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Class 435/239 - Recovery or purification


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter which involves the purification or recovery
No. of applications: 214
Last issue date: 02/23/2012


1            
Application No.Application TitleIssue Date
20120045394HUMAN AND MOUSE TARGETING PEPTIDES IDENTIFIED BY PHAGE DISPLAY
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted delivery of therapeutic agents, incl...
02/23/2012
20120039939COMPOSITIONS AND METHODS FOR VACCINE AND VIRUS PRODUCTION
The present invention features methods of producing immunogenic compositions and viruses, methods of treating and preventing viral infection, and methods of producing an immune response using cells that express a polypeptide selected from the group consisting of: cdk13,...
02/16/2012
20120034621MICROORGANISM CONCENTRATION PROCESS AND DEVICE
A process for capturing or concentrating microorganisms for detection or assay comprises (a) providing a concentration device comprising a sintered porous polymer matrix comprising at least one concentration agent that comprises an amorphous metal silicate and that has ...
02/09/2012
20120034265INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....
02/09/2012
20120028357AAV VECTORS PRODUCED IN INSECT CELLS
The present invention relates to the production of adeno-associated viral vectors in insect cells. The insect cells therefore comprise a first nucleotide sequence encoding the adeno-associated virus (AAV) capsid proteins, whereby the initiation codon for translation of ...
02/02/2012
20120020997MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided....
01/26/2012
20120018313NOVEL BIOTRACERS AND USES THEREOF FOR CONTROLLING FILTRATION PLANTS
The present invention relates to novel biotracers, to a method for preparing same, and to a method for detecting the biotracers and for monitoring filtration systems....
01/26/2012
20120021403Human Endogenous Retrovirus with Foamy-Like Properties and Uses Thereof
The invention relates to the discovery of a human endogenous retrovirus (HERV) family, Type I HERV-K (HML-2) which appear to be active in vitro and in vivo, infectious, and which have the have the salient features and properties of foamy retroviruses. Based on its natur...
01/26/2012
20120015425Cellular Permissivity Factor for Viruses and Uses Thereof
The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus....
01/19/2012
20120009624PROTEIN PARTICLES
The invention relates to a protein particle comprising chimeric protein having an aggregating part capable of forming or aggregating into a substantially insoluble protein particle when expressed by a cell; and a functional part capable of binding to, or being bound by,...
01/12/2012
20120003626SAMPLING DEVICES AND METHODS FOR CONCENTRATING MICROORGANISMS
The present disclosure describes methods for concentrating microorganisms with concentration agents in a sampling device and the sampling device described herein. More specifically, methods for concentrating microorganisms from large volume samples with concentration ag...
01/05/2012
20120003691METHOD OF ISOLATION AND PURIFICATION OF TRYPSIN FROM PRONASE PROTEASE AND USE THEREOF
The present invention provides methods of isolation and purification of Streptomyces griseus trypsin (SGT) from PRONASE protease mixture in a single affinity chromatography step and uses of the purified SGT....
01/05/2012
20120003266VIRUS LIKE PARTICLE COMPOSITIONS AND METHODS OF USE
The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases....
01/05/2012
20110318814METHODS, KITS AND SYSTEMS FOR PROCESSING SAMPLES
A method for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the method including the steps of providing a receptacle, the receptacle configured to allow filtering of the sample and to reversibly contain the sample and a co...
12/29/2011
20110312060PURIFICATION OF VACCINIA VIRUS- AND RECOMBINANT VACCINIA VIRUS-BASED VACCINES
The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus...
12/22/2011
20110306114PURIFICATION OF VACCINIA VIRUSES USING HYDROPHOBIC INTERACTION CHROMATOGRAPHY
The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus...
12/15/2011
20110306113Scalable Process for Protein Purification
The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chr...
12/15/2011
20110300603Tagged Ligands for Enrichment of Rare Analytes from a Mixed Sample
Method of enriching specific cells from cellular samples are disclosed, comprising contacting in solution a cellular sample with affinity-tagged ligands (ATLs) each comprising a first ligand linked to an affinity tag, wherein the ligand selectively binds a cellular mark...
12/08/2011
20110300181PURIFICATION OF VACCINIA VIRUS- AND RECOMBINANT VACCINIA VIRUS-BASED VACCINES
The present invention relates to methods for purification of Vaccinia viruses (W) and/or Vaccinia virus (W) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus p...
12/08/2011
20110293660NOVEL METHOD
The present invention relates to a method for purifying a virus, or a viral antigen thereof, comprising at least the following steps: a) obtaining a fluid comprising the virus, or a viral antigen thereof, and b) purifying the fluid by at least one density gradient ultra...
12/01/2011
20110287044RECOMBINANT CLASSICAL SWINE FEVER VIRUS (CSFV) COMPRISING A MODIFIED E2 PROTEIN AND METHODS FOR GENERATING SAID RECOMBINANT CSFV
The invention relates to a recombinant classical swine fever virus (CSFV). A preferred recombinant CSFV comprises a deletion of at least one amino acid in a “TAVSPTTLR” domain of the E2 protein. The invention further relates to a vaccine comprising the recombinant C...
11/24/2011
20110281329PROCESS AND SYSTEM FOR THE INDUSTRIAL SCALE PURIFICATION OF BACTERIOPHAGES INTENDED FOR BACTERIOPHAGE THERAPY
The present invention is directed towards bacteriophage therapy, the treatment of infectious diseases, caused by pathogenic bacteria, using specific bacteriophages. The purity of bacteriophage preparations has been a major obstacle for their therapeutic use in the past....
11/17/2011
20110269116Cell Line From Rousettus As Host Cell For Pathogen Amplification
The present invention relates to permanent cell lines from chiropterans suitable for amplification and production microbial agents, preferably viruses, and its use for diagnostic or therapeutic purposes....
11/03/2011
20110256576RECOVERY AND DETECTION OF MICROORGANISMS FROM MIXED CELLULOSE ESTER FILTRATION SUPPORTS BY SEQUENTIAL TREATMENT WITH METHANOL AND ACETONE
The present invention is directed to the recovery of bacteria and microparasites, particularly Cryptosporidium and Giardia, from water samples by filtration through a mixed cellulose ester membrane, partial dissolution of said membrane with methanol follow...
10/20/2011
20110256525COMPOSITIONS AND METHODS FOR PURIFYING AND CRYSTALLIZING MOLECULES OF INTEREST
A composition-of-matter is provided. The composition comprising at least one antibody binding moiety capable of binding an antibody-labeled target molecule, cell or virus of interest, said at least one antibody binding moiety being attached to at least one coordinating ...
10/20/2011
20110243986POLYNUCLEOTIDES ALLOWING THE EXPRESSION AND SECRETION OF RECOMBINANT PSEUDO-VIRUS CONTAINING FOREIGN EPITOPES, THEIR PRODUCTION, AND USE
This invention provides a new approach to the design of a virus with a defective replication cycle, which can be rescued by wild type virus co-infection, and which expresses foreign antigenic epitopes that contribute to the elimination of virus infected cells and then t...
10/06/2011
20110229957POLYMER-MEDIATED ELECTROMAGNETIC FIELD-BASED PARTICLE CONCENTRATOR
There remains an unmet need for methods to efficiently concentrate and isolate small particles, such as nano-sized and micron-sized particles. The methods herein provide means to fulfill this need through the combination of two independent particle-concentrating mechani...
09/22/2011
20110229971RECOMBINANT VIRUS PRODUCTION USING MAMMALIAN CELLS IN SUSPENSION
The invention generally provides methods for producing recombinant AAV viral particles using cells grown in suspension. The invention provides recombinant AAV particles for use in methods for delivering genes encoding therapeutic proteins, and methods for using the reco...
09/22/2011
20110217757MODIFIED VACCINIA ANKARA VIRUS VARIANT AND CULTIVATION METHOD
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus and...
09/08/2011
20110217330NOVEL METHOD
The present invention relates to a method for degrading host cell nucleic acids associated with a virus or a viral antigen thereof produced by cell culture, the method comprising at least two steps of nucleic acids degradation with a compound selected from i) an endonuc...
09/08/2011
20110207202METHOD FOR THE PRODUCTION OF ADENOVIRAL VECTORS
The invention provides methods for large-scale production of recombinant adenovirus 35, using perfusion systems and infection at very high-cell densities....
08/25/2011
20110201078LIGAND FUNCTIONALIZED POLYMERS
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed....
08/18/2011
20110182932MODIFIED VACCINIA ANKARA VIRUS VARIANT
The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus, wherein the MVA-BN virus, or a derivative thereof, induces at least substantially the same level of immunity in vaccinia virus prime/vaccina virus boost regimes whe...
07/28/2011
20110165224VACCINES FOR INCLUSION BODY HEPATITIS
A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its ...
07/07/2011
20110165645Methods Using Ion Exchange and Gel Filtration Chromatography for Poxvirus Purification
Provided herein are methods for purifying poxviruses using one or more chromatographic steps including, but not limited to, gel filtration and/or ion exchange chromatography....
07/07/2011
20110151543CELL SEPARATION METHOD USING HYDROPHOBIC SOLID SUPPORTS
Provided is a method of separating cells using a hydrophobic solid support. The method comprises contacting a solution containing cells with a hydrophobic solid support having a water contact angle between 70 and 90 degrees. By allowing cells to be adsorbed to the hydro...
06/23/2011
20110142863FLOW THROUGH PURIFICATION PROCESSES FOR LARGE BIOMOLECULES
The present invention relates, at least in part, to novel and improved flow-through purification processes for separating large biomolecules, such as, for example, encapsulated viruses, virus-like particles and conjugate vaccines from one or more contaminants in a sampl...
06/16/2011
20110129446Clone of newcastle disease virus, its manufacture and its application in the medical treatment of cancer
A new clone of Newcastle disease virus which is interferon insensitive and has an ICPI between 1.2 and 2.0 and which may be used in the treatment of cancer and other diseases....
06/02/2011
20110123559SWINE INFLUENZA HEMAGGLUTININ VARIANTS
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....
05/26/2011
20110124086Hepatitis C Virus Culture System
This disclosure provides compositions and methods for producing infectious hepatitis C virus (HCV). The produced HCV can be infectious in vivo and in vitro. In one aspect, the disclosure provides an immortalized primary hepatocyte transformed with a DNA construct compri...
05/26/2011
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