORONAVIRUS STRAIN The invention relates to the use of proteins and peptides coded by the genome of the isolated or purified strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from sample reference number 031589 and, in particular, to the use of protein S... | 04/05/2012 |
| 20120071859 | INDUCIBLE INTERLEUKIN-12 The invention provides an isolated or purified nucleic acid comprising a nucleotide sequence encoding a nuclear factor of activated T-cells (NFAT) promoter operatively associated with a nucleotide sequence encoding IL-12. The invention also provides a nucleic acid compr... | 03/22/2012 |
| 20120073016 | AXMI-150 DELTA-ENDOTOXIN GENE AND METHODS FOR ITS USE Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions including a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or express... | 03/22/2012 |
| 20120070876 | VARIANT FORM OF URATE OXIDASE AND USE THEREOF The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate oxid... | 03/22/2012 |
| 20120071394 | NOVEL POLYPEPTIDES AND USE THEREOF The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising or consisting of the amino acid sequence of SEQ ID NO: 2, or a fragment or variant th... | 03/22/2012 |
