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Class 435/23 - Involving proteinase


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter where the material to be measured or tested
No. of applications: 801
Last issue date: 05/24/2012


1                      
Application No.Application TitleIssue Date
20120129201MASS SPECTROMETRY IMAGING WITH SUBSTANCE IDENTIFICATION
A method for the identification and localization of proteins or other biomolecules of a histologic tissue section comprises enzymatically digesting the biomolecules of two similar tissue sections while substantially preserving the biomolecule positions in the tissue sec... 		05/24/2012
20120129195Method of quick laboratory diagnosis if illnesses based on the discovery of specific proteins and equipment for its implementation
A method of quick laboratory diagnosis of diseases, based on the discovery of specific protein targets characteristic to the disease in the reaction of their specific interaction with other protein reagents, distinct in that specific protein targets for the given diseas... 		05/24/2012
20120129203Novel Peptidase Substrates
The present invention relates to the use of a compound of the following formula (I) for detecting a peptidase activity and/or a variation in pH:

    		05/24/2012
    20120129202COMPOSITION FOR ASSAYING GLYCATED PROTEINS
    Compositions for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) stabilizing proteases and at least enzymes acting on glycated amino acids; 3) accurately assaying albumin; and 4) assaying glycated albumin while...     		05/24/2012
    20120129782Inhibition of ApoE Cleavage Activity in the Treatment of ApoE-Related Disorders
    The present invention provides methods for treating apoE-related disorders. The methods generally involve administering an effective amount of an agent that inhibits activity of an enzyme that cleaves apoE....     		05/24/2012
    20120129175METHOD FOR RENAL DISEASE DIAGNOSIS AND PROGNOSIS USING ANNEXIN A1 AND RAB23 AS MARKERS
    Use of Annexin A1 or Rab23 as a biomarker for diagnosing kidney disease or assessing efficacy of kidney disease treatment....     		05/24/2012
    20120107855CROSSLINKING REAGENT FOR ANALYSIS OF PROTEIN-PROTEIN INTERACTION
    Crosslinking reagents and methods for using the same for analysis of protein-protein interactions, are provided. The crosslinking reagents include a trifunctional scaffold that links two protein linking groups to each other and branches to link an affinity tag, where th...     		05/03/2012
    20120107859METHODS FOR EARLY DETECTION OF BLOOD DISORDERS
    Disclosed herein are methods of detecting blood disorders, such as diabetes. In particular examples the method includes contacting a blood sample with an amine reagent, blocking an excess of the amine reagent with a blocking reagent, digesting the modified blood sample ...     		05/03/2012
    20120107344COMPOSITION FOR TREATMENT OF MENOPAUSE
    A novel herbal extract, MF101, is effective in the treatment of symptoms of menopause....     		05/03/2012
    20120107856New Fungal Production System
    The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20% of the endogenous cellulase secretion of Chrysosporium lucknowense strain...     		05/03/2012
    20120107342Ex vivo animal or challenge model as method to measure protective immunity directed against parasites and vaccines shown to be protective in the method
    Described is an ex vivo animal or challenge model used as a method to identify protective (e.g., recombinant) proteins and rapidly measure protective immunity in intestinal segments directed against parasites and vaccines directed against parasitic infections. Further d...     		05/03/2012
    20120107843ANTI BONE-LOSS AND ANTI ATTACHMENT-LOSS EFFECTS OF AN ORAL COMPOSITION
    Methods for identifying compounds useful for treating diseases and conditions of the oral cavity are described herein....     		05/03/2012
    20120107857Di- and Poly-Ubiquitin Deubiquitinase Substrates and Uses Thereof
    Methods for detection of the activity of proteolytic enzymes, particularly isopeptidases, are disclosed....     		05/03/2012
    20120107858CANCER DIAGNOSIS METHOD USING THE GLYCOSYLATION OF A GLYCOPROTEIN
    The present invention relates to a cancer diagnosis method using peptides containing information on the glycosylation of a glycoprotein involving cancer development. More particularly, the present invention relates to a cancer diagnosis method which obtains peptides fro...     		05/03/2012
    20120107834ENCAPSULATED REAGENTS AND METHODS OF USE
    The present invention contemplates use of encapsulated aqueous and non-aqueous reagents, solutions and solvents and their use in laboratory procedures. These encapsulated aqueous or non-aqueous reagents, solutions and solvents can be completely contained or encapsulated...     		05/03/2012
    20120107832METHOD FOR THE DETECTION OF ORGAN OR TISSUE INJURY
    This invention relates to methodology for detecting, assessing and/or diagnosing the presence of organ or tissue injury. More specifically, the present invention relates to methodology for detecting particular serum biomarkers that can be used in the detection, assessme...     		05/03/2012
    20120103810HIGH-SENSITIVITY PROTEOLYSIS ASSAY
    The present invention includes a highly sensitive method for detecting the presence of proteases in a sample which are present at very low levels....     		05/03/2012
    20120083011Sensitive Methods for Detecting The Presence of Cancer
    Described herein are sensitive methods for determining if a subject has cancer. The methods generally involve quantifying the amount of one or more biomarkers derived from Galectin-3 in a biological sample from the subject by mass spectrometry, wherein an increase in th...     		04/05/2012
    20120082680ANTAGONISTS OF PCSK9
    Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associa...     		04/05/2012
    20120070844Method For Quantifying Modified Peptides
    The present invention provides a method for quantifying modified peptides in a sample, the method comprising: (a) obtaining peptides from the sample; (b) adding reference modified peptides to the peptides obtained in step (a) to produce a mixture of peptides and referen...     		03/22/2012
    20120070856CROSS-LINKING AGENTS
    The invention relates to a protein cross-linking agent of the formula, where R1 is an aryl group optionally substituted once or several times by a grouping selected from the group consisting of hydroxy, C1-C4 alkyl, OBoc, SO3N...     		03/22/2012
    20120071337METHODS
    The invention provides a method for aiding the diagnosis or prognostic monitoring of Alzheimer's disease in a subject, said method comprising; providing a sample of blood obtained from said patient; assaying the amount of gelsolin present in said sample; comparing the a...     		03/22/2012
    20120070504PHARMACEUTICAL PREPARATION FOR THE TREATMENT OF THE SYMPTOMS OF ADDICTION AND METHOD OF DIAGNOSING SAME
    A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therapeutic...     		03/22/2012
    20120052051METHOD OF TREATING DIABETES - RELATED VASCULAR COMPLICATIONS
    The method of treating diabetes-related vascular complications includes the treatment of diabetic patients with α-lipoic acid (LA) in order to mitigate the negative impact of diabetes-related vascular dysfunctions upon vascular homeostasis. The treatment method include...     		03/01/2012
    20120052506CYANINE DYES
    The invention provides a novel class of cyanine dyes that are functionalized with sulfonic acid groups and a linker moiety that facilitates their conjugation to other species and substituent groups which increase the water-solubility, and optimize the optical properties...     		03/01/2012
    20120053080PROTEIN MARKERS IDENTIFICATION FOR GASTRIC CANCER DIAGNOSIS
    Methods for detecting cancer as well as methods of diagnosis of cancer by detecting proteins secreted into biological fluids are disclosed The invention was first applied to detecting proteins secreted into serum and urine However, it is understood that the methods have...     		03/01/2012
    20120045777NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES
    The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The inv...     		02/23/2012
    20120045474Substrate peptide sequences for plague plasminogen activator and uses thereof
    The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla...     		02/23/2012
    20120040995DESIGN, SYNTHESIS AND EVALUATION OF PROCASPASE ACTIVATING COMPOUNDS AS PERSONALIZED ANTI-CANCER DRUGS
    Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction ...     		02/16/2012
    20120040389METHOD FOR DEMONSTRATION OF A MOLECULAR EVENT IN A CELL BY MEANS OF FLUORESCENT MARKER PROTEINS
    The invention relates to a method for demonstration of the occurrence of a molecular event, particularly in a cell, characterised by the detection of the ‘solubilisation’ of a fixed protein marker (or the fixing of a solubilised protein marker) which is a direct or ...     		02/16/2012
    20120034240PERLECAN AS A BIOMARKER FOR RENAL DYSFUNCTION
    The application discloses PERLECAN as a new biomarker for renal dysfunction; methods for predicting, diagnosing, prognosticating and/or monitoring said dysfunction based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing sai...     		02/09/2012
    20120034210COMPOSITIONS FOR POTENTIATING APOPOSIS SIGNALS IN TUMOUR CELLS
    The present invention concerns a composition for potentiating formation of DISC (Death Inducing Signaling Complex) macro-complex and for inducing apoptotic signal mediated by death receptors in tumour cells comprising a therapeutically effective amount of an active agen...     		02/09/2012
    20120034619METHOD OF DETERMINING THE OLIGOMERIC STATE OF A PROTEIN COMPLEX
    A method of counting protein subunits to determine the oligomeric state of an oligomeric protein complex includes tagging and expressing the protein subunits with a mass/charge tag and selectively removing each mass/charge tag. The number of protein subunits of the olig...     		02/09/2012
    20120034638Electrochemical assay for the detection of enzymatically active PSA
    The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples....     		02/09/2012
    20120035179MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
    The present invention provides compounds of Formula I useful as modulators of ABC transporter activity,

    or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD...

    		02/09/2012
    20120028266DISCOVERY OF CANDIDATE BIOMARKERS OF IN VIVO APOPTOSIS BY GLOBAL PROFILING OF CASPASE CLEAVAGE SITES
    The present invention relates to the discovery of novel biomarkers of in vivo apoptosis based on a large number of caspase-like cleavage sites. These biomarkers are useful for detection and quantification of apoptosis in a biological sample. The invention also provides ...     		02/02/2012
    20120028285Clickable cross-linker
    A clickable cross-linker compound provides an easily scanned reporter ion for effective and efficient cross-linking and identification of intermolecular and intramolecular interactions of proteins and peptides....     		02/02/2012
    20120028286METHOD FOR EVALUATING THE BREAKDOWN OF PROTEINS, POLYPEPTIDES AND PEPTIDES
    Provided is an assay for determining the protein, polypeptide, and peptides degradation of a sample. The assay for determining the protein, polypeptide, and peptides degradation of a sample includes contacting the sample with a non-fluorescent compound whereby the non-f...     		02/02/2012
    20120021923METHODS AND SYSTEMS TO DIAGNOSE A CONDITION IN AN INDIVIDUAL
    Provided herein are a method and system to detect an active protease in a sample, and related methods and systems to diagnose a condition in an individual, the condition being associated to abnormal protease activity in the individual....     		01/26/2012
    20120021925DIAGNOSTIC ASSAYS FOR PROSTATE CANCER USING PSP94 AND PSA BIOMARKERS
    The application refers to a method for diagnosing prostate cancer through the measurement of the combination of PSP94 (β-microseminoprotein) and F/T PSA biomarkers, the method using urine samples to measure PSP94 and serum samples to analyse F/T PSA. In one embodiment,...     		01/26/2012
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