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Class 435/236 - Inactivation or attenuation; producing viral subunits


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter in which the virulence of the virus is decreased
No. of applications: 163
Last issue date: 05/03/2012


1          
Application No.Application TitleIssue Date
20120107356COMPOSITION USEFUL AS ROTAVIRUS VACCINE AND A METHOD THEREFOR
Compositions and methods related to live or live attenuated pre-conditioned and typical viruses such as rotaviruses are disclosed. The live attenuated rotaviruses exhibit better stability characteristics and are useful for the prevention of a rotavirus infection and/or ...
05/03/2012
20120045468Immunogenic Compositions and Uses Thereof
Disclosed are methods of producing a purified EV71 virus antigen. Also disclosed are related immunogenic compositions and immunization methods....
02/23/2012
20120039921POULTRY VIRAL MATERIALS AND METHODS RELATED THERETO
The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis diseas...
02/16/2012
20120034265INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....
02/09/2012
20120034267INACTIVATED VARICELLA ZOSTER VIRUS VACCINES, METHODS OF PRODUCTION, AND USES THEREOF
The invention provides an inactivated varicella zoster virus (VZV), and compositions and vaccines comprising said inactivated VZV, wherein the infectivity of the VZV is undetectable and wherein the inactivated VZV induces an immune response against VZV when administered...
02/09/2012
20120034264INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided....
02/09/2012
20120027846ANTI-VIRAL AZIDE CONTAINING COMPOUNDS
Methods of using azide-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to inhibit infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are me...
02/02/2012
20120027777LJUNGAN VIRUS WITH IMPROVED REPLICATION CHARACTERISTICS
The present invention relates to a Ljungan virus with improved replication characteristic and the use of this Ljungan virus, amongst other thing, in the production of a vaccine....
02/02/2012
20120020997MULTI PLASMID SYSTEM FOR THE PRODUCTION OF INFLUENZA VIRUS
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided....
01/26/2012
20120014992N-Linked Glycosylation Alteration in E1 Glycoprotein of Classical Swine Fever Virus And Novel Classical Swine Fever Virus Vaccine
E1, along with Erns and E2 is one of the three envelope glycoproteins of Classical Swine Fever Virus (CSFV). Our previous studies indicated that glycosylation status of either E2 or Erns strongly influence viral virulence in swine. Here, we have investigated the role of...
01/19/2012
20120009654MONOPARAMUNITY INDUCERS BASED ON ATTENUATED RABBIT MYXOMAVIRUSES
The present invention relates to monoparamunity inducers based on paramunizing viruses or viral components of a myxomavirus strain from rabbits with typically generalizing disease, to a method for the production thereof and to the use thereof as medicaments for the regu...
01/12/2012
20110311586Materials and methods for respiratory disease control in canines
The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of the...
12/22/2011
20110311579Flaviviruses expressing the prM, E, and NS1 proteins of other flaviviruses and uses thereof
This invention provides flavivirus vaccines that comprise live-attenuated flaviviruses and methods of making and using these vaccines. The flavivirus vaccines described herein possess higher potency due to in situ production of additional immunogens in a way that mimics...
12/22/2011
20110305726Infectious Bronchitis Vaccines Derived From IB-qx-like Vaccine Strains
The present invention relates to infectious bronchitis (IB) viruses derived from a recently identified genotype of IB virus known as IB-QX, or from viruses that are genetically related to IB-QX, herein referred to as IB-QX-like viruses. The IB viruses of the invention m...
12/15/2011
20110293660NOVEL METHOD
The present invention relates to a method for purifying a virus, or a viral antigen thereof, comprising at least the following steps: a) obtaining a fluid comprising the virus, or a viral antigen thereof, and b) purifying the fluid by at least one density gradient ultra...
12/01/2011
20110287050RECOMBINANT KOI HERPESVIRUS (KHV) OR CYPRINID HERPESVIRUS 3 (CYHV-3) AND A VACCINE FOR THE PREVENTION OF A DISEASE CAUSED BY KHV/CYHV-3 IN CYPRINUS CARPIO CARPIO OR CYPRINUS CARPIO KOI
The present invention refers to a recombinant koi herpesvirus (KHV) or Cyprinid herpesvirus 3 (CyHV-3), which is immunogenic in fish, preferably in carps, more preferably in Cyprinus carpio, and to a vaccine for preventive and/or therapeutic treatment of a diseas...
11/24/2011
20110280905LIVE ATTENUATED CHIMERIC PORCINE CIRCOVIRUS VACCINE
The present invention provides a novel chimeric porcine circovirus infectious DNA clone and live attenuated chimeric virus with the PCV2, preferably of subtype PCV2b, capsid gene integrated into a non-pathogenic PCV1 virus genome. In a particular embodiment, the PCV2 ca...
11/17/2011
20110274661Attentuated Herpesvirus Encoding a Mek Pathway Polypeptide
The disclosure provides materials and methods for the treatment of cells exhibiting a cell proliferative disorder with a herpes simplex virus having a deficiency in the expression of active ICP34.5 and comprising an expression control element effective in modulating at ...
11/10/2011
20110262474Chimeric HIV Antigens
The invention provides polynucleotides and polypeptides encoded therefrom that are capable of inducing immune responses to a human immunodeficiency virus. Compositions and methods for utilizing polynucleotides and polypeptides of the invention are also provided....
10/27/2011
20110256174RABIES VACCINE
An attenuated rabies virus for use as a vaccine. The attenuated rabies virus expresses an immune factor that enhances immune response upon administration of the vaccine....
10/20/2011
20110243989IDNA VACCINES AND METHODS FOR USING THE SAME
Described herein are iDNA vectors and vaccines and methods for using the same. The iDNA generates live attenuated vaccines in eukaryotic cells in vitro or in vivo for pathogenic RNA viruses, particularly yellow fever virus and Venezuelan equine encephalitis virus. When ...
10/06/2011
20110223199METHOD FOR PRODUCTION OF pH STABLE ENVELOPED VIRUSES
The present invention provides a method for producing pH-stable enveloped viruses wherein said viruses are used for infection of host cells under low pH conditions and for incubation with cell culture cells under conditions of low pH, as well as influenza viruses obtain...
09/15/2011
20110212130LIVE, ATTENUATED RESPIRATORY SYNCYTIAL VIRUS
The present invention features live, attenuated respiratory syncytial viruses (RSV) useful as vaccines against RSV infection and/or the development of severe RSV-associated illnesses. The disclosed viruses are attenuated to the extent of being nonpathogenic when adminis...
09/01/2011
20110212117INFLUENZA HEMAGGLUTININ AND NEURAMINIDASE VARIANTS
Polypeptides, polynucleotides, methods, compositions, and vaccines comprising influenza hemagglutinin and neuraminidase variants are provided....
09/01/2011
20110189232RECOMBINANT HUMAN PARAINFLUENZA TYPE 1 VIRUSES (HPIV1s) CONTAINING MUTATIONS IN OR DELETION OF THE C PROTEIN ARE ATTENUATED IN AFRICAN GREEN MONKEYS AND IN CILIATED HUMAN AIRWAY EPITHELIAL CELLS AND ARE POTENTIAL VACCINE CANDIDATES FOR HPIV1
Two recently characterized live attenuated HPIV1 vaccine candidates, rHPIV1-CR84G/Δ170HNT553ALY942A and rHPIV1-CR84G/Δ170HN-T553ALΔ1710-11, which contain temperature sensitive (ts) attenuating (att) an...
08/04/2011
20110189129HEPATITIS C VIRUS INHIBITORS
The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, esters, or prodrugs thereof:


Q-G-A-L-B—W  (I),

which inhibit RNA-con...

08/04/2011
20110177125HSV-1 AND HSV-2 VACCINES AND METHODS OF USE THEREOF
This invention provides methods of vaccinating a subject against a Herpes Simplex Virus (HSV) infection and disorders and symptoms associated with same, and impeding, inhibiting, reducing the incidence of, and suppressing HSV infection, neuronal viral spread, formation ...
07/21/2011
20110177124CODON-OPTIMIZED POLYNUCLEOTIDE-BASED VACCINES AGAINST HUMAN CYTOMEGALOVIRUS INFECTION
The invention is related to polynucleotide-based cytomegalovirus vaccines. In particular, the invention is plasmids operably encoding HCMV antigens, in which the naturally-occurring coding regions for the HCMV antigens have been modified for improved translation in huma...
07/21/2011
20110177121Immunogenic Influenza Composition
Novel compositions useful as influenza immunogens are provided. The compositions enable a host response to immunogen sites normally not recognized by a host....
07/21/2011
20110171249Chimeric chikungunya virus and uses thereof
The present invention discloses a chimeric Chikungunya virus comprising a heterologous alphavirus cDNA fragment and a Chikungunya virus cDNA fragment. The heterologous alphavirus may include but is not limited to Sindbis virus, Eastern equine encephalitis virus or Venez...
07/14/2011
20110165226INFLUENZA CAP-LEADER SEQUENCE
The invention comprises a viral cap-leader sequence which comprises at least three bases complementary to the 3′-ultimate residues of a (−)ssRNA virus template sequence. Preferably said consensus sequence is represented by the general formula 7mG(N)6...
07/07/2011
20110165224VACCINES FOR INCLUSION BODY HEPATITIS
A composition comprising an isolated fowl adenovirus (FAdV), wherein the FAdV is a strain selected from FAdV-2, FAdV-7, FAdv-8a, FAdV-8b, FAdV-8a/8b or FAdV-11 serotype strains; and a suitable carrier and methods for inducing protective immunity in a subject and/or its ...
07/07/2011
20110165230ATTENUATED LIVE VACCINES
Disclosed is an attenuated flavivirus live vaccine comprising a flavivirus mutant, characterised in that the flavivirus mutant has a deletion in the capsid protein of at least more than 4 successive amino acids, wherein the carboxy-terminal hydrophobic region is not aff...
07/07/2011
20110159033WEST NILE VIRUS VACCINE
The invention provides for immunogenic compositions against West Nile Virus. The immunogenic compositions, in alternate embodiments, also include other equine pathogens. The West Nile Virus composition of the present invention advantageously provides for protection agai...
06/30/2011
20110150912Avian influenza virus live attenuated vaccine and uses thereof
Described in this application are attenuated strains of avian influenza virus containing temperature sensitive mutations in addition to a genetic tag in the PB1 gene. The attenuated viruses are useful as avian and mammalian vaccine for protective immunity against homolo...
06/23/2011
20110143424RECOMBINANT INFLUENZA VIRUSES FOR VACCINES AND GENE THERAPY
The invention provides compositions and methods useful to prepare segmented, negative strand RNA viruses, e.g., orthomyxoviruses such as influenza A viruses, entirely from cloned cDNAs and in the absence of helper virus....
06/16/2011
20110135682Recombinant Bicistronic Flaviviruses and Methods of Use Thereof
The present invention provides recombinant bicistronic flaviviruses, particularly live attenuated recombinant bicistronic flavivirus, which comprise, in order from 5′ to 3′, a viral 5′UTR, an ORF encoding all viral proteins, an internal ribosome entry site, an exo...
06/09/2011
20110117126ATTENUATED PESTIVIRUS
The present invention relates to recombinant attenuated pestiviruses, in particular to recombinant attenuated CSFV, BVDV, or BDV, wherein said recombinant attenuated pestivirus does not produce a dimeric Ems glycoprotein. The present invention also relates to...
05/19/2011
20110104199MVA Expressing Modified HIV Envelope, GAG, and POL Genes
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes....
05/05/2011
20110097353POULTRY VIRAL MATERIALS AND METHODS RELATED THERETO
The present invention provides materials and methods for researching poultry viruses, particularly for researching infectious bronchitis viruses in poultry. Also provided are materials and methods useful for reducing the economic impact that infectious bronchitis diseas...
04/28/2011
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